Measurement of skin desmosine as an indicator of altered cutaneous elastin in draft horses with chronic progressive lymphedema.
Identifieur interne : 002314 ( Ncbi/Merge ); précédent : 002313; suivant : 002315Measurement of skin desmosine as an indicator of altered cutaneous elastin in draft horses with chronic progressive lymphedema.
Auteurs : Hilde E V. De Cock [États-Unis] ; Verena K. Affolter ; Thomas B. Farver ; Leen Van Brantegem ; Brad Scheuch ; Gregory L. FerraroSource :
- Lymphatic research and biology [ 1539-6851 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- médecine vétérinaire : Lymphoedème.
- métabolisme : Desmosine, Lymphoedème, Maladies des chevaux, Peau, Élastine.
- Animaux, Equus caballus.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Desmosine, Elastin.
- metabolism : Horse Diseases, Lymphedema, Skin.
- veterinary : Lymphedema.
- Animals, Horses.
Abstract
Chronic progressive lymphedema in Clydesdale and Shire draft horses causes severe disability of the limbs which leads to premature death of these horses. Since appropriate function of lymph vessels is dependent on the presence of viable elastin fibers, the goal of this study was to document differences in skin elastin fibers in affected horse breeds, compared to a nonaffected draft horse breed.
DOI: 10.1089/lrb.2006.4.67
PubMed: 16808668
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pubmed:16808668Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Measurement of skin desmosine as an indicator of altered cutaneous elastin in draft horses with chronic progressive lymphedema.</title><author><name sortKey="De Cock, Hilde E V" sort="De Cock, Hilde E V" uniqKey="De Cock H" first="Hilde E V" last="De Cock">Hilde E V. De Cock</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Microbiology, and Immunology, University of California, Davis, 95616, USA. hdecock@ucdavis.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Microbiology, and Immunology, University of California, Davis, 95616</wicri:regionArea><wicri:noRegion>95616</wicri:noRegion></affiliation></author><author><name sortKey="Affolter, Verena K" sort="Affolter, Verena K" uniqKey="Affolter V" first="Verena K" last="Affolter">Verena K. Affolter</name></author><author><name sortKey="Farver, Thomas B" sort="Farver, Thomas B" uniqKey="Farver T" first="Thomas B" last="Farver">Thomas B. Farver</name></author><author><name sortKey="Van Brantegem, Leen" sort="Van Brantegem, Leen" uniqKey="Van Brantegem L" first="Leen" last="Van Brantegem">Leen Van Brantegem</name></author><author><name sortKey="Scheuch, Brad" sort="Scheuch, Brad" uniqKey="Scheuch B" first="Brad" last="Scheuch">Brad Scheuch</name></author><author><name sortKey="Ferraro, Gregory L" sort="Ferraro, Gregory L" uniqKey="Ferraro G" first="Gregory L" last="Ferraro">Gregory L. Ferraro</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16808668</idno><idno type="pmid">16808668</idno><idno type="doi">10.1089/lrb.2006.4.67</idno><idno type="wicri:Area/PubMed/Corpus">003949</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003949</idno><idno type="wicri:Area/PubMed/Curation">003949</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003949</idno><idno type="wicri:Area/PubMed/Checkpoint">003949</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003949</idno><idno type="wicri:Area/Ncbi/Merge">002314</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Measurement of skin desmosine as an indicator of altered cutaneous elastin in draft horses with chronic progressive lymphedema.</title><author><name sortKey="De Cock, Hilde E V" sort="De Cock, Hilde E V" uniqKey="De Cock H" first="Hilde E V" last="De Cock">Hilde E V. De Cock</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Microbiology, and Immunology, University of California, Davis, 95616, USA. hdecock@ucdavis.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Microbiology, and Immunology, University of California, Davis, 95616</wicri:regionArea><wicri:noRegion>95616</wicri:noRegion></affiliation></author><author><name sortKey="Affolter, Verena K" sort="Affolter, Verena K" uniqKey="Affolter V" first="Verena K" last="Affolter">Verena K. Affolter</name></author><author><name sortKey="Farver, Thomas B" sort="Farver, Thomas B" uniqKey="Farver T" first="Thomas B" last="Farver">Thomas B. Farver</name></author><author><name sortKey="Van Brantegem, Leen" sort="Van Brantegem, Leen" uniqKey="Van Brantegem L" first="Leen" last="Van Brantegem">Leen Van Brantegem</name></author><author><name sortKey="Scheuch, Brad" sort="Scheuch, Brad" uniqKey="Scheuch B" first="Brad" last="Scheuch">Brad Scheuch</name></author><author><name sortKey="Ferraro, Gregory L" sort="Ferraro, Gregory L" uniqKey="Ferraro G" first="Gregory L" last="Ferraro">Gregory L. Ferraro</name></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="ISSN">1539-6851</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Desmosine (metabolism)</term><term>Elastin (metabolism)</term><term>Horse Diseases (metabolism)</term><term>Horses</term><term>Lymphedema (metabolism)</term><term>Lymphedema (veterinary)</term><term>Skin (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Desmosine (métabolisme)</term><term>Equus caballus</term><term>Lymphoedème (médecine vétérinaire)</term><term>Lymphoedème (métabolisme)</term><term>Maladies des chevaux (métabolisme)</term><term>Peau (métabolisme)</term><term>Élastine (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Desmosine</term><term>Elastin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Horse Diseases</term><term>Lymphedema</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Desmosine</term><term>Lymphoedème</term><term>Maladies des chevaux</term><term>Peau</term><term>Élastine</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Horses</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Equus caballus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic progressive lymphedema in Clydesdale and Shire draft horses causes severe disability of the limbs which leads to premature death of these horses. Since appropriate function of lymph vessels is dependent on the presence of viable elastin fibers, the goal of this study was to document differences in skin elastin fibers in affected horse breeds, compared to a nonaffected draft horse breed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16808668</PMID><DateCreated><Year>2006</Year><Month>06</Month><Day>30</Day></DateCreated><DateCompleted><Year>2006</Year><Month>08</Month><Day>11</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1539-6851</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>2</Issue><PubDate><Year>2006</Year></PubDate></JournalIssue><Title>Lymphatic research and biology</Title><ISOAbbreviation>Lymphat Res Biol</ISOAbbreviation></Journal><ArticleTitle>Measurement of skin desmosine as an indicator of altered cutaneous elastin in draft horses with chronic progressive lymphedema.</ArticleTitle><Pagination><MedlinePgn>67-72</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Chronic progressive lymphedema in Clydesdale and Shire draft horses causes severe disability of the limbs which leads to premature death of these horses. Since appropriate function of lymph vessels is dependent on the presence of viable elastin fibers, the goal of this study was to document differences in skin elastin fibers in affected horse breeds, compared to a nonaffected draft horse breed.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Biochemical analysis of cutaneous desmosine, a cross-linking amino acid found only in elastin, was used to measure elastin in the skin from 110 draft horses. This included 7 normal, 38 mildly affected, 30 moderately, and 15 severely affected horses, and 20 horses of a nonaffected draft breed. Desmosine concentrations in neck, considered a nonaffected skin region, and left forelimb, an affected skin region, were compared between the groups. A significantly lower desmosine concentration was found in the skin of the neck and limb of clinically normal animals of affected draft breeds compared to a nonaffected draft horse breed. During the progression of the disease in the affected breeds, cutaneous desmosine concentrations most prominently increased in the skin of the distal limbs.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Chronic progressive lymphedema in draft horses was associated with an initially systemic lower cutaneous elastin level and a deposition of elastin during the progression of the disease. A failure of elastic fibers to appropriately support the skin and its lymphatics is proposed as a possible contributing factor for chronic progressive lymphedema in Shires and Clydesdales.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>De Cock</LastName><ForeName>Hilde E V</ForeName><Initials>HE</Initials><AffiliationInfo><Affiliation>Department of Pathology, Microbiology, and Immunology, University of California, Davis, 95616, USA. hdecock@ucdavis.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Affolter</LastName><ForeName>Verena K</ForeName><Initials>VK</Initials></Author><Author ValidYN="Y"><LastName>Farver</LastName><ForeName>Thomas B</ForeName><Initials>TB</Initials></Author><Author ValidYN="Y"><LastName>Van Brantegem</LastName><ForeName>Leen</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Scheuch</LastName><ForeName>Brad</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Ferraro</LastName><ForeName>Gregory L</ForeName><Initials>GL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lymphat Res Biol</MedlineTA><NlmUniqueID>101163587</NlmUniqueID><ISSNLinking>1539-6851</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>11003-57-9</RegistryNumber><NameOfSubstance UI="D003895">Desmosine</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-58-3</RegistryNumber><NameOfSubstance UI="D004549">Elastin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003895" MajorTopicYN="N">Desmosine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004549" MajorTopicYN="N">Elastin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006734" MajorTopicYN="N">Horse Diseases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006736" MajorTopicYN="N">Horses</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>7</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>8</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>7</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16808668</ArticleId><ArticleId IdType="doi">10.1089/lrb.2006.4.67</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Affolter, Verena K" sort="Affolter, Verena K" uniqKey="Affolter V" first="Verena K" last="Affolter">Verena K. Affolter</name><name sortKey="Farver, Thomas B" sort="Farver, Thomas B" uniqKey="Farver T" first="Thomas B" last="Farver">Thomas B. Farver</name><name sortKey="Ferraro, Gregory L" sort="Ferraro, Gregory L" uniqKey="Ferraro G" first="Gregory L" last="Ferraro">Gregory L. Ferraro</name><name sortKey="Scheuch, Brad" sort="Scheuch, Brad" uniqKey="Scheuch B" first="Brad" last="Scheuch">Brad Scheuch</name><name sortKey="Van Brantegem, Leen" sort="Van Brantegem, Leen" uniqKey="Van Brantegem L" first="Leen" last="Van Brantegem">Leen Van Brantegem</name></noCountry><country name="États-Unis"><noRegion><name sortKey="De Cock, Hilde E V" sort="De Cock, Hilde E V" uniqKey="De Cock H" first="Hilde E V" last="De Cock">Hilde E V. De Cock</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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