LymphedemaV1, Ncbi, Curation, bibRecord, 007023

Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7

Identifieur interne : 007023 ( Ncbi/Curation ); précédent : 007022; suivant : 007024

Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7

Auteurs : Tomomi Nakajima ; Kyoko Kitagawa ; Tatsuya Ohhata ; Satoshi Sakai ; Chiharu Uchida ; Kiyoshi Shibata ; Naoko Minegishi ; Kanae Yumimoto ; Keiichi I. Nakayama ; Kazuma Masumoto ; Fuminori Katou ; Hiroyuki Niida ; Masatoshi Kitagawa

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2015.

RBID : PMC:4400347

Abstract

Background: SCF-Fbw7 participates in stability control of several Cdc4 phosphodegron-containing proteins phosphorylated by glycogen synthase kinase 3, an E3 ligase.

Results: Ubiquitin-dependent degradation of GATA-binding protein 2 is promoted by Fbw7, is cyclin B-CDK1-mediated Thr¹⁷⁶ phosphorylation-dependent, and influences hematopoietic cell differentiation.

Conclusion: GATA-binding protein 2 is a novel target for Fbw7.

Significance: The molecular mechanism of post-transcriptional control of GATA-binding protein 2 is clarified.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400347

DOI: 10.1074/jbc.M114.613018
PubMed: 25670854
PubMed Central: 4400347

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PMC:4400347

Le document en format XML

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<author><name sortKey="Nakajima, Tomomi" sort="Nakajima, Tomomi" uniqKey="Nakajima T" first="Tomomi" last="Nakajima">Tomomi Nakajima</name>
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<author><name sortKey="Niida, Hiroyuki" sort="Niida, Hiroyuki" uniqKey="Niida H" first="Hiroyuki" last="Niida">Hiroyuki Niida</name>
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<author><name sortKey="Nakajima, Tomomi" sort="Nakajima, Tomomi" uniqKey="Nakajima T" first="Tomomi" last="Nakajima">Tomomi Nakajima</name>
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<author><name sortKey="Niida, Hiroyuki" sort="Niida, Hiroyuki" uniqKey="Niida H" first="Hiroyuki" last="Niida">Hiroyuki Niida</name>
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<author><name sortKey="Kitagawa, Masatoshi" sort="Kitagawa, Masatoshi" uniqKey="Kitagawa M" first="Masatoshi" last="Kitagawa">Masatoshi Kitagawa</name>
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<series><title level="j">The Journal of Biological Chemistry</title>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 SCF-Fbw7 participates in stability control of several Cdc4 phosphodegron-containing proteins phosphorylated by glycogen synthase kinase 3, an E3 ligase.</p>
<p><bold>Results:</bold>
 Ubiquitin-dependent degradation of GATA-binding protein 2 is promoted by Fbw7, is cyclin B-CDK1-mediated Thr<sup>176</sup>
 phosphorylation-dependent, and influences hematopoietic cell differentiation.</p>
<p><bold>Conclusion:</bold>
 GATA-binding protein 2 is a novel target for Fbw7.</p>
<p><bold>Significance:</bold>
 The molecular mechanism of post-transcriptional control of GATA-binding protein 2 is clarified.</p>
</div>
</front>
</TEI>
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Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7

Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7

Source :

Abstract

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