Novel Medical Strategies Combating Nonmelanoma Skin Cancer
Identifieur interne : 006E18 ( Ncbi/Curation ); précédent : 006E17; suivant : 006E19Novel Medical Strategies Combating Nonmelanoma Skin Cancer
Auteurs : Prasan R. Bhandari ; Varadraj V. PaiSource :
- Indian Journal of Dermatology [ 0019-5154 ] ; 2014.
Abstract
The incidence of nonmelanoma skin cancer (NMSC) continues to rise, partly because of aging, the frequency of early childhood sunburns, and sporadic extreme recreational sun exposure. A nonsurgical approach to selected cutaneous malignancy could possibly reduce the cost as well as morbidity of surgical treatment for NMSC. There has been growing interest in isolating compounds that could suppress or reverse the biochemical changes necessary for cutaneous malignancies to progress by pharmacologic intervention. By targeting diverse pathways recognized as important in the pathogenesis of nonmelanoma skin cancers, a combination approach with multiple agents or addition of chemopreventative agents to topical sunscreens may offer the potential for novel and synergistic therapies in treating nonmelanoma skin cancer. This preliminary information will expand to include more therapeutic options for NMSC in the future.
Url:
DOI: 10.4103/0019-5154.143503
PubMed: 25484380
PubMed Central: 4248487
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel Medical Strategies Combating Nonmelanoma Skin Cancer</title><author><name sortKey="Bhandari, Prasan R" sort="Bhandari, Prasan R" uniqKey="Bhandari P" first="Prasan R" last="Bhandari">Prasan R. Bhandari</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Pai, Varadraj V" sort="Pai, Varadraj V" uniqKey="Pai V" first="Varadraj V" last="Pai">Varadraj V. Pai</name><affiliation><nlm:aff id="aff2"><italic>Department of Dermatology, Shri Dharmasthala Manjunatheshwara College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25484380</idno><idno type="pmc">4248487</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248487</idno><idno type="RBID">PMC:4248487</idno><idno type="doi">10.4103/0019-5154.143503</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">004A39</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004A39</idno><idno type="wicri:Area/Pmc/Curation">004A38</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004A38</idno><idno type="wicri:Area/Pmc/Checkpoint">001954</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001954</idno><idno type="wicri:Area/Ncbi/Merge">006E18</idno><idno type="wicri:Area/Ncbi/Curation">006E18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel Medical Strategies Combating Nonmelanoma Skin Cancer</title><author><name sortKey="Bhandari, Prasan R" sort="Bhandari, Prasan R" uniqKey="Bhandari P" first="Prasan R" last="Bhandari">Prasan R. Bhandari</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Pai, Varadraj V" sort="Pai, Varadraj V" uniqKey="Pai V" first="Varadraj V" last="Pai">Varadraj V. Pai</name><affiliation><nlm:aff id="aff2"><italic>Department of Dermatology, Shri Dharmasthala Manjunatheshwara College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Indian Journal of Dermatology</title><idno type="ISSN">0019-5154</idno><idno type="eISSN">1998-3611</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The incidence of nonmelanoma skin cancer (NMSC) continues to rise, partly because of aging, the frequency of early childhood sunburns, and sporadic extreme recreational sun exposure. A nonsurgical approach to selected cutaneous malignancy could possibly reduce the cost as well as morbidity of surgical treatment for NMSC. There has been growing interest in isolating compounds that could suppress or reverse the biochemical changes necessary for cutaneous malignancies to progress by pharmacologic intervention. By targeting diverse pathways recognized as important in the pathogenesis of nonmelanoma skin cancers, a combination approach with multiple agents or addition of chemopreventative agents to topical sunscreens may offer the potential for novel and synergistic therapies in treating nonmelanoma skin cancer. 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Reis</name></author><author><name sortKey="Figueiredo, A" uniqKey="Figueiredo A">A Figueiredo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Panda, S" uniqKey="Panda S">S Panda</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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