Signaling “cross-talk” is integrated by transcription factors in the development of the anterior segment in the eye
Identifieur interne : 003524 ( Ncbi/Merge ); précédent : 003523; suivant : 003525Signaling “cross-talk” is integrated by transcription factors in the development of the anterior segment in the eye
Auteurs : Philip J. Gage ; Amanda L. ZachariasSource :
- Developmental dynamics : an official publication of the American Association of Anatomists [ 1058-8388 ] ; 2009.
Abstract
Extracellular signaling “cross-talk” between tissues is an important requirement for development of many organs yet the underlying mechanisms generally remain poorly understood. The anterior segment of the eye, which is constructed from four embryonic lineages, provides a unique opportunity to genetically dissect developmental processes such as signaling “cross-talk” without fear of inducing lethality. In the current review, we summarize recent data showing that PITX2, a homeodomain transcription factor, integrates retinoic acid and canonical Wnt/β-catenin signaling during anterior segment development. Because the requirements for retinoic acid signaling, canonical Wnt/β-catenin signaling, and PITX2 are not unique to the eye, this newly identified pathway may have relevance elsewhere during development and in tissue homeostasis.
Url:
DOI: 10.1002/dvdy.22033
PubMed: 19623614
PubMed Central: 2782549
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002911
- to stream Pmc, to step Curation: 002910
- to stream Pmc, to step Checkpoint: 003587
Links to Exploration step
PMC:2782549Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Signaling “cross-talk” is integrated by transcription factors in the development of the anterior segment in the eye</title><author><name sortKey="Gage, Philip J" sort="Gage, Philip J" uniqKey="Gage P" first="Philip J." last="Gage">Philip J. Gage</name></author><author><name sortKey="Zacharias, Amanda L" sort="Zacharias, Amanda L" uniqKey="Zacharias A" first="Amanda L." last="Zacharias">Amanda L. Zacharias</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19623614</idno><idno type="pmc">2782549</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782549</idno><idno type="RBID">PMC:2782549</idno><idno type="doi">10.1002/dvdy.22033</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">002911</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002911</idno><idno type="wicri:Area/Pmc/Curation">002910</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002910</idno><idno type="wicri:Area/Pmc/Checkpoint">003587</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003587</idno><idno type="wicri:Area/Ncbi/Merge">003524</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Signaling “cross-talk” is integrated by transcription factors in the development of the anterior segment in the eye</title><author><name sortKey="Gage, Philip J" sort="Gage, Philip J" uniqKey="Gage P" first="Philip J." last="Gage">Philip J. Gage</name></author><author><name sortKey="Zacharias, Amanda L" sort="Zacharias, Amanda L" uniqKey="Zacharias A" first="Amanda L." last="Zacharias">Amanda L. Zacharias</name></author></analytic><series><title level="j">Developmental dynamics : an official publication of the American Association of Anatomists</title><idno type="ISSN">1058-8388</idno><idno type="eISSN">1097-0177</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Extracellular signaling “cross-talk” between tissues is an important requirement for development of many organs yet the underlying mechanisms generally remain poorly understood. The anterior segment of the eye, which is constructed from four embryonic lineages, provides a unique opportunity to genetically dissect developmental processes such as signaling “cross-talk” without fear of inducing lethality. In the current review, we summarize recent data showing that PITX2, a homeodomain transcription factor, integrates retinoic acid and canonical Wnt/β-catenin signaling during anterior segment development. Because the requirements for retinoic acid signaling, canonical Wnt/β-catenin signaling, and PITX2 are not unique to the eye, this newly identified pathway may have relevance elsewhere during development and in tissue homeostasis.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9201927</journal-id><journal-id journal-id-type="pubmed-jr-id">1281</journal-id><journal-id journal-id-type="nlm-ta">Dev Dyn</journal-id><journal-title>Developmental dynamics : an official publication of the American Association of Anatomists</journal-title><issn pub-type="ppub">1058-8388</issn><issn pub-type="epub">1097-0177</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19623614</article-id><article-id pub-id-type="pmc">2782549</article-id><article-id pub-id-type="doi">10.1002/dvdy.22033</article-id><article-id pub-id-type="manuscript">NIHMS154078</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Signaling “cross-talk” is integrated by transcription factors in the development of the anterior segment in the eye</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gage</surname><given-names>Philip J.</given-names></name><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Zacharias</surname><given-names>Amanda L.</given-names></name></contrib><aff id="A1"> Departments of Ophthalmology & Visual Sciences, and Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48105</aff></contrib-group><author-notes><corresp id="CR1"><label>*</label>Corresponding author: Philip J. Gage Department of Ophthalmology & Visual Sciences University of Michigan Medical School 305 Kellogg Eye Center 1000 Wall Street Ann Arbor, MI 48105 734.647.4215 (Telephone) 734.936.7231 (FAX) <email>philgage@umich.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>9</month><year>2010</year></pub-date><volume>238</volume><issue>9</issue><fpage>2149</fpage><lpage>2162</lpage><abstract><p id="P1">Extracellular signaling “cross-talk” between tissues is an important requirement for development of many organs yet the underlying mechanisms generally remain poorly understood. The anterior segment of the eye, which is constructed from four embryonic lineages, provides a unique opportunity to genetically dissect developmental processes such as signaling “cross-talk” without fear of inducing lethality. In the current review, we summarize recent data showing that PITX2, a homeodomain transcription factor, integrates retinoic acid and canonical Wnt/β-catenin signaling during anterior segment development. Because the requirements for retinoic acid signaling, canonical Wnt/β-catenin signaling, and PITX2 are not unique to the eye, this newly identified pathway may have relevance elsewhere during development and in tissue homeostasis.</p></abstract><kwd-group><kwd>retinoic acid signaling</kwd><kwd>canonical Wnt signaling</kwd><kwd>anterior segment</kwd><kwd>homeobox</kwd></kwd-group><contract-num rid="EY1">R01 EY014126-07
||EY</contract-num><contract-sponsor id="EY1">National Eye Institute : NEI</contract-sponsor></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Gage, Philip J" sort="Gage, Philip J" uniqKey="Gage P" first="Philip J." last="Gage">Philip J. Gage</name><name sortKey="Zacharias, Amanda L" sort="Zacharias, Amanda L" uniqKey="Zacharias A" first="Amanda L." last="Zacharias">Amanda L. Zacharias</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003524 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 003524 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:2782549
|texte= Signaling “cross-talk” is integrated by transcription factors in the development of the anterior segment in the eye
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:19623614" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |