Genetic variability of the human filarial parasite, Wuchereria bancrofti in South India.
Identifieur interne : 000903 ( Ncbi/Merge ); précédent : 000902; suivant : 000904Genetic variability of the human filarial parasite, Wuchereria bancrofti in South India.
Auteurs : N. Pradeep Kumar [Inde] ; K P Patra ; S L Hoti ; P K DasSource :
- Acta tropica [ 0001-706X ] ; 2002.
Descripteurs français
- KwdFr :
- Animaux, Diéthylcarbamazine (usage thérapeutique), Filaricides (usage thérapeutique), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Inde (épidémiologie), Phylogénie, Réaction de polymérisation en chaîne, Résistance microbienne aux médicaments, Technique RAPD, Variation génétique, Wuchereria bancrofti (génétique).
- MESH :
- génétique : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- épidémiologie : Filariose lymphatique, Inde.
- Animaux, Humains, Phylogénie, Réaction de polymérisation en chaîne, Résistance microbienne aux médicaments, Technique RAPD, Variation génétique.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Animals, Diethylcarbamazine (therapeutic use), Drug Resistance, Microbial, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Filaricides (therapeutic use), Genetic Variation, Humans, India (epidemiology), Phylogeny, Polymerase Chain Reaction, Random Amplified Polymorphic DNA Technique, Wuchereria bancrofti (genetics).
- MESH :
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- geographic , epidemiology : India.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- genetics : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Animals, Drug Resistance, Microbial, Genetic Variation, Humans, Phylogeny, Polymerase Chain Reaction, Random Amplified Polymorphic DNA Technique.
Abstract
The genetic variability of the lymphatic filarial parasite Wuchereria bancrofti, from three localities (one urban and two rural areas) in southern India, endemic for filariasis was studied using random amplified polymorphic DNA (RAPD) markers. The RAPD profiles were generated for 21 parasite populations (7 populations from each area), using a 10-mer random primer. The analysis of profiles indicated the existence of considerable genetic variability among parasite populations. The Nei's gene diversity between the individual populations in the 2 areas (one urban and another rural) was comparatively greater (0.3372+/-0.1462 & 0.2830+/-0.1764) than that of populations in another village (0.0490+/-0.1373). The greater genetic diversity among the former areas may be due to human migration, endemicity for long time and drug (diethyl-carbamazine citrate) pressure unlike the populations of latter village where the filariasis is relatively a recent introduction and which was never under active chemotherapy. The Nei's genetic distance was estimated and the phylogenetic tree was constructed using 'UPGMA'. These analyses indicated the prevalence of at least two genetically distinct clusters, among the populations studied, their maximum genetic distance being 0.2444. The finding of two genetic 'variants' of W. bancrofti, in the present study, may have important implications in filariasis epidemiology and control/elimination programmes.
PubMed: 11904105
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004635
- to stream PubMed, to step Curation: 004635
- to stream PubMed, to step Checkpoint: 004635
Links to Exploration step
pubmed:11904105Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic variability of the human filarial parasite, Wuchereria bancrofti in South India.</title><author><name sortKey="Pradeep Kumar, N" sort="Pradeep Kumar, N" uniqKey="Pradeep Kumar N" first="N" last="Pradeep Kumar">N. Pradeep Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Vector Control Research Centre (ICMR), Indira Nagar, 605 006, Pondicherry, India. kumarnp@yayoo.com</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Vector Control Research Centre (ICMR), Indira Nagar, 605 006, Pondicherry</wicri:regionArea><wicri:noRegion>Pondicherry</wicri:noRegion></affiliation></author><author><name sortKey="Patra, K P" sort="Patra, K P" uniqKey="Patra K" first="K P" last="Patra">K P Patra</name></author><author><name sortKey="Hoti, S L" sort="Hoti, S L" uniqKey="Hoti S" first="S L" last="Hoti">S L Hoti</name></author><author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:11904105</idno><idno type="pmid">11904105</idno><idno type="wicri:Area/PubMed/Corpus">004635</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004635</idno><idno type="wicri:Area/PubMed/Curation">004635</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004635</idno><idno type="wicri:Area/PubMed/Checkpoint">004635</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004635</idno><idno type="wicri:Area/Ncbi/Merge">000903</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic variability of the human filarial parasite, Wuchereria bancrofti in South India.</title><author><name sortKey="Pradeep Kumar, N" sort="Pradeep Kumar, N" uniqKey="Pradeep Kumar N" first="N" last="Pradeep Kumar">N. Pradeep Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Vector Control Research Centre (ICMR), Indira Nagar, 605 006, Pondicherry, India. kumarnp@yayoo.com</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Vector Control Research Centre (ICMR), Indira Nagar, 605 006, Pondicherry</wicri:regionArea><wicri:noRegion>Pondicherry</wicri:noRegion></affiliation></author><author><name sortKey="Patra, K P" sort="Patra, K P" uniqKey="Patra K" first="K P" last="Patra">K P Patra</name></author><author><name sortKey="Hoti, S L" sort="Hoti, S L" uniqKey="Hoti S" first="S L" last="Hoti">S L Hoti</name></author><author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name></author></analytic><series><title level="j">Acta tropica</title><idno type="ISSN">0001-706X</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Diethylcarbamazine (therapeutic use)</term><term>Drug Resistance, Microbial</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Filaricides (therapeutic use)</term><term>Genetic Variation</term><term>Humans</term><term>India (epidemiology)</term><term>Phylogeny</term><term>Polymerase Chain Reaction</term><term>Random Amplified Polymorphic DNA Technique</term><term>Wuchereria bancrofti (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Inde (épidémiologie)</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne</term><term>Résistance microbienne aux médicaments</term><term>Technique RAPD</term><term>Variation génétique</term><term>Wuchereria bancrofti (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Inde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Resistance, Microbial</term><term>Genetic Variation</term><term>Humans</term><term>Phylogeny</term><term>Polymerase Chain Reaction</term><term>Random Amplified Polymorphic DNA Technique</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne</term><term>Résistance microbienne aux médicaments</term><term>Technique RAPD</term><term>Variation génétique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The genetic variability of the lymphatic filarial parasite Wuchereria bancrofti, from three localities (one urban and two rural areas) in southern India, endemic for filariasis was studied using random amplified polymorphic DNA (RAPD) markers. The RAPD profiles were generated for 21 parasite populations (7 populations from each area), using a 10-mer random primer. The analysis of profiles indicated the existence of considerable genetic variability among parasite populations. The Nei's gene diversity between the individual populations in the 2 areas (one urban and another rural) was comparatively greater (0.3372+/-0.1462 & 0.2830+/-0.1764) than that of populations in another village (0.0490+/-0.1373). The greater genetic diversity among the former areas may be due to human migration, endemicity for long time and drug (diethyl-carbamazine citrate) pressure unlike the populations of latter village where the filariasis is relatively a recent introduction and which was never under active chemotherapy. The Nei's genetic distance was estimated and the phylogenetic tree was constructed using 'UPGMA'. These analyses indicated the prevalence of at least two genetically distinct clusters, among the populations studied, their maximum genetic distance being 0.2444. The finding of two genetic 'variants' of W. bancrofti, in the present study, may have important implications in filariasis epidemiology and control/elimination programmes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11904105</PMID><DateCreated><Year>2002</Year><Month>03</Month><Day>20</Day></DateCreated><DateCompleted><Year>2002</Year><Month>05</Month><Day>10</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-706X</ISSN><JournalIssue CitedMedium="Print"><Volume>82</Volume><Issue>1</Issue><PubDate><Year>2002</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Acta tropica</Title><ISOAbbreviation>Acta Trop.</ISOAbbreviation></Journal><ArticleTitle>Genetic variability of the human filarial parasite, Wuchereria bancrofti in South India.</ArticleTitle><Pagination><MedlinePgn>67-76</MedlinePgn></Pagination><Abstract><AbstractText>The genetic variability of the lymphatic filarial parasite Wuchereria bancrofti, from three localities (one urban and two rural areas) in southern India, endemic for filariasis was studied using random amplified polymorphic DNA (RAPD) markers. The RAPD profiles were generated for 21 parasite populations (7 populations from each area), using a 10-mer random primer. The analysis of profiles indicated the existence of considerable genetic variability among parasite populations. The Nei's gene diversity between the individual populations in the 2 areas (one urban and another rural) was comparatively greater (0.3372+/-0.1462 & 0.2830+/-0.1764) than that of populations in another village (0.0490+/-0.1373). The greater genetic diversity among the former areas may be due to human migration, endemicity for long time and drug (diethyl-carbamazine citrate) pressure unlike the populations of latter village where the filariasis is relatively a recent introduction and which was never under active chemotherapy. The Nei's genetic distance was estimated and the phylogenetic tree was constructed using 'UPGMA'. These analyses indicated the prevalence of at least two genetically distinct clusters, among the populations studied, their maximum genetic distance being 0.2444. The finding of two genetic 'variants' of W. bancrofti, in the present study, may have important implications in filariasis epidemiology and control/elimination programmes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pradeep Kumar</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Vector Control Research Centre (ICMR), Indira Nagar, 605 006, Pondicherry, India. kumarnp@yayoo.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patra</LastName><ForeName>K P</ForeName><Initials>KP</Initials></Author><Author ValidYN="Y"><LastName>Hoti</LastName><ForeName>S L</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Das</LastName><ForeName>P K</ForeName><Initials>PK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Acta Trop</MedlineTA><NlmUniqueID>0370374</NlmUniqueID><ISSNLinking>0001-706X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005369">Filaricides</NameOfSubstance></Chemical><Chemical><RegistryNumber>V867Q8X3ZD</RegistryNumber><NameOfSubstance UI="D004049">Diethylcarbamazine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004049" MajorTopicYN="N">Diethylcarbamazine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004352" MajorTopicYN="N">Drug Resistance, Microbial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005369" MajorTopicYN="N">Filaricides</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007194" MajorTopicYN="N" Type="Geographic">India</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019105" MajorTopicYN="N">Random Amplified Polymorphic DNA Technique</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>3</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>5</Month><Day>11</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>3</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11904105</ArticleId><ArticleId IdType="pii">S0001706X02000372</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name><name sortKey="Hoti, S L" sort="Hoti, S L" uniqKey="Hoti S" first="S L" last="Hoti">S L Hoti</name><name sortKey="Patra, K P" sort="Patra, K P" uniqKey="Patra K" first="K P" last="Patra">K P Patra</name></noCountry><country name="Inde"><noRegion><name sortKey="Pradeep Kumar, N" sort="Pradeep Kumar, N" uniqKey="Pradeep Kumar N" first="N" last="Pradeep Kumar">N. Pradeep Kumar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000903 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000903 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:11904105
|texte= Genetic variability of the human filarial parasite, Wuchereria bancrofti in South India.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:11904105" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |