Short-term effects of axillary lymph node clearance surgery on lymphatic physiology of the arm in breast cancer.
Identifieur interne : 002025 ( Ncbi/Merge ); précédent : 002024; suivant : 002026Short-term effects of axillary lymph node clearance surgery on lymphatic physiology of the arm in breast cancer.
Auteurs : Simon J. Pain [Royaume-Uni] ; Robert W. Barber ; Chandra K. Solanki ; James R. Ballinger ; Tom Bennett Britton ; Peter S. Mortimer ; Anand D. Purushotham ; A Michael PetersSource :
- Journal of applied physiology (Bethesda, Md. : 1985) [ 8750-7587 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Aisselle (), Aisselle (physiopathologie), Bras (), Bras (physiopathologie), Facteurs temps, Femelle, Humains, Immunoglobuline G (sang), Lymphadénectomie, Lymphoedème (physiopathologie), Lymphoedème (étiologie), Métastase lymphatique, Noeuds lymphatiques (), Noeuds lymphatiques (physiopathologie), Sujet âgé, Transport biologique actif, Tumeurs du sein (), Tumeurs du sein (physiopathologie).
- MESH :
- physiopathologie : Aisselle, Bras, Lymphoedème, Noeuds lymphatiques, Tumeurs du sein.
- sang : Immunoglobuline G.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Aisselle, Bras, Facteurs temps, Femelle, Humains, Lymphadénectomie, Métastase lymphatique, Noeuds lymphatiques, Sujet âgé, Transport biologique actif, Tumeurs du sein.
English descriptors
- KwdEn :
- Adult, Aged, Arm (physiopathology), Arm (surgery), Axilla (physiopathology), Axilla (surgery), Biological Transport, Active, Breast Neoplasms (complications), Breast Neoplasms (physiopathology), Breast Neoplasms (surgery), Female, Humans, Immunoglobulin G (blood), Lymph Node Excision, Lymph Nodes (physiopathology), Lymph Nodes (surgery), Lymphatic Metastasis, Lymphedema (etiology), Lymphedema (physiopathology), Middle Aged, Time Factors.
- MESH :
- chemical , blood : Immunoglobulin G.
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- physiopathology : Arm, Axilla, Breast Neoplasms, Lymph Nodes, Lymphedema.
- surgery : Arm, Axilla, Breast Neoplasms, Lymph Nodes.
- Adult, Aged, Biological Transport, Active, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Middle Aged, Time Factors.
Abstract
It is not known why some women develop breast cancer-related lymphedema (BCRL) of the arm, whereas others having similar treatment do not. We speculated that increased uptake of protein into local blood may protect against BCRL. Sixteen women were given bilateral subcutaneous hand webspace injections of polyclonal immunoglobulin (HIgG), (99m)Tc-HIgG on one side and (111)In-HIgG on the other, before and 3 mo after axillary clearance surgery. The rates of clearance of activity from the depot (k) and accumulation in central blood (b(contra)) were measured using a scintillation probe and bilateral antecubital vein blood sampling, respectively. Activity accumulating in blood ipsilateral to the injected side, in excess of central blood activity (b(ipsi)) was also calculated as a measure of local vascular uptake. The k correlated with b(contra), but neither changed in response to surgery. However, b(ipsi) for injections of (99m)Tc-HIgG into the affected arm increased in all seven patients in whom data were available (0.018 +/- 0.006 to 0.038 +/- 0.007%/min; P < 0.05); indeed, in five of these seven, b(ipsi) paradoxically exceeded b(contra), and none developed BCRL at 3-yr follow-up. We conclude that uptake of protein into local blood and/or proteolysis increases after axillary surgery and may protect against BCRL.
DOI: 10.1152/japplphysiol.00372.2005
PubMed: 16288099
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Pain</name><affiliation wicri:level="1"><nlm:affiliation>Cambridge Breast Unit, Addenbrooke's Hospital, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Breast Unit, Addenbrooke's Hospital</wicri:regionArea><wicri:noRegion>Addenbrooke's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Barber, Robert W" sort="Barber, Robert W" uniqKey="Barber R" first="Robert W" last="Barber">Robert W. Barber</name></author><author><name sortKey="Solanki, Chandra K" sort="Solanki, Chandra K" uniqKey="Solanki C" first="Chandra K" last="Solanki">Chandra K. Solanki</name></author><author><name sortKey="Ballinger, James R" sort="Ballinger, James R" uniqKey="Ballinger J" first="James R" last="Ballinger">James R. Ballinger</name></author><author><name sortKey="Britton, Tom Bennett" sort="Britton, Tom Bennett" uniqKey="Britton T" first="Tom Bennett" last="Britton">Tom Bennett Britton</name></author><author><name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S" last="Mortimer">Peter S. Mortimer</name></author><author><name sortKey="Purushotham, Anand D" sort="Purushotham, Anand D" uniqKey="Purushotham A" first="Anand D" last="Purushotham">Anand D. Purushotham</name></author><author><name sortKey="Peters, A Michael" sort="Peters, A Michael" uniqKey="Peters A" first="A Michael" last="Peters">A Michael Peters</name></author></analytic><series><title level="j">Journal of applied physiology (Bethesda, Md. : 1985)</title><idno type="ISSN">8750-7587</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Arm (physiopathology)</term><term>Arm (surgery)</term><term>Axilla (physiopathology)</term><term>Axilla (surgery)</term><term>Biological Transport, Active</term><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (physiopathology)</term><term>Breast Neoplasms (surgery)</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Lymph Node Excision</term><term>Lymph Nodes (physiopathology)</term><term>Lymph Nodes (surgery)</term><term>Lymphatic Metastasis</term><term>Lymphedema (etiology)</term><term>Lymphedema (physiopathology)</term><term>Middle Aged</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aisselle ()</term><term>Aisselle (physiopathologie)</term><term>Bras ()</term><term>Bras (physiopathologie)</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Lymphadénectomie</term><term>Lymphoedème (physiopathologie)</term><term>Lymphoedème (étiologie)</term><term>Métastase lymphatique</term><term>Noeuds lymphatiques ()</term><term>Noeuds lymphatiques (physiopathologie)</term><term>Sujet âgé</term><term>Transport biologique actif</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (physiopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Aisselle</term><term>Bras</term><term>Lymphoedème</term><term>Noeuds lymphatiques</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arm</term><term>Axilla</term><term>Breast Neoplasms</term><term>Lymph Nodes</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Arm</term><term>Axilla</term><term>Breast Neoplasms</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biological Transport, Active</term><term>Female</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aisselle</term><term>Bras</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Lymphadénectomie</term><term>Métastase lymphatique</term><term>Noeuds lymphatiques</term><term>Sujet âgé</term><term>Transport biologique actif</term><term>Tumeurs du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is not known why some women develop breast cancer-related lymphedema (BCRL) of the arm, whereas others having similar treatment do not. We speculated that increased uptake of protein into local blood may protect against BCRL. Sixteen women were given bilateral subcutaneous hand webspace injections of polyclonal immunoglobulin (HIgG), (99m)Tc-HIgG on one side and (111)In-HIgG on the other, before and 3 mo after axillary clearance surgery. The rates of clearance of activity from the depot (k) and accumulation in central blood (b(contra)) were measured using a scintillation probe and bilateral antecubital vein blood sampling, respectively. Activity accumulating in blood ipsilateral to the injected side, in excess of central blood activity (b(ipsi)) was also calculated as a measure of local vascular uptake. The k correlated with b(contra), but neither changed in response to surgery. However, b(ipsi) for injections of (99m)Tc-HIgG into the affected arm increased in all seven patients in whom data were available (0.018 +/- 0.006 to 0.038 +/- 0.007%/min; P < 0.05); indeed, in five of these seven, b(ipsi) paradoxically exceeded b(contra), and none developed BCRL at 3-yr follow-up. We conclude that uptake of protein into local blood and/or proteolysis increases after axillary surgery and may protect against BCRL.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16288099</PMID><DateCreated><Year>2005</Year><Month>11</Month><Day>18</Day></DateCreated><DateCompleted><Year>2006</Year><Month>01</Month><Day>05</Day></DateCompleted><DateRevised><Year>2013</Year><Month>09</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">8750-7587</ISSN><JournalIssue CitedMedium="Print"><Volume>99</Volume><Issue>6</Issue><PubDate><Year>2005</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of applied physiology (Bethesda, Md. : 1985)</Title><ISOAbbreviation>J. Appl. Physiol.</ISOAbbreviation></Journal><ArticleTitle>Short-term effects of axillary lymph node clearance surgery on lymphatic physiology of the arm in breast cancer.</ArticleTitle><Pagination><MedlinePgn>2345-51</MedlinePgn></Pagination><Abstract><AbstractText>It is not known why some women develop breast cancer-related lymphedema (BCRL) of the arm, whereas others having similar treatment do not. We speculated that increased uptake of protein into local blood may protect against BCRL. Sixteen women were given bilateral subcutaneous hand webspace injections of polyclonal immunoglobulin (HIgG), (99m)Tc-HIgG on one side and (111)In-HIgG on the other, before and 3 mo after axillary clearance surgery. The rates of clearance of activity from the depot (k) and accumulation in central blood (b(contra)) were measured using a scintillation probe and bilateral antecubital vein blood sampling, respectively. Activity accumulating in blood ipsilateral to the injected side, in excess of central blood activity (b(ipsi)) was also calculated as a measure of local vascular uptake. The k correlated with b(contra), but neither changed in response to surgery. However, b(ipsi) for injections of (99m)Tc-HIgG into the affected arm increased in all seven patients in whom data were available (0.018 +/- 0.006 to 0.038 +/- 0.007%/min; P < 0.05); indeed, in five of these seven, b(ipsi) paradoxically exceeded b(contra), and none developed BCRL at 3-yr follow-up. We conclude that uptake of protein into local blood and/or proteolysis increases after axillary surgery and may protect against BCRL.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pain</LastName><ForeName>Simon J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Cambridge Breast Unit, Addenbrooke's Hospital, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barber</LastName><ForeName>Robert W</ForeName><Initials>RW</Initials></Author><Author ValidYN="Y"><LastName>Solanki</LastName><ForeName>Chandra K</ForeName><Initials>CK</Initials></Author><Author ValidYN="Y"><LastName>Ballinger</LastName><ForeName>James R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Britton</LastName><ForeName>Tom Bennett</ForeName><Initials>TB</Initials></Author><Author ValidYN="Y"><LastName>Mortimer</LastName><ForeName>Peter S</ForeName><Initials>PS</Initials></Author><Author ValidYN="Y"><LastName>Purushotham</LastName><ForeName>Anand D</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>A Michael</ForeName><Initials>AM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Appl Physiol (1985)</MedlineTA><NlmUniqueID>8502536</NlmUniqueID><ISSNLinking>0161-7567</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001132" MajorTopicYN="N">Arm</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001365" MajorTopicYN="N">Axilla</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001693" MajorTopicYN="N">Biological Transport, Active</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="Y">Lymph Node Excision</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>11</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>1</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>11</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16288099</ArticleId><ArticleId IdType="pii">99/6/2345</ArticleId><ArticleId IdType="doi">10.1152/japplphysiol.00372.2005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Ballinger, James R" sort="Ballinger, James R" uniqKey="Ballinger J" first="James R" last="Ballinger">James R. Ballinger</name><name sortKey="Barber, Robert W" sort="Barber, Robert W" uniqKey="Barber R" first="Robert W" last="Barber">Robert W. Barber</name><name sortKey="Britton, Tom Bennett" sort="Britton, Tom Bennett" uniqKey="Britton T" first="Tom Bennett" last="Britton">Tom Bennett Britton</name><name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S" last="Mortimer">Peter S. Mortimer</name><name sortKey="Peters, A Michael" sort="Peters, A Michael" uniqKey="Peters A" first="A Michael" last="Peters">A Michael Peters</name><name sortKey="Purushotham, Anand D" sort="Purushotham, Anand D" uniqKey="Purushotham A" first="Anand D" last="Purushotham">Anand D. Purushotham</name><name sortKey="Solanki, Chandra K" sort="Solanki, Chandra K" uniqKey="Solanki C" first="Chandra K" last="Solanki">Chandra K. Solanki</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Pain, Simon J" sort="Pain, Simon J" uniqKey="Pain S" first="Simon J" last="Pain">Simon J. Pain</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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