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An interesting case of systemic lupus erythematosus presenting with hypercalcemia: A diagnostic dilemma

Identifieur interne : 005811 ( Ncbi/Curation ); précédent : 005810; suivant : 005812

An interesting case of systemic lupus erythematosus presenting with hypercalcemia: A diagnostic dilemma

Auteurs : Abdul Halim Abdul Gafor ; Rizna Abdul Cader ; Srijit Das ; Noraidah Masir ; Fadilah Abdul Wahid

Source :

The American Journal of Case Reports [ 1941-5923 ] ; 2013.

RBID : PMC:3619043

Abstract

Background

Hypercalcemia is common in primary hyperparathyroidism malignancies and even in tuberculosis. Interestingly, systemic lupus erythematosus (SLE) rarely presents with hypercalcemia.

Case Report:

We describe an interesting case of SLE in a patient who was otherwise thought to have either tuberculosis or a malignancy. The patient initially presented with feeling unwell, with generalized lymphadenopathy, bilateral pleural effusion, and bilateral corneal calcium deposits secondary to severe hypercalcemia. The diagnosis of SLE was made based on positivity of antinuclear antibodies (ANA) and anti-dsDNA, the presence of serositis, lymphadenopathy, autoimmune hemolytic anemia, and constitutional symptoms. She was treated with steroids, with tremendous improvement in her general well-being, resolution of lymphadenopathy and pleural effusion, and normalization of her hemoglobin and serum calcium. The atypical presentation of SLE with hypercalcemia with pleural effusion is discussed.

Conclusions:

SLE should be one of the differential diagnoses in patients presenting with severe hypercalcemia.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619043

DOI: 10.12659/AJCR.883849
PubMed: 23569551
PubMed Central: 3619043

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PMC:3619043

Le document en format XML

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<author><name sortKey="Abdul Gafor, Abdul Halim" sort="Abdul Gafor, Abdul Halim" uniqKey="Abdul Gafor A" first="Abdul Halim" last="Abdul Gafor">Abdul Halim Abdul Gafor</name>
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<author><name sortKey="Cader, Rizna Abdul" sort="Cader, Rizna Abdul" uniqKey="Cader R" first="Rizna Abdul" last="Cader">Rizna Abdul Cader</name>
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<author><name sortKey="Das, Srijit" sort="Das, Srijit" uniqKey="Das S" first="Srijit" last="Das">Srijit Das</name>
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<author><name sortKey="Masir, Noraidah" sort="Masir, Noraidah" uniqKey="Masir N" first="Noraidah" last="Masir">Noraidah Masir</name>
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<author><name sortKey="Wahid, Fadilah Abdul" sort="Wahid, Fadilah Abdul" uniqKey="Wahid F" first="Fadilah Abdul" last="Wahid">Fadilah Abdul Wahid</name>
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<author><name sortKey="Masir, Noraidah" sort="Masir, Noraidah" uniqKey="Masir N" first="Noraidah" last="Masir">Noraidah Masir</name>
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<author><name sortKey="Wahid, Fadilah Abdul" sort="Wahid, Fadilah Abdul" uniqKey="Wahid F" first="Fadilah Abdul" last="Wahid">Fadilah Abdul Wahid</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Hypercalcemia is common in primary hyperparathyroidism malignancies and even in tuberculosis. Interestingly, systemic lupus erythematosus (SLE) rarely presents with hypercalcemia.</p>
</sec>
<sec><title>Case Report:</title>
<p>We describe an interesting case of SLE in a patient who was otherwise thought to have either tuberculosis or a malignancy. The patient initially presented with feeling unwell, with generalized lymphadenopathy, bilateral pleural effusion, and bilateral corneal calcium deposits secondary to severe hypercalcemia. The diagnosis of SLE was made based on positivity of antinuclear antibodies (ANA) and anti-dsDNA, the presence of serositis, lymphadenopathy, autoimmune hemolytic anemia, and constitutional symptoms. She was treated with steroids, with tremendous improvement in her general well-being, resolution of lymphadenopathy and pleural effusion, and normalization of her hemoglobin and serum calcium. The atypical presentation of SLE with hypercalcemia with pleural effusion is discussed.</p>
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<sec><title>Conclusions:</title>
<p>SLE should be one of the differential diagnoses in patients presenting with severe hypercalcemia.</p>
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An interesting case of systemic lupus erythematosus presenting with hypercalcemia: A diagnostic dilemma

An interesting case of systemic lupus erythematosus presenting with hypercalcemia: A diagnostic dilemma

Source :

Abstract

Links toward previous steps (curation, corpus...)

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki