Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes
Identifieur interne : 003643 ( Ncbi/Merge ); précédent : 003642; suivant : 003644Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes
Auteurs : Zakaria Kambris ; Peter E. Cook ; Hoang K. Phuc ; Steven P. SinkinsSource :
- Science (New York, N.Y.) [ 0036-8075 ] ; 2009.
Descripteurs français
- KwdFr :
- Aedes (génétique), Aedes (immunologie), Aedes (microbiologie), Aedes (parasitologie), Animaux, Brugia pahangi (croissance et développement), Brugia pahangi (physiologie), Filariose lymphatique (), Filariose lymphatique (transmission), Gènes d'insecte, Immunité innée (génétique), Interactions hôte-parasite, Longévité, Lutte contre les moustiques, RT-PCR, Régulation positive, Séquençage par oligonucléotides en batterie, Vecteurs insectes (immunologie), Vecteurs insectes (microbiologie), Vecteurs insectes (parasitologie), Wolbachia (physiologie).
- MESH :
- croissance et développement : Brugia pahangi.
- génétique : Aedes, Immunité innée.
- immunologie : Aedes, Vecteurs insectes.
- microbiologie : Aedes, Vecteurs insectes.
- parasitologie : Aedes, Vecteurs insectes.
- physiologie : Brugia pahangi, Wolbachia.
- Animaux, Filariose lymphatique, Gènes d'insecte, Interactions hôte-parasite, Longévité, Lutte contre les moustiques, RT-PCR, Régulation positive, Séquençage par oligonucléotides en batterie.
English descriptors
- KwdEn :
- Aedes (genetics), Aedes (immunology), Aedes (microbiology), Aedes (parasitology), Animals, Brugia pahangi (growth & development), Brugia pahangi (physiology), Elephantiasis, Filarial (prevention & control), Elephantiasis, Filarial (transmission), Genes, Insect, Host-Parasite Interactions, Immunity, Innate (genetics), Insect Vectors (immunology), Insect Vectors (microbiology), Insect Vectors (parasitology), Longevity, Mosquito Control, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation, Wolbachia (physiology).
- MESH :
- genetics : Aedes, Immunity, Innate.
- growth & development : Brugia pahangi.
- immunology : Aedes, Insect Vectors.
- microbiology : Aedes, Insect Vectors.
- parasitology : Aedes, Insect Vectors.
- physiology : Brugia pahangi, Wolbachia.
- prevention & control : Elephantiasis, Filarial.
- transmission : Elephantiasis, Filarial.
- Animals, Genes, Insect, Host-Parasite Interactions, Longevity, Mosquito Control, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation.
Abstract
Url:
DOI: 10.1126/science.1177531
PubMed: 19797660
PubMed Central: 2867033
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003394
- to stream Pmc, to step Curation: 003393
- to stream Pmc, to step Checkpoint: 003707
- to stream PubMed, to step Corpus: 002D30
- to stream PubMed, to step Curation: 002D30
- to stream PubMed, to step Checkpoint: 002D30
Links to Exploration step
PMC:2867033Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immune activation by life-shortening <italic>Wolbachia</italic> and reduced filarial competence in mosquitoes</title><author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name></author><author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E." last="Cook">Peter E. Cook</name></author><author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K." last="Phuc">Hoang K. Phuc</name></author><author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P." last="Sinkins">Steven P. Sinkins</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19797660</idno><idno type="pmc">2867033</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867033</idno><idno type="RBID">PMC:2867033</idno><idno type="doi">10.1126/science.1177531</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">003394</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003394</idno><idno type="wicri:Area/Pmc/Curation">003393</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003393</idno><idno type="wicri:Area/Pmc/Checkpoint">003707</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003707</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002D30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D30</idno><idno type="wicri:Area/PubMed/Curation">002D30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002D30</idno><idno type="wicri:Area/PubMed/Checkpoint">002D30</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D30</idno><idno type="wicri:Area/Ncbi/Merge">003643</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immune activation by life-shortening <italic>Wolbachia</italic> and reduced filarial competence in mosquitoes</title><author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name></author><author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E." last="Cook">Peter E. Cook</name></author><author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K." last="Phuc">Hoang K. Phuc</name></author><author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P." last="Sinkins">Steven P. Sinkins</name></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aedes (genetics)</term><term>Aedes (immunology)</term><term>Aedes (microbiology)</term><term>Aedes (parasitology)</term><term>Animals</term><term>Brugia pahangi (growth & development)</term><term>Brugia pahangi (physiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Elephantiasis, Filarial (transmission)</term><term>Genes, Insect</term><term>Host-Parasite Interactions</term><term>Immunity, Innate (genetics)</term><term>Insect Vectors (immunology)</term><term>Insect Vectors (microbiology)</term><term>Insect Vectors (parasitology)</term><term>Longevity</term><term>Mosquito Control</term><term>Oligonucleotide Array Sequence Analysis</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Up-Regulation</term><term>Wolbachia (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aedes (génétique)</term><term>Aedes (immunologie)</term><term>Aedes (microbiologie)</term><term>Aedes (parasitologie)</term><term>Animaux</term><term>Brugia pahangi (croissance et développement)</term><term>Brugia pahangi (physiologie)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (transmission)</term><term>Gènes d'insecte</term><term>Immunité innée (génétique)</term><term>Interactions hôte-parasite</term><term>Longévité</term><term>Lutte contre les moustiques</term><term>RT-PCR</term><term>Régulation positive</term><term>Séquençage par oligonucléotides en batterie</term><term>Vecteurs insectes (immunologie)</term><term>Vecteurs insectes (microbiologie)</term><term>Vecteurs insectes (parasitologie)</term><term>Wolbachia (physiologie)</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia pahangi</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aedes</term><term>Immunity, Innate</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia pahangi</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Aedes</term><term>Immunité innée</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Aedes</term><term>Vecteurs insectes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aedes</term><term>Insect Vectors</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Aedes</term><term>Vecteurs insectes</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Aedes</term><term>Insect Vectors</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Aedes</term><term>Vecteurs insectes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Aedes</term><term>Insect Vectors</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Brugia pahangi</term><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brugia pahangi</term><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genes, Insect</term><term>Host-Parasite Interactions</term><term>Longevity</term><term>Mosquito Control</term><term>Oligonucleotide Array Sequence Analysis</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Filariose lymphatique</term><term>Gènes d'insecte</term><term>Interactions hôte-parasite</term><term>Longévité</term><term>Lutte contre les moustiques</term><term>RT-PCR</term><term>Régulation positive</term><term>Séquençage par oligonucléotides en batterie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1"><italic>Wolbachia</italic> strain <italic>w</italic>MelPop reduces longevity of its <italic>Drosophila melanogaster</italic> host and halves lifespan when introduced into the mosquito <italic>Aedes aegypti</italic>. We show that <italic>w</italic>MelPop induces upregulation of the mosquito innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that <italic>w</italic>MelPop could be used in the global effort to eliminate lymphatic filariasis, and possibly the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune upregulation may contribute to the life-shortening phenotype.</p></div></front></TEI><double pmid="19797660"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immune activation by life-shortening <italic>Wolbachia</italic> and reduced filarial competence in mosquitoes</title><author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name></author><author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E." last="Cook">Peter E. Cook</name></author><author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K." last="Phuc">Hoang K. Phuc</name></author><author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P." last="Sinkins">Steven P. Sinkins</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19797660</idno><idno type="pmc">2867033</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867033</idno><idno type="RBID">PMC:2867033</idno><idno type="doi">10.1126/science.1177531</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">003394</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003394</idno><idno type="wicri:Area/Pmc/Curation">003393</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003393</idno><idno type="wicri:Area/Pmc/Checkpoint">003707</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003707</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immune activation by life-shortening <italic>Wolbachia</italic> and reduced filarial competence in mosquitoes</title><author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name></author><author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E." last="Cook">Peter E. Cook</name></author><author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K." last="Phuc">Hoang K. Phuc</name></author><author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P." last="Sinkins">Steven P. Sinkins</name></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1"><italic>Wolbachia</italic> strain <italic>w</italic>MelPop reduces longevity of its <italic>Drosophila melanogaster</italic> host and halves lifespan when introduced into the mosquito <italic>Aedes aegypti</italic>. We show that <italic>w</italic>MelPop induces upregulation of the mosquito innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that <italic>w</italic>MelPop could be used in the global effort to eliminate lymphatic filariasis, and possibly the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune upregulation may contribute to the life-shortening phenotype.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.</title><author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name><affiliation wicri:level="4"><nlm:affiliation>Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E" last="Cook">Peter E. Cook</name></author><author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K" last="Phuc">Hoang K. Phuc</name></author><author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P" last="Sinkins">Steven P. Sinkins</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19797660</idno><idno type="pmid">19797660</idno><idno type="doi">10.1126/science.1177531</idno><idno type="wicri:Area/PubMed/Corpus">002D30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D30</idno><idno type="wicri:Area/PubMed/Curation">002D30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002D30</idno><idno type="wicri:Area/PubMed/Checkpoint">002D30</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.</title><author><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name><affiliation wicri:level="4"><nlm:affiliation>Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E" last="Cook">Peter E. Cook</name></author><author><name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K" last="Phuc">Hoang K. Phuc</name></author><author><name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P" last="Sinkins">Steven P. Sinkins</name></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="eISSN">1095-9203</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aedes (genetics)</term><term>Aedes (immunology)</term><term>Aedes (microbiology)</term><term>Aedes (parasitology)</term><term>Animals</term><term>Brugia pahangi (growth & development)</term><term>Brugia pahangi (physiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Elephantiasis, Filarial (transmission)</term><term>Genes, Insect</term><term>Host-Parasite Interactions</term><term>Immunity, Innate (genetics)</term><term>Insect Vectors (immunology)</term><term>Insect Vectors (microbiology)</term><term>Insect Vectors (parasitology)</term><term>Longevity</term><term>Mosquito Control</term><term>Oligonucleotide Array Sequence Analysis</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Up-Regulation</term><term>Wolbachia (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aedes (génétique)</term><term>Aedes (immunologie)</term><term>Aedes (microbiologie)</term><term>Aedes (parasitologie)</term><term>Animaux</term><term>Brugia pahangi (croissance et développement)</term><term>Brugia pahangi (physiologie)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (transmission)</term><term>Gènes d'insecte</term><term>Immunité innée (génétique)</term><term>Interactions hôte-parasite</term><term>Longévité</term><term>Lutte contre les moustiques</term><term>RT-PCR</term><term>Régulation positive</term><term>Séquençage par oligonucléotides en batterie</term><term>Vecteurs insectes (immunologie)</term><term>Vecteurs insectes (microbiologie)</term><term>Vecteurs insectes (parasitologie)</term><term>Wolbachia (physiologie)</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia pahangi</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aedes</term><term>Immunity, Innate</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia pahangi</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Aedes</term><term>Immunité innée</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Aedes</term><term>Vecteurs insectes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aedes</term><term>Insect Vectors</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Aedes</term><term>Vecteurs insectes</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Aedes</term><term>Insect Vectors</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Aedes</term><term>Vecteurs insectes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Aedes</term><term>Insect Vectors</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Brugia pahangi</term><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brugia pahangi</term><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genes, Insect</term><term>Host-Parasite Interactions</term><term>Longevity</term><term>Mosquito Control</term><term>Oligonucleotide Array Sequence Analysis</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Filariose lymphatique</term><term>Gènes d'insecte</term><term>Interactions hôte-parasite</term><term>Longévité</term><term>Lutte contre les moustiques</term><term>RT-PCR</term><term>Régulation positive</term><term>Séquençage par oligonucléotides en batterie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003643 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 003643 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:2867033
|texte= Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:19797660" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |