VEGFR3 gene structure, regulatory region, and sequence polymorphisms.
Identifieur interne : 000606 ( Ncbi/Merge ); précédent : 000605; suivant : 000607VEGFR3 gene structure, regulatory region, and sequence polymorphisms.
Auteurs : K. Iljin [Finlande] ; M J Karkkainen ; E C Lawrence ; M A Kimak ; M. Uutela ; J. Taipale ; K. Pajusola ; L. Alhonen ; M. Halmekytö ; D N Finegold ; R E Ferrell ; Kari Alitalo [Finlande]Source :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology [ 0892-6638 ] ; 2001.
Descripteurs français
- KwdFr :
- Animaux, Cellules 3T3, Clonage moléculaire, Données de séquences moléculaires, Embryon de mammifère, Endothélium, Exons, Humains, Introns, Polymorphisme génétique, Récepteur facteur croissance (génétique), Récepteur-3 au facteur croissance endothéliale vasculaire, Récepteurs à activité tyrosine kinase (génétique), Régions promotrices (génétique) (génétique), Similitude de séquences d'acides nucléiques, Souris, Souris transgéniques, Séquence nucléotidique, Variation génétique.
- MESH :
- génétique : Récepteur facteur croissance, Récepteurs à activité tyrosine kinase, Régions promotrices (génétique).
- Animaux, Cellules 3T3, Clonage moléculaire, Données de séquences moléculaires, Embryon de mammifère, Endothélium, Exons, Humains, Introns, Polymorphisme génétique, Récepteur-3 au facteur croissance endothéliale vasculaire, Similitude de séquences d'acides nucléiques, Souris, Souris transgéniques, Séquence nucléotidique, Variation génétique.
English descriptors
- KwdEn :
- 3T3 Cells, Animals, Base Sequence, Cloning, Molecular, Embryo, Mammalian, Endothelium, Exons, Genetic Variation, Humans, Introns, Mice, Mice, Transgenic, Molecular Sequence Data, Polymorphism, Genetic, Promoter Regions, Genetic (genetics), Receptor Protein-Tyrosine Kinases (genetics), Receptors, Growth Factor (genetics), Sequence Homology, Nucleic Acid, Vascular Endothelial Growth Factor Receptor-3.
- MESH :
- chemical , genetics : Receptor Protein-Tyrosine Kinases, Receptors, Growth Factor.
- genetics : Promoter Regions, Genetic.
- 3T3 Cells, Animals, Base Sequence, Cloning, Molecular, Embryo, Mammalian, Endothelium, Exons, Genetic Variation, Humans, Introns, Mice, Mice, Transgenic, Molecular Sequence Data, Polymorphism, Genetic, Sequence Homology, Nucleic Acid, Vascular Endothelial Growth Factor Receptor-3.
Abstract
Vascular endothelial growth factor receptor 3 (VEGFR-3) is required for cardiovascular development during embryogenesis. In adults, this receptor is expressed in lymphatic endothelial cells, and mutant VEGFR3 alleles have been implicated in human hereditary lymphedema. To better understand the basis of its specific endothelial lineage-restricted expression, we have characterized the VEGFR3 gene and its regulatory 5' flanking region. The human gene contains 31 exons, of which exons 30a and 30b are alternatively spliced. The VEGFR3 proximal promoter is TATA-less and contains stretches of sequences homologous with the mouse Vegfr3 promoter region. In transfection experiments of cultured cells, the Vegfr3 promoter was shown to control endothelial cell-specific transcription of downstream reporter genes. This result was further confirmed in vivo; in a subset of transgenic mouse embryos, a 1.6 kb Vegfr3 promoter fragment directed weak lymphatic endothelial expression of the LacZ marker gene. This suggests that endothelial cell-specific elements occur in the proximal promoter, although further enhancer elements are probably located elsewhere. The sequence, organization, and variation in the VEGFR3 gene and its regulatory region provide important tools for the molecular genetic analysis of the lymphatic system and its disorders.
PubMed: 11292664
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004854
- to stream PubMed, to step Curation: 004854
- to stream PubMed, to step Checkpoint: 004854
Links to Exploration step
pubmed:11292664Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">VEGFR3 gene structure, regulatory region, and sequence polymorphisms.</title>
<author><name sortKey="Iljin, K" sort="Iljin, K" uniqKey="Iljin K" first="K" last="Iljin">K. Iljin</name>
<affiliation wicri:level="4"><nlm:affiliation>Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, 00014 Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, 00014 Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karkkainen, M J" sort="Karkkainen, M J" uniqKey="Karkkainen M" first="M J" last="Karkkainen">M J Karkkainen</name>
</author>
<author><name sortKey="Lawrence, E C" sort="Lawrence, E C" uniqKey="Lawrence E" first="E C" last="Lawrence">E C Lawrence</name>
</author>
<author><name sortKey="Kimak, M A" sort="Kimak, M A" uniqKey="Kimak M" first="M A" last="Kimak">M A Kimak</name>
</author>
<author><name sortKey="Uutela, M" sort="Uutela, M" uniqKey="Uutela M" first="M" last="Uutela">M. Uutela</name>
</author>
<author><name sortKey="Taipale, J" sort="Taipale, J" uniqKey="Taipale J" first="J" last="Taipale">J. Taipale</name>
</author>
<author><name sortKey="Pajusola, K" sort="Pajusola, K" uniqKey="Pajusola K" first="K" last="Pajusola">K. Pajusola</name>
</author>
<author><name sortKey="Alhonen, L" sort="Alhonen, L" uniqKey="Alhonen L" first="L" last="Alhonen">L. Alhonen</name>
</author>
<author><name sortKey="Halmekyto, M" sort="Halmekyto, M" uniqKey="Halmekyto M" first="M" last="Halmekytö">M. Halmekytö</name>
</author>
<author><name sortKey="Finegold, D N" sort="Finegold, D N" uniqKey="Finegold D" first="D N" last="Finegold">D N Finegold</name>
</author>
<author><name sortKey="Ferrell, R E" sort="Ferrell, R E" uniqKey="Ferrell R" first="R E" last="Ferrell">R E Ferrell</name>
</author>
<author><name sortKey="Alitalo, K" sort="Alitalo, K" uniqKey="Alitalo K" first="K" last="Alitalo">Kari Alitalo</name>
<affiliation><country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2001">2001</date>
<idno type="RBID">pubmed:11292664</idno>
<idno type="pmid">11292664</idno>
<idno type="wicri:Area/PubMed/Corpus">004854</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004854</idno>
<idno type="wicri:Area/PubMed/Curation">004854</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004854</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004854</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004854</idno>
<idno type="wicri:Area/Ncbi/Merge">000606</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">VEGFR3 gene structure, regulatory region, and sequence polymorphisms.</title>
<author><name sortKey="Iljin, K" sort="Iljin, K" uniqKey="Iljin K" first="K" last="Iljin">K. Iljin</name>
<affiliation wicri:level="4"><nlm:affiliation>Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, 00014 Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, 00014 Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karkkainen, M J" sort="Karkkainen, M J" uniqKey="Karkkainen M" first="M J" last="Karkkainen">M J Karkkainen</name>
</author>
<author><name sortKey="Lawrence, E C" sort="Lawrence, E C" uniqKey="Lawrence E" first="E C" last="Lawrence">E C Lawrence</name>
</author>
<author><name sortKey="Kimak, M A" sort="Kimak, M A" uniqKey="Kimak M" first="M A" last="Kimak">M A Kimak</name>
</author>
<author><name sortKey="Uutela, M" sort="Uutela, M" uniqKey="Uutela M" first="M" last="Uutela">M. Uutela</name>
</author>
<author><name sortKey="Taipale, J" sort="Taipale, J" uniqKey="Taipale J" first="J" last="Taipale">J. Taipale</name>
</author>
<author><name sortKey="Pajusola, K" sort="Pajusola, K" uniqKey="Pajusola K" first="K" last="Pajusola">K. Pajusola</name>
</author>
<author><name sortKey="Alhonen, L" sort="Alhonen, L" uniqKey="Alhonen L" first="L" last="Alhonen">L. Alhonen</name>
</author>
<author><name sortKey="Halmekyto, M" sort="Halmekyto, M" uniqKey="Halmekyto M" first="M" last="Halmekytö">M. Halmekytö</name>
</author>
<author><name sortKey="Finegold, D N" sort="Finegold, D N" uniqKey="Finegold D" first="D N" last="Finegold">D N Finegold</name>
</author>
<author><name sortKey="Ferrell, R E" sort="Ferrell, R E" uniqKey="Ferrell R" first="R E" last="Ferrell">R E Ferrell</name>
</author>
<author><name sortKey="Alitalo, K" sort="Alitalo, K" uniqKey="Alitalo K" first="K" last="Alitalo">Kari Alitalo</name>
<affiliation><country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</title>
<idno type="ISSN">0892-6638</idno>
<imprint><date when="2001" type="published">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3T3 Cells</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cloning, Molecular</term>
<term>Embryo, Mammalian</term>
<term>Endothelium</term>
<term>Exons</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Introns</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Molecular Sequence Data</term>
<term>Polymorphism, Genetic</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>Receptor Protein-Tyrosine Kinases (genetics)</term>
<term>Receptors, Growth Factor (genetics)</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules 3T3</term>
<term>Clonage moléculaire</term>
<term>Données de séquences moléculaires</term>
<term>Embryon de mammifère</term>
<term>Endothélium</term>
<term>Exons</term>
<term>Humains</term>
<term>Introns</term>
<term>Polymorphisme génétique</term>
<term>Récepteur facteur croissance (génétique)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
<term>Récepteurs à activité tyrosine kinase (génétique)</term>
<term>Régions promotrices (génétique) (génétique)</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Séquence nucléotidique</term>
<term>Variation génétique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor Protein-Tyrosine Kinases</term>
<term>Receptors, Growth Factor</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Promoter Regions, Genetic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Récepteur facteur croissance</term>
<term>Récepteurs à activité tyrosine kinase</term>
<term>Régions promotrices (génétique)</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>3T3 Cells</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cloning, Molecular</term>
<term>Embryo, Mammalian</term>
<term>Endothelium</term>
<term>Exons</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Introns</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Molecular Sequence Data</term>
<term>Polymorphism, Genetic</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules 3T3</term>
<term>Clonage moléculaire</term>
<term>Données de séquences moléculaires</term>
<term>Embryon de mammifère</term>
<term>Endothélium</term>
<term>Exons</term>
<term>Humains</term>
<term>Introns</term>
<term>Polymorphisme génétique</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Séquence nucléotidique</term>
<term>Variation génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Vascular endothelial growth factor receptor 3 (VEGFR-3) is required for cardiovascular development during embryogenesis. In adults, this receptor is expressed in lymphatic endothelial cells, and mutant VEGFR3 alleles have been implicated in human hereditary lymphedema. To better understand the basis of its specific endothelial lineage-restricted expression, we have characterized the VEGFR3 gene and its regulatory 5' flanking region. The human gene contains 31 exons, of which exons 30a and 30b are alternatively spliced. The VEGFR3 proximal promoter is TATA-less and contains stretches of sequences homologous with the mouse Vegfr3 promoter region. In transfection experiments of cultured cells, the Vegfr3 promoter was shown to control endothelial cell-specific transcription of downstream reporter genes. This result was further confirmed in vivo; in a subset of transgenic mouse embryos, a 1.6 kb Vegfr3 promoter fragment directed weak lymphatic endothelial expression of the LacZ marker gene. This suggests that endothelial cell-specific elements occur in the proximal promoter, although further enhancer elements are probably located elsewhere. The sequence, organization, and variation in the VEGFR3 gene and its regulatory region provide important tools for the molecular genetic analysis of the lymphatic system and its disorders.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11292664</PMID>
<DateCreated><Year>2001</Year>
<Month>04</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted><Year>2001</Year>
<Month>05</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2012</Year>
<Month>02</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0892-6638</ISSN>
<JournalIssue CitedMedium="Print"><Volume>15</Volume>
<Issue>6</Issue>
<PubDate><Year>2001</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>FASEB journal : official publication of the Federation of American Societies for Experimental Biology</Title>
<ISOAbbreviation>FASEB J.</ISOAbbreviation>
</Journal>
<ArticleTitle>VEGFR3 gene structure, regulatory region, and sequence polymorphisms.</ArticleTitle>
<Pagination><MedlinePgn>1028-36</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Vascular endothelial growth factor receptor 3 (VEGFR-3) is required for cardiovascular development during embryogenesis. In adults, this receptor is expressed in lymphatic endothelial cells, and mutant VEGFR3 alleles have been implicated in human hereditary lymphedema. To better understand the basis of its specific endothelial lineage-restricted expression, we have characterized the VEGFR3 gene and its regulatory 5' flanking region. The human gene contains 31 exons, of which exons 30a and 30b are alternatively spliced. The VEGFR3 proximal promoter is TATA-less and contains stretches of sequences homologous with the mouse Vegfr3 promoter region. In transfection experiments of cultured cells, the Vegfr3 promoter was shown to control endothelial cell-specific transcription of downstream reporter genes. This result was further confirmed in vivo; in a subset of transgenic mouse embryos, a 1.6 kb Vegfr3 promoter fragment directed weak lymphatic endothelial expression of the LacZ marker gene. This suggests that endothelial cell-specific elements occur in the proximal promoter, although further enhancer elements are probably located elsewhere. The sequence, organization, and variation in the VEGFR3 gene and its regulatory region provide important tools for the molecular genetic analysis of the lymphatic system and its disorders.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Iljin</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, 00014 Helsinki, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Karkkainen</LastName>
<ForeName>M J</ForeName>
<Initials>MJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lawrence</LastName>
<ForeName>E C</ForeName>
<Initials>EC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kimak</LastName>
<ForeName>M A</ForeName>
<Initials>MA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Uutela</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Taipale</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pajusola</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alhonen</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Halmekytö</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Finegold</LastName>
<ForeName>D N</ForeName>
<Initials>DN</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ferrell</LastName>
<ForeName>R E</ForeName>
<Initials>RE</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alitalo</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>HL35174</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>HL54526</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>FASEB J</MedlineTA>
<NlmUniqueID>8804484</NlmUniqueID>
<ISSNLinking>0892-6638</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017978">Receptors, Growth Factor</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="D020794">Receptor Protein-Tyrosine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="D040321">Vascular Endothelial Growth Factor Receptor-3</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D016475" MajorTopicYN="N">3T3 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004622" MajorTopicYN="N">Embryo, Mammalian</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004727" MajorTopicYN="N">Endothelium</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005091" MajorTopicYN="N">Exons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007438" MajorTopicYN="N">Introns</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020794" MajorTopicYN="N">Receptor Protein-Tyrosine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017978" MajorTopicYN="N">Receptors, Growth Factor</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012689" MajorTopicYN="N">Sequence Homology, Nucleic Acid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year>
<Month>4</Month>
<Day>9</Day>
<Hour>10</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2001</Year>
<Month>5</Month>
<Day>22</Day>
<Hour>10</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2001</Year>
<Month>4</Month>
<Day>9</Day>
<Hour>10</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">11292664</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Finlande</li>
</country>
<region><li>Uusimaa</li>
</region>
<settlement><li>Helsinki</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Alhonen, L" sort="Alhonen, L" uniqKey="Alhonen L" first="L" last="Alhonen">L. Alhonen</name>
<name sortKey="Ferrell, R E" sort="Ferrell, R E" uniqKey="Ferrell R" first="R E" last="Ferrell">R E Ferrell</name>
<name sortKey="Finegold, D N" sort="Finegold, D N" uniqKey="Finegold D" first="D N" last="Finegold">D N Finegold</name>
<name sortKey="Halmekyto, M" sort="Halmekyto, M" uniqKey="Halmekyto M" first="M" last="Halmekytö">M. Halmekytö</name>
<name sortKey="Karkkainen, M J" sort="Karkkainen, M J" uniqKey="Karkkainen M" first="M J" last="Karkkainen">M J Karkkainen</name>
<name sortKey="Kimak, M A" sort="Kimak, M A" uniqKey="Kimak M" first="M A" last="Kimak">M A Kimak</name>
<name sortKey="Lawrence, E C" sort="Lawrence, E C" uniqKey="Lawrence E" first="E C" last="Lawrence">E C Lawrence</name>
<name sortKey="Pajusola, K" sort="Pajusola, K" uniqKey="Pajusola K" first="K" last="Pajusola">K. Pajusola</name>
<name sortKey="Taipale, J" sort="Taipale, J" uniqKey="Taipale J" first="J" last="Taipale">J. Taipale</name>
<name sortKey="Uutela, M" sort="Uutela, M" uniqKey="Uutela M" first="M" last="Uutela">M. Uutela</name>
</noCountry>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Iljin, K" sort="Iljin, K" uniqKey="Iljin K" first="K" last="Iljin">K. Iljin</name>
</region>
<name sortKey="Alitalo, K" sort="Alitalo, K" uniqKey="Alitalo K" first="K" last="Alitalo">Kari Alitalo</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000606 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000606 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:11292664 |texte= VEGFR3 gene structure, regulatory region, and sequence polymorphisms. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:11292664" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |