Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries.
Identifieur interne : 005530 ( Ncbi/Merge ); précédent : 005529; suivant : 005531Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries.
Auteurs : Marek Stanczyk [Pologne] ; Magdalena Gewartowska ; Marcin Swierkowski ; Bartlomiej Grala ; Marek MaruszynskiSource :
- Chinese medical journal [ 0366-6999 ] ; 2013.
Descripteurs français
- KwdFr :
- Femelle, Humains, Hémangiosarcome (), Hémangiosarcome (anatomopathologie), Hémangiosarcome (traitement médicamenteux), Immunohistochimie, Lymphangiogenèse, Lymphangiosarcome (), Lymphangiosarcome (anatomopathologie), Lymphangiosarcome (traitement médicamenteux), Lymphographie, Microscopie confocale, Phénotype, Sujet âgé, Vaisseaux lymphatiques (anatomopathologie).
- MESH :
- anatomopathologie : Hémangiosarcome, Lymphangiosarcome, Vaisseaux lymphatiques.
- traitement médicamenteux : Hémangiosarcome, Lymphangiosarcome.
- Femelle, Humains, Hémangiosarcome, Immunohistochimie, Lymphangiogenèse, Lymphangiosarcome, Lymphographie, Microscopie confocale, Phénotype, Sujet âgé.
English descriptors
- KwdEn :
- Aged, Female, Hemangiosarcoma (blood supply), Hemangiosarcoma (drug therapy), Hemangiosarcoma (pathology), Humans, Immunohistochemistry, Lymphangiogenesis, Lymphangiosarcoma (blood supply), Lymphangiosarcoma (drug therapy), Lymphangiosarcoma (pathology), Lymphatic Vessels (pathology), Lymphography, Microscopy, Confocal, Phenotype.
- MESH :
- blood supply : Hemangiosarcoma, Lymphangiosarcoma.
- drug therapy : Hemangiosarcoma, Lymphangiosarcoma.
- pathology : Hemangiosarcoma, Lymphangiosarcoma, Lymphatic Vessels.
- Aged, Female, Humans, Immunohistochemistry, Lymphangiogenesis, Lymphography, Microscopy, Confocal, Phenotype.
Abstract
The development of angiosarcoma in oedematous tissue is referred to as Stewart-Treves syndrome (STS). This rare and fatal complication is associated with chronic post mastectomy lymphoedema and radiotherapy for breast cancer. Angiosarcoma spread is facilitated by the formation of blood vessels (angiogenesis) and lymph vessels (lymphangiogenesis). In the future antiangiogenic therapy may improve the poor outcome of current treatments. There was evidence that blocking the angiogenenesis would inhibit progression of angiosarcoma. It seems reasonable to hypothesize that blocking the lymphangiogenesis may yield similar results. Although angiosarcomas commonly derive from blood vessels, in case of STS angiosarcomas chronic lymphoedema may suggest its lymphatic origin. The goal of this study was to visualize interstitial space and lymphatics in the central and peripheral regions of STS angiosarcoma.
PubMed: 23324269
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries.</title><author><name sortKey="Stanczyk, Marek" sort="Stanczyk, Marek" uniqKey="Stanczyk M" first="Marek" last="Stanczyk">Marek Stanczyk</name><affiliation wicri:level="1"><nlm:affiliation>Department of General, Oncologic and Vascular Surgery, Military Health Service Institute, Warsaw, Poland. stanczyk@poczta.onet.pl</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of General, Oncologic and Vascular Surgery, Military Health Service Institute, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Gewartowska, Magdalena" sort="Gewartowska, Magdalena" uniqKey="Gewartowska M" first="Magdalena" last="Gewartowska">Magdalena Gewartowska</name></author><author><name sortKey="Swierkowski, Marcin" sort="Swierkowski, Marcin" uniqKey="Swierkowski M" first="Marcin" last="Swierkowski">Marcin Swierkowski</name></author><author><name sortKey="Grala, Bartlomiej" sort="Grala, Bartlomiej" uniqKey="Grala B" first="Bartlomiej" last="Grala">Bartlomiej Grala</name></author><author><name sortKey="Maruszynski, Marek" sort="Maruszynski, Marek" uniqKey="Maruszynski M" first="Marek" last="Maruszynski">Marek Maruszynski</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23324269</idno><idno type="pmid">23324269</idno><idno type="wicri:Area/PubMed/Corpus">001D50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D50</idno><idno type="wicri:Area/PubMed/Curation">001D50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D50</idno><idno type="wicri:Area/PubMed/Checkpoint">001D50</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D50</idno><idno type="wicri:Area/Ncbi/Merge">005530</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries.</title><author><name sortKey="Stanczyk, Marek" sort="Stanczyk, Marek" uniqKey="Stanczyk M" first="Marek" last="Stanczyk">Marek Stanczyk</name><affiliation wicri:level="1"><nlm:affiliation>Department of General, Oncologic and Vascular Surgery, Military Health Service Institute, Warsaw, Poland. stanczyk@poczta.onet.pl</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of General, Oncologic and Vascular Surgery, Military Health Service Institute, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Gewartowska, Magdalena" sort="Gewartowska, Magdalena" uniqKey="Gewartowska M" first="Magdalena" last="Gewartowska">Magdalena Gewartowska</name></author><author><name sortKey="Swierkowski, Marcin" sort="Swierkowski, Marcin" uniqKey="Swierkowski M" first="Marcin" last="Swierkowski">Marcin Swierkowski</name></author><author><name sortKey="Grala, Bartlomiej" sort="Grala, Bartlomiej" uniqKey="Grala B" first="Bartlomiej" last="Grala">Bartlomiej Grala</name></author><author><name sortKey="Maruszynski, Marek" sort="Maruszynski, Marek" uniqKey="Maruszynski M" first="Marek" last="Maruszynski">Marek Maruszynski</name></author></analytic><series><title level="j">Chinese medical journal</title><idno type="ISSN">0366-6999</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Hemangiosarcoma (blood supply)</term><term>Hemangiosarcoma (drug therapy)</term><term>Hemangiosarcoma (pathology)</term><term>Humans</term><term>Immunohistochemistry</term><term>Lymphangiogenesis</term><term>Lymphangiosarcoma (blood supply)</term><term>Lymphangiosarcoma (drug therapy)</term><term>Lymphangiosarcoma (pathology)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphography</term><term>Microscopy, Confocal</term><term>Phenotype</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Hémangiosarcome ()</term><term>Hémangiosarcome (anatomopathologie)</term><term>Hémangiosarcome (traitement médicamenteux)</term><term>Immunohistochimie</term><term>Lymphangiogenèse</term><term>Lymphangiosarcome ()</term><term>Lymphangiosarcome (anatomopathologie)</term><term>Lymphangiosarcome (traitement médicamenteux)</term><term>Lymphographie</term><term>Microscopie confocale</term><term>Phénotype</term><term>Sujet âgé</term><term>Vaisseaux lymphatiques (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hémangiosarcome</term><term>Lymphangiosarcome</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Hemangiosarcoma</term><term>Lymphangiosarcoma</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hemangiosarcoma</term><term>Lymphangiosarcoma</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hemangiosarcoma</term><term>Lymphangiosarcoma</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémangiosarcome</term><term>Lymphangiosarcome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Lymphangiogenesis</term><term>Lymphography</term><term>Microscopy, Confocal</term><term>Phenotype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Hémangiosarcome</term><term>Immunohistochimie</term><term>Lymphangiogenèse</term><term>Lymphangiosarcome</term><term>Lymphographie</term><term>Microscopie confocale</term><term>Phénotype</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The development of angiosarcoma in oedematous tissue is referred to as Stewart-Treves syndrome (STS). This rare and fatal complication is associated with chronic post mastectomy lymphoedema and radiotherapy for breast cancer. Angiosarcoma spread is facilitated by the formation of blood vessels (angiogenesis) and lymph vessels (lymphangiogenesis). In the future antiangiogenic therapy may improve the poor outcome of current treatments. There was evidence that blocking the angiogenenesis would inhibit progression of angiosarcoma. It seems reasonable to hypothesize that blocking the lymphangiogenesis may yield similar results. Although angiosarcomas commonly derive from blood vessels, in case of STS angiosarcomas chronic lymphoedema may suggest its lymphatic origin. The goal of this study was to visualize interstitial space and lymphatics in the central and peripheral regions of STS angiosarcoma.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23324269</PMID><DateCreated><Year>2013</Year><Month>01</Month><Day>17</Day></DateCreated><DateCompleted><Year>2013</Year><Month>12</Month><Day>27</Day></DateCompleted><DateRevised><Year>2013</Year><Month>01</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0366-6999</ISSN><JournalIssue CitedMedium="Internet"><Volume>126</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Chinese medical journal</Title><ISOAbbreviation>Chin. Med. J.</ISOAbbreviation></Journal><ArticleTitle>Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries.</ArticleTitle><Pagination><MedlinePgn>231-7</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The development of angiosarcoma in oedematous tissue is referred to as Stewart-Treves syndrome (STS). This rare and fatal complication is associated with chronic post mastectomy lymphoedema and radiotherapy for breast cancer. Angiosarcoma spread is facilitated by the formation of blood vessels (angiogenesis) and lymph vessels (lymphangiogenesis). In the future antiangiogenic therapy may improve the poor outcome of current treatments. There was evidence that blocking the angiogenenesis would inhibit progression of angiosarcoma. It seems reasonable to hypothesize that blocking the lymphangiogenesis may yield similar results. Although angiosarcomas commonly derive from blood vessels, in case of STS angiosarcomas chronic lymphoedema may suggest its lymphatic origin. The goal of this study was to visualize interstitial space and lymphatics in the central and peripheral regions of STS angiosarcoma.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">On tissue samples obtained from STS angiosarcoma we have performed: first colour stereoscopic lymphography to visualise the morphology of lymphatic vessels and extracellular spaces, second immunohistochemical staining specific for lymphatic vessels endothelium (LYVE-1) and blood endothelial cells (CD31, factor VIII) and prolymphangiogenic vascular endothelial growth factor (VEGF-C) for precise identification of lymphatic endothelia. STS angiosarcoma morphology was assessed by comparison of pictures obtained on lymphography, microscopy and confocal microscopy.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">STS angiosarcomas present heterogenous morphology with areas dominated by hemangiosarcoma and lymphangiosarcoma structures. STS angiosarcoma expressed phenotypes of both blood and lymphatic endothelia. LYVE-1 and VEGF-C is expressed by STS angiosarcoma and may be used to discriminate tumour differentiation. Morphology of lymphatic vessels and spaces in the tumour suggest absence of their normal lymphatic function.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our results confirmed both hemangio- and lymphangiogenic origin of STS angiosarcoma. Expression of VEGF-C makes STS angiosarcoma a good candidate for targeted antilymphangiogenic therapy. However, morphology of intratumoral lymphatics on colour lymphography suggested their impaired function, which can hamper drug distribution.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stanczyk</LastName><ForeName>Marek</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of General, Oncologic and Vascular Surgery, Military Health Service Institute, Warsaw, Poland. stanczyk@poczta.onet.pl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gewartowska</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Swierkowski</LastName><ForeName>Marcin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Grala</LastName><ForeName>Bartlomiej</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Maruszynski</LastName><ForeName>Marek</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Chin Med J (Engl)</MedlineTA><NlmUniqueID>7513795</NlmUniqueID><ISSNLinking>0366-6999</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C537491">Stewart Treves syndrome</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006394" MajorTopicYN="N">Hemangiosarcoma</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008204" MajorTopicYN="N">Lymphangiosarcoma</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008220" MajorTopicYN="N">Lymphography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018613" MajorTopicYN="N">Microscopy, Confocal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>12</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23324269</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pologne</li></country></list><tree><noCountry><name sortKey="Gewartowska, Magdalena" sort="Gewartowska, Magdalena" uniqKey="Gewartowska M" first="Magdalena" last="Gewartowska">Magdalena Gewartowska</name><name sortKey="Grala, Bartlomiej" sort="Grala, Bartlomiej" uniqKey="Grala B" first="Bartlomiej" last="Grala">Bartlomiej Grala</name><name sortKey="Maruszynski, Marek" sort="Maruszynski, Marek" uniqKey="Maruszynski M" first="Marek" last="Maruszynski">Marek Maruszynski</name><name sortKey="Swierkowski, Marcin" sort="Swierkowski, Marcin" uniqKey="Swierkowski M" first="Marcin" last="Swierkowski">Marcin Swierkowski</name></noCountry><country name="Pologne"><noRegion><name sortKey="Stanczyk, Marek" sort="Stanczyk, Marek" uniqKey="Stanczyk M" first="Marek" last="Stanczyk">Marek Stanczyk</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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