Disparities in Breast Cancer Treatment and Survival for Women with Disabilities
Identifieur interne : 002472 ( Ncbi/Merge ); précédent : 002471; suivant : 002473Disparities in Breast Cancer Treatment and Survival for Women with Disabilities
Auteurs : Ellen P. Mccarthy ; Long H. Ngo ; Richard G. Roetzheim ; Thomas N. Chirikos ; Donglin Li ; Reed E. Drews ; Lisa I. IezzoniSource :
- Annals of internal medicine [ 0003-4819 ] ; 2006.
Abstract
Breast-conserving surgery combined with axillary lymph node dissection and radiotherapy or mastectomy are definitive treatments for women with early-stage breast cancer. Little is known about breast cancer treatment for women with disabilities.
To compare initial treatment for early-stage breast cancer between women with and without disabilities and to examine the association of treatment differences and survival.
Retrospective cohort study.
11 Surveillance, Epidemiology, and End Results (SEER) Program tumor registries.
100 311 women who received a diagnosis of stage I to IIIA breast cancer at 21 to 64 years of age from 1988 to 1999. Women who qualified for Social Security Disability Insurance (SSDI) and Medicare at breast cancer diagnosis were considered disabled.
Receipt of breast-conserving surgery versus mastectomy. For women who had breast-conserving surgery (
Women with SSDI and Medicare coverage had lower rates of breast-conserving surgery than other women (43.2% vs. 49.2%; adjusted relative risk, 0.80 [95% CI, 0.76 to 0.84]). Among women who had breast-conserving surgery, women with SSDI and Medicare coverage were less likely than other women to receive radiotherapy (adjusted relative risk, 0.83 [CI, 0.77 to 0.90]) and axillary lymph node dissection (adjusted relative risk, 0.81 [CI, 0.74 to 0.90]). Women with SSDI and Medicare coverage had lower survival rates than those of other women in all-cause mortality (adjusted hazard ratio, 2.02 [CI, 1.88 to 2.16]) and breast cancer–specific mortality (adjusted hazard ratio, 1.31 [CI, 1.18 to 1.45]). Results were similar after adjustment for treatment differences.
Findings are limited to women who qualified for SSDI and Medicare. No data on adjuvant chemotherapy and hormonal therapy were available, and details about the underlying disability were lacking.
Women with disabilities had higher breast cancer mortality rates and were less likely to undergo standard therapy after breast-conserving surgery than other women. Differences in treatment did not explain the differences in breast cancer mortality rates.
Url:
PubMed: 17088576
PubMed Central: 2442165
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Disparities in Breast Cancer Treatment and Survival for Women with Disabilities</title><author><name sortKey="Mccarthy, Ellen P" sort="Mccarthy, Ellen P" uniqKey="Mccarthy E" first="Ellen P." last="Mccarthy">Ellen P. Mccarthy</name></author><author><name sortKey="Ngo, Long H" sort="Ngo, Long H" uniqKey="Ngo L" first="Long H." last="Ngo">Long H. Ngo</name></author><author><name sortKey="Roetzheim, Richard G" sort="Roetzheim, Richard G" uniqKey="Roetzheim R" first="Richard G." last="Roetzheim">Richard G. Roetzheim</name></author><author><name sortKey="Chirikos, Thomas N" sort="Chirikos, Thomas N" uniqKey="Chirikos T" first="Thomas N." last="Chirikos">Thomas N. Chirikos</name></author><author><name sortKey="Li, Donglin" sort="Li, Donglin" uniqKey="Li D" first="Donglin" last="Li">Donglin Li</name></author><author><name sortKey="Drews, Reed E" sort="Drews, Reed E" uniqKey="Drews R" first="Reed E." last="Drews">Reed E. Drews</name></author><author><name sortKey="Iezzoni, Lisa I" sort="Iezzoni, Lisa I" uniqKey="Iezzoni L" first="Lisa I." last="Iezzoni">Lisa I. Iezzoni</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17088576</idno><idno type="pmc">2442165</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442165</idno><idno type="RBID">PMC:2442165</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">002764</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002764</idno><idno type="wicri:Area/Pmc/Curation">002763</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002763</idno><idno type="wicri:Area/Pmc/Checkpoint">003C84</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003C84</idno><idno type="wicri:Area/Ncbi/Merge">002472</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Disparities in Breast Cancer Treatment and Survival for Women with Disabilities</title><author><name sortKey="Mccarthy, Ellen P" sort="Mccarthy, Ellen P" uniqKey="Mccarthy E" first="Ellen P." last="Mccarthy">Ellen P. Mccarthy</name></author><author><name sortKey="Ngo, Long H" sort="Ngo, Long H" uniqKey="Ngo L" first="Long H." last="Ngo">Long H. Ngo</name></author><author><name sortKey="Roetzheim, Richard G" sort="Roetzheim, Richard G" uniqKey="Roetzheim R" first="Richard G." last="Roetzheim">Richard G. Roetzheim</name></author><author><name sortKey="Chirikos, Thomas N" sort="Chirikos, Thomas N" uniqKey="Chirikos T" first="Thomas N." last="Chirikos">Thomas N. Chirikos</name></author><author><name sortKey="Li, Donglin" sort="Li, Donglin" uniqKey="Li D" first="Donglin" last="Li">Donglin Li</name></author><author><name sortKey="Drews, Reed E" sort="Drews, Reed E" uniqKey="Drews R" first="Reed E." last="Drews">Reed E. Drews</name></author><author><name sortKey="Iezzoni, Lisa I" sort="Iezzoni, Lisa I" uniqKey="Iezzoni L" first="Lisa I." last="Iezzoni">Lisa I. Iezzoni</name></author></analytic><series><title level="j">Annals of internal medicine</title><idno type="ISSN">0003-4819</idno><idno type="eISSN">1539-3704</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Breast-conserving surgery combined with axillary lymph node dissection and radiotherapy or mastectomy are definitive treatments for women with early-stage breast cancer. Little is known about breast cancer treatment for women with disabilities.</p></sec><sec id="S2"><title>Objective</title><p id="P2">To compare initial treatment for early-stage breast cancer between women with and without disabilities and to examine the association of treatment differences and survival.</p></sec><sec id="S3"><title>Design</title><p id="P3">Retrospective cohort study.</p></sec><sec id="S4"><title>Setting</title><p id="P4">11 Surveillance, Epidemiology, and End Results (SEER) Program tumor registries.</p></sec><sec id="S5"><title>Participants</title><p id="P5">100 311 women who received a diagnosis of stage I to IIIA breast cancer at 21 to 64 years of age from 1988 to 1999. Women who qualified for Social Security Disability Insurance (SSDI) and Medicare at breast cancer diagnosis were considered disabled.</p></sec><sec id="S6"><title>Measurements</title><p id="P6">Receipt of breast-conserving surgery versus mastectomy. For women who had breast-conserving surgery (<italic>n</italic> = 49 166), the authors examined receipt of radiotherapy and axillary lymph node dissection. Survival was measured from diagnosis until death or until 31 December 2001.</p></sec><sec id="S7"><title>Results</title><p id="P7">Women with SSDI and Medicare coverage had lower rates of breast-conserving surgery than other women (43.2% vs. 49.2%; adjusted relative risk, 0.80 [95% CI, 0.76 to 0.84]). Among women who had breast-conserving surgery, women with SSDI and Medicare coverage were less likely than other women to receive radiotherapy (adjusted relative risk, 0.83 [CI, 0.77 to 0.90]) and axillary lymph node dissection (adjusted relative risk, 0.81 [CI, 0.74 to 0.90]). Women with SSDI and Medicare coverage had lower survival rates than those of other women in all-cause mortality (adjusted hazard ratio, 2.02 [CI, 1.88 to 2.16]) and breast cancer–specific mortality (adjusted hazard ratio, 1.31 [CI, 1.18 to 1.45]). Results were similar after adjustment for treatment differences.</p></sec><sec id="S8"><title>Limitations</title><p id="P8">Findings are limited to women who qualified for SSDI and Medicare. No data on adjuvant chemotherapy and hormonal therapy were available, and details about the underlying disability were lacking.</p></sec><sec id="S9"><title>Conclusions</title><p id="P9">Women with disabilities had higher breast cancer mortality rates and were less likely to undergo standard therapy after breast-conserving surgery than other women. Differences in treatment did not explain the differences in breast cancer mortality rates.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372351</journal-id><journal-id journal-id-type="pubmed-jr-id">596</journal-id><journal-id journal-id-type="nlm-ta">Ann Intern Med</journal-id><journal-title>Annals of internal medicine</journal-title><issn pub-type="ppub">0003-4819</issn><issn pub-type="epub">1539-3704</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17088576</article-id><article-id pub-id-type="pmc">2442165</article-id><article-id pub-id-type="manuscript">NIHMS41802</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Disparities in Breast Cancer Treatment and Survival for Women with Disabilities</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Ellen P.</given-names></name><degrees>PhD, MPH</degrees></contrib><contrib contrib-type="author"><name><surname>Ngo</surname><given-names>Long H.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Roetzheim</surname><given-names>Richard G.</given-names></name><degrees>MD, MSPH</degrees></contrib><contrib contrib-type="author"><name><surname>Chirikos</surname><given-names>Thomas N.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Donglin</given-names></name><degrees>MD, MPH</degrees></contrib><contrib contrib-type="author"><name><surname>Drews</surname><given-names>Reed E.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Iezzoni</surname><given-names>Lisa I.</given-names></name><degrees>MD, MSc</degrees></contrib><aff id="A1">From Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, and H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, Tampa, Florida</aff></contrib-group><author-notes><corresp id="FN1">Requests for Single Reprints: Ellen P. McCarthy, PhD, MPH, Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 1309 Beacon Street, Suite 220, Brookline, MA 02444; e-mail, <email>emccarth@bidmc.harvard.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>3</month><year>2008</year></pub-date><pub-date pub-type="ppub"><day>7</day><month>11</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2008</year></pub-date><volume>145</volume><issue>9</issue><fpage>637</fpage><lpage>645</lpage><related-article journal-id-type="nlm-ta" journal-id="Ann Intern Med" related-article-type="companion" page="I16" id="N0x1bdad20N0x27896d0" xlink:href="17088572" ext-link-type="pubmed" vol="145"></related-article><related-article journal-id-type="nlm-ta" journal-id="Ann Intern Med" related-article-type="commentary" page="700" id="N0x1bdad20N0x27895f8" xlink:href="17088585" ext-link-type="pubmed" vol="145"></related-article><abstract><sec id="S1"><title>Background</title><p id="P1">Breast-conserving surgery combined with axillary lymph node dissection and radiotherapy or mastectomy are definitive treatments for women with early-stage breast cancer. Little is known about breast cancer treatment for women with disabilities.</p></sec><sec id="S2"><title>Objective</title><p id="P2">To compare initial treatment for early-stage breast cancer between women with and without disabilities and to examine the association of treatment differences and survival.</p></sec><sec id="S3"><title>Design</title><p id="P3">Retrospective cohort study.</p></sec><sec id="S4"><title>Setting</title><p id="P4">11 Surveillance, Epidemiology, and End Results (SEER) Program tumor registries.</p></sec><sec id="S5"><title>Participants</title><p id="P5">100 311 women who received a diagnosis of stage I to IIIA breast cancer at 21 to 64 years of age from 1988 to 1999. Women who qualified for Social Security Disability Insurance (SSDI) and Medicare at breast cancer diagnosis were considered disabled.</p></sec><sec id="S6"><title>Measurements</title><p id="P6">Receipt of breast-conserving surgery versus mastectomy. For women who had breast-conserving surgery (<italic>n</italic> = 49 166), the authors examined receipt of radiotherapy and axillary lymph node dissection. Survival was measured from diagnosis until death or until 31 December 2001.</p></sec><sec id="S7"><title>Results</title><p id="P7">Women with SSDI and Medicare coverage had lower rates of breast-conserving surgery than other women (43.2% vs. 49.2%; adjusted relative risk, 0.80 [95% CI, 0.76 to 0.84]). Among women who had breast-conserving surgery, women with SSDI and Medicare coverage were less likely than other women to receive radiotherapy (adjusted relative risk, 0.83 [CI, 0.77 to 0.90]) and axillary lymph node dissection (adjusted relative risk, 0.81 [CI, 0.74 to 0.90]). Women with SSDI and Medicare coverage had lower survival rates than those of other women in all-cause mortality (adjusted hazard ratio, 2.02 [CI, 1.88 to 2.16]) and breast cancer–specific mortality (adjusted hazard ratio, 1.31 [CI, 1.18 to 1.45]). Results were similar after adjustment for treatment differences.</p></sec><sec id="S8"><title>Limitations</title><p id="P8">Findings are limited to women who qualified for SSDI and Medicare. No data on adjuvant chemotherapy and hormonal therapy were available, and details about the underlying disability were lacking.</p></sec><sec id="S9"><title>Conclusions</title><p id="P9">Women with disabilities had higher breast cancer mortality rates and were less likely to undergo standard therapy after breast-conserving surgery than other women. Differences in treatment did not explain the differences in breast cancer mortality rates.</p></sec></abstract><contract-num rid="CA1">R01 CA100029-04</contract-num><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Chirikos, Thomas N" sort="Chirikos, Thomas N" uniqKey="Chirikos T" first="Thomas N." last="Chirikos">Thomas N. Chirikos</name><name sortKey="Drews, Reed E" sort="Drews, Reed E" uniqKey="Drews R" first="Reed E." last="Drews">Reed E. Drews</name><name sortKey="Iezzoni, Lisa I" sort="Iezzoni, Lisa I" uniqKey="Iezzoni L" first="Lisa I." last="Iezzoni">Lisa I. Iezzoni</name><name sortKey="Li, Donglin" sort="Li, Donglin" uniqKey="Li D" first="Donglin" last="Li">Donglin Li</name><name sortKey="Mccarthy, Ellen P" sort="Mccarthy, Ellen P" uniqKey="Mccarthy E" first="Ellen P." last="Mccarthy">Ellen P. Mccarthy</name><name sortKey="Ngo, Long H" sort="Ngo, Long H" uniqKey="Ngo L" first="Long H." last="Ngo">Long H. Ngo</name><name sortKey="Roetzheim, Richard G" sort="Roetzheim, Richard G" uniqKey="Roetzheim R" first="Richard G." last="Roetzheim">Richard G. Roetzheim</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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