Is Sentinel Lymph Node Biopsy Indicated at Completion Mastectomy for DCIS Following Attempted Breast Conservation?
Identifieur interne : 008004 ( Ncbi/Curation ); précédent : 008003; suivant : 008005Is Sentinel Lymph Node Biopsy Indicated at Completion Mastectomy for DCIS Following Attempted Breast Conservation?
Auteurs : Melissa Pilewskie [États-Unis] ; Maria Karsten [États-Unis] ; Julia Radosa [États-Unis] ; Anne Eaton [États-Unis] ; Tari A. King [États-Unis]Source :
- Annals of surgical oncology [ 1068-9265 ] ; 2016.
Abstract
Sentinel lymph node biopsy (SLNB) is recommended when mastectomy is performed for ductal carcinoma in situ (DCIS). The role of SLNB for women with DCIS who undergo mastectomy following ≥1 attempts at breast-conserving surgery (BCS) is uncertain. We examined the upgrade rate and SLNB yield in women who converted to mastectomy after ≥1 attempts at BCS for DCIS.
All patients who underwent ≥1 attempts at BCS prior to conversion to mastectomy with SLNB for DCIS were identified. Margin status as the indication for mastectomy was confirmed. Comparisons were made between patients with/without upgrade on final pathology.
From 2/2006–11/2012, 233 patients underwent completion mastectomy following ≥1 attempts at BCS for positive/close margins (median age,50 years; range 34–84). Median number of BCS attempts was 1 (range 1–4). Overall, 20 (9%) patients were upgraded on final pathology; 15 (6%)stage I, 5(3%) stage II (3 micrometastasis,2 macrometastasis). In 2 of 5 cases with a positive SLN, invasive carcinoma was not identified in the mastectomy specimen. The only factor associated with any upgrade was the presence of micropapillary DCIS (80% versus 55%, with and without upgrade; p = 0.03).
In this cohort of patients with DCIS who converted to mastectomy for positive/close margins after ≥1 attempts at BCS, 18 (8%) would have required second-stage axillary surgery had a SLNB not been performed and in 2 (1%) patients the SLN provided the only evidence of invasion. These findings support the recommendation for SLNB at the time of completion mastectomy.
Url:
DOI: 10.1245/s10434-016-5145-z
PubMed: 26960927
PubMed Central: 4943570
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003989
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :003988
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000859
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :008004
Links to Exploration step
PMC:4943570Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Is Sentinel Lymph Node Biopsy Indicated at Completion Mastectomy for DCIS Following Attempted Breast Conservation?</title><author><name sortKey="Pilewskie, Melissa" sort="Pilewskie, Melissa" uniqKey="Pilewskie M" first="Melissa" last="Pilewskie">Melissa Pilewskie</name><affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Karsten, Maria" sort="Karsten, Maria" uniqKey="Karsten M" first="Maria" last="Karsten">Maria Karsten</name><affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Radosa, Julia" sort="Radosa, Julia" uniqKey="Radosa J" first="Julia" last="Radosa">Julia Radosa</name><affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Eaton, Anne" sort="Eaton, Anne" uniqKey="Eaton A" first="Anne" last="Eaton">Anne Eaton</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="King, Tari A" sort="King, Tari A" uniqKey="King T" first="Tari A." last="King">Tari A. King</name><affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26960927</idno><idno type="pmc">4943570</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943570</idno><idno type="RBID">PMC:4943570</idno><idno type="doi">10.1245/s10434-016-5145-z</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">003989</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003989</idno><idno type="wicri:Area/Pmc/Curation">003988</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003988</idno><idno type="wicri:Area/Pmc/Checkpoint">000859</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000859</idno><idno type="wicri:Area/Ncbi/Merge">008004</idno><idno type="wicri:Area/Ncbi/Curation">008004</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Is Sentinel Lymph Node Biopsy Indicated at Completion Mastectomy for DCIS Following Attempted Breast Conservation?</title><author><name sortKey="Pilewskie, Melissa" sort="Pilewskie, Melissa" uniqKey="Pilewskie M" first="Melissa" last="Pilewskie">Melissa Pilewskie</name><affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Karsten, Maria" sort="Karsten, Maria" uniqKey="Karsten M" first="Maria" last="Karsten">Maria Karsten</name><affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Radosa, Julia" sort="Radosa, Julia" uniqKey="Radosa J" first="Julia" last="Radosa">Julia Radosa</name><affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Eaton, Anne" sort="Eaton, Anne" uniqKey="Eaton A" first="Anne" last="Eaton">Anne Eaton</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="King, Tari A" sort="King, Tari A" uniqKey="King T" first="Tari A." last="King">Tari A. King</name><affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author></analytic><series><title level="j">Annals of surgical oncology</title><idno type="ISSN">1068-9265</idno><idno type="eISSN">1534-4681</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Sentinel lymph node biopsy (SLNB) is recommended when mastectomy is performed for ductal carcinoma in situ (DCIS). The role of SLNB for women with DCIS who undergo mastectomy following ≥1 attempts at breast-conserving surgery (BCS) is uncertain. We examined the upgrade rate and SLNB yield in women who converted to mastectomy after ≥1 attempts at BCS for DCIS.</p></sec><sec id="S2"><title>Methods</title><p id="P2">All patients who underwent ≥1 attempts at BCS prior to conversion to mastectomy with SLNB for DCIS were identified. Margin status as the indication for mastectomy was confirmed. Comparisons were made between patients with/without upgrade on final pathology.</p></sec><sec id="S3"><title>Results</title><p id="P3">From 2/2006–11/2012, 233 patients underwent completion mastectomy following ≥1 attempts at BCS for positive/close margins (median age,50 years; range 34–84). Median number of BCS attempts was 1 (range 1–4). Overall, 20 (9%) patients were upgraded on final pathology; 15 (6%)stage I, 5(3%) stage II (3 micrometastasis,2 macrometastasis). In 2 of 5 cases with a positive SLN, invasive carcinoma was not identified in the mastectomy specimen. The only factor associated with any upgrade was the presence of micropapillary DCIS (80% versus 55%, with and without upgrade; p = 0.03).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">In this cohort of patients with DCIS who converted to mastectomy for positive/close margins after ≥1 attempts at BCS, 18 (8%) would have required second-stage axillary surgery had a SLNB not been performed and in 2 (1%) patients the SLN provided the only evidence of invasion. These findings support the recommendation for SLNB at the time of completion mastectomy.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008004 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 008004 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:4943570
|texte= Is Sentinel Lymph Node Biopsy Indicated at Completion Mastectomy for DCIS Following Attempted Breast Conservation?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:26960927" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |