Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
Identifieur interne : 005685 ( Ncbi/Merge ); précédent : 005684; suivant : 005686Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
Auteurs : Jean-Leon Thomas ; Kasey Baker ; Jinah Han ; Charles Calvo ; Harri Nurmi ; Anne C. Eichmann ; Kari Alitalo [Finlande]Source :
- Cellular and molecular life sciences : CMLS [ 1420-682X ] ; 2013.
Abstract
Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.
Url:
DOI: 10.1007/s00018-013-1312-6
PubMed: 23479133
PubMed Central: 3648205
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PMC:3648205Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9705402</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20436</journal-id>
<journal-id journal-id-type="nlm-ta">Cell Mol Life Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Cell. Mol. Life Sci.</journal-id>
<journal-title-group><journal-title>Cellular and molecular life sciences : CMLS</journal-title>
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<article-id pub-id-type="manuscript">NIHMS454940</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Thomas</surname>
<given-names>Jean-Leon</given-names>
</name>
<aff id="A1">Department of Neurology, Yale University School of Medicine, New Haven, CT 06510-3221, USA. Université Pierre and Marie Curie–Paris 6, CRICM, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France. INSERM, UMRS 975, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France. APHP, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France</aff>
<email>jean-leon.thomas@yale.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Baker</surname>
<given-names>Kasey</given-names>
</name>
<aff id="A2">Department of Cardiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA</aff>
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<contrib contrib-type="author"><name><surname>Han</surname>
<given-names>Jinah</given-names>
</name>
<aff id="A3">Department of Cardiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Calvo</surname>
<given-names>Charles</given-names>
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<aff id="A4">Université Pierre and Marie Curie–Paris 6, CRICM, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France. INSERM, UMRS 975, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France. APHP, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Nurmi</surname>
<given-names>Harri</given-names>
</name>
<aff id="A5">Wihuri Institute and Molecular Molecular/Cancer Biology Laboratory, Biomedicum Helsinki and Department of Pathology Haartman Institute, University of Helsinki, Helsinki, Finland</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Eichmann</surname>
<given-names>Anne C.</given-names>
</name>
<aff id="A6">Department of Cardiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA. CNRS/UMR, Center for Interdisciplinary Research in Biology, 7241-INSERM U1050, Collège de France, 75005 Paris, France</aff>
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<contrib contrib-type="author"><name><surname>Alitalo</surname>
<given-names>Kari</given-names>
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<aff id="A7">Wihuri Institute and Molecular Molecular/Cancer Biology Laboratory, Biomedicum Helsinki and Department of Pathology Haartman Institute, University of Helsinki, Helsinki, Finland</aff>
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<pub-date pub-type="nihms-submitted"><day>18</day>
<month>4</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>12</day>
<month>3</month>
<year>2013</year>
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<pub-date pub-type="ppub"><month>5</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>5</month>
<year>2014</year>
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<volume>70</volume>
<issue>10</issue>
<fpage>1779</fpage>
<lpage>1792</lpage>
<permissions><copyright-statement>© Springer Basel 2013</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p id="P1">Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.</p>
</abstract>
<kwd-group><kwd>Angiogenesis</kwd>
<kwd>Neurogenesis</kwd>
<kwd>Neurovascular interactions</kwd>
<kwd>Notch</kwd>
<kwd>VEGFs</kwd>
<kwd>VEGFRs</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source>
<award-id>R01 HL111504 || HL</award-id>
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