Observation of viable alloskin vs xenoskin grafted onto subcutaneous tissue wounds after tangential excision in massive burns
Identifieur interne : 008747 ( Ncbi/Curation ); précédent : 008746; suivant : 008748Observation of viable alloskin vs xenoskin grafted onto subcutaneous tissue wounds after tangential excision in massive burns
Auteurs : Haibin Zuo ; Guodong Song ; Wen Shi ; Jun Jia ; Yonghu ZhangSource :
- Burns & Trauma [ 2321-3868 ] ; 2016.
Abstract
Staged excision and grafting with viable cryopreserved alloskin or fresh pigskin at an early stage is a main strategy for wound management in massive burns. Alloskin is the gold standard of a biological temporary skin substitute, and the main drawback to its wider use is the limited number of donors. In this paper, we compare the use of fresh pigskins to cryopreserved alloskins as temporary skin substitutes on subcutaneous tissue wounds after tangential excision by observing the clinical performances of these grafts in cases of a massive burn.
We selected six adult massive burn patients undergoing tangential excision and skin grafting on subcutaneous tissue wounds (TESGSTW) at our burn center from January 1, 2003 to December 31, 2013. The general clinical data and survival percentage of skins at postoperative weeks (POWs) 1, 2, and 3 were analyzed. In our clinical practice, we also observed the phenomenon that several viable cryopreserved alloskin or fresh pigskin grafts used as temporary coverage on subcutaneous tissue wounds had long-term survival after repeated desquamation. The macroscopic and histological results of one typical case were also analyzed.
In this study, the first three TESGSTW operations were performed at 2–3, 5–8, and 11–16 days post-injury. The operation areas were 30.3 ± 7.9 % total body surface area (TBSA), 19.0 ± 6.0 % TBSA, and 12.0 ± 1.7 % TBSA, respectively. The survival percentage of the cryopreserved alloskins or fresh pigskins at POWs 1, 2, and 3 were 80.0 ± 10.0 % vs 75.7 ± 5.3 % (
From the clinical observations, fresh pigskin and cryopreserved alloskins could be used with equal effectiveness at an early stage (within 2 weeks post-operation) as temporary coverage on massive burns after TESGSTW. After engraftment, several cryopreserved alloskins or fresh pigskins could co-survive in a massive burn patient for an extended amount of time. The co-survival of alloskin and pigskin will provide clues for further research into skin transplantation.
The online version of this article (doi:10.1186/s41038-016-0045-9) contains supplementary material, which is available to authorized users.
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DOI: 10.1186/s41038-016-0045-9
PubMed: 27574692
PubMed Central: 4964051
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Haibin Zuo<affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Observation of viable alloskin vs xenoskin grafted onto subcutaneous tissue wounds after tangential excision in massive burns</title><author><name sortKey="Zuo, Haibin" sort="Zuo, Haibin" uniqKey="Zuo H" first="Haibin" last="Zuo">Haibin Zuo</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author><author><name sortKey="Song, Guodong" sort="Song, Guodong" uniqKey="Song G" first="Guodong" last="Song">Guodong Song</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author><author><name sortKey="Shi, Wen" sort="Shi, Wen" uniqKey="Shi W" first="Wen" last="Shi">Wen Shi</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author><author><name sortKey="Jia, Jun" sort="Jia, Jun" uniqKey="Jia J" first="Jun" last="Jia">Jun Jia</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Yonghu" sort="Zhang, Yonghu" uniqKey="Zhang Y" first="Yonghu" last="Zhang">Yonghu Zhang</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR 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type="wicri:Area/Ncbi/Curation">008747</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Observation of viable alloskin vs xenoskin grafted onto subcutaneous tissue wounds after tangential excision in massive burns</title><author><name sortKey="Zuo, Haibin" sort="Zuo, Haibin" uniqKey="Zuo H" first="Haibin" last="Zuo">Haibin Zuo</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author><author><name sortKey="Song, Guodong" sort="Song, Guodong" uniqKey="Song G" first="Guodong" last="Song">Guodong Song</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author><author><name sortKey="Shi, Wen" sort="Shi, Wen" uniqKey="Shi W" first="Wen" last="Shi">Wen Shi</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author><author><name sortKey="Jia, Jun" sort="Jia, Jun" uniqKey="Jia J" first="Jun" last="Jia">Jun Jia</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Yonghu" sort="Zhang, Yonghu" uniqKey="Zhang Y" first="Yonghu" last="Zhang">Yonghu Zhang</name><affiliation><nlm:aff id="Aff1">Department of Burns, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong 250013 PR China</nlm:aff><wicri:noCountry code="subfield">Shandong 250013 PR China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Burns & Trauma</title><idno type="ISSN">2321-3868</idno><idno type="eISSN">2321-3876</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Staged excision and grafting with viable cryopreserved alloskin or fresh pigskin at an early stage is a main strategy for wound management in massive burns. Alloskin is the gold standard of a biological temporary skin substitute, and the main drawback to its wider use is the limited number of donors. In this paper, we compare the use of fresh pigskins to cryopreserved alloskins as temporary skin substitutes on subcutaneous tissue wounds after tangential excision by observing the clinical performances of these grafts in cases of a massive burn.</p></sec><sec><title>Methods</title><p>We selected six adult massive burn patients undergoing tangential excision and skin grafting on subcutaneous tissue wounds (TESGSTW) at our burn center from January 1, 2003 to December 31, 2013. The general clinical data and survival percentage of skins at postoperative weeks (POWs) 1, 2, and 3 were analyzed. In our clinical practice, we also observed the phenomenon that several viable cryopreserved alloskin or fresh pigskin grafts used as temporary coverage on subcutaneous tissue wounds had long-term survival after repeated desquamation. The macroscopic and histological results of one typical case were also analyzed.</p></sec><sec><title>Results</title><p>In this study, the first three TESGSTW operations were performed at 2–3, 5–8, and 11–16 days post-injury. The operation areas were 30.3 ± 7.9 % total body surface area (TBSA), 19.0 ± 6.0 % TBSA, and 12.0 ± 1.7 % TBSA, respectively. The survival percentage of the cryopreserved alloskins or fresh pigskins at POWs 1, 2, and 3 were 80.0 ± 10.0 % vs 75.7 ± 5.3 % (<italic>t</italic> = 1.01, <italic>P</italic> = 0.16), 71.2 ± 10.6 % vs 66.4 ± 6.2 % (<italic>t</italic> = 1.09, <italic>P</italic> = 0.30), and 48.7 ± 2.5 % vs 35.0 ± 7.0 % (<italic>t</italic> = 3.83, <italic>P</italic> = 0.03), respectively. The microscopic observation of the survival of alloskins or pigskins in one typical case showed rete ridges and a basilar membrane at the joint of the epidermis and dermis at an early stage; these structures disappeared with extended time post-operation.</p></sec><sec><title>Conclusions</title><p>From the clinical observations, fresh pigskin and cryopreserved alloskins could be used with equal effectiveness at an early stage (within 2 weeks post-operation) as temporary coverage on massive burns after TESGSTW. After engraftment, several cryopreserved alloskins or fresh pigskins could co-survive in a massive burn patient for an extended amount of time. The co-survival of alloskin and pigskin will provide clues for further research into skin transplantation.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s41038-016-0045-9) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chih Chun, Y" uniqKey="Chih Chun Y">Y Chih-chun</name></author><author><name sortKey="Tsi Siang, S" uniqKey="Tsi Siang S">S Tsi-siang</name></author><author><name sortKey="Wei Shia, X" uniqKey="Wei Shia X">X Wei-shia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hermans, Mh" uniqKey="Hermans M">MH Hermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burke, Jf" uniqKey="Burke J">JF Burke</name></author><author><name sortKey="Bondoc, Cc" uniqKey="Bondoc C">CC Bondoc</name></author><author><name 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