Regulatory T‐cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17‐mediated pro‐inflammatory response
Identifieur interne : 007A72 ( Ncbi/Curation ); précédent : 007A71; suivant : 007A73Regulatory T‐cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17‐mediated pro‐inflammatory response
Auteurs : Manisha Pathak ; Pankaj Sharma ; Aditi Sharma ; Meenakshi Verma ; Mrigank Srivastava ; Shailja Misra-BhattacharyaSource :
- Immunology [ 0019-2805 ] ; 2015.
Descripteurs français
- KwdFr :
- Activation des macrophages (), Animaux, Anticorps neutralisants (pharmacologie), Antigènes CD40 (immunologie), Antigènes CD40 (métabolisme), Cellules Th17 (), Cellules Th17 (immunologie), Cellules Th17 (métabolisme), Cellules Th17 (parasitologie), Cellules cultivées, Cellules dendritiques (), Cellules dendritiques (immunologie), Cellules dendritiques (parasitologie), Facteurs temps, Filariose lymphatique (immunologie), Filariose lymphatique (métabolisme), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Granulocytes éosinophiles (), Granulocytes éosinophiles (immunologie), Granulocytes éosinophiles (parasitologie), Immunisation, Interactions hôte-parasite, Interféron gamma (immunologie), Interféron gamma (métabolisme), Interleukine-10 (immunologie), Interleukine-10 (métabolisme), Lymphocytes T régulateurs (), Lymphocytes T régulateurs (immunologie), Lymphocytes T régulateurs (métabolisme), Lymphocytes T régulateurs (parasitologie), Modèles animaux de maladie humaine, Médiateurs de l'inflammation (immunologie), Médiateurs de l'inflammation (métabolisme), Protéine associée au récepteur du TNF induit par les corticoïdes (antagonistes et inhibiteurs), Protéine associée au récepteur du TNF induit par les corticoïdes (immunologie), Protéine associée au récepteur du TNF induit par les corticoïdes (métabolisme), Protéines de la membrane externe bactérienne (immunologie), Souris de lignée BALB C, Sous-unité alpha du récepteur à l'interleukine-2 (antagonistes et inhibiteurs), Sous-unité alpha du récepteur à l'interleukine-2 (immunologie), Sous-unité alpha du récepteur à l'interleukine-2 (métabolisme).
- MESH :
- antagonistes et inhibiteurs : Protéine associée au récepteur du TNF induit par les corticoïdes, Sous-unité alpha du récepteur à l'interleukine-2.
- immunologie : Antigènes CD40, Cellules Th17, Cellules dendritiques, Filariose lymphatique, Granulocytes éosinophiles, Interféron gamma, Interleukine-10, Lymphocytes T régulateurs, Médiateurs de l'inflammation, Protéine associée au récepteur du TNF induit par les corticoïdes, Protéines de la membrane externe bactérienne, Sous-unité alpha du récepteur à l'interleukine-2.
- métabolisme : Antigènes CD40, Cellules Th17, Filariose lymphatique, Interféron gamma, Interleukine-10, Lymphocytes T régulateurs, Médiateurs de l'inflammation, Protéine associée au récepteur du TNF induit par les corticoïdes, Sous-unité alpha du récepteur à l'interleukine-2.
- parasitologie : Cellules Th17, Cellules dendritiques, Filariose lymphatique, Granulocytes éosinophiles, Lymphocytes T régulateurs.
- pharmacologie : Anticorps neutralisants.
- traitement médicamenteux : Filariose lymphatique.
- Activation des macrophages, Animaux, Cellules Th17, Cellules cultivées, Cellules dendritiques, Facteurs temps, Granulocytes éosinophiles, Immunisation, Interactions hôte-parasite, Lymphocytes T régulateurs, Modèles animaux de maladie humaine, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (pharmacology), Antigens, CD40 (immunology), Antigens, CD40 (metabolism), Bacterial Outer Membrane Proteins (immunology), Cells, Cultured, Dendritic Cells (drug effects), Dendritic Cells (immunology), Dendritic Cells (parasitology), Disease Models, Animal, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (metabolism), Elephantiasis, Filarial (parasitology), Eosinophils (drug effects), Eosinophils (immunology), Eosinophils (parasitology), Glucocorticoid-Induced TNFR-Related Protein (antagonists & inhibitors), Glucocorticoid-Induced TNFR-Related Protein (immunology), Glucocorticoid-Induced TNFR-Related Protein (metabolism), Host-Parasite Interactions, Immunization, Inflammation Mediators (immunology), Inflammation Mediators (metabolism), Interferon-gamma (immunology), Interferon-gamma (metabolism), Interleukin-10 (immunology), Interleukin-10 (metabolism), Interleukin-2 Receptor alpha Subunit (antagonists & inhibitors), Interleukin-2 Receptor alpha Subunit (immunology), Interleukin-2 Receptor alpha Subunit (metabolism), Macrophage Activation (drug effects), Mice, Inbred BALB C, T-Lymphocytes, Regulatory (drug effects), T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (metabolism), T-Lymphocytes, Regulatory (parasitology), Th17 Cells (drug effects), Th17 Cells (immunology), Th17 Cells (metabolism), Th17 Cells (parasitology), Time Factors.
- MESH :
- chemical , antagonists & inhibitors : Glucocorticoid-Induced TNFR-Related Protein, Interleukin-2 Receptor alpha Subunit.
- chemical , immunology : Antigens, CD40, Bacterial Outer Membrane Proteins, Glucocorticoid-Induced TNFR-Related Protein, Inflammation Mediators, Interferon-gamma, Interleukin-10, Interleukin-2 Receptor alpha Subunit.
- chemical , metabolism : Antigens, CD40, Glucocorticoid-Induced TNFR-Related Protein, Inflammation Mediators, Interferon-gamma, Interleukin-10, Interleukin-2 Receptor alpha Subunit.
- chemical , pharmacology : Antibodies, Neutralizing.
- drug effects : Dendritic Cells, Eosinophils, Macrophage Activation, T-Lymphocytes, Regulatory, Th17 Cells.
- drug therapy : Elephantiasis, Filarial.
- immunology : Dendritic Cells, Elephantiasis, Filarial, Eosinophils, T-Lymphocytes, Regulatory, Th17 Cells.
- metabolism : Elephantiasis, Filarial, T-Lymphocytes, Regulatory, Th17 Cells.
- parasitology : Dendritic Cells, Elephantiasis, Filarial, Eosinophils, T-Lymphocytes, Regulatory, Th17 Cells.
- Animals, Cells, Cultured, Disease Models, Animal, Host-Parasite Interactions, Immunization, Mice, Inbred BALB C, Time Factors.
Abstract
Lymphatic filariasis leads to profound impairment of parasite‐specific T helper type 1 (Th1) and Th2 immune responses and significantly increases the expression of regulatory networks and regulatory effectors like transforming growth factor‐
Url:
DOI: 10.1111/imm.12550
PubMed: 26501838
PubMed Central: 4717239
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PMC:4717239Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Neutralizing (pharmacology)</term>
<term>Antigens, CD40 (immunology)</term>
<term>Antigens, CD40 (metabolism)</term>
<term>Bacterial Outer Membrane Proteins (immunology)</term>
<term>Cells, Cultured</term>
<term>Dendritic Cells (drug effects)</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (parasitology)</term>
<term>Disease Models, Animal</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (metabolism)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Eosinophils (drug effects)</term>
<term>Eosinophils (immunology)</term>
<term>Eosinophils (parasitology)</term>
<term>Glucocorticoid-Induced TNFR-Related Protein (antagonists & inhibitors)</term>
<term>Glucocorticoid-Induced TNFR-Related Protein (immunology)</term>
<term>Glucocorticoid-Induced TNFR-Related Protein (metabolism)</term>
<term>Host-Parasite Interactions</term>
<term>Immunization</term>
<term>Inflammation Mediators (immunology)</term>
<term>Inflammation Mediators (metabolism)</term>
<term>Interferon-gamma (immunology)</term>
<term>Interferon-gamma (metabolism)</term>
<term>Interleukin-10 (immunology)</term>
<term>Interleukin-10 (metabolism)</term>
<term>Interleukin-2 Receptor alpha Subunit (antagonists & inhibitors)</term>
<term>Interleukin-2 Receptor alpha Subunit (immunology)</term>
<term>Interleukin-2 Receptor alpha Subunit (metabolism)</term>
<term>Macrophage Activation (drug effects)</term>
<term>Mice, Inbred BALB C</term>
<term>T-Lymphocytes, Regulatory (drug effects)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>T-Lymphocytes, Regulatory (metabolism)</term>
<term>T-Lymphocytes, Regulatory (parasitology)</term>
<term>Th17 Cells (drug effects)</term>
<term>Th17 Cells (immunology)</term>
<term>Th17 Cells (metabolism)</term>
<term>Th17 Cells (parasitology)</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des macrophages ()</term>
<term>Animaux</term>
<term>Anticorps neutralisants (pharmacologie)</term>
<term>Antigènes CD40 (immunologie)</term>
<term>Antigènes CD40 (métabolisme)</term>
<term>Cellules Th17 ()</term>
<term>Cellules Th17 (immunologie)</term>
<term>Cellules Th17 (métabolisme)</term>
<term>Cellules Th17 (parasitologie)</term>
<term>Cellules cultivées</term>
<term>Cellules dendritiques ()</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (parasitologie)</term>
<term>Facteurs temps</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (métabolisme)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Granulocytes éosinophiles ()</term>
<term>Granulocytes éosinophiles (immunologie)</term>
<term>Granulocytes éosinophiles (parasitologie)</term>
<term>Immunisation</term>
<term>Interactions hôte-parasite</term>
<term>Interféron gamma (immunologie)</term>
<term>Interféron gamma (métabolisme)</term>
<term>Interleukine-10 (immunologie)</term>
<term>Interleukine-10 (métabolisme)</term>
<term>Lymphocytes T régulateurs ()</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Lymphocytes T régulateurs (métabolisme)</term>
<term>Lymphocytes T régulateurs (parasitologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Médiateurs de l'inflammation (immunologie)</term>
<term>Médiateurs de l'inflammation (métabolisme)</term>
<term>Protéine associée au récepteur du TNF induit par les corticoïdes (antagonistes et inhibiteurs)</term>
<term>Protéine associée au récepteur du TNF induit par les corticoïdes (immunologie)</term>
<term>Protéine associée au récepteur du TNF induit par les corticoïdes (métabolisme)</term>
<term>Protéines de la membrane externe bactérienne (immunologie)</term>
<term>Souris de lignée BALB C</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2 (antagonistes et inhibiteurs)</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2 (immunologie)</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2 (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Glucocorticoid-Induced TNFR-Related Protein</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD40</term>
<term>Bacterial Outer Membrane Proteins</term>
<term>Glucocorticoid-Induced TNFR-Related Protein</term>
<term>Inflammation Mediators</term>
<term>Interferon-gamma</term>
<term>Interleukin-10</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD40</term>
<term>Glucocorticoid-Induced TNFR-Related Protein</term>
<term>Inflammation Mediators</term>
<term>Interferon-gamma</term>
<term>Interleukin-10</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibodies, Neutralizing</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéine associée au récepteur du TNF induit par les corticoïdes</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Dendritic Cells</term>
<term>Eosinophils</term>
<term>Macrophage Activation</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD40</term>
<term>Cellules Th17</term>
<term>Cellules dendritiques</term>
<term>Filariose lymphatique</term>
<term>Granulocytes éosinophiles</term>
<term>Interféron gamma</term>
<term>Interleukine-10</term>
<term>Lymphocytes T régulateurs</term>
<term>Médiateurs de l'inflammation</term>
<term>Protéine associée au récepteur du TNF induit par les corticoïdes</term>
<term>Protéines de la membrane externe bactérienne</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dendritic Cells</term>
<term>Elephantiasis, Filarial</term>
<term>Eosinophils</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD40</term>
<term>Cellules Th17</term>
<term>Filariose lymphatique</term>
<term>Interféron gamma</term>
<term>Interleukine-10</term>
<term>Lymphocytes T régulateurs</term>
<term>Médiateurs de l'inflammation</term>
<term>Protéine associée au récepteur du TNF induit par les corticoïdes</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Cellules Th17</term>
<term>Cellules dendritiques</term>
<term>Filariose lymphatique</term>
<term>Granulocytes éosinophiles</term>
<term>Lymphocytes T régulateurs</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Dendritic Cells</term>
<term>Elephantiasis, Filarial</term>
<term>Eosinophils</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anticorps neutralisants</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Disease Models, Animal</term>
<term>Host-Parasite Interactions</term>
<term>Immunization</term>
<term>Mice, Inbred BALB C</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des macrophages</term>
<term>Animaux</term>
<term>Cellules Th17</term>
<term>Cellules cultivées</term>
<term>Cellules dendritiques</term>
<term>Facteurs temps</term>
<term>Granulocytes éosinophiles</term>
<term>Immunisation</term>
<term>Interactions hôte-parasite</term>
<term>Lymphocytes T régulateurs</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris de lignée BALB C</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Lymphatic filariasis leads to profound impairment of parasite‐specific T helper type 1 (Th1) and Th2 immune responses and significantly increases the expression of regulatory networks and regulatory effectors like transforming growth factor‐<italic>β</italic>
, CD25, cytotoxic T‐lymphocyte antigen 4, glucocorticoid‐induced tumour necrosis factor receptor (GITR) and regulatory T (Treg) cells, which together play an important role in immunosuppression. While Treg cells suppress the activity of effector cells, monocyte dysfunction, characterized by an alternatively activated immunoregulatory phenotype, is one hypothesis that explains the lack of an antigen‐specific T‐cell response in infected individuals. In the present study, we administered neutralizing antibodies against the Treg cell‐associated markers CD25 and GITR and observed its effects on filaria‐induced immunosuppression. Our results show that administration of anti‐CD25 and anti‐GITR in infected animals not only arrested the accumulation of Treg cells and reduced arginase activity, but also led to an increase in the percentages of Th17 cells in the secondary lymphoid organs of mice. Elevated levels of interferon‐<italic>γ</italic>
and decreased levels of interleukin‐10 were also noted in the culture supernatants of mouse splenocytes that were treated with neutralizing antibodies. Furthermore, treatment with neutralizing antibodies enhanced the expression of inducible nitric oxide synthase on host macrophages and CD40 on host dendritic cells with concomitant decreased expression of alternative activation markers Arg1, Ym1 and Fizz1, which together lead to reduced parasite burden in treated animals. In summary, administration of neutralizing antibodies helps in breaking the regulatory network in mice and limits parasite‐induced immunosuppression at the earliest host–parasite interface.</p>
</div>
</front>
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