Near-infrared fluorescent silica-coated gold nanoparticle clusters for x-ray computed tomography/optical dual modal imaging of the lymphatic system.
Identifieur interne : 005344 ( Ncbi/Merge ); précédent : 005343; suivant : 005345Near-infrared fluorescent silica-coated gold nanoparticle clusters for x-ray computed tomography/optical dual modal imaging of the lymphatic system.
Auteurs : Koichiro Hayashi [Japon] ; Michihiro Nakamura ; Kazunori IshimuraSource :
- Advanced healthcare materials [ 2192-2640 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- cytologie : Système lymphatique.
- synthèse chimique : Produits de contraste.
- Animaux, Colorants fluorescents, Lymphographie, Microscopie de fluorescence, Nanoparticules métalliques, Or, Souris, Souris de lignée C57BL, Technique de soustraction, Tomodensitométrie.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Contrast Media.
- chemistry : Metal Nanoparticles.
- cytology : Lymphatic System.
- methods : Lymphography, Microscopy, Fluorescence, Tomography, X-Ray Computed.
- Animals, Fluorescent Dyes, Gold, Mice, Mice, Inbred C57BL, Subtraction Technique.
Abstract
Lymph nodes (LNs) are often removed to prevent the spread of cancer because they are frequently the first site of metastases. However, the enucleation of LNs requires difficult operative techniques and lymphedema can result as a complication. Although lymphedema can be cured by anastomosis of a lymph vessel (LV) to a vein, the operative procedure is extremely difficult because LNs and LVs are too small and indistinct to be identified. Therefore, visualization of LNs and LVs is important. The combination of X-ray computed tomography (CT) and fluorescence imaging, CT/fluorescence dual modal imaging, enables the visualization of LNs and LVs before and during surgery. To accomplish this, near-infrared fluorescent silica-coated gold nanoparticle clusters (Au@SiO₂) with a high X-ray absorption coefficient are synthesized. Both fluorescence imaging and CT show that the Au@SiO₂ nanoparticles gradually accumulate in LNs through LVs. CT determines the location and size of the LNs and LVs without dissection, and fluorescence imaging facilitates their identification. The Au@SiO₂ nanoparticles have neither hepatotoxicity nor nephrotoxicity. The results demonstrate that CT/fluorescence dual modal imaging using Au@SiO₂ nanoparticles provides anatomical information, including the location and size of LNs and LVs for determining a surgery plan, and provides intraoperative visualization of LNs and LVs to facilitate the operation.
DOI: 10.1002/adhm.201200238
PubMed: 23184510
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pubmed:23184510Le document en format XML
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<author><name sortKey="Hayashi, Koichiro" sort="Hayashi, Koichiro" uniqKey="Hayashi K" first="Koichiro" last="Hayashi">Koichiro Hayashi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Japan. khayashi@basic.med.tokushima-u.ac.jp</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho</wicri:regionArea>
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<author><name sortKey="Nakamura, Michihiro" sort="Nakamura, Michihiro" uniqKey="Nakamura M" first="Michihiro" last="Nakamura">Michihiro Nakamura</name>
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<term>Lymphatic System (cytology)</term>
<term>Lymphography (methods)</term>
<term>Metal Nanoparticles (chemistry)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
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<term>Souris</term>
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<term>Système lymphatique (cytologie)</term>
<term>Technique de soustraction</term>
<term>Tomodensitométrie ()</term>
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<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lymphatic System</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymphography</term>
<term>Microscopy, Fluorescence</term>
<term>Tomography, X-Ray Computed</term>
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<term>Fluorescent Dyes</term>
<term>Gold</term>
<term>Mice</term>
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<term>Subtraction Technique</term>
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<term>Colorants fluorescents</term>
<term>Lymphographie</term>
<term>Microscopie de fluorescence</term>
<term>Nanoparticules métalliques</term>
<term>Or</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Technique de soustraction</term>
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<front><div type="abstract" xml:lang="en">Lymph nodes (LNs) are often removed to prevent the spread of cancer because they are frequently the first site of metastases. However, the enucleation of LNs requires difficult operative techniques and lymphedema can result as a complication. Although lymphedema can be cured by anastomosis of a lymph vessel (LV) to a vein, the operative procedure is extremely difficult because LNs and LVs are too small and indistinct to be identified. Therefore, visualization of LNs and LVs is important. The combination of X-ray computed tomography (CT) and fluorescence imaging, CT/fluorescence dual modal imaging, enables the visualization of LNs and LVs before and during surgery. To accomplish this, near-infrared fluorescent silica-coated gold nanoparticle clusters (Au@SiO₂) with a high X-ray absorption coefficient are synthesized. Both fluorescence imaging and CT show that the Au@SiO₂ nanoparticles gradually accumulate in LNs through LVs. CT determines the location and size of the LNs and LVs without dissection, and fluorescence imaging facilitates their identification. The Au@SiO₂ nanoparticles have neither hepatotoxicity nor nephrotoxicity. The results demonstrate that CT/fluorescence dual modal imaging using Au@SiO₂ nanoparticles provides anatomical information, including the location and size of LNs and LVs for determining a surgery plan, and provides intraoperative visualization of LNs and LVs to facilitate the operation.</div>
</front>
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<Abstract><AbstractText>Lymph nodes (LNs) are often removed to prevent the spread of cancer because they are frequently the first site of metastases. However, the enucleation of LNs requires difficult operative techniques and lymphedema can result as a complication. Although lymphedema can be cured by anastomosis of a lymph vessel (LV) to a vein, the operative procedure is extremely difficult because LNs and LVs are too small and indistinct to be identified. Therefore, visualization of LNs and LVs is important. The combination of X-ray computed tomography (CT) and fluorescence imaging, CT/fluorescence dual modal imaging, enables the visualization of LNs and LVs before and during surgery. To accomplish this, near-infrared fluorescent silica-coated gold nanoparticle clusters (Au@SiO₂) with a high X-ray absorption coefficient are synthesized. Both fluorescence imaging and CT show that the Au@SiO₂ nanoparticles gradually accumulate in LNs through LVs. CT determines the location and size of the LNs and LVs without dissection, and fluorescence imaging facilitates their identification. The Au@SiO₂ nanoparticles have neither hepatotoxicity nor nephrotoxicity. The results demonstrate that CT/fluorescence dual modal imaging using Au@SiO₂ nanoparticles provides anatomical information, including the location and size of LNs and LVs for determining a surgery plan, and provides intraoperative visualization of LNs and LVs to facilitate the operation.</AbstractText>
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