Radiochemotherapy including cisplatin alone versus cisplatin + 5-fluorouracil for locally advanced unresectable stage IV squamous cell carcinoma of the head and neck.
Identifieur interne : 003652 ( Ncbi/Merge ); précédent : 003651; suivant : 003653Radiochemotherapy including cisplatin alone versus cisplatin + 5-fluorouracil for locally advanced unresectable stage IV squamous cell carcinoma of the head and neck.
Auteurs : Silke Tribius [Allemagne] ; Stefanie Kronemann ; Yasemin Kilic ; Ursula Schroeder ; Samer Hakim ; Steven E. Schild ; Dirk RadesSource :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [ 1439-099X ] ; 2009.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse de survie, Association thérapeutique, Calendrier d'administration des médicaments, Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (mortalité), Carcinome épidermoïde (radiothérapie), Carcinome épidermoïde (traitement médicamenteux), Cisplatine (administration et posologie), Cisplatine (effets indésirables), Femelle, Fluorouracil (administration et posologie), Fluorouracil (effets indésirables), Fractionnement de la dose d'irradiation, Humains, Lésions radio-induites (étiologie), Mâle, Protocoles de polychimiothérapie antinéoplasique (effets indésirables), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Stade de la tumeur, Survie sans rechute, Traitement médicamenteux adjuvant, Tumeurs oto-rhino-laryngologiques (anatomopathologie), Tumeurs oto-rhino-laryngologiques (mortalité), Tumeurs oto-rhino-laryngologiques (radiothérapie), Tumeurs oto-rhino-laryngologiques (traitement médicamenteux), Études de suivi, Études rétrospectives.
- MESH :
- administration et posologie : Cisplatine, Fluorouracil.
- anatomopathologie : Carcinome épidermoïde, Tumeurs oto-rhino-laryngologiques.
- effets indésirables : Cisplatine, Fluorouracil, Protocoles de polychimiothérapie antinéoplasique.
- mortalité : Carcinome épidermoïde, Tumeurs oto-rhino-laryngologiques.
- radiothérapie : Carcinome épidermoïde, Tumeurs oto-rhino-laryngologiques.
- traitement médicamenteux : Carcinome épidermoïde, Tumeurs oto-rhino-laryngologiques.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- étiologie : Lésions radio-induites.
- Adulte d'âge moyen, Analyse de survie, Association thérapeutique, Calendrier d'administration des médicaments, Femelle, Fractionnement de la dose d'irradiation, Humains, Mâle, Stade de la tumeur, Survie sans rechute, Traitement médicamenteux adjuvant, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Antineoplastic Combined Chemotherapy Protocols (adverse effects), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Carcinoma, Squamous Cell (drug therapy), Carcinoma, Squamous Cell (mortality), Carcinoma, Squamous Cell (pathology), Carcinoma, Squamous Cell (radiotherapy), Chemotherapy, Adjuvant, Cisplatin (administration & dosage), Cisplatin (adverse effects), Combined Modality Therapy, Disease-Free Survival, Dose Fractionation, Drug Administration Schedule, Female, Fluorouracil (administration & dosage), Fluorouracil (adverse effects), Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Otorhinolaryngologic Neoplasms (drug therapy), Otorhinolaryngologic Neoplasms (mortality), Otorhinolaryngologic Neoplasms (pathology), Otorhinolaryngologic Neoplasms (radiotherapy), Radiation Injuries (etiology), Retrospective Studies, Survival Analysis.
- MESH :
- chemical , administration & dosage : Cisplatin, Fluorouracil.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols, Cisplatin, Fluorouracil.
- drug therapy : Carcinoma, Squamous Cell, Otorhinolaryngologic Neoplasms.
- etiology : Radiation Injuries.
- mortality : Carcinoma, Squamous Cell, Otorhinolaryngologic Neoplasms.
- pathology : Carcinoma, Squamous Cell, Otorhinolaryngologic Neoplasms.
- radiotherapy : Carcinoma, Squamous Cell, Otorhinolaryngologic Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Chemotherapy, Adjuvant, Combined Modality Therapy, Disease-Free Survival, Dose Fractionation, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Survival Analysis.
Abstract
The optimal radiochemotherapy regimen for advanced head-and-neck cancer is still debated. This nonrandomized study compares two cisplatin-based radiochemotherapy regimens in 128 patients with locally advanced unresectable stage IV squamous cell carcinoma of the head and neck (SCCHN).
DOI: 10.1007/s00066-009-1992-x
PubMed: 19806333
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002D24
- to stream PubMed, to step Curation: 002D24
- to stream PubMed, to step Checkpoint: 002D24
Links to Exploration step
pubmed:19806333Le document en format XML
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<term>Carcinoma, Squamous Cell (mortality)</term>
<term>Carcinoma, Squamous Cell (pathology)</term>
<term>Carcinoma, Squamous Cell (radiotherapy)</term>
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<term>Carcinome épidermoïde (radiothérapie)</term>
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<term>Cisplatine (administration et posologie)</term>
<term>Cisplatine (effets indésirables)</term>
<term>Femelle</term>
<term>Fluorouracil (administration et posologie)</term>
<term>Fluorouracil (effets indésirables)</term>
<term>Fractionnement de la dose d'irradiation</term>
<term>Humains</term>
<term>Lésions radio-induites (étiologie)</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term>
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<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term>
<term>Otorhinolaryngologic Neoplasms</term>
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<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Carcinome épidermoïde</term>
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<term>Analyse de survie</term>
<term>Association thérapeutique</term>
<term>Calendrier d'administration des médicaments</term>
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<term>Fractionnement de la dose d'irradiation</term>
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<front><div type="abstract" xml:lang="en">The optimal radiochemotherapy regimen for advanced head-and-neck cancer is still debated. This nonrandomized study compares two cisplatin-based radiochemotherapy regimens in 128 patients with locally advanced unresectable stage IV squamous cell carcinoma of the head and neck (SCCHN).</div>
</front>
</TEI>
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<DateCreated><Year>2009</Year>
<Month>10</Month>
<Day>06</Day>
</DateCreated>
<DateCompleted><Year>2009</Year>
<Month>10</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1439-099X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>185</Volume>
<Issue>10</Issue>
<PubDate><Year>2009</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]</Title>
<ISOAbbreviation>Strahlenther Onkol</ISOAbbreviation>
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<ArticleTitle>Radiochemotherapy including cisplatin alone versus cisplatin + 5-fluorouracil for locally advanced unresectable stage IV squamous cell carcinoma of the head and neck.</ArticleTitle>
<Pagination><MedlinePgn>675-81</MedlinePgn>
</Pagination>
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<Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">The optimal radiochemotherapy regimen for advanced head-and-neck cancer is still debated. This nonrandomized study compares two cisplatin-based radiochemotherapy regimens in 128 patients with locally advanced unresectable stage IV squamous cell carcinoma of the head and neck (SCCHN).</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Concurrent chemotherapy consisted of either two courses cisplatin (20 mg/m(2)/d1-5 + 29-33; n = 54) or two courses cisplatin (20 mg/m(2)/d1-5 + 29-33) + 5-fluorouracil (5-FU; 600 mg/m(2)/d1-5 + 29-33; n = 74).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">At least one grade 3 toxicity occurred in 25 of 54 patients (46%) receiving cisplatin alone and in 52 of 74 patients (70%) receiving cisplatin + 5-FU. The latter regimen was particularly associated with increased rates of mucositis (p = 0.027) and acute skin toxicity (p = 0.001). Seven of 54 (13%) and 20 of 74 patients (27%) received only one chemotherapy course due to treatment-related acute toxicity. Late toxicity in terms of xerostomia, neck fibrosis, skin toxicity, and lymphedema was not significantly different. The 2-year locoregional control rates were 67% after cisplatin alone and 52% after cisplatin + 5-FU (p = 0.35). The metastases-free survival rates were 79% and 69%, respectively (p = 0.65), and the overall survival rates 70% and 51%, respectively (p = 0.10). On multivariate analysis, outcome was significantly associated with performance status, T-category, N-category, hemoglobin level prior to radiotherapy, and radiotherapy break > 1 week.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Two courses of fractionated cisplatin (20 mg/m(2)/day) alone appear preferable, as this regimen resulted in similar outcome and late toxicity as two courses of cisplatin + 5-FU, but in significantly less acute toxicity.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tribius</LastName>
<ForeName>Silke</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Radiation Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Kronemann</LastName>
<ForeName>Stefanie</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kilic</LastName>
<ForeName>Yasemin</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schroeder</LastName>
<ForeName>Ursula</ForeName>
<Initials>U</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hakim</LastName>
<ForeName>Samer</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schild</LastName>
<ForeName>Steven E</ForeName>
<Initials>SE</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rades</LastName>
<ForeName>Dirk</ForeName>
<Initials>D</Initials>
</Author>
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<Month>10</Month>
<Day>06</Day>
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<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year>
<Month>01</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2009</Year>
<Month>07</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2009</Year>
<Month>10</Month>
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<PubMedPubDate PubStatus="pubmed"><Year>2009</Year>
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<PubMedPubDate PubStatus="medline"><Year>2009</Year>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">19806333</ArticleId>
<ArticleId IdType="doi">10.1007/s00066-009-1992-x</ArticleId>
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<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Hambourg</li>
</region>
<settlement><li>Hambourg</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Hakim, Samer" sort="Hakim, Samer" uniqKey="Hakim S" first="Samer" last="Hakim">Samer Hakim</name>
<name sortKey="Kilic, Yasemin" sort="Kilic, Yasemin" uniqKey="Kilic Y" first="Yasemin" last="Kilic">Yasemin Kilic</name>
<name sortKey="Kronemann, Stefanie" sort="Kronemann, Stefanie" uniqKey="Kronemann S" first="Stefanie" last="Kronemann">Stefanie Kronemann</name>
<name sortKey="Rades, Dirk" sort="Rades, Dirk" uniqKey="Rades D" first="Dirk" last="Rades">Dirk Rades</name>
<name sortKey="Schild, Steven E" sort="Schild, Steven E" uniqKey="Schild S" first="Steven E" last="Schild">Steven E. Schild</name>
<name sortKey="Schroeder, Ursula" sort="Schroeder, Ursula" uniqKey="Schroeder U" first="Ursula" last="Schroeder">Ursula Schroeder</name>
</noCountry>
<country name="Allemagne"><region name="Hambourg"><name sortKey="Tribius, Silke" sort="Tribius, Silke" uniqKey="Tribius S" first="Silke" last="Tribius">Silke Tribius</name>
</region>
</country>
</tree>
</affiliations>
</record>
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