FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.
Identifieur interne : 000D44 ( Ncbi/Merge ); précédent : 000D43; suivant : 000D45FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.
Auteurs : Benjamin M. Kriederman [États-Unis] ; Teressa L. Myloyde ; Marlys H. Witte ; Susan L. Dagenais ; Charles L. Witte ; Margaret Rennels ; Michael J. Bernas ; Michelle T. Lynch ; Robert P. Erickson ; Mark S. Caulder ; Naoyuki Miura ; David Jackson ; Brian P. Brooks ; Thomas W. GloverSource :
- Human molecular genetics [ 0964-6906 ] ; 2003.
Descripteurs français
- KwdFr :
- Animaux, Cils (malformations), Facteurs de transcription (génétique), Facteurs de transcription (métabolisme), Facteurs de transcription Forkhead, Gènes dominants, Humains, Hétérozygote, Lymphoedème (génétique), Lymphoedème (métabolisme), Malformations lymphatiques (anatomopathologie), Malformations lymphatiques (génétique), Modèles animaux de maladie humaine, Protéines de liaison à l'ADN (génétique), Protéines de liaison à l'ADN (métabolisme), Souris.
- MESH :
- anatomopathologie : Malformations lymphatiques.
- génétique : Facteurs de transcription, Lymphoedème, Malformations lymphatiques, Protéines de liaison à l'ADN.
- malformations : Cils.
- métabolisme : Facteurs de transcription, Lymphoedème, Protéines de liaison à l'ADN.
- Animaux, Facteurs de transcription Forkhead, Gènes dominants, Humains, Hétérozygote, Modèles animaux de maladie humaine, Souris.
English descriptors
- KwdEn :
- Animals, DNA-Binding Proteins (genetics), DNA-Binding Proteins (metabolism), Disease Models, Animal, Eyelashes (abnormalities), Forkhead Transcription Factors, Genes, Dominant, Heterozygote, Humans, Lymphatic Abnormalities (genetics), Lymphatic Abnormalities (pathology), Lymphedema (genetics), Lymphedema (metabolism), Mice, Transcription Factors (genetics), Transcription Factors (metabolism).
- MESH :
- chemical , genetics : DNA-Binding Proteins, Transcription Factors.
- chemical , metabolism : DNA-Binding Proteins, Transcription Factors.
- abnormalities : Eyelashes.
- genetics : Lymphatic Abnormalities, Lymphedema.
- metabolism : Lymphedema.
- pathology : Lymphatic Abnormalities.
- Animals, Disease Models, Animal, Forkhead Transcription Factors, Genes, Dominant, Heterozygote, Humans, Mice.
Abstract
Lymphedema-distichiasis (LD) (OMIM 153400) is a rare autosomal-dominant condition characterized by pubertal onset of lower limb lymphedema and an aberrant second row of eyelashes arising from the meibomian glands. In some patients cardiac, skeletal and other defects coexist. We previously identified inactivating, nonsense and frameshift mutations in the forkhead transcription factor FOXC2 in affected members of LD families. To further delineate the relationship of FOXC2 deficiency to the clinical (and lymphangiodysplastic) phenotype in this syndrome, we performed dynamic lymphatic imaging and immunohistochemical examination of lymphatic tissues in mice heterozygous (+/-) for a targeted disruption of Foxc2. Adult heterozygote mice characteristically exhibited a generalized lymphatic vessel and lymph node hyper plasia and rarely exhibited hindlimb swelling. Retrograde lymph flow through apparently incompetent interlymphangion valves into the mesenteric nodes, intestinal wall and liver was also observed. In addition, Foxc2 +/- mice uniformly displayed distichiasis. We conclude that Foxc2 haploinsufficient mice mimic closely the distinctive lymphatic and ocular phenotype of LD patients. Furthermore, the craniofacial, cardiovascular and skeletal abnormalities sometimes associated with LD have previously been shown to be fully penetrant in homozygous Foxc2 null mice. This Foxc2 mutant mouse thus provides an ideal model for exploring molecular mechanisms and physiologic events in mesenchymal differentiation associated with lymphatic growth and development and the clinical abnormalities seen in human LD syndrome.
PubMed: 12719382
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Kriederman</name><affiliation wicri:level="2"><nlm:affiliation>University of Arizona, Department of Surgery, Tucson, Arizona, USA. lymph@u.arizona.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Arizona, Department of Surgery, Tucson, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Myloyde, Teressa L" sort="Myloyde, Teressa L" uniqKey="Myloyde T" first="Teressa L" last="Myloyde">Teressa L. Myloyde</name></author><author><name sortKey="Witte, Marlys H" sort="Witte, Marlys H" uniqKey="Witte M" first="Marlys H" last="Witte">Marlys H. Witte</name></author><author><name sortKey="Dagenais, Susan L" sort="Dagenais, Susan L" uniqKey="Dagenais S" first="Susan L" last="Dagenais">Susan L. Dagenais</name></author><author><name sortKey="Witte, Charles L" sort="Witte, Charles L" uniqKey="Witte C" first="Charles L" last="Witte">Charles L. Witte</name></author><author><name sortKey="Rennels, Margaret" sort="Rennels, Margaret" uniqKey="Rennels M" first="Margaret" last="Rennels">Margaret Rennels</name></author><author><name sortKey="Bernas, Michael J" sort="Bernas, Michael J" uniqKey="Bernas M" first="Michael J" last="Bernas">Michael J. Bernas</name></author><author><name sortKey="Lynch, Michelle T" sort="Lynch, Michelle T" uniqKey="Lynch M" first="Michelle T" last="Lynch">Michelle T. Lynch</name></author><author><name sortKey="Erickson, Robert P" sort="Erickson, Robert P" uniqKey="Erickson R" first="Robert P" last="Erickson">Robert P. Erickson</name></author><author><name sortKey="Caulder, Mark S" sort="Caulder, Mark S" uniqKey="Caulder M" first="Mark S" last="Caulder">Mark S. Caulder</name></author><author><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name></author><author><name sortKey="Jackson, David" sort="Jackson, David" uniqKey="Jackson D" first="David" last="Jackson">David Jackson</name></author><author><name sortKey="Brooks, Brian P" sort="Brooks, Brian P" uniqKey="Brooks B" first="Brian P" last="Brooks">Brian P. Brooks</name></author><author><name sortKey="Glover, Thomas W" sort="Glover, Thomas W" uniqKey="Glover T" first="Thomas W" last="Glover">Thomas W. Glover</name></author></analytic><series><title level="j">Human molecular genetics</title><idno type="ISSN">0964-6906</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>DNA-Binding Proteins (genetics)</term><term>DNA-Binding Proteins (metabolism)</term><term>Disease Models, Animal</term><term>Eyelashes (abnormalities)</term><term>Forkhead Transcription Factors</term><term>Genes, Dominant</term><term>Heterozygote</term><term>Humans</term><term>Lymphatic Abnormalities (genetics)</term><term>Lymphatic Abnormalities (pathology)</term><term>Lymphedema (genetics)</term><term>Lymphedema (metabolism)</term><term>Mice</term><term>Transcription Factors (genetics)</term><term>Transcription Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cils (malformations)</term><term>Facteurs de transcription (génétique)</term><term>Facteurs de transcription (métabolisme)</term><term>Facteurs de transcription Forkhead</term><term>Gènes dominants</term><term>Humains</term><term>Hétérozygote</term><term>Lymphoedème (génétique)</term><term>Lymphoedème (métabolisme)</term><term>Malformations lymphatiques (anatomopathologie)</term><term>Malformations lymphatiques (génétique)</term><term>Modèles animaux de maladie humaine</term><term>Protéines de liaison à l'ADN (génétique)</term><term>Protéines de liaison à l'ADN (métabolisme)</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Binding Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA-Binding Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Eyelashes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Malformations lymphatiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphatic Abnormalities</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term><term>Lymphoedème</term><term>Malformations lymphatiques</term><term>Protéines de liaison à l'ADN</term></keywords><keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Cils</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term><term>Lymphoedème</term><term>Protéines de liaison à l'ADN</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Abnormalities</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Forkhead Transcription Factors</term><term>Genes, Dominant</term><term>Heterozygote</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs de transcription Forkhead</term><term>Gènes dominants</term><term>Humains</term><term>Hétérozygote</term><term>Modèles animaux de maladie humaine</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema-distichiasis (LD) (OMIM 153400) is a rare autosomal-dominant condition characterized by pubertal onset of lower limb lymphedema and an aberrant second row of eyelashes arising from the meibomian glands. In some patients cardiac, skeletal and other defects coexist. We previously identified inactivating, nonsense and frameshift mutations in the forkhead transcription factor FOXC2 in affected members of LD families. To further delineate the relationship of FOXC2 deficiency to the clinical (and lymphangiodysplastic) phenotype in this syndrome, we performed dynamic lymphatic imaging and immunohistochemical examination of lymphatic tissues in mice heterozygous (+/-) for a targeted disruption of Foxc2. Adult heterozygote mice characteristically exhibited a generalized lymphatic vessel and lymph node hyper plasia and rarely exhibited hindlimb swelling. Retrograde lymph flow through apparently incompetent interlymphangion valves into the mesenteric nodes, intestinal wall and liver was also observed. In addition, Foxc2 +/- mice uniformly displayed distichiasis. We conclude that Foxc2 haploinsufficient mice mimic closely the distinctive lymphatic and ocular phenotype of LD patients. Furthermore, the craniofacial, cardiovascular and skeletal abnormalities sometimes associated with LD have previously been shown to be fully penetrant in homozygous Foxc2 null mice. This Foxc2 mutant mouse thus provides an ideal model for exploring molecular mechanisms and physiologic events in mesenchymal differentiation associated with lymphatic growth and development and the clinical abnormalities seen in human LD syndrome.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12719382</PMID><DateCreated><Year>2003</Year><Month>04</Month><Day>29</Day></DateCreated><DateCompleted><Year>2004</Year><Month>02</Month><Day>11</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0964-6906</ISSN><JournalIssue CitedMedium="Print"><Volume>12</Volume><Issue>10</Issue><PubDate><Year>2003</Year><Month>May</Month><Day>15</Day></PubDate></JournalIssue><Title>Human molecular genetics</Title><ISOAbbreviation>Hum. Mol. Genet.</ISOAbbreviation></Journal><ArticleTitle>FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.</ArticleTitle><Pagination><MedlinePgn>1179-85</MedlinePgn></Pagination><Abstract><AbstractText>Lymphedema-distichiasis (LD) (OMIM 153400) is a rare autosomal-dominant condition characterized by pubertal onset of lower limb lymphedema and an aberrant second row of eyelashes arising from the meibomian glands. In some patients cardiac, skeletal and other defects coexist. We previously identified inactivating, nonsense and frameshift mutations in the forkhead transcription factor FOXC2 in affected members of LD families. To further delineate the relationship of FOXC2 deficiency to the clinical (and lymphangiodysplastic) phenotype in this syndrome, we performed dynamic lymphatic imaging and immunohistochemical examination of lymphatic tissues in mice heterozygous (+/-) for a targeted disruption of Foxc2. Adult heterozygote mice characteristically exhibited a generalized lymphatic vessel and lymph node hyper plasia and rarely exhibited hindlimb swelling. Retrograde lymph flow through apparently incompetent interlymphangion valves into the mesenteric nodes, intestinal wall and liver was also observed. In addition, Foxc2 +/- mice uniformly displayed distichiasis. We conclude that Foxc2 haploinsufficient mice mimic closely the distinctive lymphatic and ocular phenotype of LD patients. Furthermore, the craniofacial, cardiovascular and skeletal abnormalities sometimes associated with LD have previously been shown to be fully penetrant in homozygous Foxc2 null mice. This Foxc2 mutant mouse thus provides an ideal model for exploring molecular mechanisms and physiologic events in mesenchymal differentiation associated with lymphatic growth and development and the clinical abnormalities seen in human LD syndrome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kriederman</LastName><ForeName>Benjamin M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>University of Arizona, Department of Surgery, Tucson, Arizona, USA. lymph@u.arizona.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Myloyde</LastName><ForeName>Teressa L</ForeName><Initials>TL</Initials></Author><Author ValidYN="Y"><LastName>Witte</LastName><ForeName>Marlys H</ForeName><Initials>MH</Initials></Author><Author ValidYN="Y"><LastName>Dagenais</LastName><ForeName>Susan L</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Witte</LastName><ForeName>Charles L</ForeName><Initials>CL</Initials></Author><Author ValidYN="Y"><LastName>Rennels</LastName><ForeName>Margaret</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bernas</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Lynch</LastName><ForeName>Michelle T</ForeName><Initials>MT</Initials></Author><Author ValidYN="Y"><LastName>Erickson</LastName><ForeName>Robert P</ForeName><Initials>RP</Initials></Author><Author ValidYN="Y"><LastName>Caulder</LastName><ForeName>Mark S</ForeName><Initials>MS</Initials></Author><Author ValidYN="Y"><LastName>Miura</LastName><ForeName>Naoyuki</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Brooks</LastName><ForeName>Brian P</ForeName><Initials>BP</Initials></Author><Author ValidYN="Y"><LastName>Glover</LastName><ForeName>Thomas W</ForeName><Initials>TW</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HL71206</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R25RR15670</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Hum Mol Genet</MedlineTA><NlmUniqueID>9208958</NlmUniqueID><ISSNLinking>0964-6906</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051858">Forkhead Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C082078">mesenchyme fork head 1 protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004268" MajorTopicYN="N">DNA-Binding Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="Y">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005140" MajorTopicYN="N">Eyelashes</DescriptorName><QualifierName UI="Q000002" MajorTopicYN="Y">abnormalities</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051858" MajorTopicYN="N">Forkhead Transcription Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005799" MajorTopicYN="N">Genes, Dominant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006579" MajorTopicYN="N">Heterozygote</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044148" MajorTopicYN="N">Lymphatic Abnormalities</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>4</Month><Day>30</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>2</Month><Day>12</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>4</Month><Day>30</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12719382</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li></region></list><tree><noCountry><name sortKey="Bernas, Michael J" sort="Bernas, Michael J" uniqKey="Bernas M" first="Michael J" last="Bernas">Michael J. Bernas</name><name sortKey="Brooks, Brian P" sort="Brooks, Brian P" uniqKey="Brooks B" first="Brian P" last="Brooks">Brian P. Brooks</name><name sortKey="Caulder, Mark S" sort="Caulder, Mark S" uniqKey="Caulder M" first="Mark S" last="Caulder">Mark S. Caulder</name><name sortKey="Dagenais, Susan L" sort="Dagenais, Susan L" uniqKey="Dagenais S" first="Susan L" last="Dagenais">Susan L. Dagenais</name><name sortKey="Erickson, Robert P" sort="Erickson, Robert P" uniqKey="Erickson R" first="Robert P" last="Erickson">Robert P. Erickson</name><name sortKey="Glover, Thomas W" sort="Glover, Thomas W" uniqKey="Glover T" first="Thomas W" last="Glover">Thomas W. Glover</name><name sortKey="Jackson, David" sort="Jackson, David" uniqKey="Jackson D" first="David" last="Jackson">David Jackson</name><name sortKey="Lynch, Michelle T" sort="Lynch, Michelle T" uniqKey="Lynch M" first="Michelle T" last="Lynch">Michelle T. Lynch</name><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name><name sortKey="Myloyde, Teressa L" sort="Myloyde, Teressa L" uniqKey="Myloyde T" first="Teressa L" last="Myloyde">Teressa L. Myloyde</name><name sortKey="Rennels, Margaret" sort="Rennels, Margaret" uniqKey="Rennels M" first="Margaret" last="Rennels">Margaret Rennels</name><name sortKey="Witte, Charles L" sort="Witte, Charles L" uniqKey="Witte C" first="Charles L" last="Witte">Charles L. Witte</name><name sortKey="Witte, Marlys H" sort="Witte, Marlys H" uniqKey="Witte M" first="Marlys H" last="Witte">Marlys H. Witte</name></noCountry><country name="États-Unis"><region name="Arizona"><name sortKey="Kriederman, Benjamin M" sort="Kriederman, Benjamin M" uniqKey="Kriederman B" first="Benjamin M" last="Kriederman">Benjamin M. Kriederman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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