Podoconiosis: a tropical model for gene-environment interactions?
Identifieur interne : 002353 ( Ncbi/Merge ); précédent : 002352; suivant : 002354Podoconiosis: a tropical model for gene-environment interactions?
Auteurs : Gail Davey [Éthiopie] ; Ewenat Gebrehanna ; Adebowale Adeyemo ; Charles Rotimi ; Melanie Newport ; Kelemu DestaSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Éléphantiasis.
- épidémiologie : Éléphantiasis, Éthiopie.
- Facteurs de risque, Femelle, Humains, Mâle, Pedigree, Récidive, Santé en zone rurale, Âge de début.
- Wicri :
- geographic : Éthiopie.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Ethiopia.
- epidemiology : Elephantiasis.
- genetics : Elephantiasis.
- Age of Onset, Female, Humans, Male, Pedigree, Recurrence, Risk Factors, Rural Health.
Abstract
Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (lambda(s)) and heritability for podoconiosis, and conducted segregation analysis on 59 multigenerational affected families from Wolaitta Zone, southern Ethiopia. We estimated the lambda(s) to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1x10(-7)). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.
DOI: 10.1016/j.trstmh.2006.05.002
PubMed: 16884751
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Charles" uniqKey="Rotimi C" first="Charles" last="Rotimi">Charles Rotimi</name></author><author><name sortKey="Newport, Melanie" sort="Newport, Melanie" uniqKey="Newport M" first="Melanie" last="Newport">Melanie Newport</name></author><author><name sortKey="Desta, Kelemu" sort="Desta, Kelemu" uniqKey="Desta K" first="Kelemu" last="Desta">Kelemu Desta</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:16884751</idno><idno type="pmid">16884751</idno><idno type="doi">10.1016/j.trstmh.2006.05.002</idno><idno type="wicri:Area/PubMed/Corpus">003922</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003922</idno><idno type="wicri:Area/PubMed/Curation">003922</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003922</idno><idno type="wicri:Area/PubMed/Checkpoint">003922</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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last="Adeyemo">Adebowale Adeyemo</name></author><author><name sortKey="Rotimi, Charles" sort="Rotimi, Charles" uniqKey="Rotimi C" first="Charles" last="Rotimi">Charles Rotimi</name></author><author><name sortKey="Newport, Melanie" sort="Newport, Melanie" uniqKey="Newport M" first="Melanie" last="Newport">Melanie Newport</name></author><author><name sortKey="Desta, Kelemu" sort="Desta, Kelemu" uniqKey="Desta K" first="Kelemu" last="Desta">Kelemu Desta</name></author></analytic><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><idno type="ISSN">0035-9203</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Elephantiasis (epidemiology)</term><term>Elephantiasis (genetics)</term><term>Ethiopia 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xml:lang="fr"><term>Éléphantiasis</term><term>Éthiopie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Female</term><term>Humans</term><term>Male</term><term>Pedigree</term><term>Recurrence</term><term>Risk Factors</term><term>Rural Health</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pedigree</term><term>Récidive</term><term>Santé en zone rurale</term><term>Âge de début</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Éthiopie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (lambda(s)) and heritability for podoconiosis, and conducted segregation analysis on 59 multigenerational affected families from Wolaitta Zone, southern Ethiopia. We estimated the lambda(s) to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1x10(-7)). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16884751</PMID><DateCreated><Year>2006</Year><Month>11</Month><Day>07</Day></DateCreated><DateCompleted><Year>2007</Year><Month>06</Month><Day>05</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0035-9203</ISSN><JournalIssue CitedMedium="Print"><Volume>101</Volume><Issue>1</Issue><PubDate><Year>2007</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Transactions of the Royal Society of Tropical Medicine and Hygiene</Title><ISOAbbreviation>Trans. R. Soc. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Podoconiosis: a tropical model for gene-environment interactions?</ArticleTitle><Pagination><MedlinePgn>91-6</MedlinePgn></Pagination><Abstract><AbstractText>Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (lambda(s)) and heritability for podoconiosis, and conducted segregation analysis on 59 multigenerational affected families from Wolaitta Zone, southern Ethiopia. We estimated the lambda(s) to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1x10(-7)). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Davey</LastName><ForeName>Gail</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia. gailinaddis@hotmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gebrehanna</LastName><ForeName>Ewenat</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Adeyemo</LastName><ForeName>Adebowale</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rotimi</LastName><ForeName>Charles</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Newport</LastName><ForeName>Melanie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Desta</LastName><ForeName>Kelemu</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>08</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trans R Soc Trop Med Hyg</MedlineTA><NlmUniqueID>7506129</NlmUniqueID><ISSNLinking>0035-9203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017668" MajorTopicYN="N">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004604" MajorTopicYN="N">Elephantiasis</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005002" MajorTopicYN="N" Type="Geographic">Ethiopia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010375" MajorTopicYN="N">Pedigree</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012423" MajorTopicYN="N">Rural Health</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>11</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2006</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2006</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>8</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>6</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>8</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16884751</ArticleId><ArticleId IdType="pii">S0035-9203(06)00170-2</ArticleId><ArticleId IdType="doi">10.1016/j.trstmh.2006.05.002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Éthiopie</li></country></list><tree><noCountry><name sortKey="Adeyemo, Adebowale" sort="Adeyemo, Adebowale" uniqKey="Adeyemo A" first="Adebowale" last="Adeyemo">Adebowale Adeyemo</name><name sortKey="Desta, Kelemu" sort="Desta, Kelemu" uniqKey="Desta K" first="Kelemu" last="Desta">Kelemu Desta</name><name sortKey="Gebrehanna, Ewenat" sort="Gebrehanna, Ewenat" uniqKey="Gebrehanna E" first="Ewenat" last="Gebrehanna">Ewenat Gebrehanna</name><name sortKey="Newport, Melanie" sort="Newport, Melanie" uniqKey="Newport M" first="Melanie" last="Newport">Melanie Newport</name><name sortKey="Rotimi, Charles" sort="Rotimi, Charles" uniqKey="Rotimi C" first="Charles" last="Rotimi">Charles Rotimi</name></noCountry><country name="Éthiopie"><noRegion><name sortKey="Davey, Gail" sort="Davey, Gail" uniqKey="Davey G" first="Gail" last="Davey">Gail Davey</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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