Increased numbers of CD23+CD21hi Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes
Identifieur interne : 008210 ( Ncbi/Curation ); précédent : 008209; suivant : 008211Increased numbers of CD23+CD21hi Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes
Auteurs : Igor I. Kuzin [États-Unis] ; Stephen L. Kates [États-Unis] ; Yawen Ju [États-Unis] ; Longze Zhang [États-Unis] ; Homaira Rahimi [États-Unis] ; Wojciech Wojciechowski [États-Unis] ; Steven H. Bernstein [États-Unis] ; Richard Burack [États-Unis] ; Edward M. Schwarz [États-Unis] ; Andrea Bottaro [États-Unis]Source :
- European journal of immunology [ 0014-2980 ] ; 2016.
Abstract
A unique population of CD23+ CD21high
Url:
DOI: 10.1002/eji.201546266
PubMed: 27105894
PubMed Central: 4942352
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CD21<sup>hi</sup>
Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Increased numbers of CD23<sup>+</sup>
CD21<sup>hi</sup>
Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes</title>
<author><name sortKey="Kuzin, Igor I" sort="Kuzin, Igor I" uniqKey="Kuzin I" first="Igor I." last="Kuzin">Igor I. Kuzin</name>
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<author><name sortKey="Wojciechowski, Wojciech" sort="Wojciechowski, Wojciech" uniqKey="Wojciechowski W" first="Wojciech" last="Wojciechowski">Wojciech Wojciechowski</name>
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<author><name sortKey="Burack, Richard" sort="Burack, Richard" uniqKey="Burack R" first="Richard" last="Burack">Richard Burack</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine; University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea>
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<author><name sortKey="Schwarz, Edward M" sort="Schwarz, Edward M" uniqKey="Schwarz E" first="Edward M." last="Schwarz">Edward M. Schwarz</name>
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<author><name sortKey="Bottaro, Andrea" sort="Bottaro, Andrea" uniqKey="Bottaro A" first="Andrea" last="Bottaro">Andrea Bottaro</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<series><title level="j">European journal of immunology</title>
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<front><div type="abstract" xml:lang="en"><p id="P2">A unique population of CD23<sup>+</sup>
CD21<sup>high</sup>
<underline>B</underline>
cells in inflamed <underline>n</underline>
odes (Bin) has been shown to accumulate in lymph nodes (LNs) draining inflamed joints of TNF-transgenic (TNF-tg) mice. Bin cells contribute to arthritis flare in mice by distorting node architecture and hampering lymphatic flow, but their existence in human inflamed LNs has not yet been described. Here, we report the characterization of resident B-cell populations in fresh popliteal lymph nodes (PLNs) from patients with severe lower limb diseases (non-RA) and rheumatoid arthritis (RA) patients, and from banked, cryopreserved reactive and normal human LN single cell suspension samples. Bin-like B cells were shown to be significantly increased in reactive LNs, and strikingly elevated (>30% of total) in RA samples. Histopathology and immunofluorescence analyses were consistent with B follicular hyperplasia and histological alterations in RA vs. non-RA PLNs. This is the first description of Bin-like B cells in human inflamed LNs. Consistent with published mouse data, this population appears to be associated with inflammatory arthritis and distortion of LN architecture. Further analyses are necessary to assess the role of CD23<sup>+</sup>
CD21<sup>hi</sup>
Bin-like B cells in RA pathogenesis and arthritic flare.</p>
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