Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)
Identifieur interne : 005415 ( Ncbi/Merge ); précédent : 005414; suivant : 005416Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)
Auteurs : Caroline Biver-Dalle [France] ; Eve Puzenat [France] ; Marc Puyraveau [France] ; Delphine Delroeux [France] ; Hatem Boulahdour [France] ; Frances Sheppard [France] ; Fabien Pelletier [France] ; Philippe Humbert [France] ; François Aubin [France]Source :
- BMC Dermatology [ 1471-5945 ] ; 2012.
Abstract
Since the introduction of sentinel lymph node biopsy (SLNB), its use as a standard of care for patients with clinically node-negative cutaneous melanoma remains controversial. We wished to evaluate our experience of SLNB for melanoma.
A single center observational cohort of 203 melanoma patients with a primary cutaneous melanoma (tumour thickness > 1 mm) and without clinical evidence of metastasis was investigated from 2002 to 2009. Head and neck melanoma were excluded. SLN was identified following preoperative lymphoscintigraphy and intraoperative gamma probe interrogation.
The SLN identification rate was 97%. The SLN was tumor positive in 44 patients (22%). Positive SLN was significantly associated with primary tumor thickness and microscopic ulceration. The median follow-up was 39.5 (5–97) months. Disease progression was significantly more frequent in SLN positive patients (32% vs 13%, p = 0.002). Five-year DFS and OS of the entire cohort were 79.6% and 84.6%, respectively, with a statistical significant difference between SLN positive (58.7% and 69.7%) and SLN negative (85% and 90.3%) patients (p = 0.0006 and p = 0.0096 respectively). Postoperative complications after SLNB were observed in 12% of patients.
Our data confirm previous studies and support the clinical usefulness of SLNB as a reliable and accurate staging method in patients with cutaneous melanoma. However, the benefit of additional CLND in patients with positive SLN remains to be demonstrated.
Url:
DOI: 10.1186/1471-5945-12-21
PubMed: 23228015
PubMed Central: 3538072
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002A61
- to stream Pmc, to step Curation: 002A60
- to stream Pmc, to step Checkpoint: 002706
Links to Exploration step
PMC:3538072Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)</title>
<author><name sortKey="Biver Dalle, Caroline" sort="Biver Dalle, Caroline" uniqKey="Biver Dalle C" first="Caroline" last="Biver-Dalle">Caroline Biver-Dalle</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puzenat, Eve" sort="Puzenat, Eve" uniqKey="Puzenat E" first="Eve" last="Puzenat">Eve Puzenat</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puyraveau, Marc" sort="Puyraveau, Marc" uniqKey="Puyraveau M" first="Marc" last="Puyraveau">Marc Puyraveau</name>
<affiliation wicri:level="3"><nlm:aff id="I2">Clinical Methodology Center, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinical Methodology Center, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delroeux, Delphine" sort="Delroeux, Delphine" uniqKey="Delroeux D" first="Delphine" last="Delroeux">Delphine Delroeux</name>
<affiliation wicri:level="3"><nlm:aff id="I3">Department of Digestive Surgery, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Digestive Surgery, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boulahdour, Hatem" sort="Boulahdour, Hatem" uniqKey="Boulahdour H" first="Hatem" last="Boulahdour">Hatem Boulahdour</name>
<affiliation wicri:level="3"><nlm:aff id="I4">Department of Nuclear Medicine, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Nuclear Medicine, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sheppard, Frances" sort="Sheppard, Frances" uniqKey="Sheppard F" first="Frances" last="Sheppard">Frances Sheppard</name>
<affiliation wicri:level="3"><nlm:aff id="I2">Clinical Methodology Center, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinical Methodology Center, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pelletier, Fabien" sort="Pelletier, Fabien" uniqKey="Pelletier F" first="Fabien" last="Pelletier">Fabien Pelletier</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I5">University of Franche Comté, UMR1098, SFR FED4234, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Franche Comté, UMR1098, SFR FED4234, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Humbert, Philippe" sort="Humbert, Philippe" uniqKey="Humbert P" first="Philippe" last="Humbert">Philippe Humbert</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I5">University of Franche Comté, UMR1098, SFR FED4234, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Franche Comté, UMR1098, SFR FED4234, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aubin, Francois" sort="Aubin, Francois" uniqKey="Aubin F" first="François" last="Aubin">François Aubin</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I6">University of Franche Comté, EA3181, SFR FED4234, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Franche Comté, EA3181, SFR FED4234, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I7">Service de Dermatologie, 2 Place Saint-Jacques, 25030, Besançon, cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Dermatologie, 2 Place Saint-Jacques, 25030, Besançon, cedex</wicri:regionArea>
<wicri:noRegion>cedex</wicri:noRegion>
<wicri:noRegion>cedex</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23228015</idno>
<idno type="pmc">3538072</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538072</idno>
<idno type="RBID">PMC:3538072</idno>
<idno type="doi">10.1186/1471-5945-12-21</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">002A61</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A61</idno>
<idno type="wicri:Area/Pmc/Curation">002A60</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A60</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002706</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002706</idno>
<idno type="wicri:Area/Ncbi/Merge">005415</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)</title>
<author><name sortKey="Biver Dalle, Caroline" sort="Biver Dalle, Caroline" uniqKey="Biver Dalle C" first="Caroline" last="Biver-Dalle">Caroline Biver-Dalle</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puzenat, Eve" sort="Puzenat, Eve" uniqKey="Puzenat E" first="Eve" last="Puzenat">Eve Puzenat</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puyraveau, Marc" sort="Puyraveau, Marc" uniqKey="Puyraveau M" first="Marc" last="Puyraveau">Marc Puyraveau</name>
<affiliation wicri:level="3"><nlm:aff id="I2">Clinical Methodology Center, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinical Methodology Center, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delroeux, Delphine" sort="Delroeux, Delphine" uniqKey="Delroeux D" first="Delphine" last="Delroeux">Delphine Delroeux</name>
<affiliation wicri:level="3"><nlm:aff id="I3">Department of Digestive Surgery, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Digestive Surgery, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boulahdour, Hatem" sort="Boulahdour, Hatem" uniqKey="Boulahdour H" first="Hatem" last="Boulahdour">Hatem Boulahdour</name>
<affiliation wicri:level="3"><nlm:aff id="I4">Department of Nuclear Medicine, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Nuclear Medicine, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sheppard, Frances" sort="Sheppard, Frances" uniqKey="Sheppard F" first="Frances" last="Sheppard">Frances Sheppard</name>
<affiliation wicri:level="3"><nlm:aff id="I2">Clinical Methodology Center, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinical Methodology Center, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pelletier, Fabien" sort="Pelletier, Fabien" uniqKey="Pelletier F" first="Fabien" last="Pelletier">Fabien Pelletier</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I5">University of Franche Comté, UMR1098, SFR FED4234, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Franche Comté, UMR1098, SFR FED4234, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Humbert, Philippe" sort="Humbert, Philippe" uniqKey="Humbert P" first="Philippe" last="Humbert">Philippe Humbert</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I5">University of Franche Comté, UMR1098, SFR FED4234, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Franche Comté, UMR1098, SFR FED4234, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aubin, Francois" sort="Aubin, Francois" uniqKey="Aubin F" first="François" last="Aubin">François Aubin</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Dermatology, Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I6">University of Franche Comté, EA3181, SFR FED4234, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Franche Comté, EA3181, SFR FED4234, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I7">Service de Dermatologie, 2 Place Saint-Jacques, 25030, Besançon, cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Dermatologie, 2 Place Saint-Jacques, 25030, Besançon, cedex</wicri:regionArea>
<wicri:noRegion>cedex</wicri:noRegion>
<wicri:noRegion>cedex</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Dermatology</title>
<idno type="eISSN">1471-5945</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Since the introduction of sentinel lymph node biopsy (SLNB), its use as a standard of care for patients with clinically node-negative cutaneous melanoma remains controversial. We wished to evaluate our experience of SLNB for melanoma.</p>
</sec>
<sec><title>Methods</title>
<p>A single center observational cohort of 203 melanoma patients with a primary cutaneous melanoma (tumour thickness > 1 mm) and without clinical evidence of metastasis was investigated from 2002 to 2009. Head and neck melanoma were excluded. SLN was identified following preoperative lymphoscintigraphy and intraoperative gamma probe interrogation.</p>
</sec>
<sec><title>Results</title>
<p>The SLN identification rate was 97%. The SLN was tumor positive in 44 patients (22%). Positive SLN was significantly associated with primary tumor thickness and microscopic ulceration. The median follow-up was 39.5 (5–97) months. Disease progression was significantly more frequent in SLN positive patients (32% vs 13%, p = 0.002). Five-year DFS and OS of the entire cohort were 79.6% and 84.6%, respectively, with a statistical significant difference between SLN positive (58.7% and 69.7%) and SLN negative (85% and 90.3%) patients (p = 0.0006 and p = 0.0096 respectively). Postoperative complications after SLNB were observed in 12% of patients.</p>
</sec>
<sec><title>Conclusion</title>
<p>Our data confirm previous studies and support the clinical usefulness of SLNB as a reliable and accurate staging method in patients with cutaneous melanoma. However, the benefit of additional CLND in patients with positive SLN remains to be demonstrated.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name>
</author>
<author><name sortKey="Wen, Dr" uniqKey="Wen D">DR Wen</name>
</author>
<author><name sortKey="Wong, Jh" uniqKey="Wong J">JH Wong</name>
</author>
<author><name sortKey="Economou, Js" uniqKey="Economou J">JS Economou</name>
</author>
<author><name sortKey="Cagle, La" uniqKey="Cagle L">LA Cagle</name>
</author>
<author><name sortKey="Storm, Fk" uniqKey="Storm F">FK Storm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lourari, S" uniqKey="Lourari S">S Lourari</name>
</author>
<author><name sortKey="Paul, C" uniqKey="Paul C">C Paul</name>
</author>
<author><name sortKey="Gouraud, Pa" uniqKey="Gouraud P">PA Gouraud</name>
</author>
<author><name sortKey="Tavitian, S" uniqKey="Tavitian S">S Tavitian</name>
</author>
<author><name sortKey="Viraben, R" uniqKey="Viraben R">R Viraben</name>
</author>
<author><name sortKey="Leccia, Mt" uniqKey="Leccia M">MT Leccia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balch, Cm" uniqKey="Balch C">CM Balch</name>
</author>
<author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name>
</author>
<author><name sortKey="Soong, S J" uniqKey="Soong S">S-J Soong</name>
</author>
<author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name>
</author>
<author><name sortKey="Atkins, Mb" uniqKey="Atkins M">MB Atkins</name>
</author>
<author><name sortKey="Byrd, Dr" uniqKey="Byrd D">DR Byrd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name>
</author>
<author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name>
</author>
<author><name sortKey="Cochran, Aj" uniqKey="Cochran A">AJ Cochran</name>
</author>
<author><name sortKey="Mozzillo, N" uniqKey="Mozzillo N">N Mozzillo</name>
</author>
<author><name sortKey="Elashoff, R" uniqKey="Elashoff R">R Elashoff</name>
</author>
<author><name sortKey="Essner, R" uniqKey="Essner R">R Essner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thomas, Jm" uniqKey="Thomas J">JM Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saltman, Be" uniqKey="Saltman B">BE Saltman</name>
</author>
<author><name sortKey="Ganly, I" uniqKey="Ganly I">I Ganly</name>
</author>
<author><name sortKey="Patel, Sg" uniqKey="Patel S">SG Patel</name>
</author>
<author><name sortKey="Coit, Dg" uniqKey="Coit D">DG Coit</name>
</author>
<author><name sortKey="Brady, Ms" uniqKey="Brady M">MS Brady</name>
</author>
<author><name sortKey="Wong, Rj" uniqKey="Wong R">RJ Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Savoia, P" uniqKey="Savoia P">P Savoia</name>
</author>
<author><name sortKey="Fava, P" uniqKey="Fava P">P Fava</name>
</author>
<author><name sortKey="Caliendo, V" uniqKey="Caliendo V">V Caliendo</name>
</author>
<author><name sortKey="Osella Abate, S" uniqKey="Osella Abate S">S Osella-Abate</name>
</author>
<author><name sortKey="Ribero, S" uniqKey="Ribero S">S Ribero</name>
</author>
<author><name sortKey="Quaglino, P" uniqKey="Quaglino P">P Quaglino</name>
</author>
<author><name sortKey="Macrip, G" uniqKey="Macrip G">G Macripò</name>
</author>
<author><name sortKey="Bernengo, Mg" uniqKey="Bernengo M">MG Bernengo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name>
</author>
<author><name sortKey="Thompson, W" uniqKey="Thompson W">W Thompson</name>
</author>
<author><name sortKey="Mansfield, Pf" uniqKey="Mansfield P">PF Mansfield</name>
</author>
<author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name>
</author>
<author><name sortKey="Colome, Mi" uniqKey="Colome M">MI Colome</name>
</author>
<author><name sortKey="Tseng, Ch" uniqKey="Tseng C">CH Tseng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name>
</author>
<author><name sortKey="Andtbacka, Rhi" uniqKey="Andtbacka R">RHI Andtbacka</name>
</author>
<author><name sortKey="Prieto, Vg" uniqKey="Prieto V">VG Prieto</name>
</author>
<author><name sortKey="Johnson, Mm" uniqKey="Johnson M">MM Johnson</name>
</author>
<author><name sortKey="Diwan, Ah" uniqKey="Diwan A">AH Diwan</name>
</author>
<author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kunte, C" uniqKey="Kunte C">C Kunte</name>
</author>
<author><name sortKey="Geimer, T" uniqKey="Geimer T">T Geimer</name>
</author>
<author><name sortKey="Baumert, J" uniqKey="Baumert J">J Baumert</name>
</author>
<author><name sortKey="Konz, B" uniqKey="Konz B">B Konz</name>
</author>
<author><name sortKey="Volkenandt, M" uniqKey="Volkenandt M">M Volkenandt</name>
</author>
<author><name sortKey="Flaig, M" uniqKey="Flaig M">M Flaig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rhodes, Ar" uniqKey="Rhodes A">AR Rhodes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Testori, A" uniqKey="Testori A">A Testori</name>
</author>
<author><name sortKey="De Salvo, Gl" uniqKey="De Salvo G">GL De Salvo</name>
</author>
<author><name sortKey="Montesco, Mc" uniqKey="Montesco M">MC Montesco</name>
</author>
<author><name sortKey="Trifir, G" uniqKey="Trifir G">G Trifirò</name>
</author>
<author><name sortKey="Mocellin, S" uniqKey="Mocellin S">S Mocellin</name>
</author>
<author><name sortKey="Landi, G" uniqKey="Landi G">G Landi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, Sl" uniqKey="Wong S">SL Wong</name>
</author>
<author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name>
</author>
<author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name>
</author>
<author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name>
</author>
<author><name sortKey="Leong, Spl" uniqKey="Leong S">SPL Leong</name>
</author>
<author><name sortKey="Reintgen, Ds" uniqKey="Reintgen D">DS Reintgen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kretschmer, L" uniqKey="Kretschmer L">L Kretschmer</name>
</author>
<author><name sortKey="Neumann, C" uniqKey="Neumann C">C Neumann</name>
</author>
<author><name sortKey="Marsch, Wc" uniqKey="Marsch W">WC Marsch</name>
</author>
<author><name sortKey="Lee, Rj" uniqKey="Lee R">RJ Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pasquali, S" uniqKey="Pasquali S">S Pasquali</name>
</author>
<author><name sortKey="Mocellin, S" uniqKey="Mocellin S">S Mocellin</name>
</author>
<author><name sortKey="Campana, Lg" uniqKey="Campana L">LG Campana</name>
</author>
<author><name sortKey="Bonandini, E" uniqKey="Bonandini E">E Bonandini</name>
</author>
<author><name sortKey="Montesco, Mc" uniqKey="Montesco M">MC Montesco</name>
</author>
<author><name sortKey="Tregnaghi, A" uniqKey="Tregnaghi A">A Tregnaghi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name>
</author>
<author><name sortKey="Colome, Mi" uniqKey="Colome M">MI Colome</name>
</author>
<author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name>
</author>
<author><name sortKey="Mansfield, Pf" uniqKey="Mansfield P">PF Mansfield</name>
</author>
<author><name sortKey="Tseng, C" uniqKey="Tseng C">C Tseng</name>
</author>
<author><name sortKey="Lee, Jj" uniqKey="Lee J">JJ Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Akkooi, Ac" uniqKey="Van Akkooi A">AC van Akkooi</name>
</author>
<author><name sortKey="Voit, Ca" uniqKey="Voit C">CA Voit</name>
</author>
<author><name sortKey="Verhoef, C" uniqKey="Verhoef C">C Verhoef</name>
</author>
<author><name sortKey="Eggermont, Am" uniqKey="Eggermont A">AM Eggermont</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nieweg, Oe" uniqKey="Nieweg O">OE Nieweg</name>
</author>
<author><name sortKey="Estourgie, Sh" uniqKey="Estourgie S">SH Estourgie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Veenstra, Hj" uniqKey="Veenstra H">HJ Veenstra</name>
</author>
<author><name sortKey="Wouters, Mjwm" uniqKey="Wouters M">MJWM Wouters</name>
</author>
<author><name sortKey="Kroon, Bbr" uniqKey="Kroon B">BBR Kroon</name>
</author>
<author><name sortKey="Olmos, Rav" uniqKey="Olmos R">RAV Olmos</name>
</author>
<author><name sortKey="Nieweg, Oe" uniqKey="Nieweg O">OE Nieweg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balch, Cm" uniqKey="Balch C">CM Balch</name>
</author>
<author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name>
</author>
<author><name sortKey="Soong, S J" uniqKey="Soong S">S-J Soong</name>
</author>
<author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name>
</author>
<author><name sortKey="Ding, S" uniqKey="Ding S">S Ding</name>
</author>
<author><name sortKey="Byrd, Dr" uniqKey="Byrd D">DR Byrd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kingham, Tp" uniqKey="Kingham T">TP Kingham</name>
</author>
<author><name sortKey="Panageas, Ks" uniqKey="Panageas K">KS Panageas</name>
</author>
<author><name sortKey="Ariyan, Ce" uniqKey="Ariyan C">CE Ariyan</name>
</author>
<author><name sortKey="Busam, Kj" uniqKey="Busam K">KJ Busam</name>
</author>
<author><name sortKey="Brady, Ms" uniqKey="Brady M">MS Brady</name>
</author>
<author><name sortKey="Coit, Dg" uniqKey="Coit D">DG Coit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moroi, Y" uniqKey="Moroi Y">Y Moroi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Akkooi, Acj" uniqKey="Van Akkooi A">ACJ van Akkooi</name>
</author>
<author><name sortKey="Nowecki, Zi" uniqKey="Nowecki Z">ZI Nowecki</name>
</author>
<author><name sortKey="Voit, C" uniqKey="Voit C">C Voit</name>
</author>
<author><name sortKey="Sch Fer Hesterberg, G" uniqKey="Sch Fer Hesterberg G">G Schäfer-Hesterberg</name>
</author>
<author><name sortKey="Michej, W" uniqKey="Michej W">W Michej</name>
</author>
<author><name sortKey="De Wilt, Jhw" uniqKey="De Wilt J">JHW de Wilt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Ploeg, Apt" uniqKey="Van Der Ploeg A">APT van der Ploeg</name>
</author>
<author><name sortKey="Van Akkooi, Acj" uniqKey="Van Akkooi A">ACJ van Akkooi</name>
</author>
<author><name sortKey="Rutkowski, P" uniqKey="Rutkowski P">P Rutkowski</name>
</author>
<author><name sortKey="Nowecki, Zi" uniqKey="Nowecki Z">ZI Nowecki</name>
</author>
<author><name sortKey="Michej, W" uniqKey="Michej W">W Michej</name>
</author>
<author><name sortKey="Mitra, A" uniqKey="Mitra A">A Mitra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cadili, A" uniqKey="Cadili A">A Cadili</name>
</author>
<author><name sortKey="Scolyer, Ra" uniqKey="Scolyer R">RA Scolyer</name>
</author>
<author><name sortKey="Brown, Pt" uniqKey="Brown P">PT Brown</name>
</author>
<author><name sortKey="Dabbs, K" uniqKey="Dabbs K">K Dabbs</name>
</author>
<author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, Rl" uniqKey="White R">RL White</name>
</author>
<author><name sortKey="Ayers, Gd" uniqKey="Ayers G">GD Ayers</name>
</author>
<author><name sortKey="Stell, Vh" uniqKey="Stell V">VH Stell</name>
</author>
<author><name sortKey="Ding, S" uniqKey="Ding S">S Ding</name>
</author>
<author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name>
</author>
<author><name sortKey="Salo, Jc" uniqKey="Salo J">JC Salo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scolyer, Ra" uniqKey="Scolyer R">RA Scolyer</name>
</author>
<author><name sortKey="Li, Lx" uniqKey="Li L">LX Li</name>
</author>
<author><name sortKey="Mccarthy, Sw" uniqKey="Mccarthy S">SW McCarthy</name>
</author>
<author><name sortKey="Shaw, Hm" uniqKey="Shaw H">HM Shaw</name>
</author>
<author><name sortKey="Stretch, Jr" uniqKey="Stretch J">JR Stretch</name>
</author>
<author><name sortKey="Sharma, R" uniqKey="Sharma R">R Sharma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Debarbieux, S" uniqKey="Debarbieux S">S Debarbieux</name>
</author>
<author><name sortKey="Duru, G" uniqKey="Duru G">G Duru</name>
</author>
<author><name sortKey="Dalle, S" uniqKey="Dalle S">S Dalle</name>
</author>
<author><name sortKey="Beatrix, O" uniqKey="Beatrix O">O Béatrix</name>
</author>
<author><name sortKey="Balme, B" uniqKey="Balme B">B Balme</name>
</author>
<author><name sortKey="Thomas, L" uniqKey="Thomas L">L Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kretschmer, L" uniqKey="Kretschmer L">L Kretschmer</name>
</author>
<author><name sortKey="Thoms, K M" uniqKey="Thoms K">K-M Thoms</name>
</author>
<author><name sortKey="Peeters, S" uniqKey="Peeters S">S Peeters</name>
</author>
<author><name sortKey="Haenssle, H" uniqKey="Haenssle H">H Haenssle</name>
</author>
<author><name sortKey="Bertsch, H P" uniqKey="Bertsch H">H-P Bertsch</name>
</author>
<author><name sortKey="Emmert, S" uniqKey="Emmert S">S Emmert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Voit, Ca" uniqKey="Voit C">CA Voit</name>
</author>
<author><name sortKey="Van Akkooi, Ajc" uniqKey="Van Akkooi A">AJC van Akkooi</name>
</author>
<author><name sortKey="Sch Fer Hesterberg, G" uniqKey="Sch Fer Hesterberg G">G Schäfer-Hesterberg</name>
</author>
<author><name sortKey="Sterry, W" uniqKey="Sterry W">W Sterry</name>
</author>
<author><name sortKey="Eggermont, Amm" uniqKey="Eggermont A">AMM Eggermont</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Dermatol</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Dermatol</journal-id>
<journal-title-group><journal-title>BMC Dermatology</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-5945</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23228015</article-id>
<article-id pub-id-type="pmc">3538072</article-id>
<article-id pub-id-type="publisher-id">1471-5945-12-21</article-id>
<article-id pub-id-type="doi">10.1186/1471-5945-12-21</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="A1"><name><surname>Biver-Dalle</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>krobiver@yahoo.fr</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Puzenat</surname>
<given-names>Eve</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>epuzenat@chu-besancon.fr</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Puyraveau</surname>
<given-names>Marc</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>marc.puyraveau@univ-fcomte.fr</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Delroeux</surname>
<given-names>Delphine</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>d2delroeux@chu-besancon.fr</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Boulahdour</surname>
<given-names>Hatem</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>hboulahdour@chu-besancon.fr</email>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Sheppard</surname>
<given-names>Frances</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>fmsheppard@chu-besancon.fr</email>
</contrib>
<contrib contrib-type="author" id="A7"><name><surname>Pelletier</surname>
<given-names>Fabien</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I5">5</xref>
<email>Fabien.pelletier@univ-fcomte.fr</email>
</contrib>
<contrib contrib-type="author" id="A8"><name><surname>Humbert</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I5">5</xref>
<email>philippe.humbert@univ-fcomte.fr</email>
</contrib>
<contrib contrib-type="author" corresp="yes" id="A9"><name><surname>Aubin</surname>
<given-names>François</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I6">6</xref>
<xref ref-type="aff" rid="I7">7</xref>
<email>francois.aubin@univ-fcomte.fr</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Department of Dermatology, Besançon University Hospital, Besançon, France</aff>
<aff id="I2"><label>2</label>
Clinical Methodology Center, Besançon University Hospital, Besançon, France</aff>
<aff id="I3"><label>3</label>
Department of Digestive Surgery, Besançon University Hospital, Besançon, France</aff>
<aff id="I4"><label>4</label>
Department of Nuclear Medicine, Besançon University Hospital, Besançon, France</aff>
<aff id="I5"><label>5</label>
University of Franche Comté, UMR1098, SFR FED4234, Besançon, France</aff>
<aff id="I6"><label>6</label>
University of Franche Comté, EA3181, SFR FED4234, Besançon, France</aff>
<aff id="I7"><label>7</label>
Service de Dermatologie, 2 Place Saint-Jacques, 25030, Besançon, cedex, France</aff>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>12</month>
<year>2012</year>
</pub-date>
<volume>12</volume>
<fpage>21</fpage>
<lpage>21</lpage>
<history><date date-type="received"><day>26</day>
<month>7</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>28</day>
<month>11</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright ©2012 Biver-Dalle et al.; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>Biver-Dalle et al.; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.biomedcentral.com/1471-5945/12/21"></self-uri>
<abstract><sec><title>Background</title>
<p>Since the introduction of sentinel lymph node biopsy (SLNB), its use as a standard of care for patients with clinically node-negative cutaneous melanoma remains controversial. We wished to evaluate our experience of SLNB for melanoma.</p>
</sec>
<sec><title>Methods</title>
<p>A single center observational cohort of 203 melanoma patients with a primary cutaneous melanoma (tumour thickness > 1 mm) and without clinical evidence of metastasis was investigated from 2002 to 2009. Head and neck melanoma were excluded. SLN was identified following preoperative lymphoscintigraphy and intraoperative gamma probe interrogation.</p>
</sec>
<sec><title>Results</title>
<p>The SLN identification rate was 97%. The SLN was tumor positive in 44 patients (22%). Positive SLN was significantly associated with primary tumor thickness and microscopic ulceration. The median follow-up was 39.5 (5–97) months. Disease progression was significantly more frequent in SLN positive patients (32% vs 13%, p = 0.002). Five-year DFS and OS of the entire cohort were 79.6% and 84.6%, respectively, with a statistical significant difference between SLN positive (58.7% and 69.7%) and SLN negative (85% and 90.3%) patients (p = 0.0006 and p = 0.0096 respectively). Postoperative complications after SLNB were observed in 12% of patients.</p>
</sec>
<sec><title>Conclusion</title>
<p>Our data confirm previous studies and support the clinical usefulness of SLNB as a reliable and accurate staging method in patients with cutaneous melanoma. However, the benefit of additional CLND in patients with positive SLN remains to be demonstrated.</p>
</sec>
</abstract>
<kwd-group><kwd>Melanoma</kwd>
<kwd>Sentinel lymph node</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
</country>
<region><li>Bourgogne-Franche-Comté</li>
<li>Franche-Comté</li>
</region>
<settlement><li>Besançon</li>
</settlement>
</list>
<tree><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Biver Dalle, Caroline" sort="Biver Dalle, Caroline" uniqKey="Biver Dalle C" first="Caroline" last="Biver-Dalle">Caroline Biver-Dalle</name>
</region>
<name sortKey="Aubin, Francois" sort="Aubin, Francois" uniqKey="Aubin F" first="François" last="Aubin">François Aubin</name>
<name sortKey="Aubin, Francois" sort="Aubin, Francois" uniqKey="Aubin F" first="François" last="Aubin">François Aubin</name>
<name sortKey="Aubin, Francois" sort="Aubin, Francois" uniqKey="Aubin F" first="François" last="Aubin">François Aubin</name>
<name sortKey="Boulahdour, Hatem" sort="Boulahdour, Hatem" uniqKey="Boulahdour H" first="Hatem" last="Boulahdour">Hatem Boulahdour</name>
<name sortKey="Delroeux, Delphine" sort="Delroeux, Delphine" uniqKey="Delroeux D" first="Delphine" last="Delroeux">Delphine Delroeux</name>
<name sortKey="Humbert, Philippe" sort="Humbert, Philippe" uniqKey="Humbert P" first="Philippe" last="Humbert">Philippe Humbert</name>
<name sortKey="Humbert, Philippe" sort="Humbert, Philippe" uniqKey="Humbert P" first="Philippe" last="Humbert">Philippe Humbert</name>
<name sortKey="Pelletier, Fabien" sort="Pelletier, Fabien" uniqKey="Pelletier F" first="Fabien" last="Pelletier">Fabien Pelletier</name>
<name sortKey="Pelletier, Fabien" sort="Pelletier, Fabien" uniqKey="Pelletier F" first="Fabien" last="Pelletier">Fabien Pelletier</name>
<name sortKey="Puyraveau, Marc" sort="Puyraveau, Marc" uniqKey="Puyraveau M" first="Marc" last="Puyraveau">Marc Puyraveau</name>
<name sortKey="Puzenat, Eve" sort="Puzenat, Eve" uniqKey="Puzenat E" first="Eve" last="Puzenat">Eve Puzenat</name>
<name sortKey="Sheppard, Frances" sort="Sheppard, Frances" uniqKey="Sheppard F" first="Frances" last="Sheppard">Frances Sheppard</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005415 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 005415 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:3538072 |texte= Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009) }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:23228015" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |