Massive localized lymphedema of the male external genitalia: a clinicopathologic study of 6 cases.
Identifieur interne : 005147 ( Ncbi/Curation ); précédent : 005146; suivant : 005148Massive localized lymphedema of the male external genitalia: a clinicopathologic study of 6 cases.
Auteurs : Stephen Lee [États-Unis] ; Jeong S. Han ; Hillary M. Ross ; Jonathan I. EpsteinSource :
- Human pathology [ 1532-8392 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Cellules stromales (anatomopathologie), Humains, Indice de masse corporelle, Lymphoedème (anatomopathologie), Maladies de l'appareil génital mâle (anatomopathologie), Mâle, Obésité morbide (), Pénis (anatomopathologie), Scrotum (anatomopathologie), Sujet âgé, Tissu adipeux, Études de suivi, Études rétrospectives.
- MESH :
English descriptors
- KwdEn :
- MESH :
- complications : Obesity, Morbid.
- pathology : Genital Diseases, Male, Lymphedema, Penis, Scrotum, Stromal Cells.
- Adipose Tissue, Adolescent, Adult, Aged, Body Mass Index, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
Massive localized lymphedema is a reactive pseudotumor strongly associated with obesity. The tumor most commonly presents as pendulous masses in the lower limbs with only 3 reported cases involving external male genitalia. In this study, we report an additional 6 cases localized to the external male genitalia. The cases were retrospectively identified from the surgical pathology database of the Johns Hopkins Hospital. All 6 patients were obese (5 presented with diffuse scrotal edema and 1 with a penile mass). In all cases, the clinical impression was of a benign chronic process developing over 3 months to 1 year. All 3 cases from outside institutions were referred with benign pathologic diagnoses. The lesions ranged in size from 4 to 55 cm. Microscopically, all cases exhibited stromal fibrosis and edema, multinucleated stromal cells, perivascular chronic inflammation, and lymphangiectasia. Entrapped fat was a minor feature and seen in only 3 cases. Variable hyperplasia and hypertrophy of dartos muscle were noted in 6 lesions. Three cases showed prominent microvascular proliferation around the edge of individual dartos muscle bundles. In summary, diagnosis of massive localized lymphedema requires appropriate correlation between clinical and microscopic findings. Lesions in the male external genitalia share many microscopic findings with massive localized lymphedema at other sites, although entrapped adipose tissue is not prominent. Additional, although not specific, findings include variably hyperplastic and hypertrophic dartos muscle and capillary neoangiogenesis at the interface between smooth muscle bundles and stroma.
DOI: 10.1016/j.humpath.2012.05.023
PubMed: 22995331
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001F51
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001F51
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001F51
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :005147
Links to Exploration step
pubmed:22995331Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Massive localized lymphedema of the male external genitalia: a clinicopathologic study of 6 cases.</title>
<author><name sortKey="Lee, Stephen" sort="Lee, Stephen" uniqKey="Lee S" first="Stephen" last="Lee">Stephen Lee</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Han, Jeong S" sort="Han, Jeong S" uniqKey="Han J" first="Jeong S" last="Han">Jeong S. Han</name>
</author>
<author><name sortKey="Ross, Hillary M" sort="Ross, Hillary M" uniqKey="Ross H" first="Hillary M" last="Ross">Hillary M. Ross</name>
</author>
<author><name sortKey="Epstein, Jonathan I" sort="Epstein, Jonathan I" uniqKey="Epstein J" first="Jonathan I" last="Epstein">Jonathan I. Epstein</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:22995331</idno>
<idno type="pmid">22995331</idno>
<idno type="doi">10.1016/j.humpath.2012.05.023</idno>
<idno type="wicri:Area/PubMed/Corpus">001F51</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F51</idno>
<idno type="wicri:Area/PubMed/Curation">001F51</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F51</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001F51</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F51</idno>
<idno type="wicri:Area/Ncbi/Merge">005147</idno>
<idno type="wicri:Area/Ncbi/Curation">005147</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Massive localized lymphedema of the male external genitalia: a clinicopathologic study of 6 cases.</title>
<author><name sortKey="Lee, Stephen" sort="Lee, Stephen" uniqKey="Lee S" first="Stephen" last="Lee">Stephen Lee</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Han, Jeong S" sort="Han, Jeong S" uniqKey="Han J" first="Jeong S" last="Han">Jeong S. Han</name>
</author>
<author><name sortKey="Ross, Hillary M" sort="Ross, Hillary M" uniqKey="Ross H" first="Hillary M" last="Ross">Hillary M. Ross</name>
</author>
<author><name sortKey="Epstein, Jonathan I" sort="Epstein, Jonathan I" uniqKey="Epstein J" first="Jonathan I" last="Epstein">Jonathan I. Epstein</name>
</author>
</analytic>
<series><title level="j">Human pathology</title>
<idno type="eISSN">1532-8392</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipose Tissue</term>
<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Body Mass Index</term>
<term>Follow-Up Studies</term>
<term>Genital Diseases, Male (pathology)</term>
<term>Humans</term>
<term>Lymphedema (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Obesity, Morbid (complications)</term>
<term>Penis (pathology)</term>
<term>Retrospective Studies</term>
<term>Scrotum (pathology)</term>
<term>Stromal Cells (pathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Cellules stromales (anatomopathologie)</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Maladies de l'appareil génital mâle (anatomopathologie)</term>
<term>Mâle</term>
<term>Obésité morbide ()</term>
<term>Pénis (anatomopathologie)</term>
<term>Scrotum (anatomopathologie)</term>
<term>Sujet âgé</term>
<term>Tissu adipeux</term>
<term>Études de suivi</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules stromales</term>
<term>Lymphoedème</term>
<term>Maladies de l'appareil génital mâle</term>
<term>Pénis</term>
<term>Scrotum</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Obesity, Morbid</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Genital Diseases, Male</term>
<term>Lymphedema</term>
<term>Penis</term>
<term>Scrotum</term>
<term>Stromal Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adipose Tissue</term>
<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Body Mass Index</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Mâle</term>
<term>Obésité morbide</term>
<term>Sujet âgé</term>
<term>Tissu adipeux</term>
<term>Études de suivi</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Massive localized lymphedema is a reactive pseudotumor strongly associated with obesity. The tumor most commonly presents as pendulous masses in the lower limbs with only 3 reported cases involving external male genitalia. In this study, we report an additional 6 cases localized to the external male genitalia. The cases were retrospectively identified from the surgical pathology database of the Johns Hopkins Hospital. All 6 patients were obese (5 presented with diffuse scrotal edema and 1 with a penile mass). In all cases, the clinical impression was of a benign chronic process developing over 3 months to 1 year. All 3 cases from outside institutions were referred with benign pathologic diagnoses. The lesions ranged in size from 4 to 55 cm. Microscopically, all cases exhibited stromal fibrosis and edema, multinucleated stromal cells, perivascular chronic inflammation, and lymphangiectasia. Entrapped fat was a minor feature and seen in only 3 cases. Variable hyperplasia and hypertrophy of dartos muscle were noted in 6 lesions. Three cases showed prominent microvascular proliferation around the edge of individual dartos muscle bundles. In summary, diagnosis of massive localized lymphedema requires appropriate correlation between clinical and microscopic findings. Lesions in the male external genitalia share many microscopic findings with massive localized lymphedema at other sites, although entrapped adipose tissue is not prominent. Additional, although not specific, findings include variably hyperplastic and hypertrophic dartos muscle and capillary neoangiogenesis at the interface between smooth muscle bundles and stroma.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005147 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 005147 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:22995331 |texte= Massive localized lymphedema of the male external genitalia: a clinicopathologic study of 6 cases. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:22995331" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |