Contractile Physiology of Lymphatics
Identifieur interne : 003470 ( Ncbi/Merge ); précédent : 003469; suivant : 003471Contractile Physiology of Lymphatics
Auteurs : David C. ZawiejaSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2009.
Abstract
The lymphatic system has important roles in body fluid regulation, macromolecular homeostasis, lipid absorption, and immune function. To accomplish these roles, lymphatics must move fluid and its other contents (macromolecules, lipids/chylomicra, immune cells) from the interstitium through the lymphatics, across the nodes, and into the great veins. Thus, the principal task of the lymphatic vascular system is transport. The body must impart energy to the lymph via pumping mechanisms to propel it along the lymphatic network and use pumps and valves to generate lymph flow and prevent its backflow. The lymphatic system utilizes both extrinsic pumps, which rely on the cyclical compression and expansion of lymphatics by surrounding tissue forces, and intrinsic pumps, which rely on the intrinsic rapid/phasic contractions of lymphatic muscle. The intrinsic lymph pump function can be modulated by neural, humoral, and physical factors. Generally, increased lymph pressure/stretch of the muscular lymphatics activates the intrinsic lymph pump, while increased lymph flow/shear in the muscular lymphatics can either activate or inhibit the intrinsic lymph pump depending on the pattern and magnitude of the flow. To regulate lymph transport, lymphatic pumping and resistance must be controlled. A better understanding of these mechanisms could provide the basis for the development of better diagnostic and treatment modalities for lymphatic dysfunction.
Url:
DOI: 10.1089/lrb.2009.0007
PubMed: 19534632
PubMed Central: 2925033
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PMC:2925033Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>The lymphatic system has important roles in body fluid regulation, macromolecular homeostasis, lipid absorption, and immune function. To accomplish these roles, lymphatics must move fluid and its other contents (macromolecules, lipids/chylomicra, immune cells) from the interstitium through the lymphatics, across the nodes, and into the great veins. Thus, the principal task of the lymphatic vascular system is transport. The body must impart energy to the lymph via pumping mechanisms to propel it along the lymphatic network and use pumps and valves to generate lymph flow and prevent its backflow. The lymphatic system utilizes both extrinsic pumps, which rely on the cyclical compression and expansion of lymphatics by surrounding tissue forces, and intrinsic pumps, which rely on the intrinsic rapid/phasic contractions of lymphatic muscle. The intrinsic lymph pump function can be modulated by neural, humoral, and physical factors. Generally, increased lymph pressure/stretch of the muscular lymphatics activates the intrinsic lymph pump, while increased lymph flow/shear in the muscular lymphatics can either activate or inhibit the intrinsic lymph pump depending on the pattern and magnitude of the flow. To regulate lymph transport, lymphatic pumping and resistance must be controlled. A better understanding of these mechanisms could provide the basis for the development of better diagnostic and treatment modalities for lymphatic dysfunction.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Lymphat Res Biol</journal-id>
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<publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name>
<publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc>
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<article-categories><subj-group subj-group-type="heading"><subject>Proceedings of a Mini-Symposium: Lymphedema: An Overview of the Biology, Diagnosis, and Treatment of the Disease</subject>
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<title-group><article-title>Contractile Physiology of Lymphatics</article-title>
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<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Zawieja</surname>
<given-names>David C.</given-names>
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<degrees>Ph.D.</degrees>
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<aff id="aff1">Department of Systems Biology and Translational Medicine,<institution>Cardiovascular Research Institute Division of Lymphatic Biology</institution>
, Texas A&M Health Science Center College of Medicine, Temple, Texas.</aff>
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<author-notes><corresp>Address correspondence to: <italic>David C. Zawieja, Ph.D., Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A&M Health Science Center College of Medicine, 702 SW HK Dodgen Loop, Temple, Texas 77843-1114. E-mail:</italic>
<email xlink:href="mailto:dcz@tamu.edu">dcz@tamu.edu</email>
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<pub-date pub-type="ppub"><month>6</month>
<year>2009</year>
<pmc-comment>string-date: June 2009</pmc-comment>
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<volume>7</volume>
<issue>2</issue>
<fpage>87</fpage>
<lpage>96</lpage>
<permissions><copyright-statement>Copyright 2009, Mary Ann Liebert, Inc.</copyright-statement>
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<abstract><title>Abstract</title>
<p>The lymphatic system has important roles in body fluid regulation, macromolecular homeostasis, lipid absorption, and immune function. To accomplish these roles, lymphatics must move fluid and its other contents (macromolecules, lipids/chylomicra, immune cells) from the interstitium through the lymphatics, across the nodes, and into the great veins. Thus, the principal task of the lymphatic vascular system is transport. The body must impart energy to the lymph via pumping mechanisms to propel it along the lymphatic network and use pumps and valves to generate lymph flow and prevent its backflow. The lymphatic system utilizes both extrinsic pumps, which rely on the cyclical compression and expansion of lymphatics by surrounding tissue forces, and intrinsic pumps, which rely on the intrinsic rapid/phasic contractions of lymphatic muscle. The intrinsic lymph pump function can be modulated by neural, humoral, and physical factors. Generally, increased lymph pressure/stretch of the muscular lymphatics activates the intrinsic lymph pump, while increased lymph flow/shear in the muscular lymphatics can either activate or inhibit the intrinsic lymph pump depending on the pattern and magnitude of the flow. To regulate lymph transport, lymphatic pumping and resistance must be controlled. A better understanding of these mechanisms could provide the basis for the development of better diagnostic and treatment modalities for lymphatic dysfunction.</p>
</abstract>
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