Kaposi Sarcoma Pathogenesis: A Triad of Viral Infection, Oncogenesis and Chronic Inflammation
Identifieur interne : 005228 ( Ncbi/Merge ); précédent : 005227; suivant : 005229Kaposi Sarcoma Pathogenesis: A Triad of Viral Infection, Oncogenesis and Chronic Inflammation
Auteurs : Janet L. Douglas [États-Unis] ; Jean K. Gustin [États-Unis] ; Ashlee V. Moses [États-Unis] ; Bruce J. Dezube [États-Unis] ; Liron Pantanowitz [États-Unis]Source :
- Translational biomedicine [ 2172-0479 ] ; 2010.
Abstract
Kaposi sarcoma (KS) is a complex cancer that arises from the initial infection of an appropriate endothelial or progenitor cell by Kaposi Sarcoma Herpesvirus/Human Herpesvirus-8 (KSHV/HHV8). However, the majority of KS cases occur when infected patients also suffer from some coincident form of immune deregulation, providing a favorable microenvironment for tumor development. Cellular hallmarks of KS progression include both the hyper-proliferation of KSHV-infected cells and the infiltration of immune modulatory cells into KS lesions, which together result in chronic inflammation, the induction of angiogenesis and tumor growth. This review describes the current understanding of the interactions between KSHV and host responses that result in this unusual cancer, along with existing treatments and prospects for future therapeutic approaches.
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PubMed: 23082307
PubMed Central: 3472629
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Moses</name><affiliation wicri:level="2"><nlm:aff id="A1">Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton, OR</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton</wicri:cityArea></affiliation></author><author><name sortKey="Dezube, Bruce J" sort="Dezube, Bruce J" uniqKey="Dezube B" first="Bruce J." last="Dezube">Bruce J. 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Douglas</name><affiliation wicri:level="2"><nlm:aff id="A1">Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton, OR</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton</wicri:cityArea></affiliation></author><author><name sortKey="Gustin, Jean K" sort="Gustin, Jean K" uniqKey="Gustin J" first="Jean K." last="Gustin">Jean K. Gustin</name><affiliation wicri:level="2"><nlm:aff id="A1">Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton, OR</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton</wicri:cityArea></affiliation></author><author><name sortKey="Moses, Ashlee V" sort="Moses, Ashlee V" uniqKey="Moses A" first="Ashlee V." last="Moses">Ashlee V. Moses</name><affiliation wicri:level="2"><nlm:aff id="A1">Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton, OR</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton</wicri:cityArea></affiliation></author><author><name sortKey="Dezube, Bruce J" sort="Dezube, Bruce J" uniqKey="Dezube B" first="Bruce J." last="Dezube">Bruce J. Dezube</name><affiliation wicri:level="2"><nlm:aff id="A2">Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Beth Israel Deaconess Medical Center, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Pantanowitz, Liron" sort="Pantanowitz, Liron" uniqKey="Pantanowitz L" first="Liron" last="Pantanowitz">Liron Pantanowitz</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Translational biomedicine</title><idno type="eISSN">2172-0479</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Kaposi sarcoma (KS) is a complex cancer that arises from the initial infection of an appropriate endothelial or progenitor cell by Kaposi Sarcoma Herpesvirus/Human Herpesvirus-8 (KSHV/HHV8). However, the majority of KS cases occur when infected patients also suffer from some coincident form of immune deregulation, providing a favorable microenvironment for tumor development. Cellular hallmarks of KS progression include both the hyper-proliferation of KSHV-infected cells and the infiltration of immune modulatory cells into KS lesions, which together result in chronic inflammation, the induction of angiogenesis and tumor growth. This review describes the current understanding of the interactions between KSHV and host responses that result in this unusual cancer, along with existing treatments and prospects for future therapeutic approaches.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101574282</journal-id><journal-id journal-id-type="pubmed-jr-id">39779</journal-id><journal-id journal-id-type="nlm-ta">Transl Biomed</journal-id><journal-id journal-id-type="iso-abbrev">Transl Biomed</journal-id><journal-title-group><journal-title>Translational biomedicine</journal-title></journal-title-group><issn pub-type="epub">2172-0479</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23082307</article-id><article-id pub-id-type="pmc">3472629</article-id><article-id pub-id-type="manuscript">NIHMS359817</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Kaposi Sarcoma Pathogenesis: A Triad of Viral Infection, Oncogenesis and Chronic Inflammation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Douglas</surname><given-names>Janet L.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gustin</surname><given-names>Jean K.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Moses</surname><given-names>Ashlee V.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Dezube</surname><given-names>Bruce J.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pantanowitz</surname><given-names>Liron</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Beaverton, OR</aff><aff id="A2"><label>2</label>Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA</aff><aff id="A3"><label>3</label>Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author: Ashlee V. Moses, VGTI-Oregon Health & Science University, 505 NW 185<sup>th</sup> Ave. Beaverton, OR 97006, Phone: 503-418-2712, <email>mosesa@ohsu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="epub"><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>16</day><month>10</month><year>2012</year></pub-date><volume>1</volume><issue>2</issue><elocation-id>172</elocation-id><abstract><p id="P1">Kaposi sarcoma (KS) is a complex cancer that arises from the initial infection of an appropriate endothelial or progenitor cell by Kaposi Sarcoma Herpesvirus/Human Herpesvirus-8 (KSHV/HHV8). However, the majority of KS cases occur when infected patients also suffer from some coincident form of immune deregulation, providing a favorable microenvironment for tumor development. Cellular hallmarks of KS progression include both the hyper-proliferation of KSHV-infected cells and the infiltration of immune modulatory cells into KS lesions, which together result in chronic inflammation, the induction of angiogenesis and tumor growth. This review describes the current understanding of the interactions between KSHV and host responses that result in this unusual cancer, along with existing treatments and prospects for future therapeutic approaches.</p></abstract><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA099906-01A2 || CA</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>Oregon</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Oregon"><name sortKey="Douglas, Janet L" sort="Douglas, Janet L" uniqKey="Douglas J" first="Janet L." last="Douglas">Janet L. Douglas</name></region><name sortKey="Dezube, Bruce J" sort="Dezube, Bruce J" uniqKey="Dezube B" first="Bruce J." last="Dezube">Bruce J. Dezube</name><name sortKey="Gustin, Jean K" sort="Gustin, Jean K" uniqKey="Gustin J" first="Jean K." last="Gustin">Jean K. Gustin</name><name sortKey="Moses, Ashlee V" sort="Moses, Ashlee V" uniqKey="Moses A" first="Ashlee V." last="Moses">Ashlee V. Moses</name><name sortKey="Pantanowitz, Liron" sort="Pantanowitz, Liron" uniqKey="Pantanowitz L" first="Liron" last="Pantanowitz">Liron Pantanowitz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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