Differences in the Frequency of Cytokine-Producing Cells in Antigenemic and Nonantigenemic Individuals with Bancroftian Filariasis
Identifieur interne : 00BB48 ( Ncbi/Curation ); précédent : 00BB47; suivant : 00BB49Differences in the Frequency of Cytokine-Producing Cells in Antigenemic and Nonantigenemic Individuals with Bancroftian Filariasis
Auteurs : Adriana B. De Almeida ; Maria Carmelita Maia E Silva ; Cynthia Braga ; David O. FreedmanSource :
- Infection and Immunity [ 0019-9567 ] ; 1998.
Abstract
Individuals with clinical manifestations of lymphatic filariasis may be currently infected or not. Twenty-five individuals from a
Url:
PubMed: 9529056
PubMed Central: 108063
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<author><name sortKey="De Almeida, Adriana B" sort="De Almeida, Adriana B" uniqKey="De Almeida A" first="Adriana B." last="De Almeida">Adriana B. De Almeida</name>
<affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff>
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<author><name sortKey="E Silva, Maria Carmelita Maia" sort="E Silva, Maria Carmelita Maia" uniqKey="E Silva M" first="Maria Carmelita Maia" last="E Silva">Maria Carmelita Maia E Silva</name>
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</affiliation>
</author>
<author><name sortKey="Braga, Cynthia" sort="Braga, Cynthia" uniqKey="Braga C" first="Cynthia" last="Braga">Cynthia Braga</name>
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</affiliation>
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<author><name sortKey="Freedman, David O" sort="Freedman, David O" uniqKey="Freedman D" first="David O." last="Freedman">David O. Freedman</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differences in the Frequency of Cytokine-Producing Cells in Antigenemic and Nonantigenemic Individuals with Bancroftian Filariasis</title>
<author><name sortKey="De Almeida, Adriana B" sort="De Almeida, Adriana B" uniqKey="De Almeida A" first="Adriana B." last="De Almeida">Adriana B. De Almeida</name>
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<author><name sortKey="E Silva, Maria Carmelita Maia" sort="E Silva, Maria Carmelita Maia" uniqKey="E Silva M" first="Maria Carmelita Maia" last="E Silva">Maria Carmelita Maia E Silva</name>
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<author><name sortKey="Braga, Cynthia" sort="Braga, Cynthia" uniqKey="Braga C" first="Cynthia" last="Braga">Cynthia Braga</name>
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<author><name sortKey="Freedman, David O" sort="Freedman, David O" uniqKey="Freedman D" first="David O." last="Freedman">David O. Freedman</name>
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<series><title level="j">Infection and Immunity</title>
<idno type="ISSN">0019-9567</idno>
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<front><div type="abstract" xml:lang="en"><p>Individuals with clinical manifestations of lymphatic filariasis may be currently infected or not. Twenty-five individuals from a <italic>Wuchereria bancrofti</italic>
-endemic area of Brazil were classified as being asymptomatic microfilaremic individuals, antigenemic individuals with clinical filariasis, or nonantigenemic individuals with clinical filariasis. Intracellular cytokine staining of mitogen-stimulated peripheral blood mononuclear cells (PBMC) showed that the frequency of either gamma interferon (IFN-γ)- or interleukin-4 (IL-4)-producing cells was higher in the nonantigenemic individuals with clinical filariasis than in the asymptomatic microfilaremic individuals (geometric means, 22.1 versus 10.7% [<italic>P</italic>
= 0.02] and 2.9 versus 1.4% [<italic>P</italic>
= 0.01], respectively). When the asymptomatic microfilaremic individuals and antigenemic individuals with clinical filariasis were grouped together to constitute all actively infected individuals, the frequency of IFN-γ-producing cells was also lower than in the nonantigenemic individuals with clinical filariasis (<italic>P</italic>
= 0.04). Likewise, the frequency of IL-4-producing cells in the actively infected individuals was also lower than in the nonantigenemic individuals with clinical filariasis (<italic>P</italic>
= 0.02). No differences in the frequency of IFN-γ-, IL-4-, or IL-5-producing cells in purified CD4 T lymphocytes were found among the groups. These findings suggest that the presence of antigenemia, which is an indicator of current active infection, is closely associated with the frequency of IFN-γ- and IL-4-producing cells in lymphatic filariasis. The differences found in the frequency of cytokine-producing cells among the three groups appear to be due to a subset of cells other than CD4 T cells.</p>
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