Breast Cancer Subtype is Associated With Axillary Lymph Node Metastasis
Identifieur interne : 007B93 ( Ncbi/Curation ); précédent : 007B92; suivant : 007B94Breast Cancer Subtype is Associated With Axillary Lymph Node Metastasis
Auteurs : Zhen-Yu He ; San-Gang Wu ; Qi Yang ; Jia-Yuan Sun ; Feng-Yan Li ; Qin Lin ; Huan-Xin LinSource :
- Medicine [ 0025-7974 ] ; 2015.
Abstract
The purpose of this study was to assess whether breast cancer subtype (BCS) as determined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 can predict the axillary lymph node metastasis in breast cancer.
Patients who received breast conserving surgery or mastectomy and axillary lymph node dissection were identified from 2 cancer centers. The associations between clinicopathological variables and axillary lymph node involvement were evaluated in univariate and multivariate regression analyses.
A total of 3471 patients met the inclusion criteria, and 53.0% had axillary lymph node metastases at diagnosis. Patients with hormone receptor (HR)−/human epidermal growth factor receptor 2 (HER2)− subtype had a higher grade disease and the lowest rate of lymphovascular invasion. Univariate and multivariable logistic regression analyses showed that BCS was significantly associated with lymph node involvement. Patients with the HR−/HER2− subtype had the lowest odds of having nodal positivity than those with other BCSs. HR+/HER2− (odds ratio [OR] 1.651, 95% confidence interval [CI]: 1.349–2.021,
Breast cancer subtype can predict the presence of axillary lymph node metastasis in breast cancer. HR−/HER2− is associated with a reduced risk of axillary lymph node metastasis compared to other BCSs. Our findings may play an important role in guiding axillary treatment considerations if further confirmed in larger sample size studies.
Url:
DOI: 10.1097/MD.0000000000002213
PubMed: 26632910
PubMed Central: 4674213
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Breast Cancer Subtype is Associated With Axillary Lymph Node Metastasis</title><author><name sortKey="He, Zhen Yu" sort="He, Zhen Yu" uniqKey="He Z" first="Zhen-Yu" last="He">Zhen-Yu He</name></author><author><name sortKey="Wu, San Gang" sort="Wu, San Gang" uniqKey="Wu S" first="San-Gang" last="Wu">San-Gang Wu</name></author><author><name sortKey="Yang, Qi" sort="Yang, Qi" uniqKey="Yang Q" first="Qi" last="Yang">Qi Yang</name></author><author><name sortKey="Sun, Jia Yuan" sort="Sun, Jia Yuan" uniqKey="Sun J" first="Jia-Yuan" last="Sun">Jia-Yuan Sun</name></author><author><name sortKey="Li, Feng Yan" sort="Li, Feng Yan" uniqKey="Li F" first="Feng-Yan" last="Li">Feng-Yan Li</name></author><author><name sortKey="Lin, Qin" sort="Lin, Qin" uniqKey="Lin Q" first="Qin" last="Lin">Qin Lin</name></author><author><name sortKey="Lin, Huan Xin" sort="Lin, Huan Xin" uniqKey="Lin H" first="Huan-Xin" last="Lin">Huan-Xin Lin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26632910</idno><idno type="pmc">4674213</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674213</idno><idno type="RBID">PMC:4674213</idno><idno type="doi">10.1097/MD.0000000000002213</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000378</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000378</idno><idno type="wicri:Area/Pmc/Curation">000378</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000378</idno><idno type="wicri:Area/Pmc/Checkpoint">001462</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001462</idno><idno type="wicri:Area/Ncbi/Merge">007B93</idno><idno type="wicri:Area/Ncbi/Curation">007B93</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Breast Cancer Subtype is Associated With Axillary Lymph Node Metastasis</title><author><name sortKey="He, Zhen Yu" sort="He, Zhen Yu" uniqKey="He Z" first="Zhen-Yu" last="He">Zhen-Yu He</name></author><author><name sortKey="Wu, San Gang" sort="Wu, San Gang" uniqKey="Wu S" first="San-Gang" last="Wu">San-Gang Wu</name></author><author><name sortKey="Yang, Qi" sort="Yang, Qi" uniqKey="Yang Q" first="Qi" last="Yang">Qi Yang</name></author><author><name sortKey="Sun, Jia Yuan" sort="Sun, Jia Yuan" uniqKey="Sun J" first="Jia-Yuan" last="Sun">Jia-Yuan Sun</name></author><author><name sortKey="Li, Feng Yan" sort="Li, Feng Yan" uniqKey="Li F" first="Feng-Yan" last="Li">Feng-Yan Li</name></author><author><name sortKey="Lin, Qin" sort="Lin, Qin" uniqKey="Lin Q" first="Qin" last="Lin">Qin Lin</name></author><author><name sortKey="Lin, Huan Xin" sort="Lin, Huan Xin" uniqKey="Lin H" first="Huan-Xin" last="Lin">Huan-Xin Lin</name></author></analytic><series><title level="j">Medicine</title><idno type="ISSN">0025-7974</idno><idno type="eISSN">1536-5964</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The purpose of this study was to assess whether breast cancer subtype (BCS) as determined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 can predict the axillary lymph node metastasis in breast cancer.</p><p>Patients who received breast conserving surgery or mastectomy and axillary lymph node dissection were identified from 2 cancer centers. The associations between clinicopathological variables and axillary lymph node involvement were evaluated in univariate and multivariate regression analyses.</p><p>A total of 3471 patients met the inclusion criteria, and 53.0% had axillary lymph node metastases at diagnosis. Patients with hormone receptor (HR)−/human epidermal growth factor receptor 2 (HER2)− subtype had a higher grade disease and the lowest rate of lymphovascular invasion. Univariate and multivariable logistic regression analyses showed that BCS was significantly associated with lymph node involvement. Patients with the HR−/HER2− subtype had the lowest odds of having nodal positivity than those with other BCSs. HR+/HER2− (odds ratio [OR] 1.651, 95% confidence interval [CI]: 1.349–2.021, <italic>P</italic> < 0.001), HR+/HER2+ (OR 1.958, 95%CI 1.542–2.486, <italic>P</italic> < 0.001), and HR−/HER2+ (OR 1.525, 95%CI 1.181–1.970, <italic>P</italic> < 0.001) tumors had higher risk of nodal positivity than the HR−/HER2− subtype. The other independent predictors of nodal metastases included tumor size, tumor grade, and lymphovascular invasion.</p><p>Breast cancer subtype can predict the presence of axillary lymph node metastasis in breast cancer. HR−/HER2− is associated with a reduced risk of axillary lymph node metastasis compared to other BCSs. Our findings may play an important role in guiding axillary treatment considerations if further confirmed in larger sample size studies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Layeequr Rahman, R" uniqKey="Layeequr Rahman R">R Layeequr Rahman</name></author><author><name sortKey="Crawford, Sl" uniqKey="Crawford S">SL Crawford</name></author><author><name sortKey="Siwawa, P" uniqKey="Siwawa P">P Siwawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Mccall, L" uniqKey="Mccall L">L McCall</name></author><author><name sortKey="Beitsch, P" uniqKey="Beitsch P">P Beitsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name></author><author><name 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