Protective immunity in human Bancroftian filariasis: inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens.
Identifieur interne : 000504 ( Ncbi/Merge ); précédent : 000503; suivant : 000505Protective immunity in human Bancroftian filariasis: inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens.
Auteurs : B. Ravindran [Inde] ; A K Satapathy ; P K Sahoo ; J J Babu GeddamSource :
- Parasite immunology [ 0141-9838 ] ; 2000.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (sang), Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Filarioses (immunologie), Humains, Immunité, Inde (épidémiologie), Sujet âgé, Wuchereria bancrofti (immunologie), Éléphantiasis (immunologie), Études de cohortes.
- MESH :
- immunologie : Filarioses, Wuchereria bancrofti, Éléphantiasis.
- sang : Anticorps antihelminthe, Antigènes d'helminthe.
- épidémiologie : Inde.
- Adolescent, Adulte, Animaux, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Humains, Immunité, Sujet âgé, Études de cohortes.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Helminth, Antigens, Helminth.
- geographic , epidemiology : India.
- immunology : Elephantiasis, Filariasis, Wuchereria bancrofti.
- Adolescent, Adult, Age Factors, Aged, Animals, Child, Child, Preschool, Cohort Studies, Humans, Immunity.
Abstract
The existence and the nature of protective immunity in human filariasis continues to be a subject of intense debate. While there is no broad consensus on functional immunity against larval and adult stage parasites, anti-microfilarial immunity has been demonstrated to be mediated by antibodies to the microfilarial sheath. In the present study, circulating filarial antigens (CFA), a marker of active filarial infection in human Bancroftian filariasis, was found to be inversely associated with antibodies to microfilarial sheath in a cohort of 411 subjects representing all categories of filariasis across the clinical spectrum of the disease. Approximately 80% of humans of all age groups (5-65 years) were found to have either CFA or anti-sheath antibodies. The inverse relationship observed between these two parameters was found to be independent of the clinical manifestation; both symptomatic and asymptomatic cases were found to display similar inverse association between CFA and anti-sheath antibodies. The prevalence of anti-sheath antibodies in the paediatric group was found to be very high as compared to adults; 78% of children below the age of 10 years tested positive for anti-sheath antibodies although the mf rate and CFA rate were only 4.5% and 22.7%, respectively, in this age group, indicating that developing larvae or juvenile adult stage parasites could have been the source of antigenic stimulus for induction of antibodies to the microfilarial sheath.
PubMed: 11123755
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Ravindran</name><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology, Regional Medical Research Centre, ICMR, Bhubaneswar, India. immunol@dte.vsnl.net.in</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Immunology, Regional Medical Research Centre, ICMR, Bhubaneswar</wicri:regionArea><wicri:noRegion>Bhubaneswar</wicri:noRegion></affiliation></author><author><name sortKey="Satapathy, A K" sort="Satapathy, A K" uniqKey="Satapathy A" first="A K" last="Satapathy">A K Satapathy</name></author><author><name sortKey="Sahoo, P K" sort="Sahoo, P K" uniqKey="Sahoo P" first="P K" last="Sahoo">P K Sahoo</name></author><author><name sortKey="Babu Geddam, J J" sort="Babu Geddam, J J" uniqKey="Babu Geddam J" first="J J" last="Babu Geddam">J J Babu Geddam</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:11123755</idno><idno type="pmid">11123755</idno><idno type="wicri:Area/PubMed/Corpus">004937</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004937</idno><idno type="wicri:Area/PubMed/Curation">004937</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004937</idno><idno type="wicri:Area/PubMed/Checkpoint">004937</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004937</idno><idno type="wicri:Area/Ncbi/Merge">000504</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Protective immunity in human Bancroftian filariasis: inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens.</title><author><name sortKey="Ravindran, B" sort="Ravindran, B" uniqKey="Ravindran B" first="B" last="Ravindran">B. 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While there is no broad consensus on functional immunity against larval and adult stage parasites, anti-microfilarial immunity has been demonstrated to be mediated by antibodies to the microfilarial sheath. In the present study, circulating filarial antigens (CFA), a marker of active filarial infection in human Bancroftian filariasis, was found to be inversely associated with antibodies to microfilarial sheath in a cohort of 411 subjects representing all categories of filariasis across the clinical spectrum of the disease. Approximately 80% of humans of all age groups (5-65 years) were found to have either CFA or anti-sheath antibodies. The inverse relationship observed between these two parameters was found to be independent of the clinical manifestation; both symptomatic and asymptomatic cases were found to display similar inverse association between CFA and anti-sheath antibodies. The prevalence of anti-sheath antibodies in the paediatric group was found to be very high as compared to adults; 78% of children below the age of 10 years tested positive for anti-sheath antibodies although the mf rate and CFA rate were only 4.5% and 22.7%, respectively, in this age group, indicating that developing larvae or juvenile adult stage parasites could have been the source of antigenic stimulus for induction of antibodies to the microfilarial sheath.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11123755</PMID><DateCreated><Year>2001</Year><Month>01</Month><Day>23</Day></DateCreated><DateCompleted><Year>2001</Year><Month>01</Month><Day>26</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0141-9838</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>12</Issue><PubDate><Year>2000</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Parasite immunology</Title><ISOAbbreviation>Parasite Immunol.</ISOAbbreviation></Journal><ArticleTitle>Protective immunity in human Bancroftian filariasis: inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens.</ArticleTitle><Pagination><MedlinePgn>633-7</MedlinePgn></Pagination><Abstract><AbstractText>The existence and the nature of protective immunity in human filariasis continues to be a subject of intense debate. While there is no broad consensus on functional immunity against larval and adult stage parasites, anti-microfilarial immunity has been demonstrated to be mediated by antibodies to the microfilarial sheath. In the present study, circulating filarial antigens (CFA), a marker of active filarial infection in human Bancroftian filariasis, was found to be inversely associated with antibodies to microfilarial sheath in a cohort of 411 subjects representing all categories of filariasis across the clinical spectrum of the disease. Approximately 80% of humans of all age groups (5-65 years) were found to have either CFA or anti-sheath antibodies. The inverse relationship observed between these two parameters was found to be independent of the clinical manifestation; both symptomatic and asymptomatic cases were found to display similar inverse association between CFA and anti-sheath antibodies. The prevalence of anti-sheath antibodies in the paediatric group was found to be very high as compared to adults; 78% of children below the age of 10 years tested positive for anti-sheath antibodies although the mf rate and CFA rate were only 4.5% and 22.7%, respectively, in this age group, indicating that developing larvae or juvenile adult stage parasites could have been the source of antigenic stimulus for induction of antibodies to the microfilarial sheath.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ravindran</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Immunology, Regional Medical Research Centre, ICMR, Bhubaneswar, India. immunol@dte.vsnl.net.in</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Satapathy</LastName><ForeName>A K</ForeName><Initials>AK</Initials></Author><Author ValidYN="Y"><LastName>Sahoo</LastName><ForeName>P K</ForeName><Initials>PK</Initials></Author><Author ValidYN="Y"><LastName>Babu Geddam</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parasite Immunol</MedlineTA><NlmUniqueID>7910948</NlmUniqueID><ISSNLinking>0141-9838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" 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Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004604" MajorTopicYN="N">Elephantiasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007109" MajorTopicYN="N">Immunity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007194" MajorTopicYN="N" Type="Geographic">India</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>12</Month><Day>21</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>2</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>12</Month><Day>21</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11123755</ArticleId><ArticleId IdType="pii">pim347</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Babu Geddam, J J" sort="Babu Geddam, J J" uniqKey="Babu Geddam J" first="J J" last="Babu Geddam">J J Babu Geddam</name><name sortKey="Sahoo, P K" sort="Sahoo, P K" uniqKey="Sahoo P" first="P K" last="Sahoo">P K Sahoo</name><name sortKey="Satapathy, A K" sort="Satapathy, A K" uniqKey="Satapathy A" first="A K" last="Satapathy">A K Satapathy</name></noCountry><country name="Inde"><noRegion><name sortKey="Ravindran, B" sort="Ravindran, B" uniqKey="Ravindran B" first="B" last="Ravindran">B. 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