Genetic Predisposition Syndromes: When Should They Be Considered In The Work-up of MDS?
Identifieur interne : 007003 ( Ncbi/Curation ); précédent : 007002; suivant : 007004Genetic Predisposition Syndromes: When Should They Be Considered In The Work-up of MDS?
Auteurs : Daria V. Babushok ; Monica BesslerSource :
- Best practice & research. Clinical haematology [ 1521-6926 ] ; 2014.
Abstract
Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by cytopenias, ineffective hematopoiesis, myelodysplasia, and an increased risk of acute myeloid leukemia (AML). While sporadic MDS is primarily a disease of the elderly, MDS in children and young and middle-aged adults is frequently associated with underlying genetic predisposition syndromes. In addition to the classic hereditary bone marrow failure syndromes (BMFS) such as Fanconi Anemia and Dyskeratosis Congenita, in recent years there has been an increased awareness of non-syndromic familial MDS/AML predisposition syndromes such as those caused by mutations in
Url:
DOI: 10.1016/j.beha.2014.11.004
PubMed: 25659730
PubMed Central: 4323616
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