Oral Cavity Squamous Cell Carcinoma and the Clinically N0 Neck: The Past, Present, and Future of Sentinel Lymph Node Biopsy
Identifieur interne : 003A77 ( Ncbi/Merge ); précédent : 003A76; suivant : 003A78Oral Cavity Squamous Cell Carcinoma and the Clinically N0 Neck: The Past, Present, and Future of Sentinel Lymph Node Biopsy
Auteurs : Andrew Coughlin ; Vicente A. RestoSource :
- Current oncology reports [ 1523-3790 ] ; 2010.
Abstract
Oral cavity squamous cell carcinoma (OCSCC) has a yearly incidence of 274,000 patients. Twenty percent to 30% of patients will harbor occult regional metastases, an important feature that correlates with worse outcomes. Supraomohyoid neck dissection (SND) is the gold standard treatment, but because of recent successes of sentinel lymph node (SLN) biopsy in the management of breast cancer and melanoma, many have begun evaluating its use in head and neck mucosal cancers. SLN biopsy offers patients decreased morbidity compared with SND, and has shown reproducibly low false-negative rates, high-negative predictive values, and high sensitivities. Limitations with floor-of-mouth primaries and delayed secondary SNDs have been described, but a new agent designed to address these shortcomings, Lymphoseek (Neoprobe Corp.; Dublin, OH), is currently under investigation. This article reviews the current literature on SLN biopsy and introduces a phase 3 study evaluating the efficacy of Lymphoseek in SLN biopsy of OCSCCs.
Url:
DOI: 10.1007/s11912-010-0090-7
PubMed: 20425598
PubMed Central: 2862587
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PMC:2862587Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Oral cavity squamous cell carcinoma (OCSCC) has a yearly incidence of 274,000 patients. Twenty percent to 30% of patients will harbor occult regional metastases, an important feature that correlates with worse outcomes. Supraomohyoid neck dissection (SND) is the gold standard treatment, but because of recent successes of sentinel lymph node (SLN) biopsy in the management of breast cancer and melanoma, many have begun evaluating its use in head and neck mucosal cancers. SLN biopsy offers patients decreased morbidity compared with SND, and has shown reproducibly low false-negative rates, high-negative predictive values, and high sensitivities. Limitations with floor-of-mouth primaries and delayed secondary SNDs have been described, but a new agent designed to address these shortcomings, Lymphoseek (Neoprobe Corp.; Dublin, OH), is currently under investigation. This article reviews the current literature on SLN biopsy and introduces a phase 3 study evaluating the efficacy of Lymphoseek in SLN biopsy of OCSCCs.</p>
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<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Coughlin</surname>
<given-names>Andrew</given-names>
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<email>amcoughl@utmb.edu</email>
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<contrib contrib-type="author"><name><surname>Resto</surname>
<given-names>Vicente A.</given-names>
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<email>varesto@utmb.edu</email>
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<aff id="A1">Department of Otolaryngology, Head and Neck Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA</aff>
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<pub-date pub-type="nihms-submitted"><day>16</day>
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<volume>12</volume>
<issue>2</issue>
<fpage>129</fpage>
<lpage>135</lpage>
<permissions><copyright-statement>© Springer Science+Business Media, LLC 2010</copyright-statement>
<copyright-year>2010</copyright-year>
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<abstract><p id="P1">Oral cavity squamous cell carcinoma (OCSCC) has a yearly incidence of 274,000 patients. Twenty percent to 30% of patients will harbor occult regional metastases, an important feature that correlates with worse outcomes. Supraomohyoid neck dissection (SND) is the gold standard treatment, but because of recent successes of sentinel lymph node (SLN) biopsy in the management of breast cancer and melanoma, many have begun evaluating its use in head and neck mucosal cancers. SLN biopsy offers patients decreased morbidity compared with SND, and has shown reproducibly low false-negative rates, high-negative predictive values, and high sensitivities. Limitations with floor-of-mouth primaries and delayed secondary SNDs have been described, but a new agent designed to address these shortcomings, Lymphoseek (Neoprobe Corp.; Dublin, OH), is currently under investigation. This article reviews the current literature on SLN biopsy and introduces a phase 3 study evaluating the efficacy of Lymphoseek in SLN biopsy of OCSCCs.</p>
</abstract>
<kwd-group><kwd>Sentinel lymph node mapping</kwd>
<kwd>Oral cavity cancer</kwd>
<kwd>Staging</kwd>
<kwd>Lymphoscintigraphy</kwd>
<kwd>Occult lymph node metastases</kwd>
</kwd-group>
<contract-num rid="CA1">K08 CA132988-01A2
||CA</contract-num>
<contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor>
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