Near-infrared fluorescent silica-coated gold nanoparticle clusters for x-ray computed tomography/optical dual modal imaging of the lymphatic system.
Identifieur interne : 005344 ( Ncbi/Merge ); précédent : 005343; suivant : 005345Near-infrared fluorescent silica-coated gold nanoparticle clusters for x-ray computed tomography/optical dual modal imaging of the lymphatic system.
Auteurs : Koichiro Hayashi [Japon] ; Michihiro Nakamura ; Kazunori IshimuraSource :
- Advanced healthcare materials [ 2192-2640 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- cytologie : Système lymphatique.
- synthèse chimique : Produits de contraste.
- Animaux, Colorants fluorescents, Lymphographie, Microscopie de fluorescence, Nanoparticules métalliques, Or, Souris, Souris de lignée C57BL, Technique de soustraction, Tomodensitométrie.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Contrast Media.
- chemistry : Metal Nanoparticles.
- cytology : Lymphatic System.
- methods : Lymphography, Microscopy, Fluorescence, Tomography, X-Ray Computed.
- Animals, Fluorescent Dyes, Gold, Mice, Mice, Inbred C57BL, Subtraction Technique.
Abstract
Lymph nodes (LNs) are often removed to prevent the spread of cancer because they are frequently the first site of metastases. However, the enucleation of LNs requires difficult operative techniques and lymphedema can result as a complication. Although lymphedema can be cured by anastomosis of a lymph vessel (LV) to a vein, the operative procedure is extremely difficult because LNs and LVs are too small and indistinct to be identified. Therefore, visualization of LNs and LVs is important. The combination of X-ray computed tomography (CT) and fluorescence imaging, CT/fluorescence dual modal imaging, enables the visualization of LNs and LVs before and during surgery. To accomplish this, near-infrared fluorescent silica-coated gold nanoparticle clusters (Au@SiO₂) with a high X-ray absorption coefficient are synthesized. Both fluorescence imaging and CT show that the Au@SiO₂ nanoparticles gradually accumulate in LNs through LVs. CT determines the location and size of the LNs and LVs without dissection, and fluorescence imaging facilitates their identification. The Au@SiO₂ nanoparticles have neither hepatotoxicity nor nephrotoxicity. The results demonstrate that CT/fluorescence dual modal imaging using Au@SiO₂ nanoparticles provides anatomical information, including the location and size of LNs and LVs for determining a surgery plan, and provides intraoperative visualization of LNs and LVs to facilitate the operation.
DOI: 10.1002/adhm.201200238
PubMed: 23184510
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Near-infrared fluorescent silica-coated gold nanoparticle clusters for x-ray computed tomography/optical dual modal imaging of the lymphatic system.</title><author><name sortKey="Hayashi, Koichiro" sort="Hayashi, Koichiro" uniqKey="Hayashi K" first="Koichiro" last="Hayashi">Koichiro Hayashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Japan. khayashi@basic.med.tokushima-u.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho</wicri:regionArea><wicri:noRegion>3-18-15 Kuramoto-cho</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Michihiro" sort="Nakamura, Michihiro" uniqKey="Nakamura M" first="Michihiro" last="Nakamura">Michihiro Nakamura</name></author><author><name sortKey="Ishimura, Kazunori" sort="Ishimura, Kazunori" uniqKey="Ishimura K" first="Kazunori" last="Ishimura">Kazunori Ishimura</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23184510</idno><idno type="pmid">23184510</idno><idno type="doi">10.1002/adhm.201200238</idno><idno type="wicri:Area/PubMed/Corpus">001E51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E51</idno><idno type="wicri:Area/PubMed/Curation">001E51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001E51</idno><idno type="wicri:Area/PubMed/Checkpoint">001E51</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001E51</idno><idno type="wicri:Area/Ncbi/Merge">005344</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Near-infrared fluorescent silica-coated gold nanoparticle clusters for x-ray computed tomography/optical dual modal imaging of the lymphatic system.</title><author><name sortKey="Hayashi, Koichiro" sort="Hayashi, Koichiro" uniqKey="Hayashi K" first="Koichiro" last="Hayashi">Koichiro Hayashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Japan. khayashi@basic.med.tokushima-u.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho</wicri:regionArea><wicri:noRegion>3-18-15 Kuramoto-cho</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Michihiro" sort="Nakamura, Michihiro" uniqKey="Nakamura M" first="Michihiro" last="Nakamura">Michihiro Nakamura</name></author><author><name sortKey="Ishimura, Kazunori" sort="Ishimura, Kazunori" uniqKey="Ishimura K" first="Kazunori" last="Ishimura">Kazunori Ishimura</name></author></analytic><series><title level="j">Advanced healthcare materials</title><idno type="ISSN">2192-2640</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Contrast Media (chemical synthesis)</term><term>Fluorescent Dyes</term><term>Gold</term><term>Lymphatic System (cytology)</term><term>Lymphography (methods)</term><term>Metal Nanoparticles (chemistry)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Microscopy, Fluorescence (methods)</term><term>Subtraction Technique</term><term>Tomography, X-Ray Computed (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Colorants fluorescents</term><term>Lymphographie ()</term><term>Microscopie de fluorescence ()</term><term>Nanoparticules métalliques ()</term><term>Or</term><term>Produits de contraste (synthèse chimique)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Système lymphatique (cytologie)</term><term>Technique de soustraction</term><term>Tomodensitométrie ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Contrast Media</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymphography</term><term>Microscopy, Fluorescence</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Produits de contraste</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Fluorescent Dyes</term><term>Gold</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Subtraction Technique</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Colorants fluorescents</term><term>Lymphographie</term><term>Microscopie de fluorescence</term><term>Nanoparticules métalliques</term><term>Or</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Technique de soustraction</term><term>Tomodensitométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymph nodes (LNs) are often removed to prevent the spread of cancer because they are frequently the first site of metastases. However, the enucleation of LNs requires difficult operative techniques and lymphedema can result as a complication. Although lymphedema can be cured by anastomosis of a lymph vessel (LV) to a vein, the operative procedure is extremely difficult because LNs and LVs are too small and indistinct to be identified. Therefore, visualization of LNs and LVs is important. The combination of X-ray computed tomography (CT) and fluorescence imaging, CT/fluorescence dual modal imaging, enables the visualization of LNs and LVs before and during surgery. To accomplish this, near-infrared fluorescent silica-coated gold nanoparticle clusters (Au@SiO₂) with a high X-ray absorption coefficient are synthesized. Both fluorescence imaging and CT show that the Au@SiO₂ nanoparticles gradually accumulate in LNs through LVs. CT determines the location and size of the LNs and LVs without dissection, and fluorescence imaging facilitates their identification. The Au@SiO₂ nanoparticles have neither hepatotoxicity nor nephrotoxicity. The results demonstrate that CT/fluorescence dual modal imaging using Au@SiO₂ nanoparticles provides anatomical information, including the location and size of LNs and LVs for determining a surgery plan, and provides intraoperative visualization of LNs and LVs to facilitate the operation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23184510</PMID><DateCreated><Year>2013</Year><Month>05</Month><Day>02</Day></DateCreated><DateCompleted><Year>2013</Year><Month>07</Month><Day>16</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2192-2640</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><Issue>5</Issue><PubDate><Year>2013</Year><Month>May</Month></PubDate></JournalIssue><Title>Advanced healthcare materials</Title><ISOAbbreviation>Adv Healthc Mater</ISOAbbreviation></Journal><ArticleTitle>Near-infrared fluorescent silica-coated gold nanoparticle clusters for x-ray computed tomography/optical dual modal imaging of the lymphatic system.</ArticleTitle><Pagination><MedlinePgn>756-63</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/adhm.201200238</ELocationID><Abstract><AbstractText>Lymph nodes (LNs) are often removed to prevent the spread of cancer because they are frequently the first site of metastases. However, the enucleation of LNs requires difficult operative techniques and lymphedema can result as a complication. Although lymphedema can be cured by anastomosis of a lymph vessel (LV) to a vein, the operative procedure is extremely difficult because LNs and LVs are too small and indistinct to be identified. Therefore, visualization of LNs and LVs is important. The combination of X-ray computed tomography (CT) and fluorescence imaging, CT/fluorescence dual modal imaging, enables the visualization of LNs and LVs before and during surgery. To accomplish this, near-infrared fluorescent silica-coated gold nanoparticle clusters (Au@SiO₂) with a high X-ray absorption coefficient are synthesized. Both fluorescence imaging and CT show that the Au@SiO₂ nanoparticles gradually accumulate in LNs through LVs. CT determines the location and size of the LNs and LVs without dissection, and fluorescence imaging facilitates their identification. The Au@SiO₂ nanoparticles have neither hepatotoxicity nor nephrotoxicity. The results demonstrate that CT/fluorescence dual modal imaging using Au@SiO₂ nanoparticles provides anatomical information, including the location and size of LNs and LVs for determining a surgery plan, and provides intraoperative visualization of LNs and LVs to facilitate the operation.</AbstractText><CopyrightInformation>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hayashi</LastName><ForeName>Koichiro</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Japan. khayashi@basic.med.tokushima-u.ac.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakamura</LastName><ForeName>Michihiro</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ishimura</LastName><ForeName>Kazunori</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Adv Healthc Mater</MedlineTA><NlmUniqueID>101581613</NlmUniqueID><ISSNLinking>2192-2640</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003287">Contrast Media</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005456">Fluorescent Dyes</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-57-5</RegistryNumber><NameOfSubstance UI="D006046">Gold</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003287" MajorTopicYN="N">Contrast Media</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005456" MajorTopicYN="N">Fluorescent Dyes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006046" MajorTopicYN="Y">Gold</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008220" MajorTopicYN="N">Lymphography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053768" MajorTopicYN="N">Metal Nanoparticles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008856" MajorTopicYN="N">Microscopy, Fluorescence</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013382" MajorTopicYN="N">Subtraction Technique</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>07</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>09</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23184510</ArticleId><ArticleId IdType="doi">10.1002/adhm.201200238</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Ishimura, Kazunori" sort="Ishimura, Kazunori" uniqKey="Ishimura K" first="Kazunori" last="Ishimura">Kazunori Ishimura</name><name sortKey="Nakamura, Michihiro" sort="Nakamura, Michihiro" uniqKey="Nakamura M" first="Michihiro" last="Nakamura">Michihiro Nakamura</name></noCountry><country name="Japon"><noRegion><name sortKey="Hayashi, Koichiro" sort="Hayashi, Koichiro" uniqKey="Hayashi K" first="Koichiro" last="Hayashi">Koichiro Hayashi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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