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Molecular and cellular mechanisms of lymphangiogenesis.

Identifieur interne : 001D15 ( Ncbi/Merge ); précédent : 001D14; suivant : 001D16

Molecular and cellular mechanisms of lymphangiogenesis.

Auteurs : M A A. Al-Rawi [Royaume-Uni] ; R E Mansel ; W G Jiang

Source :

RBID : pubmed:15698725

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English descriptors

Abstract

Lymphangiogenesis is the growth and formation of new lymphatic vessels. It occurs in normally developing tissues and in pathological processes like inflammation, wound healing, lymphoedema and in cancer. New molecular markers that are specific to the lymphatic endothelium include: podoplanin, prox-1 and LYVE-1. The molecular mechanisms of lymphangiogenesis are not clear, but vascular endothelial growth factors (VEGF-C and VEGF-D) within tumours may simulate endothelial cells within tumour tissues to grow and generate new lymphatics. We report the current knowledge of molecular and cellular mechanisms of lymphangiogenesis.

DOI: 10.1016/j.ejso.2004.08.015
PubMed: 15698725

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pubmed:15698725

Le document en format XML

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<div type="abstract" xml:lang="en">Lymphangiogenesis is the growth and formation of new lymphatic vessels. It occurs in normally developing tissues and in pathological processes like inflammation, wound healing, lymphoedema and in cancer. New molecular markers that are specific to the lymphatic endothelium include: podoplanin, prox-1 and LYVE-1. The molecular mechanisms of lymphangiogenesis are not clear, but vascular endothelial growth factors (VEGF-C and VEGF-D) within tumours may simulate endothelial cells within tumour tissues to grow and generate new lymphatics. We report the current knowledge of molecular and cellular mechanisms of lymphangiogenesis.</div>
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