Functionally specialized junctions between endothelial cells of lymphatic vessels
Identifieur interne : 002895 ( Ncbi/Merge ); précédent : 002894; suivant : 002896Functionally specialized junctions between endothelial cells of lymphatic vessels
Auteurs : Peter Baluk [États-Unis] ; Jonas Fuxe [États-Unis] ; Hiroya Hashizume [États-Unis] ; Talia Romano [États-Unis] ; Erin Lashnits [États-Unis] ; Stefan Butz [Allemagne] ; Dietmar Vestweber [Allemagne] ; Monica Corada [Italie] ; Cinzia Molendini [Italie] ; Elisabetta Dejana [Italie] ; Donald M. Mcdonald [États-Unis]Source :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2007.
Abstract
Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding lymphatic function (Alitalo, K., T. Tammela, and T.V. Petrova. 2005.
Url:
DOI: 10.1084/jem.20062596
PubMed: 17846148
PubMed Central: 2118470
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001B97
- to stream Pmc, to step Curation: 001B96
- to stream Pmc, to step Checkpoint: 003B50
Links to Exploration step
PMC:2118470Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functionally specialized junctions between endothelial cells of lymphatic vessels</title>
<author><name sortKey="Baluk, Peter" sort="Baluk, Peter" uniqKey="Baluk P" first="Peter" last="Baluk">Peter Baluk</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fuxe, Jonas" sort="Fuxe, Jonas" uniqKey="Fuxe J" first="Jonas" last="Fuxe">Jonas Fuxe</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hashizume, Hiroya" sort="Hashizume, Hiroya" uniqKey="Hashizume H" first="Hiroya" last="Hashizume">Hiroya Hashizume</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Romano, Talia" sort="Romano, Talia" uniqKey="Romano T" first="Talia" last="Romano">Talia Romano</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lashnits, Erin" sort="Lashnits, Erin" uniqKey="Lashnits E" first="Erin" last="Lashnits">Erin Lashnits</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Butz, Stefan" sort="Butz, Stefan" uniqKey="Butz S" first="Stefan" last="Butz">Stefan Butz</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vestweber, Dietmar" sort="Vestweber, Dietmar" uniqKey="Vestweber D" first="Dietmar" last="Vestweber">Dietmar Vestweber</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corada, Monica" sort="Corada, Monica" uniqKey="Corada M" first="Monica" last="Corada">Monica Corada</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>FIRC Institute of Molecular Oncology Foundation, 20139 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Molendini, Cinzia" sort="Molendini, Cinzia" uniqKey="Molendini C" first="Cinzia" last="Molendini">Cinzia Molendini</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>FIRC Institute of Molecular Oncology Foundation, 20139 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>FIRC Institute of Molecular Oncology Foundation, 20139 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Biomolecular Sciences and Biotechnology, Faculty of Sciences, University of Milan, 20133 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomolecular Sciences and Biotechnology, Faculty of Sciences, University of Milan, 20133 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7">Mario Negri Institute for Pharmacological Research, 20156 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Mario Negri Institute for Pharmacological Research, 20156 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdonald, Donald M" sort="Mcdonald, Donald M" uniqKey="Mcdonald D" first="Donald M." last="Mcdonald">Donald M. Mcdonald</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17846148</idno>
<idno type="pmc">2118470</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118470</idno>
<idno type="RBID">PMC:2118470</idno>
<idno type="doi">10.1084/jem.20062596</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">001B97</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B97</idno>
<idno type="wicri:Area/Pmc/Curation">001B96</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B96</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003B50</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003B50</idno>
<idno type="wicri:Area/Ncbi/Merge">002895</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Functionally specialized junctions between endothelial cells of lymphatic vessels</title>
<author><name sortKey="Baluk, Peter" sort="Baluk, Peter" uniqKey="Baluk P" first="Peter" last="Baluk">Peter Baluk</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fuxe, Jonas" sort="Fuxe, Jonas" uniqKey="Fuxe J" first="Jonas" last="Fuxe">Jonas Fuxe</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hashizume, Hiroya" sort="Hashizume, Hiroya" uniqKey="Hashizume H" first="Hiroya" last="Hashizume">Hiroya Hashizume</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Romano, Talia" sort="Romano, Talia" uniqKey="Romano T" first="Talia" last="Romano">Talia Romano</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lashnits, Erin" sort="Lashnits, Erin" uniqKey="Lashnits E" first="Erin" last="Lashnits">Erin Lashnits</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Butz, Stefan" sort="Butz, Stefan" uniqKey="Butz S" first="Stefan" last="Butz">Stefan Butz</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vestweber, Dietmar" sort="Vestweber, Dietmar" uniqKey="Vestweber D" first="Dietmar" last="Vestweber">Dietmar Vestweber</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corada, Monica" sort="Corada, Monica" uniqKey="Corada M" first="Monica" last="Corada">Monica Corada</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>FIRC Institute of Molecular Oncology Foundation, 20139 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Molendini, Cinzia" sort="Molendini, Cinzia" uniqKey="Molendini C" first="Cinzia" last="Molendini">Cinzia Molendini</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>FIRC Institute of Molecular Oncology Foundation, 20139 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>FIRC Institute of Molecular Oncology Foundation, 20139 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Biomolecular Sciences and Biotechnology, Faculty of Sciences, University of Milan, 20133 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomolecular Sciences and Biotechnology, Faculty of Sciences, University of Milan, 20133 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7">Mario Negri Institute for Pharmacological Research, 20156 Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Mario Negri Institute for Pharmacological Research, 20156 Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdonald, Donald M" sort="Mcdonald, Donald M" uniqKey="Mcdonald D" first="Donald M." last="Mcdonald">Donald M. Mcdonald</name>
<affiliation><nlm:aff id="N0x8f8e20N0x3bf0bd8">Cardiovascular Research Institute,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="N0x8f8e20N0x3bf0bd8">Comprehensive Cancer Center</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="N0x8f8e20N0x3bf0bd8">Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Anatomy, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Experimental Medicine</title>
<idno type="ISSN">0022-1007</idno>
<idno type="eISSN">1540-9538</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding lymphatic function (Alitalo, K., T. Tammela, and T.V. Petrova. 2005. <italic>Nature</italic>
. 438:946–953), the cellular features responsible for entry of fluid and cells into lymphatics are incompletely understood. We report the presence of novel junctions between endothelial cells of initial lymphatics at likely sites of fluid entry. Overlapping flaps at borders of oak leaf–shaped endothelial cells of initial lymphatics lacked junctions at the tip but were anchored on the sides by discontinuous button-like junctions (buttons) that differed from conventional, continuous, zipper-like junctions (zippers) in collecting lymphatics and blood vessels. However, both buttons and zippers were composed of vascular endothelial cadherin (VE-cadherin) and tight junction–associated proteins, including occludin, claudin-5, zonula occludens–1, junctional adhesion molecule–A, and endothelial cell–selective adhesion molecule. In C57BL/6 mice, VE-cadherin was required for maintenance of junctional integrity, but platelet/endothelial cell adhesion molecule–1 was not. Growing tips of lymphatic sprouts had zippers, not buttons, suggesting that buttons are specialized junctions rather than immature ones. Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Med</journal-id>
<journal-title>The Journal of Experimental Medicine</journal-title>
<issn pub-type="ppub">0022-1007</issn>
<issn pub-type="epub">1540-9538</issn>
<publisher><publisher-name>The Rockefeller University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17846148</article-id>
<article-id pub-id-type="pmc">2118470</article-id>
<article-id pub-id-type="publisher-id">20062596</article-id>
<article-id pub-id-type="doi">10.1084/jem.20062596</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
<subj-group><subject>Article</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Functionally specialized junctions between endothelial cells of lymphatic vessels</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Baluk</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">1</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">2</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fuxe</surname>
<given-names>Jonas</given-names>
</name>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">1</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">2</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hashizume</surname>
<given-names>Hiroya</given-names>
</name>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">1</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">2</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Romano</surname>
<given-names>Talia</given-names>
</name>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">1</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">2</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lashnits</surname>
<given-names>Erin</given-names>
</name>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">1</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">2</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Butz</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vestweber</surname>
<given-names>Dietmar</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Corada</surname>
<given-names>Monica</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Molendini</surname>
<given-names>Cinzia</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dejana</surname>
<given-names>Elisabetta</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
<xref ref-type="aff" rid="aff6">6</xref>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McDonald</surname>
<given-names>Donald M.</given-names>
</name>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">1</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">2</xref>
<xref ref-type="aff" rid="N0x8f8e20N0x3bf0bd8">3</xref>
</contrib>
</contrib-group>
<aff id="N0x8f8e20N0x3bf0bd8"><label>1</label>
Cardiovascular Research Institute,<label>2</label>
Comprehensive Cancer Center, and<label>3</label>
Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143</aff>
<aff id="aff4"><label>4</label>
Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, 48149 Münster, Germany</aff>
<aff id="aff5"><label>5</label>
FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy</aff>
<aff id="aff6"><label>6</label>
Department of Biomolecular Sciences and Biotechnology, Faculty of Sciences, University of Milan, 20133 Milan, Italy</aff>
<aff id="aff7"><label>7</label>
Mario Negri Institute for Pharmacological Research, 20156 Milan, Italy</aff>
<author-notes><fn><p>CORRESPONDENCE Donald M. McDonald: <email>donald.mcdonald@ucsf.edu</email>
</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>10</month>
<year>2007</year>
</pub-date>
<volume>204</volume>
<issue>10</issue>
<fpage>2349</fpage>
<lpage>2362</lpage>
<history><date date-type="received"><day>12</day>
<month>12</month>
<year>2006</year>
</date>
<date date-type="accepted"><day>15</day>
<month>8</month>
<year>2007</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2007, The Rockefeller University Press</copyright-statement>
</permissions>
<self-uri xlink:title="pdf" xlink:href="jem2042349.pdf"></self-uri>
<abstract><p>Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding lymphatic function (Alitalo, K., T. Tammela, and T.V. Petrova. 2005. <italic>Nature</italic>
. 438:946–953), the cellular features responsible for entry of fluid and cells into lymphatics are incompletely understood. We report the presence of novel junctions between endothelial cells of initial lymphatics at likely sites of fluid entry. Overlapping flaps at borders of oak leaf–shaped endothelial cells of initial lymphatics lacked junctions at the tip but were anchored on the sides by discontinuous button-like junctions (buttons) that differed from conventional, continuous, zipper-like junctions (zippers) in collecting lymphatics and blood vessels. However, both buttons and zippers were composed of vascular endothelial cadherin (VE-cadherin) and tight junction–associated proteins, including occludin, claudin-5, zonula occludens–1, junctional adhesion molecule–A, and endothelial cell–selective adhesion molecule. In C57BL/6 mice, VE-cadherin was required for maintenance of junctional integrity, but platelet/endothelial cell adhesion molecule–1 was not. Growing tips of lymphatic sprouts had zippers, not buttons, suggesting that buttons are specialized junctions rather than immature ones. Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics.</p>
</abstract>
</article-meta>
<notes><fn-group><fn><p>Abbreviations used: button, button-like junction; EM, electron microscopy; ESAM, endothelial cell–selective adhesion molecule; JAM-A, junctional adhesion molecule–A; LYVE-1, lymphatic vascular endothelial hyaluronan receptor–1; MHC II, MHC class II; PECAM-1, platelet/endothelial adhesion molecule–1; VE-cadherin, vascular endothelial cadherin; zipper, zipper-like junction; ZO-1, zonula occludens–1.</p>
</fn>
<fn><p>P. Baluk and J. Fuxe contributed equally to this work.</p>
</fn>
</fn-group>
</notes>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Italie</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>District de Münster</li>
<li>Lombardie</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Milan</li>
<li>Münster</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Baluk, Peter" sort="Baluk, Peter" uniqKey="Baluk P" first="Peter" last="Baluk">Peter Baluk</name>
</region>
<name sortKey="Fuxe, Jonas" sort="Fuxe, Jonas" uniqKey="Fuxe J" first="Jonas" last="Fuxe">Jonas Fuxe</name>
<name sortKey="Hashizume, Hiroya" sort="Hashizume, Hiroya" uniqKey="Hashizume H" first="Hiroya" last="Hashizume">Hiroya Hashizume</name>
<name sortKey="Lashnits, Erin" sort="Lashnits, Erin" uniqKey="Lashnits E" first="Erin" last="Lashnits">Erin Lashnits</name>
<name sortKey="Mcdonald, Donald M" sort="Mcdonald, Donald M" uniqKey="Mcdonald D" first="Donald M." last="Mcdonald">Donald M. Mcdonald</name>
<name sortKey="Romano, Talia" sort="Romano, Talia" uniqKey="Romano T" first="Talia" last="Romano">Talia Romano</name>
</country>
<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Butz, Stefan" sort="Butz, Stefan" uniqKey="Butz S" first="Stefan" last="Butz">Stefan Butz</name>
</region>
<name sortKey="Vestweber, Dietmar" sort="Vestweber, Dietmar" uniqKey="Vestweber D" first="Dietmar" last="Vestweber">Dietmar Vestweber</name>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="Corada, Monica" sort="Corada, Monica" uniqKey="Corada M" first="Monica" last="Corada">Monica Corada</name>
</region>
<name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name>
<name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name>
<name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name>
<name sortKey="Molendini, Cinzia" sort="Molendini, Cinzia" uniqKey="Molendini C" first="Cinzia" last="Molendini">Cinzia Molendini</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002895 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002895 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:2118470 |texte= Functionally specialized junctions between endothelial cells of lymphatic vessels }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:17846148" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |