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Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer.

Identifieur interne : 002C57 ( Ncbi/Merge ); précédent : 002C56; suivant : 002C58

Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer.

Auteurs : Jürgen Füller [Allemagne] ; Dorothee Guderian ; Christhardt Köhler ; Achim Schneider ; Thomas G. Wendt

Source :

RBID : pubmed:18398585

Descripteurs français

English descriptors

Abstract

To assess the incidence of clinical lymph edema after lymphadenectomy and postoperative radiotherapy (RT).

DOI: 10.1007/s00066-008-1728-3
PubMed: 18398585

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pubmed:18398585

Le document en format XML

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<title xml:lang="en">Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer.</title>
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<name sortKey="Fuller, Jurgen" sort="Fuller, Jurgen" uniqKey="Fuller J" first="Jürgen" last="Füller">Jürgen Füller</name>
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<nlm:affiliation>Department of Radiooncology, University Hospital, Friedrich Schiller University of Jena, Germany. Juergen.Fueller@med.uni-jena.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiooncology, University Hospital, Friedrich Schiller University of Jena</wicri:regionArea>
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<wicri:noRegion>Friedrich Schiller University of Jena</wicri:noRegion>
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<name sortKey="Guderian, Dorothee" sort="Guderian, Dorothee" uniqKey="Guderian D" first="Dorothee" last="Guderian">Dorothee Guderian</name>
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<name sortKey="Kohler, Christhardt" sort="Kohler, Christhardt" uniqKey="Kohler C" first="Christhardt" last="Köhler">Christhardt Köhler</name>
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<name sortKey="Schneider, Achim" sort="Schneider, Achim" uniqKey="Schneider A" first="Achim" last="Schneider">Achim Schneider</name>
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<name sortKey="Wendt, Thomas G" sort="Wendt, Thomas G" uniqKey="Wendt T" first="Thomas G" last="Wendt">Thomas G. Wendt</name>
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<title xml:lang="en">Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer.</title>
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<nlm:affiliation>Department of Radiooncology, University Hospital, Friedrich Schiller University of Jena, Germany. Juergen.Fueller@med.uni-jena.de</nlm:affiliation>
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<name sortKey="Kohler, Christhardt" sort="Kohler, Christhardt" uniqKey="Kohler C" first="Christhardt" last="Köhler">Christhardt Köhler</name>
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<name sortKey="Schneider, Achim" sort="Schneider, Achim" uniqKey="Schneider A" first="Achim" last="Schneider">Achim Schneider</name>
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<term>Adult</term>
<term>Combined Modality Therapy (adverse effects)</term>
<term>Female</term>
<term>Humans</term>
<term>Lymph Node Excision (adverse effects)</term>
<term>Lymphatic Metastasis (pathology)</term>
<term>Lymphedema (epidemiology)</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Retrospective Studies</term>
<term>Survival Analysis</term>
<term>Uterine Cervical Neoplasms (classification)</term>
<term>Uterine Cervical Neoplasms (mortality)</term>
<term>Uterine Cervical Neoplasms (pathology)</term>
<term>Uterine Cervical Neoplasms (radiotherapy)</term>
<term>Uterine Cervical Neoplasms (surgery)</term>
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<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Association thérapeutique (effets indésirables)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphadénectomie (effets indésirables)</term>
<term>Lymphoedème (épidémiologie)</term>
<term>Métastase lymphatique (anatomopathologie)</term>
<term>Stade de la tumeur</term>
<term>Tumeurs du col de l'utérus ()</term>
<term>Tumeurs du col de l'utérus (anatomopathologie)</term>
<term>Tumeurs du col de l'utérus (mortalité)</term>
<term>Tumeurs du col de l'utérus (radiothérapie)</term>
<term>Études rétrospectives</term>
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<term>Combined Modality Therapy</term>
<term>Lymph Node Excision</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Métastase lymphatique</term>
<term>Tumeurs du col de l'utérus</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en">
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr">
<term>Association thérapeutique</term>
<term>Lymphadénectomie</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Tumeurs du col de l'utérus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Lymphatic Metastasis</term>
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en">
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr">
<term>Tumeurs du col de l'utérus</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Retrospective Studies</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Femelle</term>
<term>Humains</term>
<term>Stade de la tumeur</term>
<term>Tumeurs du col de l'utérus</term>
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<front>
<div type="abstract" xml:lang="en">To assess the incidence of clinical lymph edema after lymphadenectomy and postoperative radiotherapy (RT).</div>
</front>
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<PMID Version="1">18398585</PMID>
<DateCreated>
<Year>2008</Year>
<Month>04</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted>
<Year>2008</Year>
<Month>07</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised>
<Year>2008</Year>
<Month>04</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Print">0179-7158</ISSN>
<JournalIssue CitedMedium="Print">
<Volume>184</Volume>
<Issue>4</Issue>
<PubDate>
<Year>2008</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]</Title>
<ISOAbbreviation>Strahlenther Onkol</ISOAbbreviation>
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<ArticleTitle>Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer.</ArticleTitle>
<Pagination>
<MedlinePgn>206-11</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00066-008-1728-3</ELocationID>
<Abstract>
<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To assess the incidence of clinical lymph edema after lymphadenectomy and postoperative radiotherapy (RT).</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">From 1994-2002 192 patients with risk factors for recurrence received radiotherapy with FIGO I (58.8%), II (35.4%), III (4.2%) or IV (1.6%). RT consisted of teletherapy (10.4%), brachytherapy of the vaginal vault (20.8%) or a combination of both (68.8%). Additional chemotherapy was given in 69 patients (35.9%). Surgery comprised laparoscopically assisted radical vaginal hysterectomy (LARVH) (35.4%), radical abdominal hysterectomy (RAH) (48.4%), simple hysterectomy (HE) (11.5%) or exenteration (4.7%).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">73 patients had lymph node metastases, 119 had negative lymph nodes. In patients with LARVH 6-74 (median 30) lymph nodes were removed, with RAH 3-70 (median 21 lymph nodes), and after HE or exenteration 5-50 (median 13 lymph nodes). 90 patients had 25 or less lymph nodes removed, 83 patients more than 25 lymph nodes removed. Prognostic factors, such as age, FIGO stages, histologic grading and type of histology were well balanced in these cohorts. 45 (23.4%) of all patients developed clinically relevant lymph edema of the lower limb with a median latency of 11 (1-121) months. When 25 or less lymph nodes were removed 17.8% of patients developed leg edema, when more than 25 lymph nodes were removed 32.5% of patients were diagnosed with lymph edema (p = 0.025). Radiotherapy and chemotherapy had no influence on the incidence of leg edema. Overall survival at 5 (10) years was independent of number of lymph nodes removed.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The data suggest increasing rates of leg edema with increasing number of lymph nodes dissected independent of the type of radiotherapy and chemotherapy performed. The lymph node sampling policy should be planned carefully in respect to minimize the risk of leg lymph edema.</AbstractText>
</Abstract>
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<LastName>Füller</LastName>
<ForeName>Jürgen</ForeName>
<Initials>J</Initials>
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<Affiliation>Department of Radiooncology, University Hospital, Friedrich Schiller University of Jena, Germany. Juergen.Fueller@med.uni-jena.de</Affiliation>
</AffiliationInfo>
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<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName>
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<DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
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<DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
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<DescriptorName UI="D002583" MajorTopicYN="N">Uterine Cervical Neoplasms</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
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<name sortKey="Kohler, Christhardt" sort="Kohler, Christhardt" uniqKey="Kohler C" first="Christhardt" last="Köhler">Christhardt Köhler</name>
<name sortKey="Schneider, Achim" sort="Schneider, Achim" uniqKey="Schneider A" first="Achim" last="Schneider">Achim Schneider</name>
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