Gene and protein therapies utilizing VEGF for ALS
Identifieur interne : 005E84 ( Ncbi/Curation ); précédent : 005E83; suivant : 005E85Gene and protein therapies utilizing VEGF for ALS
Auteurs : Orion P. Keifer ; Deirdre M. O'Connor ; Nicholas M. BoulisSource :
- Pharmacology & therapeutics [ 0163-7258 ] ; 2013.
Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that is usually fatal within 2–5 years. Unfortunately, the only treatment currently available is riluzole, which has a limited efficacy. As a redress, there is an expanding literature focusing on other potential treatments. One such potential treatment option utilizes the vascular endothelial growth factor (VEGF) family, which includes factors that are primarily associated with angiogenesis but are now increasingly recognized to have neurotrophic effects. Reduced expression of a member of this family, VEGF-A, in mice results in neurodegeneration similar to that of ALS, while treatment of animal models of ALS with either VEGF-A gene therapy or VEGF-A protein has yielded positive therapeutic outcomes. These basic research findings raise the potential for a VEGF therapy to be translated to the clinic for the treatment of ALS. This review covers the VEGF family, its receptors and neurotrophic effects as well as VEGF therapy in animal models of ALS and advances towards clinical trials.
Url:
DOI: 10.1016/j.pharmthera.2013.10.009
PubMed: 24177067
PubMed Central: 4659499
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003722
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :003721
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002320
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :005E84
Links to Exploration step
PMC:4659499Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gene and protein therapies utilizing VEGF for ALS</title><author><name sortKey="Keifer, Orion P" sort="Keifer, Orion P" uniqKey="Keifer O" first="Orion P." last="Keifer">Orion P. Keifer</name></author><author><name sortKey="O Connor, Deirdre M" sort="O Connor, Deirdre M" uniqKey="O Connor D" first="Deirdre M." last="O'Connor">Deirdre M. O'Connor</name></author><author><name sortKey="Boulis, Nicholas M" sort="Boulis, Nicholas M" uniqKey="Boulis N" first="Nicholas M." last="Boulis">Nicholas M. Boulis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24177067</idno><idno type="pmc">4659499</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659499</idno><idno type="RBID">PMC:4659499</idno><idno type="doi">10.1016/j.pharmthera.2013.10.009</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003722</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003722</idno><idno type="wicri:Area/Pmc/Curation">003721</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003721</idno><idno type="wicri:Area/Pmc/Checkpoint">002320</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002320</idno><idno type="wicri:Area/Ncbi/Merge">005E84</idno><idno type="wicri:Area/Ncbi/Curation">005E84</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gene and protein therapies utilizing VEGF for ALS</title><author><name sortKey="Keifer, Orion P" sort="Keifer, Orion P" uniqKey="Keifer O" first="Orion P." last="Keifer">Orion P. Keifer</name></author><author><name sortKey="O Connor, Deirdre M" sort="O Connor, Deirdre M" uniqKey="O Connor D" first="Deirdre M." last="O'Connor">Deirdre M. O'Connor</name></author><author><name sortKey="Boulis, Nicholas M" sort="Boulis, Nicholas M" uniqKey="Boulis N" first="Nicholas M." last="Boulis">Nicholas M. Boulis</name></author></analytic><series><title level="j">Pharmacology & therapeutics</title><idno type="ISSN">0163-7258</idno><idno type="eISSN">1879-016X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that is usually fatal within 2–5 years. Unfortunately, the only treatment currently available is riluzole, which has a limited efficacy. As a redress, there is an expanding literature focusing on other potential treatments. One such potential treatment option utilizes the vascular endothelial growth factor (VEGF) family, which includes factors that are primarily associated with angiogenesis but are now increasingly recognized to have neurotrophic effects. Reduced expression of a member of this family, VEGF-A, in mice results in neurodegeneration similar to that of ALS, while treatment of animal models of ALS with either VEGF-A gene therapy or VEGF-A protein has yielded positive therapeutic outcomes. These basic research findings raise the potential for a VEGF therapy to be translated to the clinic for the treatment of ALS. This review covers the VEGF family, its receptors and neurotrophic effects as well as VEGF therapy in animal models of ALS and advances towards clinical trials.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005E84 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 005E84 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:4659499
|texte= Gene and protein therapies utilizing VEGF for ALS
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:24177067" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |