Imaging the developing lymphatic system using the zebrafish.
Identifieur interne : 002B85 ( Ncbi/Merge ); précédent : 002B84; suivant : 002B86Imaging the developing lymphatic system using the zebrafish.
Auteurs : Karina Yaniv [États-Unis] ; Sumio Isogai ; Daniel Castranova ; Louis Dye ; Jiro Hitomi ; Brant M. WeinsteinSource :
- Novartis Foundation symposium [ 1528-2511 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- embryology : Blood Vessels, Lymphatic System, Lymphatic Vessels, Zebrafish.
- methods : Imaging, Three-Dimensional.
- Animals.
Abstract
The lymphatic system is essential for immune responses, fluid homeostasis, and fat absorption, and is involved in many pathological processes, including tumour metastasis and lymphoedema. Despite its importance, progress in understanding the origins and early development of this system has been hampered by difficulties in observing lymphatic cells in vivo and performing genetic and experimental manipulation of the lymphatic system. These difficulties stem in part from the lack of a model organism combining these features. The zebrafish is a genetically accessible vertebrate with an optically clear embryo permitting high-resolution in vivo imaging, but the existence of a lymphatic vascular system has not been previously reported in this model organism. Using a series of morphological, molecular and functional studies we have visualized and characterized lymphatic vessels in the developing zebrafish. Our studies show that the zebrafish possesses a lymphatic system that shares many of the characteristic features of lymphatic vessels found in other vertebrates. Using multiphoton time-lapse imaging we have carried out in vivo cell tracking experiments to trace the origins of lymphatic endothelial cells. Our data provide conclusive new evidence supporting a venous origin for primitive lymphatic endothelial cells.
PubMed: 18300419
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Despite its importance, progress in understanding the origins and early development of this system has been hampered by difficulties in observing lymphatic cells in vivo and performing genetic and experimental manipulation of the lymphatic system. These difficulties stem in part from the lack of a model organism combining these features. The zebrafish is a genetically accessible vertebrate with an optically clear embryo permitting high-resolution in vivo imaging, but the existence of a lymphatic vascular system has not been previously reported in this model organism. Using a series of morphological, molecular and functional studies we have visualized and characterized lymphatic vessels in the developing zebrafish. Our studies show that the zebrafish possesses a lymphatic system that shares many of the characteristic features of lymphatic vessels found in other vertebrates. Using multiphoton time-lapse imaging we have carried out in vivo cell tracking experiments to trace the origins of lymphatic endothelial cells. Our data provide conclusive new evidence supporting a venous origin for primitive lymphatic endothelial cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18300419</PMID><DateCreated><Year>2008</Year><Month>02</Month><Day>27</Day></DateCreated><DateCompleted><Year>2008</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2008</Year><Month>02</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1528-2511</ISSN><JournalIssue CitedMedium="Print"><Volume>283</Volume><PubDate><Year>2007</Year></PubDate></JournalIssue><Title>Novartis Foundation symposium</Title><ISOAbbreviation>Novartis Found. Symp.</ISOAbbreviation></Journal><ArticleTitle>Imaging the developing lymphatic system using the zebrafish.</ArticleTitle><Pagination><MedlinePgn>139-48; discussion 148-51, 238-41</MedlinePgn></Pagination><Abstract><AbstractText>The lymphatic system is essential for immune responses, fluid homeostasis, and fat absorption, and is involved in many pathological processes, including tumour metastasis and lymphoedema. Despite its importance, progress in understanding the origins and early development of this system has been hampered by difficulties in observing lymphatic cells in vivo and performing genetic and experimental manipulation of the lymphatic system. These difficulties stem in part from the lack of a model organism combining these features. The zebrafish is a genetically accessible vertebrate with an optically clear embryo permitting high-resolution in vivo imaging, but the existence of a lymphatic vascular system has not been previously reported in this model organism. Using a series of morphological, molecular and functional studies we have visualized and characterized lymphatic vessels in the developing zebrafish. Our studies show that the zebrafish possesses a lymphatic system that shares many of the characteristic features of lymphatic vessels found in other vertebrates. Using multiphoton time-lapse imaging we have carried out in vivo cell tracking experiments to trace the origins of lymphatic endothelial cells. 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Weinstein</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Yaniv, Karina" sort="Yaniv, Karina" uniqKey="Yaniv K" first="Karina" last="Yaniv">Karina Yaniv</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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