Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program
Identifieur interne : 007996 ( Ncbi/Curation ); précédent : 007995; suivant : 007997Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program
Auteurs : Roland Morley ; Alison Cardenas ; Peter Hawkins ; Yasuyo Suzuki ; Virginia Paton ; See-Chun Phan ; Mark Merchant ; Jessie Hsu ; Wei Yu ; Qi Xia ; Daniel Koralek ; Patricia Luhn ; Wassim AldairySource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Onartuzumab, a recombinant humanized monovalent monoclonal antibody directed against MET, the receptor for the hepatocyte growth factor, has been investigated for the treatment of solid tumors. This publication describes the safety profile of onartuzumab in patients with solid tumors using data from the global onartuzumab clinical development program.
Adverse event (AE) and laboratory data from onartuzumab phase II/III studies were analyzed and coded into standardized terms according to industry standards. The severity of AEs was assessed using the NCI Common Toxicity Criteria, Version 4. Medical Dictionary for Regulatory Activities (MedDRA) AEs were grouped using the standardized MedDRA queries (SMQs) “gastrointestinal (GI) perforation”, “embolic and thrombotic events, venous (VTE)”, and “embolic and thrombotic events, arterial (ATE)”, and the Adverse Event Group Term (AEGT) “edema.” The safety evaluable populations (patients who received at least one dose of study treatment) for each study were included in this analysis.
A total of 773 onartuzumab-treated patients from seven studies (phase II, n = 6; phase III, n = 1) were included. Edema and VTEs were reported in onartuzumab-treated patients in all seven studies. Edema events in onartuzumab arms were generally grade 1–2 in severity, observed more frequently than in control arms and at incidences ranging from 25.4−65.7% for all grades and from 1.2−14.1% for grade 3. Hypoalbuminemia was also more frequent in onartuzumab arms and observed at frequencies between 77.8% and 98.3%. The highest frequencies of all grade and grade ≥3 VTE events were 30.3% and 17.2%, respectively in onartuzumab arms. The cumulative incidence of all grade ATE events ranged from 0−5.6% (grade ≥3, 0−5.1%) in onartuzumab arms. The frequency of GI perforation was below 10% in all studies; the highest estimates were observed in studies with onartuzumab plus bevacizumab for all grades (0−6.2%) and grade ≥3 (0−6.2%).
The frequencies of VTE, ATE, GI perforation, hypoalbuminemia, and edema in clinical studies were higher in patients receiving onartuzumab than in control arms; these are considered to be expected events in patients receiving onartuzumab.
Url:
DOI: 10.1371/journal.pone.0139679
PubMed: 26445503
PubMed Central: 4596876
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000436
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000436
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000E85
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :007996
Links to Exploration step
PMC:4596876Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program</title><author><name sortKey="Morley, Roland" sort="Morley, Roland" uniqKey="Morley R" first="Roland" last="Morley">Roland Morley</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Cardenas, Alison" sort="Cardenas, Alison" uniqKey="Cardenas A" first="Alison" last="Cardenas">Alison Cardenas</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Hawkins, Peter" sort="Hawkins, Peter" uniqKey="Hawkins P" first="Peter" last="Hawkins">Peter Hawkins</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Yasuyo" sort="Suzuki, Yasuyo" uniqKey="Suzuki Y" first="Yasuyo" last="Suzuki">Yasuyo Suzuki</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Paton, Virginia" sort="Paton, Virginia" uniqKey="Paton V" first="Virginia" last="Paton">Virginia Paton</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Phan, See Chun" sort="Phan, See Chun" uniqKey="Phan S" first="See-Chun" last="Phan">See-Chun Phan</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Merchant, Mark" sort="Merchant, Mark" uniqKey="Merchant M" first="Mark" last="Merchant">Mark Merchant</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Hsu, Jessie" sort="Hsu, Jessie" uniqKey="Hsu J" first="Jessie" last="Hsu">Jessie Hsu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Wei" sort="Yu, Wei" uniqKey="Yu W" first="Wei" last="Yu">Wei Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Xia, Qi" sort="Xia, Qi" uniqKey="Xia Q" first="Qi" last="Xia">Qi Xia</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Koralek, Daniel" sort="Koralek, Daniel" uniqKey="Koralek D" first="Daniel" last="Koralek">Daniel Koralek</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Luhn, Patricia" sort="Luhn, Patricia" uniqKey="Luhn P" first="Patricia" last="Luhn">Patricia Luhn</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Aldairy, Wassim" sort="Aldairy, Wassim" uniqKey="Aldairy W" first="Wassim" last="Aldairy">Wassim Aldairy</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26445503</idno><idno type="pmc">4596876</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596876</idno><idno type="RBID">PMC:4596876</idno><idno type="doi">10.1371/journal.pone.0139679</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000436</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000436</idno><idno type="wicri:Area/Pmc/Curation">000436</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000436</idno><idno type="wicri:Area/Pmc/Checkpoint">000E85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E85</idno><idno type="wicri:Area/Ncbi/Merge">007996</idno><idno type="wicri:Area/Ncbi/Curation">007996</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program</title><author><name sortKey="Morley, Roland" sort="Morley, Roland" uniqKey="Morley R" first="Roland" last="Morley">Roland Morley</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Cardenas, Alison" sort="Cardenas, Alison" uniqKey="Cardenas A" first="Alison" last="Cardenas">Alison Cardenas</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Hawkins, Peter" sort="Hawkins, Peter" uniqKey="Hawkins P" first="Peter" last="Hawkins">Peter Hawkins</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Yasuyo" sort="Suzuki, Yasuyo" uniqKey="Suzuki Y" first="Yasuyo" last="Suzuki">Yasuyo Suzuki</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Paton, Virginia" sort="Paton, Virginia" uniqKey="Paton V" first="Virginia" last="Paton">Virginia Paton</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Phan, See Chun" sort="Phan, See Chun" uniqKey="Phan S" first="See-Chun" last="Phan">See-Chun Phan</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Merchant, Mark" sort="Merchant, Mark" uniqKey="Merchant M" first="Mark" last="Merchant">Mark Merchant</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Hsu, Jessie" sort="Hsu, Jessie" uniqKey="Hsu J" first="Jessie" last="Hsu">Jessie Hsu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Wei" sort="Yu, Wei" uniqKey="Yu W" first="Wei" last="Yu">Wei Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Xia, Qi" sort="Xia, Qi" uniqKey="Xia Q" first="Qi" last="Xia">Qi Xia</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Koralek, Daniel" sort="Koralek, Daniel" uniqKey="Koralek D" first="Daniel" last="Koralek">Daniel Koralek</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Luhn, Patricia" sort="Luhn, Patricia" uniqKey="Luhn P" first="Patricia" last="Luhn">Patricia Luhn</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Aldairy, Wassim" sort="Aldairy, Wassim" uniqKey="Aldairy W" first="Wassim" last="Aldairy">Wassim Aldairy</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Onartuzumab, a recombinant humanized monovalent monoclonal antibody directed against MET, the receptor for the hepatocyte growth factor, has been investigated for the treatment of solid tumors. This publication describes the safety profile of onartuzumab in patients with solid tumors using data from the global onartuzumab clinical development program.</p></sec><sec id="sec002"><title>Methods</title><p>Adverse event (AE) and laboratory data from onartuzumab phase II/III studies were analyzed and coded into standardized terms according to industry standards. The severity of AEs was assessed using the NCI Common Toxicity Criteria, Version 4. Medical Dictionary for Regulatory Activities (MedDRA) AEs were grouped using the standardized MedDRA queries (SMQs) “gastrointestinal (GI) perforation”, “embolic and thrombotic events, venous (VTE)”, and “embolic and thrombotic events, arterial (ATE)”, and the Adverse Event Group Term (AEGT) “edema.” The safety evaluable populations (patients who received at least one dose of study treatment) for each study were included in this analysis.</p></sec><sec id="sec003"><title>Results</title><p>A total of 773 onartuzumab-treated patients from seven studies (phase II, n = 6; phase III, n = 1) were included. Edema and VTEs were reported in onartuzumab-treated patients in all seven studies. Edema events in onartuzumab arms were generally grade 1–2 in severity, observed more frequently than in control arms and at incidences ranging from 25.4−65.7% for all grades and from 1.2−14.1% for grade 3. Hypoalbuminemia was also more frequent in onartuzumab arms and observed at frequencies between 77.8% and 98.3%. The highest frequencies of all grade and grade ≥3 VTE events were 30.3% and 17.2%, respectively in onartuzumab arms. The cumulative incidence of all grade ATE events ranged from 0−5.6% (grade ≥3, 0−5.1%) in onartuzumab arms. The frequency of GI perforation was below 10% in all studies; the highest estimates were observed in studies with onartuzumab plus bevacizumab for all grades (0−6.2%) and grade ≥3 (0−6.2%).</p></sec><sec id="sec004"><title>Conclusions</title><p>The frequencies of VTE, ATE, GI perforation, hypoalbuminemia, and edema in clinical studies were higher in patients receiving onartuzumab than in control arms; these are considered to be expected events in patients receiving onartuzumab.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Merchant, M" uniqKey="Merchant M">M Merchant</name></author><author><name sortKey="Ma, X" uniqKey="Ma X">X Ma</name></author><author><name sortKey="Maun, Hr" uniqKey="Maun H">HR Maun</name></author><author><name sortKey="Zheng, Z" uniqKey="Zheng Z">Z Zheng</name></author><author><name sortKey="Peng, J" uniqKey="Peng J">J Peng</name></author><author><name sortKey="Romero, M" uniqKey="Romero M">M Romero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gherardi, E" uniqKey="Gherardi E">E Gherardi</name></author><author><name sortKey="Birchmeier, W" uniqKey="Birchmeier W">W Birchmeier</name></author><author><name sortKey="Birchmeier, C" uniqKey="Birchmeier C">C Birchmeier</name></author><author><name sortKey="Vande Woude, G" uniqKey="Vande Woude G">G Vande Woude</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Birchmeier, C" uniqKey="Birchmeier C">C Birchmeier</name></author><author><name sortKey="Birchmeier, W" uniqKey="Birchmeier W">W Birchmeier</name></author><author><name sortKey="Gherardi, E" uniqKey="Gherardi E">E Gherardi</name></author><author><name sortKey="Vande Woude, Gf" uniqKey="Vande Woude G">GF Vande Woude</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bussolino, F" uniqKey="Bussolino F">F Bussolino</name></author><author><name sortKey="Di Renzo, Mf" uniqKey="Di Renzo M">MF Di Renzo</name></author><author><name sortKey="Ziche, M" uniqKey="Ziche M">M Ziche</name></author><author><name sortKey="Bocchietto, E" uniqKey="Bocchietto E">E Bocchietto</name></author><author><name sortKey="Olivero, M" uniqKey="Olivero M">M Olivero</name></author><author><name sortKey="Naldini, L" uniqKey="Naldini L">L Naldini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, T" uniqKey="Nakamura T">T Nakamura</name></author><author><name sortKey="Mizuno, S" uniqKey="Mizuno S">S Mizuno</name></author><author><name sortKey="Matsumoto, K" uniqKey="Matsumoto K">K Matsumoto</name></author><author><name sortKey="Sawa, Y" uniqKey="Sawa Y">Y Sawa</name></author><author><name sortKey="Matsuda, H" uniqKey="Matsuda H">H Matsuda</name></author><author><name sortKey="Nakamura, T" uniqKey="Nakamura T">T Nakamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chmielowiec, J" uniqKey="Chmielowiec J">J Chmielowiec</name></author><author><name sortKey="Borowiak, M" uniqKey="Borowiak M">M Borowiak</name></author><author><name sortKey="Morkel, M" uniqKey="Morkel M">M Morkel</name></author><author><name sortKey="Stradal, T" uniqKey="Stradal T">T Stradal</name></author><author><name sortKey="Munz, B" uniqKey="Munz B">B Munz</name></author><author><name sortKey="Werner, S" uniqKey="Werner S">S Werner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Previdi, S" uniqKey="Previdi S">S Previdi</name></author><author><name sortKey="Maroni, P" uniqKey="Maroni P">P Maroni</name></author><author><name sortKey="Matteucci, E" uniqKey="Matteucci E">E Matteucci</name></author><author><name sortKey="Broggini, M" uniqKey="Broggini M">M Broggini</name></author><author><name sortKey="Bendinelli, P" uniqKey="Bendinelli P">P Bendinelli</name></author><author><name sortKey="Desiderio, Ma" uniqKey="Desiderio M">MA Desiderio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conway, K" uniqKey="Conway K">K Conway</name></author><author><name sortKey="Price, P" uniqKey="Price P">P Price</name></author><author><name sortKey="Harding, Kg" uniqKey="Harding K">KG Harding</name></author><author><name sortKey="Jiang, Wg" uniqKey="Jiang W">WG Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dignass, Au" uniqKey="Dignass A">AU Dignass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prat, M" uniqKey="Prat M">M Prat</name></author><author><name sortKey="Crepaldi, T" uniqKey="Crepaldi T">T Crepaldi</name></author><author><name sortKey="Pennacchietti, S" uniqKey="Pennacchietti S">S Pennacchietti</name></author><author><name sortKey="Bussolino, F" uniqKey="Bussolino F">F Bussolino</name></author><author><name sortKey="Comoglio, Pm" uniqKey="Comoglio P">PM Comoglio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bardelli, C" uniqKey="Bardelli C">C Bardelli</name></author><author><name sortKey="Sala, M" uniqKey="Sala M">M Sala</name></author><author><name sortKey="Cavallazzi, U" uniqKey="Cavallazzi U">U Cavallazzi</name></author><author><name sortKey="Prat, M" uniqKey="Prat M">M Prat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Jm" uniqKey="Lee J">JM Lee</name></author><author><name sortKey="Kim, B" uniqKey="Kim B">B Kim</name></author><author><name sortKey="Lee, Sb" uniqKey="Lee S">SB Lee</name></author><author><name sortKey="Jeong, Y" uniqKey="Jeong Y">Y Jeong</name></author><author><name sortKey="Oh, Ym" uniqKey="Oh Y">YM Oh</name></author><author><name sortKey="Song, Yj" uniqKey="Song Y">YJ Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrelli, A" uniqKey="Petrelli A">A Petrelli</name></author><author><name sortKey="Circosta, P" uniqKey="Circosta P">P Circosta</name></author><author><name sortKey="Granziero, L" uniqKey="Granziero L">L Granziero</name></author><author><name sortKey="Mazzone, M" uniqKey="Mazzone M">M Mazzone</name></author><author><name sortKey="Pisacane, A" uniqKey="Pisacane A">A Pisacane</name></author><author><name sortKey="Fenoglio, S" uniqKey="Fenoglio S">S Fenoglio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenall, Sa" uniqKey="Greenall S">SA Greenall</name></author><author><name sortKey="Gherardi, E" uniqKey="Gherardi E">E Gherardi</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Donoghue, Jf" uniqKey="Donoghue J">JF Donoghue</name></author><author><name sortKey="Vitali, Aa" uniqKey="Vitali A">AA Vitali</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mai, E" uniqKey="Mai E">E Mai</name></author><author><name sortKey="Zheng, Z" uniqKey="Zheng Z">Z Zheng</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Peng, J" uniqKey="Peng J">J Peng</name></author><author><name sortKey="Severin, C" uniqKey="Severin C">C Severin</name></author><author><name sortKey="Filvaroff, E" uniqKey="Filvaroff E">E Filvaroff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiang, H" uniqKey="Xiang H">H Xiang</name></author><author><name sortKey="Bender, Bc" uniqKey="Bender B">BC Bender</name></author><author><name sortKey="Reyes, Ae" uniqKey="Reyes A">AE Reyes</name></author><author><name sortKey="Merchant, M" uniqKey="Merchant M">M Merchant</name></author><author><name sortKey="Jumbe, Nl" uniqKey="Jumbe N">NL Jumbe</name></author><author><name sortKey="Romero, M" uniqKey="Romero M">M Romero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xin, Y" uniqKey="Xin Y">Y Xin</name></author><author><name sortKey="Jin, D" uniqKey="Jin D">D Jin</name></author><author><name sortKey="Eppler, S" uniqKey="Eppler S">S Eppler</name></author><author><name sortKey="Damico Beyer, La" uniqKey="Damico Beyer L">LA Damico-Beyer</name></author><author><name sortKey="Joshi, A" uniqKey="Joshi A">A Joshi</name></author><author><name sortKey="Davis, Jd" uniqKey="Davis J">JD Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cloughesy, T" uniqKey="Cloughesy T">T Cloughesy</name></author><author><name sortKey="Finocchiaro, G" uniqKey="Finocchiaro G">G Finocchiaro</name></author><author><name sortKey="Belda Iniesta, C" uniqKey="Belda Iniesta C">C Belda-Iniesta</name></author><author><name sortKey="Recht, L" uniqKey="Recht L">L Recht</name></author><author><name sortKey="Brandes, Aa" uniqKey="Brandes A">AA Brandes</name></author><author><name sortKey="Pineda, E" uniqKey="Pineda E">E Pineda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirsch, Fr" uniqKey="Hirsch F">FR Hirsch</name></author><author><name sortKey="Govindan, R" uniqKey="Govindan R">R Govindan</name></author><author><name sortKey="Zvirbule, Z" uniqKey="Zvirbule Z">Z Zvirbule</name></author><author><name sortKey="Braiteh, F" uniqKey="Braiteh F">F Braiteh</name></author><author><name sortKey="Rittmeyer, A" uniqKey="Rittmeyer A">A Rittmeyer</name></author><author><name sortKey="Belda Iniesta, C" uniqKey="Belda Iniesta C">C Belda Iniesta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wakelee, Ha" uniqKey="Wakelee H">HA Wakelee</name></author><author><name sortKey="Zvirbule, Z" uniqKey="Zvirbule Z">Z Zvirbule</name></author><author><name sortKey="De Braud, F" uniqKey="De Braud F">F De Braud</name></author><author><name sortKey="Kingsley, Cd" uniqKey="Kingsley C">CD Kingsley</name></author><author><name sortKey="Mekhail, T" uniqKey="Mekhail T">T Mekhail</name></author><author><name sortKey="Schutte, W" uniqKey="Schutte W">W Schütte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bendell, Jc" uniqKey="Bendell J">JC Bendell</name></author><author><name sortKey="Hochster, Hs" uniqKey="Hochster H">HS Hochster</name></author><author><name sortKey="Hart, Ll" uniqKey="Hart L">LL Hart</name></author><author><name sortKey="Firdaus, I" uniqKey="Firdaus I">I Firdaus</name></author><author><name sortKey="Mace, Jr" uniqKey="Mace J">JR Mace</name></author><author><name sortKey="Mcfarlane, Jj" uniqKey="Mcfarlane J">JJ McFarlane</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Spigel, Dr" uniqKey="Spigel D">DR Spigel</name></author><author><name sortKey="Edelman, Mj" uniqKey="Edelman M">MJ Edelman</name></author><author><name sortKey="O Byrne, K" uniqKey="O Byrne K">K O'Byrne</name></author><author><name sortKey="Paz Ares, L" uniqKey="Paz Ares L">L Paz-Ares</name></author><author><name sortKey="Shames, Ds" uniqKey="Shames D">DS Shames</name></author><author><name sortKey="Yu, W" uniqKey="Yu W">W Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, Ma" uniqKey="Shah M">MA Shah</name></author><author><name sortKey="Cho, Jy" uniqKey="Cho J">JY Cho</name></author><author><name sortKey="Bee, Huat It" uniqKey="Bee H">Huat IT Bee</name></author><author><name sortKey="Tebbutt, Nc" uniqKey="Tebbutt N">NC Tebbutt</name></author><author><name sortKey="Yen, C J" uniqKey="Yen C">C-J Yen</name></author><author><name sortKey="Kang, A" uniqKey="Kang A">A Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stoker, M" uniqKey="Stoker M">M Stoker</name></author><author><name sortKey="Gherardi, E" uniqKey="Gherardi E">E Gherardi</name></author><author><name sortKey="Perryman, M" uniqKey="Perryman M">M Perryman</name></author><author><name sortKey="Gray, J" uniqKey="Gray J">J Gray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyazawa, K" uniqKey="Miyazawa K">K Miyazawa</name></author><author><name sortKey="Tsubouchi, H" uniqKey="Tsubouchi H">H Tsubouchi</name></author><author><name sortKey="Naka, D" uniqKey="Naka D">D Naka</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Okigaki, M" uniqKey="Okigaki M">M Okigaki</name></author><author><name sortKey="Arakaki, N" uniqKey="Arakaki N">N Arakaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, T" uniqKey="Nakamura T">T Nakamura</name></author><author><name sortKey="Nishizawa, T" uniqKey="Nishizawa T">T Nishizawa</name></author><author><name sortKey="Hagiya, M" uniqKey="Hagiya M">M Hagiya</name></author><author><name sortKey="Seki, T" uniqKey="Seki T">T Seki</name></author><author><name sortKey="Shimonishi, M" uniqKey="Shimonishi M">M Shimonishi</name></author><author><name sortKey="Sugimura, A" uniqKey="Sugimura A">A Sugimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zarnegar, R" uniqKey="Zarnegar R">R Zarnegar</name></author><author><name sortKey="Michalopoulos, G" uniqKey="Michalopoulos G">G Michalopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gherardi, E" uniqKey="Gherardi E">E Gherardi</name></author><author><name sortKey="Stoker, M" uniqKey="Stoker M">M Stoker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bottaro, Dp" uniqKey="Bottaro D">DP Bottaro</name></author><author><name sortKey="Rubin, Js" uniqKey="Rubin J">JS Rubin</name></author><author><name sortKey="Faletto, Dl" uniqKey="Faletto D">DL Faletto</name></author><author><name sortKey="Chan, Am" uniqKey="Chan A">AM Chan</name></author><author><name sortKey="Kmiecik, Te" uniqKey="Kmiecik T">TE Kmiecik</name></author><author><name sortKey="Vande Woude, Gf" uniqKey="Vande Woude G">GF Vande Woude</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weidner, Km" uniqKey="Weidner K">KM Weidner</name></author><author><name sortKey="Arakaki, N" uniqKey="Arakaki N">N Arakaki</name></author><author><name sortKey="Hartmann, G" uniqKey="Hartmann G">G Hartmann</name></author><author><name sortKey="Vandekerckhove, J" uniqKey="Vandekerckhove J">J Vandekerckhove</name></author><author><name sortKey="Weingart, S" uniqKey="Weingart S">S Weingart</name></author><author><name sortKey="Rieder, H" uniqKey="Rieder H">H Rieder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, Pc" uniqKey="Ma P">PC Ma</name></author><author><name sortKey="Maulik, G" uniqKey="Maulik G">G Maulik</name></author><author><name sortKey="Christensen, J" uniqKey="Christensen J">J Christensen</name></author><author><name sortKey="Salgia, R" uniqKey="Salgia R">R Salgia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ely, Jw" uniqKey="Ely J">JW Ely</name></author><author><name sortKey="Osheroff, Ja" uniqKey="Osheroff J">JA Osheroff</name></author><author><name sortKey="Chambliss, Ml" uniqKey="Chambliss M">ML Chambliss</name></author><author><name sortKey="Ebell, Mh" uniqKey="Ebell M">MH Ebell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, S" uniqKey="Cho S">S Cho</name></author><author><name sortKey="Atwood, Je" uniqKey="Atwood J">JE Atwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, W" uniqKey="Hou W">W Hou</name></author><author><name sortKey="Sanyal, Aj" uniqKey="Sanyal A">AJ Sanyal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawenda, Bd" uniqKey="Lawenda B">BD Lawenda</name></author><author><name sortKey="Mondry, Te" uniqKey="Mondry T">TE Mondry</name></author><author><name sortKey="Johnstone, Pa" uniqKey="Johnstone P">PA Johnstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samsky, Md" uniqKey="Samsky M">MD Samsky</name></author><author><name sortKey="Patel, Cb" uniqKey="Patel C">CB Patel</name></author><author><name sortKey="Dewald, Ta" uniqKey="Dewald T">TA DeWald</name></author><author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name></author><author><name sortKey="Felker, Gm" uniqKey="Felker G">GM Felker</name></author><author><name sortKey="Rogers, Jg" uniqKey="Rogers J">JG Rogers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silverberg, Ds" uniqKey="Silverberg D">DS Silverberg</name></author><author><name sortKey="Wexler, D" uniqKey="Wexler D">D Wexler</name></author><author><name sortKey="Iaina, A" uniqKey="Iaina A">A Iaina</name></author><author><name sortKey="Steinbruch, S" uniqKey="Steinbruch S">S Steinbruch</name></author><author><name sortKey="Wollman, Y" uniqKey="Wollman Y">Y Wollman</name></author><author><name sortKey="Schwartz, D" uniqKey="Schwartz D">D Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messerli, Fh" uniqKey="Messerli F">FH Messerli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frishman, Wh" uniqKey="Frishman W">WH Frishman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Birukova, Aa" uniqKey="Birukova A">AA Birukova</name></author><author><name sortKey="Cokic, I" uniqKey="Cokic I">I Cokic</name></author><author><name sortKey="Moldobaeva, N" uniqKey="Moldobaeva N">N Moldobaeva</name></author><author><name sortKey="Birukov, Kg" uniqKey="Birukov K">KG Birukov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saito, Y" uniqKey="Saito Y">Y Saito</name></author><author><name sortKey="Nakagami, H" uniqKey="Nakagami H">H Nakagami</name></author><author><name sortKey="Morishita, R" uniqKey="Morishita R">R Morishita</name></author><author><name sortKey="Takami, Y" uniqKey="Takami Y">Y Takami</name></author><author><name sortKey="Kikuchi, Y" uniqKey="Kikuchi Y">Y Kikuchi</name></author><author><name sortKey="Hayashi, H" uniqKey="Hayashi H">H Hayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, D" uniqKey="Shin D">D Shin</name></author><author><name sortKey="Monga, Sp" uniqKey="Monga S">SP Monga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singleton, Pa" uniqKey="Singleton P">PA Singleton</name></author><author><name sortKey="Salgia, R" uniqKey="Salgia R">R Salgia</name></author><author><name sortKey="Moreno Vinasco, L" uniqKey="Moreno Vinasco L">L Moreno-Vinasco</name></author><author><name sortKey="Moitra, J" uniqKey="Moitra J">J Moitra</name></author><author><name sortKey="Sammani, S" uniqKey="Sammani S">S Sammani</name></author><author><name sortKey="Mirzapoiazova, T" uniqKey="Mirzapoiazova T">T Mirzapoiazova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pietrapiana, D" uniqKey="Pietrapiana D">D Pietrapiana</name></author><author><name sortKey="Sala, M" uniqKey="Sala M">M Sala</name></author><author><name sortKey="Prat, M" uniqKey="Prat M">M Prat</name></author><author><name sortKey="Sinigaglia, F" uniqKey="Sinigaglia F">F Sinigaglia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimomura, T" uniqKey="Shimomura T">T Shimomura</name></author><author><name sortKey="Kondo, J" uniqKey="Kondo J">J Kondo</name></author><author><name sortKey="Ochiai, M" uniqKey="Ochiai M">M Ochiai</name></author><author><name sortKey="Naka, D" uniqKey="Naka D">D Naka</name></author><author><name sortKey="Miyazawa, K" uniqKey="Miyazawa K">K Miyazawa</name></author><author><name sortKey="Morimoto, Y" uniqKey="Morimoto Y">Y Morimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyazawa, K" uniqKey="Miyazawa K">K Miyazawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heit, Ja" uniqKey="Heit J">JA Heit</name></author><author><name sortKey="Silverstein, Md" uniqKey="Silverstein M">MD Silverstein</name></author><author><name sortKey="Mohr, Dn" uniqKey="Mohr D">DN Mohr</name></author><author><name sortKey="Petterson, Tm" uniqKey="Petterson T">TM Petterson</name></author><author><name sortKey="O Fallon, Wm" uniqKey="O Fallon W">WM O'Fallon</name></author><author><name sortKey="Melton, Lj" uniqKey="Melton L">LJ Melton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heit, Ja" uniqKey="Heit J">JA Heit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ageno, W" uniqKey="Ageno W">W Ageno</name></author><author><name sortKey="Squizzato, A" uniqKey="Squizzato A">A Squizzato</name></author><author><name sortKey="Garcia, D" uniqKey="Garcia D">D Garcia</name></author><author><name sortKey="Imberti, D" uniqKey="Imberti D">D Imberti</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kakkar, T" uniqKey="Kakkar T">T Kakkar</name></author><author><name sortKey="Ma, M" uniqKey="Ma M">M Ma</name></author><author><name sortKey="Zhuang, Y" uniqKey="Zhuang Y">Y Zhuang</name></author><author><name sortKey="Patton, A" uniqKey="Patton A">A Patton</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name></author><author><name sortKey="Mounho, B" uniqKey="Mounho B">B Mounho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ryan, Cj" uniqKey="Ryan C">CJ Ryan</name></author><author><name sortKey="Rosenthal, M" uniqKey="Rosenthal M">M Rosenthal</name></author><author><name sortKey="Ng, S" uniqKey="Ng S">S Ng</name></author><author><name sortKey="Alumkal, J" uniqKey="Alumkal J">J Alumkal</name></author><author><name sortKey="Picus, J" uniqKey="Picus J">J Picus</name></author><author><name sortKey="Gravis, G" uniqKey="Gravis G">G Gravis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mok, Tsk" uniqKey="Mok T">TSK Mok</name></author><author><name sortKey="Park, K" uniqKey="Park K">K Park</name></author><author><name sortKey="Geater, Sl" uniqKey="Geater S">SL Geater</name></author><author><name sortKey="Agarwal, S" uniqKey="Agarwal S">S Agarwal</name></author><author><name sortKey="Han, M" uniqKey="Han M">M Han</name></author><author><name sortKey="Credi, M" uniqKey="Credi M">M Credi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smyth, Ec" uniqKey="Smyth E">EC Smyth</name></author><author><name sortKey="Sclafani, F" uniqKey="Sclafani F">F Sclafani</name></author><author><name sortKey="Cunningham, D" uniqKey="Cunningham D">D Cunningham</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007996 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 007996 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:4596876
|texte= Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:26445503" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |