Fibrosis is a key inhibitor of lymphatic regeneration.
Identifieur interne : 003545 ( Ncbi/Merge ); précédent : 003544; suivant : 003546Fibrosis is a key inhibitor of lymphatic regeneration.
Auteurs : Tomer Avraham [États-Unis] ; Nicholas W. Clavin ; Sanjay V. Daluvoy ; John Fernandez ; Marc A. Soares ; Andrew P. Cordeiro ; Babak J. MehraraSource :
- Plastic and reconstructive surgery [ 1529-4242 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Cellules endothéliales (physiologie), Cicatrisation de plaie (physiologie), Collagène de type I (administration et posologie), Facteur de croissance endothéliale vasculaire de type C (métabolisme), Femelle, Fibrose, Gels, Immunohistochimie, Lignées consanguines de souris, Lymphoedème (physiopathologie), Modèles animaux, Prolifération cellulaire, Queue, Réaction de polymérisation en chaîne, Régénération (physiologie), Souris, Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme), Vaisseaux lymphatiques (physiopathologie).
- MESH :
- administration et posologie : Collagène de type I.
- anatomopathologie : Vaisseaux lymphatiques.
- métabolisme : Facteur de croissance endothéliale vasculaire de type C, Vaisseaux lymphatiques.
- physiologie : Cellules endothéliales, Cicatrisation de plaie, Régénération.
- physiopathologie : Lymphoedème, Vaisseaux lymphatiques.
- Animaux, Femelle, Fibrose, Gels, Immunohistochimie, Lignées consanguines de souris, Modèles animaux, Prolifération cellulaire, Queue, Réaction de polymérisation en chaîne, Souris.
English descriptors
- KwdEn :
- Animals, Cell Proliferation, Collagen Type I (administration & dosage), Endothelial Cells (physiology), Female, Fibrosis, Gels, Immunohistochemistry, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Lymphedema (physiopathology), Mice, Mice, Inbred Strains, Models, Animal, Polymerase Chain Reaction, Regeneration (physiology), Tail, Vascular Endothelial Growth Factor C (metabolism), Wound Healing (physiology).
- MESH :
- chemical , administration & dosage : Collagen Type I.
- metabolism : Lymphatic Vessels, Vascular Endothelial Growth Factor C.
- pathology : Lymphatic Vessels.
- physiology : Endothelial Cells, Regeneration, Wound Healing.
- physiopathology : Lymphatic Vessels, Lymphedema.
- Animals, Cell Proliferation, Female, Fibrosis, Gels, Immunohistochemistry, Mice, Mice, Inbred Strains, Models, Animal, Polymerase Chain Reaction, Tail.
Abstract
Lymphedema is a common debilitating sequela of lymph node dissection. Although numerous clinical studies suggest that factors that lead to fibrosis are associated with the development of lymphedema, this relationship has not been proven. The purpose of these experiments was therefore to evaluate lymphatic regeneration in the setting of variable soft-tissue fibrosis.
DOI: 10.1097/PRS.0b013e3181adcf4b
PubMed: 19644258
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Clavin</name></author><author><name sortKey="Daluvoy, Sanjay V" sort="Daluvoy, Sanjay V" uniqKey="Daluvoy S" first="Sanjay V" last="Daluvoy">Sanjay V. Daluvoy</name></author><author><name sortKey="Fernandez, John" sort="Fernandez, John" uniqKey="Fernandez J" first="John" last="Fernandez">John Fernandez</name></author><author><name sortKey="Soares, Marc A" sort="Soares, Marc A" uniqKey="Soares M" first="Marc A" last="Soares">Marc A. Soares</name></author><author><name sortKey="Cordeiro, Andrew P" sort="Cordeiro, Andrew P" uniqKey="Cordeiro A" first="Andrew P" last="Cordeiro">Andrew P. Cordeiro</name></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. 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Clavin</name></author><author><name sortKey="Daluvoy, Sanjay V" sort="Daluvoy, Sanjay V" uniqKey="Daluvoy S" first="Sanjay V" last="Daluvoy">Sanjay V. Daluvoy</name></author><author><name sortKey="Fernandez, John" sort="Fernandez, John" uniqKey="Fernandez J" first="John" last="Fernandez">John Fernandez</name></author><author><name sortKey="Soares, Marc A" sort="Soares, Marc A" uniqKey="Soares M" first="Marc A" last="Soares">Marc A. Soares</name></author><author><name sortKey="Cordeiro, Andrew P" sort="Cordeiro, Andrew P" uniqKey="Cordeiro A" first="Andrew P" last="Cordeiro">Andrew P. Cordeiro</name></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name></author></analytic><series><title level="j">Plastic and reconstructive surgery</title><idno type="eISSN">1529-4242</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Collagen Type I (administration & dosage)</term><term>Endothelial Cells (physiology)</term><term>Female</term><term>Fibrosis</term><term>Gels</term><term>Immunohistochemistry</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (physiopathology)</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Models, Animal</term><term>Polymerase Chain Reaction</term><term>Regeneration (physiology)</term><term>Tail</term><term>Vascular Endothelial Growth Factor C (metabolism)</term><term>Wound Healing (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules endothéliales (physiologie)</term><term>Cicatrisation de plaie (physiologie)</term><term>Collagène de type I (administration et posologie)</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Femelle</term><term>Fibrose</term><term>Gels</term><term>Immunohistochimie</term><term>Lignées consanguines de souris</term><term>Lymphoedème (physiopathologie)</term><term>Modèles animaux</term><term>Prolifération cellulaire</term><term>Queue</term><term>Réaction de polymérisation en chaîne</term><term>Régénération (physiologie)</term><term>Souris</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term><term>Vaisseaux lymphatiques (physiopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Collagen Type I</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Collagène de type I</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphatic Vessels</term><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules endothéliales</term><term>Cicatrisation de plaie</term><term>Régénération</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelial Cells</term><term>Regeneration</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Female</term><term>Fibrosis</term><term>Gels</term><term>Immunohistochemistry</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Models, Animal</term><term>Polymerase Chain Reaction</term><term>Tail</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Fibrose</term><term>Gels</term><term>Immunohistochimie</term><term>Lignées consanguines de souris</term><term>Modèles animaux</term><term>Prolifération cellulaire</term><term>Queue</term><term>Réaction de polymérisation en chaîne</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema is a common debilitating sequela of lymph node dissection. Although numerous clinical studies suggest that factors that lead to fibrosis are associated with the development of lymphedema, this relationship has not been proven. The purpose of these experiments was therefore to evaluate lymphatic regeneration in the setting of variable soft-tissue fibrosis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19644258</PMID><DateCreated><Year>2009</Year><Month>07</Month><Day>31</Day></DateCreated><DateCompleted><Year>2009</Year><Month>09</Month><Day>22</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1529-4242</ISSN><JournalIssue CitedMedium="Internet"><Volume>124</Volume><Issue>2</Issue><PubDate><Year>2009</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Plastic and reconstructive surgery</Title><ISOAbbreviation>Plast. Reconstr. Surg.</ISOAbbreviation></Journal><ArticleTitle>Fibrosis is a key inhibitor of lymphatic regeneration.</ArticleTitle><Pagination><MedlinePgn>438-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/PRS.0b013e3181adcf4b</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lymphedema is a common debilitating sequela of lymph node dissection. Although numerous clinical studies suggest that factors that lead to fibrosis are associated with the development of lymphedema, this relationship has not been proven. The purpose of these experiments was therefore to evaluate lymphatic regeneration in the setting of variable soft-tissue fibrosis.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A section of mouse tail skin including the capillary and collecting lymphatics was excised. Experimental animals (n = 20) were treated with topical collagen type I gel and a moist dressing, whereas control animals (n = 20) underwent excision followed by moist dressing alone. Fibrosis, acute lymphedema, lymphatic function, gene expression, lymphatic endothelial cell proliferation, and lymphatic fibrosis were evaluated at various time points.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Collagen gel treatment significantly decreased fibrosis, with an attendant decrease in acute lymphedema and improved lymphatic function. Tails treated with collagen gel demonstrated greater numbers of lymphatic vessels, more normal lymphatic architecture, and more proliferating lymphatic endothelial cells. These findings appeared to be independent of vascular endothelial growth factor C expression. Decreased fibrosis was associated with a significant decrease in the expression of extracellular matrix components. Finally, decreased soft-tissue fibrosis was associated with a significant decrease in lymphatic fibrosis as evidenced by the number of lymphatic endothelial cells that coexpressed lymphatic and fibroblast markers.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Soft-tissue fibrosis is associated with impairment in lymphatic regeneration and lymphatic function. These defects occur as a consequence of impaired lymphatic endothelial cell proliferation, abnormal lymphatic microarchitecture, and lymphatic fibrosis. Inhibition of fibrosis using a simple topical dressing can markedly accelerate lymphatic repair and promote regeneration of normal capillary lymphatics.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Avraham</LastName><ForeName>Tomer</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clavin</LastName><ForeName>Nicholas W</ForeName><Initials>NW</Initials></Author><Author ValidYN="Y"><LastName>Daluvoy</LastName><ForeName>Sanjay V</ForeName><Initials>SV</Initials></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Soares</LastName><ForeName>Marc A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Cordeiro</LastName><ForeName>Andrew P</ForeName><Initials>AP</Initials></Author><Author ValidYN="Y"><LastName>Mehrara</LastName><ForeName>Babak J</ForeName><Initials>BJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Plast Reconstr Surg</MedlineTA><NlmUniqueID>1306050</NlmUniqueID><ISSNLinking>0032-1052</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024042">Collagen Type I</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005782">Gels</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042582">Vascular Endothelial Growth Factor C</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C467483">vascular endothelial growth factor C, mouse</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024042" MajorTopicYN="N">Collagen Type I</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042783" MajorTopicYN="N">Endothelial Cells</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005355" MajorTopicYN="N">Fibrosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005782" MajorTopicYN="N">Gels</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008815" MajorTopicYN="N">Mice, Inbred Strains</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023421" MajorTopicYN="N">Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012038" MajorTopicYN="N">Regeneration</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013623" MajorTopicYN="N">Tail</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042582" MajorTopicYN="N">Vascular Endothelial Growth Factor C</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014945" MajorTopicYN="N">Wound Healing</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19644258</ArticleId><ArticleId IdType="doi">10.1097/PRS.0b013e3181adcf4b</ArticleId><ArticleId IdType="pii">00006534-200908000-00013</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Clavin, Nicholas W" sort="Clavin, Nicholas W" uniqKey="Clavin N" first="Nicholas W" last="Clavin">Nicholas W. Clavin</name><name sortKey="Cordeiro, Andrew P" sort="Cordeiro, Andrew P" uniqKey="Cordeiro A" first="Andrew P" last="Cordeiro">Andrew P. Cordeiro</name><name sortKey="Daluvoy, Sanjay V" sort="Daluvoy, Sanjay V" uniqKey="Daluvoy S" first="Sanjay V" last="Daluvoy">Sanjay V. Daluvoy</name><name sortKey="Fernandez, John" sort="Fernandez, John" uniqKey="Fernandez J" first="John" last="Fernandez">John Fernandez</name><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name><name sortKey="Soares, Marc A" sort="Soares, Marc A" uniqKey="Soares M" first="Marc A" last="Soares">Marc A. Soares</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Avraham, Tomer" sort="Avraham, Tomer" uniqKey="Avraham T" first="Tomer" last="Avraham">Tomer Avraham</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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