High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
Identifieur interne : 005689 ( Ncbi/Merge ); précédent : 005688; suivant : 005690High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
Auteurs : Tommaso Cutilli ; Secondo Scarsella ; Desiderio Di Fabio ; Antonio Oliva ; Pasqualino CarginiSource :
- Annals of Maxillofacial Surgery [ 2231-0746 ] ; 2011.
Abstract
Osteosarcomas (OS) are extremely uncommon in maxillofacial region (6%-10% of all sarcomas). Jaw lesions are diagnosed on average two decades later than sarcomas of long bone, with a peak incidence between 20 and 40 years. Head and neck OS (HNOS) are associated with a lower metastatic rate than long bone OS, and they have a better 5-year survival rate, ranging between 27% and 84%. Approximately 80% of HNOS originate from soft tissues, while 20% arise from bone. The majority of OS were classified as osteoblastic HNOS (77.0%), followed by chondroblastic (15.8%) and fibroblastic (3.4%). Patients older than 60 years were more likely to be diagnosed with other histologic types compared with patients 60 years or younger. The authors describe a rare case of Stage II high-grade mixed chondroblastic and fibroblastic osteosarcoma of the upper jaw diagnosed in a subject older than 60 years. CT i.e., total body scintigraphy, radiograph of chest, and epathic ultrasonography have been executed to staging (T3N0M0). The size of the tumor >6 cm, histopathological findings, and patient older than 60 years, made necessary a multimodality therapy. Surgery (right subtotal maxillectomy with closure of surgical area by local sliding and advanced cheek flap) and adjuvant radiotherapy (for overall 6500 Gy) were the definitive treatment. Follow-up at 2 years shows no local recurrence and the patient is disease free.
Url:
DOI: 10.4103/2231-0746.92790
PubMed: 23482406
PubMed Central: 3591009
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Italy</nlm:aff><wicri:noCountry code="subfield">University of L’Aquila - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Scarsella, Secondo" sort="Scarsella, Secondo" uniqKey="Scarsella S" first="Secondo" last="Scarsella">Secondo Scarsella</name><affiliation><nlm:aff id="aff1">Health Sciences Department Maxillofacial Surgery, University of L’Aquila - Italy</nlm:aff><wicri:noCountry code="subfield">University of L’Aquila - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Fabio, Desiderio Di" sort="Fabio, Desiderio Di" uniqKey="Fabio D" first="Desiderio Di" last="Fabio">Desiderio Di Fabio</name><affiliation><nlm:aff id="aff1">Health Sciences Department Maxillofacial Surgery, University of L’Aquila - Italy</nlm:aff><wicri:noCountry code="subfield">University of L’Aquila - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Oliva, Antonio" sort="Oliva, Antonio" uniqKey="Oliva A" first="Antonio" last="Oliva">Antonio Oliva</name><affiliation><nlm:aff id="aff1">Health Sciences Department Maxillofacial Surgery, University of L’Aquila - Italy</nlm:aff><wicri:noCountry code="subfield">University of L’Aquila - Italy</wicri:noCountry></affiliation></author><author><name sortKey="Cargini, Pasqualino" sort="Cargini, Pasqualino" uniqKey="Cargini P" first="Pasqualino" last="Cargini">Pasqualino Cargini</name><affiliation><nlm:aff id="aff1">Health Sciences Department Maxillofacial Surgery, University of L’Aquila - Italy</nlm:aff><wicri:noCountry code="subfield">University of L’Aquila - Italy</wicri:noCountry></affiliation></author></analytic><series><title level="j">Annals of Maxillofacial Surgery</title><idno type="ISSN">2231-0746</idno><idno type="eISSN">2249-3816</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Osteosarcomas (OS) are extremely uncommon in maxillofacial region (6%-10% of all sarcomas). Jaw lesions are diagnosed on average two decades later than sarcomas of long bone, with a peak incidence between 20 and 40 years. Head and neck OS (HNOS) are associated with a lower metastatic rate than long bone OS, and they have a better 5-year survival rate, ranging between 27% and 84%. Approximately 80% of HNOS originate from soft tissues, while 20% arise from bone. The majority of OS were classified as osteoblastic HNOS (77.0%), followed by chondroblastic (15.8%) and fibroblastic (3.4%). Patients older than 60 years were more likely to be diagnosed with other histologic types compared with patients 60 years or younger. The authors describe a rare case of Stage II high-grade mixed chondroblastic and fibroblastic osteosarcoma of the upper jaw diagnosed in a subject older than 60 years. CT i.e., total body scintigraphy, radiograph of chest, and epathic ultrasonography have been executed to staging (T3N0M0). The size of the tumor >6 cm, histopathological findings, and patient older than 60 years, made necessary a multimodality therapy. Surgery (right subtotal maxillectomy with closure of surgical area by local sliding and advanced cheek flap) and adjuvant radiotherapy (for overall 6500 Gy) were the definitive treatment. Follow-up at 2 years shows no local recurrence and the patient is disease free.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kassir, Rr" uniqKey="Kassir R">RR Kassir</name></author><author><name sortKey="Rassekh, Ch" uniqKey="Rassekh C">CH Rassekh</name></author><author><name sortKey="Kinsella, Jb" uniqKey="Kinsella J">JB Kinsella</name></author><author><name sortKey="Segas, J" uniqKey="Segas J">J Segas</name></author><author><name sortKey="Carrau, Rl" uniqKey="Carrau R">RL Carrau</name></author><author><name sortKey="Hokanson, Ja" uniqKey="Hokanson J">JA Hokanson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandes, R" uniqKey="Fernandes R">R Fernandes</name></author><author><name sortKey="Nikitakis, Ng" uniqKey="Nikitakis N">NG Nikitakis</name></author><author><name sortKey="Pazoki, A" uniqKey="Pazoki A">A Pazoki</name></author><author><name sortKey="Ord, Ra" uniqKey="Ord R">RA 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Maxillofac Surg</journal-id><journal-id journal-id-type="iso-abbrev">Ann Maxillofac Surg</journal-id><journal-id journal-id-type="publisher-id">AMS</journal-id><journal-title-group><journal-title>Annals of Maxillofacial Surgery</journal-title></journal-title-group><issn pub-type="ppub">2231-0746</issn><issn pub-type="epub">2249-3816</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23482406</article-id><article-id pub-id-type="pmc">3591009</article-id><article-id pub-id-type="publisher-id">AMS-1-176</article-id><article-id pub-id-type="doi">10.4103/2231-0746.92790</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report - Surgical Pathology</subject></subj-group></article-categories><title-group><article-title>High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cutilli</surname><given-names>Tommaso</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Scarsella</surname><given-names>Secondo</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Fabio</surname><given-names>Desiderio Di</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Oliva</surname><given-names>Antonio</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Cargini</surname><given-names>Pasqualino</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1">Health Sciences Department Maxillofacial Surgery, University of L’Aquila - Italy</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Prof. Tommaso Cutilli, via della Comunità Europea, 13, L’Aquila-Italy. E-mail: <email xlink:href="tommaso.cutilli@alice.it">tommaso.cutilli@alice.it</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jul-Dec</season><year>2011</year></pub-date><volume>1</volume><issue>2</issue><fpage>176</fpage><lpage>180</lpage><permissions><copyright-statement>Copyright: © Annals of Maxillofacial Surgery</copyright-statement><copyright-year>2011</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Osteosarcomas (OS) are extremely uncommon in maxillofacial region (6%-10% of all sarcomas). Jaw lesions are diagnosed on average two decades later than sarcomas of long bone, with a peak incidence between 20 and 40 years. Head and neck OS (HNOS) are associated with a lower metastatic rate than long bone OS, and they have a better 5-year survival rate, ranging between 27% and 84%. Approximately 80% of HNOS originate from soft tissues, while 20% arise from bone. The majority of OS were classified as osteoblastic HNOS (77.0%), followed by chondroblastic (15.8%) and fibroblastic (3.4%). Patients older than 60 years were more likely to be diagnosed with other histologic types compared with patients 60 years or younger. The authors describe a rare case of Stage II high-grade mixed chondroblastic and fibroblastic osteosarcoma of the upper jaw diagnosed in a subject older than 60 years. CT i.e., total body scintigraphy, radiograph of chest, and epathic ultrasonography have been executed to staging (T3N0M0). The size of the tumor >6 cm, histopathological findings, and patient older than 60 years, made necessary a multimodality therapy. Surgery (right subtotal maxillectomy with closure of surgical area by local sliding and advanced cheek flap) and adjuvant radiotherapy (for overall 6500 Gy) were the definitive treatment. Follow-up at 2 years shows no local recurrence and the patient is disease free.</p></abstract><kwd-group><kwd>Maxilla</kwd><kwd>osteosarcoma</kwd><kwd>surgery</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Cargini, Pasqualino" sort="Cargini, Pasqualino" uniqKey="Cargini P" first="Pasqualino" last="Cargini">Pasqualino Cargini</name><name sortKey="Cutilli, Tommaso" sort="Cutilli, Tommaso" uniqKey="Cutilli T" first="Tommaso" last="Cutilli">Tommaso Cutilli</name><name sortKey="Fabio, Desiderio Di" sort="Fabio, Desiderio Di" uniqKey="Fabio D" first="Desiderio Di" last="Fabio">Desiderio Di Fabio</name><name sortKey="Oliva, Antonio" sort="Oliva, Antonio" uniqKey="Oliva A" first="Antonio" last="Oliva">Antonio Oliva</name><name sortKey="Scarsella, Secondo" sort="Scarsella, Secondo" uniqKey="Scarsella S" first="Secondo" last="Scarsella">Secondo Scarsella</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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