Roles of transcriptional network during the formation of lymphatic vessels.
Identifieur interne : 004F69 ( Ncbi/Curation ); précédent : 004F68; suivant : 004F70Roles of transcriptional network during the formation of lymphatic vessels.
Auteurs : Tetsuro Watabe [Japon]Source :
- Journal of biochemistry [ 1756-2651 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Vaisseaux lymphatiques.
- génétique : Lymphangiogenèse, Maladie, Réseaux de régulation génique.
- métabolisme : Facteurs de transcription, Vaisseaux lymphatiques.
- Animaux, Humains, Santé.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Transcription Factors.
- genetics : Disease, Gene Regulatory Networks, Lymphangiogenesis.
- metabolism : Lymphatic Vessels.
- pathology : Lymphatic Vessels.
- Animals, Health, Humans.
Abstract
The lymphatic vascular system, also known as the second vascular system in vertebrates, plays crucial roles in various physiological and pathological processes. It participates in the maintenance of normal tissue fluid balance, trafficking of the immune cells and absorption of fatty acids in the gut. Furthermore, lymphatic system is associated with the pathogenesis of a number of diseases, including lymphedema, inflammatory diseases and tumour metastasis. Lymphatic vessels are comprised of lymphatic endothelial cells (LECs), which are differentiated from blood vascular endothelial cells. This review highlights recent advances in our understanding of the transcriptional control of LEC fate determination and reflects on efforts to understand the roles of transcriptional networks during this discrete developmental process.
DOI: 10.1093/jb/mvs081
PubMed: 22825883
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pubmed:22825883Le document en format XML
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It participates in the maintenance of normal tissue fluid balance, trafficking of the immune cells and absorption of fatty acids in the gut. Furthermore, lymphatic system is associated with the pathogenesis of a number of diseases, including lymphedema, inflammatory diseases and tumour metastasis. Lymphatic vessels are comprised of lymphatic endothelial cells (LECs), which are differentiated from blood vascular endothelial cells. This review highlights recent advances in our understanding of the transcriptional control of LEC fate determination and reflects on efforts to understand the roles of transcriptional networks during this discrete developmental process.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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