LymphedemaV1, Ncbi, Merge, bibRecord, 002399

Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations.

Identifieur interne : 002399 ( Ncbi/Merge ); précédent : 002398; suivant : 002400

Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations.

Auteurs : A. Ghalamkarpour [Belgique] ; S. Morlot ; A. Raas-Rothschild ; A. Utkus ; J B Mulliken ; L M Boon ; M. Vikkula

Source :

Clinical genetics [ 0009-9163 ] ; 2006.

RBID : pubmed:16965327

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Elephantiasis (genetics), Exons, Fetal Diseases (genetics), Genetic Predisposition to Disease, Humans, Lymphedema (congenital), Lymphedema (genetics), Molecular Sequence Data, Mutation, Pedigree, Pleural Effusion (embryology), Pleural Effusion (genetics), Vascular Endothelial Growth Factor Receptor-3 (genetics).
MESH :
- chemical , genetics : Vascular Endothelial Growth Factor Receptor-3.
- congenital : Lymphedema.
- embryology : Pleural Effusion.
- genetics : Elephantiasis, Fetal Diseases, Lymphedema, Pleural Effusion.
- Amino Acid Sequence, Exons, Genetic Predisposition to Disease, Humans, Molecular Sequence Data, Mutation, Pedigree.

Abstract

Mutations in the vascular endothelial growth factor receptor 3 gene, VEGFR3/FLT4, have been identified in a subset of families with hereditary lymphedema type I or Milroy disease (MIM 153100). Individuals carrying a VEGFR3 mutation exhibit congenital edema of the lower limbs, usually bilaterally and below the knees, sometimes associated with cellulitis, prominent veins, papillomatosis, upturned toenails, and hydrocele. In this study, we report the first de novo VEGFR3 mutation in a patient with sporadic congenital lymphedema. We also describe three other families with a VEGFR3 mutation. In each family, one individual had an atypical clinical presentation of hereditary lymphedema type I, whereas the others had the classical VEGFR3 mutation-caused phenotype. The atypical presentations included pre-natal pleural effusion, spontaneous resorption of lymphedema and elephantiasis. Three of the four identified mutations were novel. These data show that de novo VEGFR3 mutations may be present in patients without family history of congenital lymphedema. This has implications for follow-up care, as such individuals have nearly a 50% risk for occurrence of lymphedema in their children. Our findings also indicate that although most patients with a VEGFR3 mutation have the well-defined phenotype for hereditary lymphedema type I, there are exceptions that should be considered in genetic counseling. Because VEGFR3 mutation can cause generalized lymphatic dysfunction and can thus result in hydrops fetalis, VEGFR3 screening should be added to the investigation of cases of hydrops fetalis of an unknown etiology.

DOI: 10.1111/j.1399-0004.2006.00687.x
PubMed: 16965327

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pubmed:16965327

Le document en format XML

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<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation>
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<term>Fetal Diseases (genetics)</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Lymphedema (congenital)</term>
<term>Lymphedema (genetics)</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Pedigree</term>
<term>Pleural Effusion (embryology)</term>
<term>Pleural Effusion (genetics)</term>
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<term>Lymphoedème (génétique)</term>
<term>Maladies foetales (génétique)</term>
<term>Mutation</term>
<term>Pedigree</term>
<term>Prédisposition génétique à une maladie</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (génétique)</term>
<term>Séquence d'acides aminés</term>
<term>Éléphantiasis (génétique)</term>
<term>Épanchement pleural (embryologie)</term>
<term>Épanchement pleural (génétique)</term>
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<term>Maladies foetales</term>
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<term>Éléphantiasis</term>
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<front><div type="abstract" xml:lang="en">Mutations in the vascular endothelial growth factor receptor 3 gene, VEGFR3/FLT4, have been identified in a subset of families with hereditary lymphedema type I or Milroy disease (MIM 153100). Individuals carrying a VEGFR3 mutation exhibit congenital edema of the lower limbs, usually bilaterally and below the knees, sometimes associated with cellulitis, prominent veins, papillomatosis, upturned toenails, and hydrocele. In this study, we report the first de novo VEGFR3 mutation in a patient with sporadic congenital lymphedema. We also describe three other families with a VEGFR3 mutation. In each family, one individual had an atypical clinical presentation of hereditary lymphedema type I, whereas the others had the classical VEGFR3 mutation-caused phenotype. The atypical presentations included pre-natal pleural effusion, spontaneous resorption of lymphedema and elephantiasis. Three of the four identified mutations were novel. These data show that de novo VEGFR3 mutations may be present in patients without family history of congenital lymphedema. This has implications for follow-up care, as such individuals have nearly a 50% risk for occurrence of lymphedema in their children. Our findings also indicate that although most patients with a VEGFR3 mutation have the well-defined phenotype for hereditary lymphedema type I, there are exceptions that should be considered in genetic counseling. Because VEGFR3 mutation can cause generalized lymphatic dysfunction and can thus result in hydrops fetalis, VEGFR3 screening should be added to the investigation of cases of hydrops fetalis of an unknown etiology.</div>
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<Abstract><AbstractText>Mutations in the vascular endothelial growth factor receptor 3 gene, VEGFR3/FLT4, have been identified in a subset of families with hereditary lymphedema type I or Milroy disease (MIM 153100). Individuals carrying a VEGFR3 mutation exhibit congenital edema of the lower limbs, usually bilaterally and below the knees, sometimes associated with cellulitis, prominent veins, papillomatosis, upturned toenails, and hydrocele. In this study, we report the first de novo VEGFR3 mutation in a patient with sporadic congenital lymphedema. We also describe three other families with a VEGFR3 mutation. In each family, one individual had an atypical clinical presentation of hereditary lymphedema type I, whereas the others had the classical VEGFR3 mutation-caused phenotype. The atypical presentations included pre-natal pleural effusion, spontaneous resorption of lymphedema and elephantiasis. Three of the four identified mutations were novel. These data show that de novo VEGFR3 mutations may be present in patients without family history of congenital lymphedema. This has implications for follow-up care, as such individuals have nearly a 50% risk for occurrence of lymphedema in their children. Our findings also indicate that although most patients with a VEGFR3 mutation have the well-defined phenotype for hereditary lymphedema type I, there are exceptions that should be considered in genetic counseling. Because VEGFR3 mutation can cause generalized lymphatic dysfunction and can thus result in hydrops fetalis, VEGFR3 screening should be added to the investigation of cases of hydrops fetalis of an unknown etiology.</AbstractText>
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Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations.

Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations.

Source :

Descripteurs français

English descriptors

Abstract

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Pour générer des pages wiki