Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata.
Identifieur interne : 005B77 ( Ncbi/Curation ); précédent : 005B76; suivant : 005B78Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata.
Auteurs : J W Mak [Malaisie] ; P L Lam ; M F Choong ; K. SureshSource :
- Journal of helminthology [ 0022-149X ] ; 1990.
Descripteurs français
- KwdFr :
- Administration par voie orale, Animaux, Brugia (), Brugia (croissance et développement), Cercopithecidae, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (usage thérapeutique), Femelle, Filariose lymphatique (traitement médicamenteux), Filarioses (traitement médicamenteux), Injections veineuses, Microfilaria (), Microfilaria (croissance et développement), Modèles animaux de maladie humaine, Mâle, Suramine (administration et posologie), Suramine (usage thérapeutique).
- MESH :
- administration et posologie : Diéthylcarbamazine, Suramine.
- croissance et développement : Brugia, Microfilaria.
- traitement médicamenteux : Filariose lymphatique, Filarioses.
- usage thérapeutique : Diéthylcarbamazine, Suramine.
- Administration par voie orale, Animaux, Brugia, Cercopithecidae, Femelle, Injections veineuses, Microfilaria, Modèles animaux de maladie humaine, Mâle.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Brugia (drug effects), Brugia (growth & development), Cercopithecidae, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (therapeutic use), Disease Models, Animal, Elephantiasis, Filarial (drug therapy), Female, Filariasis (drug therapy), Injections, Intravenous, Male, Microfilariae (drug effects), Microfilariae (growth & development), Suramin (administration & dosage), Suramin (therapeutic use).
- MESH :
- chemical , administration & dosage : Diethylcarbamazine, Suramin.
- drug effects : Brugia, Microfilariae.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- growth & development : Brugia, Microfilariae.
- chemical , therapeutic use : Diethylcarbamazine, Suramin.
- Administration, Oral, Animals, Cercopithecidae, Disease Models, Animal, Female, Injections, Intravenous, Male.
Abstract
The known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis cristata. As expected, intravenous suramin at 10 mg/kg daily x 5 days or 17 mg/kg weekly x 5 weeks, did not show any microfilaricidal activity, but substantially reduced the recovery of live adult worms to 50.6% and 13.6% of controls respectively. Oral diethylcarbamazine citrate at 6 mg/kg daily x 6 or 10 days reduced final microfilarial counts to 30% of initial counts four weeks post-treatment and adult worm recovery was reduced to 4.5% and 0% of controls respectively. Although the antifilarial activity of these drugs against the infection in this non-human primate model appears to be similar to that seen in man, these results have to be confirmed using larger groups of animals.
PubMed: 2387979
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pubmed:2387979Le document en format XML
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Suresh</name></author></analytic><series><title level="j">Journal of helminthology</title><idno type="ISSN">0022-149X</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Brugia (drug effects)</term><term>Brugia (growth & development)</term><term>Cercopithecidae</term><term>Diethylcarbamazine (administration & dosage)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Disease Models, Animal</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Female</term><term>Filariasis (drug therapy)</term><term>Injections, Intravenous</term><term>Male</term><term>Microfilariae (drug effects)</term><term>Microfilariae (growth & development)</term><term>Suramin (administration & dosage)</term><term>Suramin (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Brugia ()</term><term>Brugia (croissance et développement)</term><term>Cercopithecidae</term><term>Diéthylcarbamazine (administration et posologie)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filarioses (traitement médicamenteux)</term><term>Injections veineuses</term><term>Microfilaria ()</term><term>Microfilaria (croissance et développement)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Suramine (administration et posologie)</term><term>Suramine (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Diethylcarbamazine</term><term>Suramin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Suramine</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia</term><term>Microfilaria</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia</term><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia</term><term>Microfilariae</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Suramin</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Suramine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Cercopithecidae</term><term>Disease Models, Animal</term><term>Female</term><term>Injections, Intravenous</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Brugia</term><term>Cercopithecidae</term><term>Femelle</term><term>Injections veineuses</term><term>Microfilaria</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis cristata. As expected, intravenous suramin at 10 mg/kg daily x 5 days or 17 mg/kg weekly x 5 weeks, did not show any microfilaricidal activity, but substantially reduced the recovery of live adult worms to 50.6% and 13.6% of controls respectively. Oral diethylcarbamazine citrate at 6 mg/kg daily x 6 or 10 days reduced final microfilarial counts to 30% of initial counts four weeks post-treatment and adult worm recovery was reduced to 4.5% and 0% of controls respectively. Although the antifilarial activity of these drugs against the infection in this non-human primate model appears to be similar to that seen in man, these results have to be confirmed using larger groups of animals.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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