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Applications of high-throughput DNA sequencing to benign hematology

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Applications of high-throughput DNA sequencing to benign hematology

Auteurs : Vijay G. Sankaran [États-Unis] ; Patrick G. Gallagher [États-Unis]

Source :

Blood [ 0006-4971 ] ; 2013.

RBID : PMC:3837507

Abstract

The development of novel technologies for high-throughput DNA sequencing is having a major impact on our ability to measure and define normal and pathologic variation in humans. This review discusses advances in DNA sequencing that have been applied to benign hematologic disorders, including those affecting the red blood cell, the neutrophil, and other white blood cell lineages. Relevant examples of how these approaches have been used for disease diagnosis, gene discovery, and studying complex traits are provided. High-throughput DNA sequencing technology holds significant promise for impacting clinical care. This includes development of improved disease detection and diagnosis, better understanding of disease progression and stratification of risk of disease-specific complications, and development of improved therapeutic strategies, particularly patient-specific pharmacogenomics-based therapy, with monitoring of therapy by genomic biomarkers.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837507

DOI: 10.1182/blood-2013-07-460337
PubMed: 24021670
PubMed Central: 3837507

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PMC:3837507

Le document en format XML

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<placeName><region type="state">Connecticut</region>
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Applications of high-throughput DNA sequencing to benign hematology

Applications of high-throughput DNA sequencing to benign hematology

Source :

Abstract

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