Hypofractionated irradiation in elderly patients with breast cancer after breast conserving surgery and mastectomy : Analysis of 205 cases
Identifieur interne : 007704 ( Ncbi/Curation ); précédent : 007703; suivant : 007705Hypofractionated irradiation in elderly patients with breast cancer after breast conserving surgery and mastectomy : Analysis of 205 cases
Auteurs : Mélanie Doré [France] ; Bruno Cutuli [France] ; Patrice Cellier [France] ; Loïc Campion [France] ; Magali Le Blanc [France]Source :
- Radiation Oncology (London, England) [ 1748-717X ] ; 2015.
Abstract
Several randomized trials and meta-analyses confirmed a wide benefit of radiotherapy (RT), both after breast conserving surgery (BCS) and mastectomy. However, many elderly women don't receive RT. Hypofractionated (HF) RT allows « simplified » and more accessible treatments with equivalent results to classic RT in three large randomized trials. However, there are few available data on HF-RT for nodal irradiation, as well as for the boost.
We evaluated patients treated for IBC by HF-RT between 2004 and 2012 in two regional cancer centres. We used an original scheme delivering 45 Gy in 15 fractions three times a week, both after BCS or mastectomy, with or without nodal irradiation. After BCS, a 9 Gy boost in 3 fractions was delivered. Local, regional and distant recurrences were assessed, as well as acute and late cutaneous, cardiac or pulmonary toxicities.
205 patients were analysed, 116 after BCS (57 %) and 89 after mastectomy (43 %). Median age was 81 years (range: 52-91); 44 % had axillary nodal involvement (pN+). The Nottingham Prognostic Index (NPI) scored 0, 1, 2 and 3 in 10 %, 27 %, 44 % and 19 % of the cases. A nodal HF-RT was delivered in 65 patients (32 %) and boost in 98 patients (84 % of BCS) by 9 Gy/3 fr scheme. Fifty (24 %) patients underwent chemotherapy and 156 (75 %) hormonal treatment.
With a 49-month median follow-up, 3/116 (2.6 %) patients and 4/89 (4.5 %) had local recurrence (LR) after BCS and mastectomy, respectively. The overall 5-year LR rate was 4.4 %. In univariate and multivariate analysis, LR risk factors were: high NPI (HR 5.46;
Our HF-RT scheme (with or without nodal irradiation) confirms in elderly patients the data from randomized trials, both after BCS or mastectomy. Toxicity seems very acceptable but requires a longer follow-up. A larger evaluation is still ongoing in several other centres in France.
Url:
DOI: 10.1186/s13014-015-0448-y
PubMed: 26238442
PubMed Central: 4554320
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000E24
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000E23
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001194
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :007704
Links to Exploration step
PMC:4554320Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hypofractionated irradiation in elderly patients with breast cancer after breast conserving surgery and mastectomy : Analysis of 205 cases</title>
<author><name sortKey="Dore, Melanie" sort="Dore, Melanie" uniqKey="Dore M" first="Mélanie" last="Doré">Mélanie Doré</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cutuli, Bruno" sort="Cutuli, Bruno" uniqKey="Cutuli B" first="Bruno" last="Cutuli">Bruno Cutuli</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Radiation Oncology Department, Institut de Cancérologie de Courlancy, Reims, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de Courlancy, Reims</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Champagne-Ardenne</region>
<settlement type="city">Reims</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cellier, Patrice" sort="Cellier, Patrice" uniqKey="Cellier P" first="Patrice" last="Cellier">Patrice Cellier</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Angers, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Angers</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Angers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campion, Loic" sort="Campion, Loic" uniqKey="Campion L" first="Loïc" last="Campion">Loïc Campion</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Blanc, Magali" sort="Le Blanc, Magali" uniqKey="Le Blanc M" first="Magali" last="Le Blanc">Magali Le Blanc</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26238442</idno>
<idno type="pmc">4554320</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554320</idno>
<idno type="RBID">PMC:4554320</idno>
<idno type="doi">10.1186/s13014-015-0448-y</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000E24</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E24</idno>
<idno type="wicri:Area/Pmc/Curation">000E23</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E23</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001194</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001194</idno>
<idno type="wicri:Area/Ncbi/Merge">007704</idno>
<idno type="wicri:Area/Ncbi/Curation">007704</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hypofractionated irradiation in elderly patients with breast cancer after breast conserving surgery and mastectomy : Analysis of 205 cases</title>
<author><name sortKey="Dore, Melanie" sort="Dore, Melanie" uniqKey="Dore M" first="Mélanie" last="Doré">Mélanie Doré</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cutuli, Bruno" sort="Cutuli, Bruno" uniqKey="Cutuli B" first="Bruno" last="Cutuli">Bruno Cutuli</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Radiation Oncology Department, Institut de Cancérologie de Courlancy, Reims, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de Courlancy, Reims</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Champagne-Ardenne</region>
<settlement type="city">Reims</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cellier, Patrice" sort="Cellier, Patrice" uniqKey="Cellier P" first="Patrice" last="Cellier">Patrice Cellier</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Angers, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Angers</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Angers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campion, Loic" sort="Campion, Loic" uniqKey="Campion L" first="Loïc" last="Campion">Loïc Campion</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Blanc, Magali" sort="Le Blanc, Magali" uniqKey="Le Blanc M" first="Magali" last="Le Blanc">Magali Le Blanc</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiation Oncology Department, Institut de Cancérologie de l’Ouest, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Radiation Oncology (London, England)</title>
<idno type="eISSN">1748-717X</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Several randomized trials and meta-analyses confirmed a wide benefit of radiotherapy (RT), both after breast conserving surgery (BCS) and mastectomy. However, many elderly women don't receive RT. Hypofractionated (HF) RT allows « simplified » and more accessible treatments with equivalent results to classic RT in three large randomized trials. However, there are few available data on HF-RT for nodal irradiation, as well as for the boost.</p>
</sec>
<sec><title>Methods</title>
<p>We evaluated patients treated for IBC by HF-RT between 2004 and 2012 in two regional cancer centres. We used an original scheme delivering 45 Gy in 15 fractions three times a week, both after BCS or mastectomy, with or without nodal irradiation. After BCS, a 9 Gy boost in 3 fractions was delivered. Local, regional and distant recurrences were assessed, as well as acute and late cutaneous, cardiac or pulmonary toxicities.</p>
</sec>
<sec><title>Results</title>
<p>205 patients were analysed, 116 after BCS (57 %) and 89 after mastectomy (43 %). Median age was 81 years (range: 52-91); 44 % had axillary nodal involvement (pN+). The Nottingham Prognostic Index (NPI) scored 0, 1, 2 and 3 in 10 %, 27 %, 44 % and 19 % of the cases. A nodal HF-RT was delivered in 65 patients (32 %) and boost in 98 patients (84 % of BCS) by 9 Gy/3 fr scheme. Fifty (24 %) patients underwent chemotherapy and 156 (75 %) hormonal treatment.</p>
<p>With a 49-month median follow-up, 3/116 (2.6 %) patients and 4/89 (4.5 %) had local recurrence (LR) after BCS and mastectomy, respectively. The overall 5-year LR rate was 4.4 %. In univariate and multivariate analysis, LR risk factors were: high NPI (HR 5.46; <italic>p</italic>
= 0.028), and triple negative tumour (HR 9.78; <italic>p</italic>
= 0.006). Only 8 (4.5 %) patients had grade III skin toxicity; 29 (14 %) late fibrosis and 16 (8 %) telangiectasia. No pulmonary or cardiac toxicity was observed.</p>
</sec>
<sec><title>Conclusion</title>
<p>Our HF-RT scheme (with or without nodal irradiation) confirms in elderly patients the data from randomized trials, both after BCS or mastectomy. Toxicity seems very acceptable but requires a longer follow-up. A larger evaluation is still ongoing in several other centres in France.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Biganzoli, L" uniqKey="Biganzoli L">L Biganzoli</name>
</author>
<author><name sortKey="Wildiers, H" uniqKey="Wildiers H">H Wildiers</name>
</author>
<author><name sortKey="Oakman, C" uniqKey="Oakman C">C Oakman</name>
</author>
<author><name sortKey="Marotti, L" uniqKey="Marotti L">L Marotti</name>
</author>
<author><name sortKey="Loibl, S" uniqKey="Loibl S">S Loibl</name>
</author>
<author><name sortKey="Kunkler, I" uniqKey="Kunkler I">I Kunkler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cutuli, B" uniqKey="Cutuli B">B Cutuli</name>
</author>
<author><name sortKey="Cottu, Ph" uniqKey="Cottu P">PH Cottu</name>
</author>
<author><name sortKey="Guastalla, Jp" uniqKey="Guastalla J">JP Guastalla</name>
</author>
<author><name sortKey="Mechin, H" uniqKey="Mechin H">H Mechin</name>
</author>
<author><name sortKey="Costa, A" uniqKey="Costa A">A Costa</name>
</author>
<author><name sortKey="Jourdan, R" uniqKey="Jourdan R">R Jourdan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cazzaniga, Me" uniqKey="Cazzaniga M">ME Cazzaniga</name>
</author>
<author><name sortKey="Mustacchi, G" uniqKey="Mustacchi G">G Mustacchi</name>
</author>
<author><name sortKey="Pronzato, P" uniqKey="Pronzato P">P Pronzato</name>
</author>
<author><name sortKey="De Matteis, A" uniqKey="De Matteis A">A De Matteis</name>
</author>
<author><name sortKey="Di Costanzo, F" uniqKey="Di Costanzo F">F Di Costanzo</name>
</author>
<author><name sortKey="Floriani, I" uniqKey="Floriani I">I Floriani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Joerger, M" uniqKey="Joerger M">M Joerger</name>
</author>
<author><name sortKey="Thurlimann, B" uniqKey="Thurlimann B">B Thürlimann</name>
</author>
<author><name sortKey="Savidan, A" uniqKey="Savidan A">A Savidan</name>
</author>
<author><name sortKey="Frick, H" uniqKey="Frick H">H Frick</name>
</author>
<author><name sortKey="Rageth, C" uniqKey="Rageth C">C Rageth</name>
</author>
<author><name sortKey="Lutolf, U" uniqKey="Lutolf U">U Lütolf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U Veronesi</name>
</author>
<author><name sortKey="Cascinelli, N" uniqKey="Cascinelli N">N Cascinelli</name>
</author>
<author><name sortKey="Mariani, L" uniqKey="Mariani L">L Mariani</name>
</author>
<author><name sortKey="Greco, M" uniqKey="Greco M">M Greco</name>
</author>
<author><name sortKey="Saccozzi, R" uniqKey="Saccozzi R">R Saccozzi</name>
</author>
<author><name sortKey="Luini, A" uniqKey="Luini A">A Luini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fisher, B" uniqKey="Fisher B">B Fisher</name>
</author>
<author><name sortKey="Anderson, S" uniqKey="Anderson S">S Anderson</name>
</author>
<author><name sortKey="Bryant, J" uniqKey="Bryant J">J Bryant</name>
</author>
<author><name sortKey="Margolese, Rg" uniqKey="Margolese R">RG Margolese</name>
</author>
<author><name sortKey="Deutsch, M" uniqKey="Deutsch M">M Deutsch</name>
</author>
<author><name sortKey="Fisher, Er" uniqKey="Fisher E">ER Fisher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Darby, S" uniqKey="Darby S">S Darby</name>
</author>
<author><name sortKey="Mcgale, P" uniqKey="Mcgale P">P McGale</name>
</author>
<author><name sortKey="Correa, C" uniqKey="Correa C">C Correa</name>
</author>
<author><name sortKey="Taylor, C" uniqKey="Taylor C">C Taylor</name>
</author>
<author><name sortKey="Arriagada, R" uniqKey="Arriagada R">R Arriagada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouchardy, C" uniqKey="Bouchardy C">C Bouchardy</name>
</author>
<author><name sortKey="Rapiti, E" uniqKey="Rapiti E">E Rapiti</name>
</author>
<author><name sortKey="Fioretta, G" uniqKey="Fioretta G">G Fioretta</name>
</author>
<author><name sortKey="Laissue, P" uniqKey="Laissue P">P Laissue</name>
</author>
<author><name sortKey="Neyroud Caspar, I" uniqKey="Neyroud Caspar I">I Neyroud-Caspar</name>
</author>
<author><name sortKey="Sch Fer, P" uniqKey="Sch Fer P">P Schäfer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Bd" uniqKey="Smith B">BD Smith</name>
</author>
<author><name sortKey="Haffty, Bg" uniqKey="Haffty B">BG Haffty</name>
</author>
<author><name sortKey="Hurria, A" uniqKey="Hurria A">A Hurria</name>
</author>
<author><name sortKey="Galusha, Dh" uniqKey="Galusha D">DH Galusha</name>
</author>
<author><name sortKey="Gross, Cp" uniqKey="Gross C">CP Gross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bentzen, Sm" uniqKey="Bentzen S">SM Bentzen</name>
</author>
<author><name sortKey="Agrawal, Rk" uniqKey="Agrawal R">RK Agrawal</name>
</author>
<author><name sortKey="Aird, Ega" uniqKey="Aird E">EGA Aird</name>
</author>
<author><name sortKey="Barrett, Jm" uniqKey="Barrett J">JM Barrett</name>
</author>
<author><name sortKey="Barrett Lee, Pj" uniqKey="Barrett Lee P">PJ Barrett-Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bentzen, Sm" uniqKey="Bentzen S">SM Bentzen</name>
</author>
<author><name sortKey="Agrawal, Rk" uniqKey="Agrawal R">RK Agrawal</name>
</author>
<author><name sortKey="Aird, Ega" uniqKey="Aird E">EGA Aird</name>
</author>
<author><name sortKey="Barrett, Jm" uniqKey="Barrett J">JM Barrett</name>
</author>
<author><name sortKey="Barrett Lee, Pj" uniqKey="Barrett Lee P">PJ Barrett-Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Whelan, Tj" uniqKey="Whelan T">TJ Whelan</name>
</author>
<author><name sortKey="Pignol, J P" uniqKey="Pignol J">J-P Pignol</name>
</author>
<author><name sortKey="Levine, Mn" uniqKey="Levine M">MN Levine</name>
</author>
<author><name sortKey="Julian, Ja" uniqKey="Julian J">JA Julian</name>
</author>
<author><name sortKey="Mackenzie, R" uniqKey="Mackenzie R">R MacKenzie</name>
</author>
<author><name sortKey="Parpia, S" uniqKey="Parpia S">S Parpia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cutuli, B" uniqKey="Cutuli B">B Cutuli</name>
</author>
<author><name sortKey="De Lafontan, B" uniqKey="De Lafontan B">B De Lafontan</name>
</author>
<author><name sortKey="Vitali, E" uniqKey="Vitali E">E Vitali</name>
</author>
<author><name sortKey="Costa, L" uniqKey="Costa L">L Costa</name>
</author>
<author><name sortKey="Aristei, C" uniqKey="Aristei C">C Aristei</name>
</author>
<author><name sortKey="Marchal, C" uniqKey="Marchal C">C Marchal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortholan, C" uniqKey="Ortholan C">C Ortholan</name>
</author>
<author><name sortKey="Hannoun Levi, J M" uniqKey="Hannoun Levi J">J-M Hannoun-Lévi</name>
</author>
<author><name sortKey="Ferrero, J M" uniqKey="Ferrero J">J-M Ferrero</name>
</author>
<author><name sortKey="Largillier, R" uniqKey="Largillier R">R Largillier</name>
</author>
<author><name sortKey="Courdi, A" uniqKey="Courdi A">A Courdi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kirova, Ym" uniqKey="Kirova Y">YM Kirova</name>
</author>
<author><name sortKey="Campana, F" uniqKey="Campana F">F Campana</name>
</author>
<author><name sortKey="Savignoni, A" uniqKey="Savignoni A">A Savignoni</name>
</author>
<author><name sortKey="Laki, F" uniqKey="Laki F">F Laki</name>
</author>
<author><name sortKey="Muresan, M" uniqKey="Muresan M">M Muresan</name>
</author>
<author><name sortKey="Dendale, R" uniqKey="Dendale R">R Dendale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dragun, Ae" uniqKey="Dragun A">AE Dragun</name>
</author>
<author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name>
</author>
<author><name sortKey="Tucker, Tc" uniqKey="Tucker T">TC Tucker</name>
</author>
<author><name sortKey="Spanos, Wj" uniqKey="Spanos W">WJ Spanos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Leeuwen, Bl" uniqKey="Van Leeuwen B">BL Van Leeuwen</name>
</author>
<author><name sortKey="Rosenkranz, Km" uniqKey="Rosenkranz K">KM Rosenkranz</name>
</author>
<author><name sortKey="Feng, Ll" uniqKey="Feng L">LL Feng</name>
</author>
<author><name sortKey="Bedrosian, I" uniqKey="Bedrosian I">I Bedrosian</name>
</author>
<author><name sortKey="Hartmann, K" uniqKey="Hartmann K">K Hartmann</name>
</author>
<author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crivellari, D" uniqKey="Crivellari D">D Crivellari</name>
</author>
<author><name sortKey="Price, K" uniqKey="Price K">K Price</name>
</author>
<author><name sortKey="Gelber, Rd" uniqKey="Gelber R">RD Gelber</name>
</author>
<author><name sortKey="Castiglione Gertsch, M" uniqKey="Castiglione Gertsch M">M Castiglione-Gertsch</name>
</author>
<author><name sortKey="Rudenstam, C M" uniqKey="Rudenstam C">C-M Rudenstam</name>
</author>
<author><name sortKey="Lindtner, J" uniqKey="Lindtner J">J Lindtner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, R" uniqKey="Singh R">R Singh</name>
</author>
<author><name sortKey="Hellman, S" uniqKey="Hellman S">S Hellman</name>
</author>
<author><name sortKey="Heimann, R" uniqKey="Heimann R">R Heimann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Daidone, Mg" uniqKey="Daidone M">MG Daidone</name>
</author>
<author><name sortKey="Coradini, D" uniqKey="Coradini D">D Coradini</name>
</author>
<author><name sortKey="Martelli, G" uniqKey="Martelli G">G Martelli</name>
</author>
<author><name sortKey="Veneroni, S" uniqKey="Veneroni S">S Veneroni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haviland, Js" uniqKey="Haviland J">JS Haviland</name>
</author>
<author><name sortKey="Owen, Jr" uniqKey="Owen J">JR Owen</name>
</author>
<author><name sortKey="Dewar, Ja" uniqKey="Dewar J">JA Dewar</name>
</author>
<author><name sortKey="Agrawal, Rk" uniqKey="Agrawal R">RK Agrawal</name>
</author>
<author><name sortKey="Barrett, J" uniqKey="Barrett J">J Barrett</name>
</author>
<author><name sortKey="Barrett Lee, Pj" uniqKey="Barrett Lee P">PJ Barrett-Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yarnold, J" uniqKey="Yarnold J">J Yarnold</name>
</author>
<author><name sortKey="Ashton, A" uniqKey="Ashton A">A Ashton</name>
</author>
<author><name sortKey="Bliss, J" uniqKey="Bliss J">J Bliss</name>
</author>
<author><name sortKey="Homewood, J" uniqKey="Homewood J">J Homewood</name>
</author>
<author><name sortKey="Harper, C" uniqKey="Harper C">C Harper</name>
</author>
<author><name sortKey="Hanson, J" uniqKey="Hanson J">J Hanson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Dragun, Ae" uniqKey="Dragun A">AE Dragun</name>
</author>
<author><name sortKey="Quillo, Ar" uniqKey="Quillo A">AR Quillo</name>
</author>
<author><name sortKey="Riley, Ec" uniqKey="Riley E">EC Riley</name>
</author>
<author><name sortKey="Roberts, Tl" uniqKey="Roberts T">TL Roberts</name>
</author>
<author><name sortKey="Hunter, Am" uniqKey="Hunter A">AM Hunter</name>
</author>
<author><name sortKey="Rai, Sn" uniqKey="Rai S">SN Rai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pinitpatcharalert, A" uniqKey="Pinitpatcharalert A">A Pinitpatcharalert</name>
</author>
<author><name sortKey="Chitapanarux, I" uniqKey="Chitapanarux I">I Chitapanarux</name>
</author>
<author><name sortKey="Euathrongchit, J" uniqKey="Euathrongchit J">J Euathrongchit</name>
</author>
<author><name sortKey="Tharavichikul, E" uniqKey="Tharavichikul E">E Tharavichikul</name>
</author>
<author><name sortKey="Sukthomya, V" uniqKey="Sukthomya V">V Sukthomya</name>
</author>
<author><name sortKey="Lorvidhaya, V" uniqKey="Lorvidhaya V">V Lorvidhaya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Truong, Pt" uniqKey="Truong P">PT Truong</name>
</author>
<author><name sortKey="Bernstein, V" uniqKey="Bernstein V">V Bernstein</name>
</author>
<author><name sortKey="Lesperance, M" uniqKey="Lesperance M">M Lesperance</name>
</author>
<author><name sortKey="Speers, Ch" uniqKey="Speers C">CH Speers</name>
</author>
<author><name sortKey="Olivotto, Ia" uniqKey="Olivotto I">IA Olivotto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Bd" uniqKey="Smith B">BD Smith</name>
</author>
<author><name sortKey="Gross, Cp" uniqKey="Gross C">CP Gross</name>
</author>
<author><name sortKey="Smith, Gl" uniqKey="Smith G">GL Smith</name>
</author>
<author><name sortKey="Galusha, Dh" uniqKey="Galusha D">DH Galusha</name>
</author>
<author><name sortKey="Bekelman, Je" uniqKey="Bekelman J">JE Bekelman</name>
</author>
<author><name sortKey="Haffty, Bg" uniqKey="Haffty B">BG Haffty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shahid, A" uniqKey="Shahid A">A Shahid</name>
</author>
<author><name sortKey="Athar, Ma" uniqKey="Athar M">MA Athar</name>
</author>
<author><name sortKey="Asghar, S" uniqKey="Asghar S">S Asghar</name>
</author>
<author><name sortKey="Zubairi, T" uniqKey="Zubairi T">T Zubairi</name>
</author>
<author><name sortKey="Murad, S" uniqKey="Murad S">S Murad</name>
</author>
<author><name sortKey="Yunas, N" uniqKey="Yunas N">N Yunas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hojris, I" uniqKey="Hojris I">I Hojris</name>
</author>
<author><name sortKey="Overgaard, M" uniqKey="Overgaard M">M Overgaard</name>
</author>
<author><name sortKey="Christensen, Jj" uniqKey="Christensen J">JJ Christensen</name>
</author>
<author><name sortKey="Overgaard, J" uniqKey="Overgaard J">J Overgaard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stokes, El" uniqKey="Stokes E">EL Stokes</name>
</author>
<author><name sortKey="Tyldesley, S" uniqKey="Tyldesley S">S Tyldesley</name>
</author>
<author><name sortKey="Woods, R" uniqKey="Woods R">R Woods</name>
</author>
<author><name sortKey="Wai, E" uniqKey="Wai E">E Wai</name>
</author>
<author><name sortKey="Olivotto, Ia" uniqKey="Olivotto I">IA Olivotto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Badiyan, Sn" uniqKey="Badiyan S">SN Badiyan</name>
</author>
<author><name sortKey="Shah, C" uniqKey="Shah C">C Shah</name>
</author>
<author><name sortKey="Arthur, D" uniqKey="Arthur D">D Arthur</name>
</author>
<author><name sortKey="Khan, Aj" uniqKey="Khan A">AJ Khan</name>
</author>
<author><name sortKey="Freedman, G" uniqKey="Freedman G">G Freedman</name>
</author>
<author><name sortKey="Poppe, Mm" uniqKey="Poppe M">MM Poppe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collette, S" uniqKey="Collette S">S Collette</name>
</author>
<author><name sortKey="Collette, L" uniqKey="Collette L">L Collette</name>
</author>
<author><name sortKey="Budiharto, T" uniqKey="Budiharto T">T Budiharto</name>
</author>
<author><name sortKey="Horiot, Jc" uniqKey="Horiot J">JC Horiot</name>
</author>
<author><name sortKey="Poortmans, Pm" uniqKey="Poortmans P">PM Poortmans</name>
</author>
<author><name sortKey="Struikmans, H" uniqKey="Struikmans H">H Struikmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deantonio, L" uniqKey="Deantonio L">L Deantonio</name>
</author>
<author><name sortKey="Gambaro, G" uniqKey="Gambaro G">G Gambaro</name>
</author>
<author><name sortKey="Beldi, D" uniqKey="Beldi D">D Beldì</name>
</author>
<author><name sortKey="Masini, L" uniqKey="Masini L">L Masini</name>
</author>
<author><name sortKey="Tunesi, S" uniqKey="Tunesi S">S Tunesi</name>
</author>
<author><name sortKey="Magnani, C" uniqKey="Magnani C">C Magnani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name>
</author>
<author><name sortKey="Collins, R" uniqKey="Collins R">R Collins</name>
</author>
<author><name sortKey="Darby, S" uniqKey="Darby S">S Darby</name>
</author>
<author><name sortKey="Davies, C" uniqKey="Davies C">C Davies</name>
</author>
<author><name sortKey="Elphinstone, P" uniqKey="Elphinstone P">P Elphinstone</name>
</author>
<author><name sortKey="Evans, E" uniqKey="Evans E">E Evans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Owen, Jr" uniqKey="Owen J">JR Owen</name>
</author>
<author><name sortKey="Ashton, A" uniqKey="Ashton A">A Ashton</name>
</author>
<author><name sortKey="Bliss, Jm" uniqKey="Bliss J">JM Bliss</name>
</author>
<author><name sortKey="Homewood, J" uniqKey="Homewood J">J Homewood</name>
</author>
<author><name sortKey="Harper, C" uniqKey="Harper C">C Harper</name>
</author>
<author><name sortKey="Hanson, J" uniqKey="Hanson J">J Hanson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cutuli, B" uniqKey="Cutuli B">B Cutuli</name>
</author>
<author><name sortKey="Fourquet, A" uniqKey="Fourquet A">A Fourquet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Bd" uniqKey="Smith B">BD Smith</name>
</author>
<author><name sortKey="Bentzen, Sm" uniqKey="Bentzen S">SM Bentzen</name>
</author>
<author><name sortKey="Correa, Cr" uniqKey="Correa C">CR Correa</name>
</author>
<author><name sortKey="Hahn, Ca" uniqKey="Hahn C">CA Hahn</name>
</author>
<author><name sortKey="Hardenberg, Ph" uniqKey="Hardenberg P">PH Hardenberg</name>
</author>
<author><name sortKey="Ibbott, Gs" uniqKey="Ibbott G">GS Ibbott</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007704 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 007704 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:4554320 |texte= Hypofractionated irradiation in elderly patients with breast cancer after breast conserving surgery and mastectomy : Analysis of 205 cases }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:26238442" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |