Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria
Identifieur interne : 004A76 ( Ncbi/Curation ); précédent : 004A75; suivant : 004A77Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria
Auteurs : D. Evans [États-Unis] ; D. Mcfarland [États-Unis] ; W. Adamani [Nigeria] ; A. Eigege [Nigeria] ; E. Miri [Nigeria] ; J. Schulz [États-Unis] ; E. Pede [Nigeria] ; C. Umbugadu [Nigeria] ; P. Ogbu-Pearse [Nigeria] ; F O Richards [États-Unis]Source :
- Annals of Tropical Medicine and Parasitology [ 0003-4983 ] ; 2011.
Abstract
Onchocerciasis, lymphatic filariasis (LF), schistosomiasis and soil transmitted, helminthiasis (STH) are all co-endemic in Nigeria. Annual mass drug administration (MDA) with ivermectin (for onchocerciasis), albendazole (for STH and with ivermectin for LF) and praziquantel (for schistosomiasis) is the WHO-recommended treatment strategy for preventive chemotherapy. Separate delivery rounds for distribution of these drugs have been the usual approach to MDA. All three drugs, however, have now been shown to be clinically and programmatically safe for co-administration with what has come to be known as triple drug administration (TDA). We examined the cost savings of converting from separate delivery rounds to TDA in two states in Nigeria. In 2008, eight local government areas received a single round of ivermectin with albendazole followed at least 1 week later by a single round of praziquantel to school-aged children. The following year, a single round was administered with TDA. The number of treated individuals was essentially unchanged during both years (1 301 864 in 2008 and 1 297 509 in 2009) and no change in adverse events was reported. The total programmatic costs for the MDA, not including drug and overhead costs, reduced by 41% from $123, 624 to $72, 870. Cost savings were limited in larger populations due to economies of scale. TDA is recommended for mature MDA.
Url:
DOI: 10.1179/2047773211Y.0000000010
PubMed: 22325813
PubMed Central: 4089800
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002C28
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002C27
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003023
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :004A76
Links to Exploration step
PMC:4089800Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria</title>
<author><name sortKey="Evans, D" sort="Evans, D" uniqKey="Evans D" first="D" last="Evans">D. Evans</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307</wicri:regionArea>
<wicri:noRegion>GA 30307</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcfarland, D" sort="Mcfarland, D" uniqKey="Mcfarland D" first="D" last="Mcfarland">D. Mcfarland</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Emory University, Rollings School of Public Health, Atlanta, GA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Emory University, Rollings School of Public Health, Atlanta, GA</wicri:regionArea>
<wicri:noRegion>GA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adamani, W" sort="Adamani, W" uniqKey="Adamani W" first="W" last="Adamani">W. Adamani</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>The Carter Center, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>The Carter Center</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eigege, A" sort="Eigege, A" uniqKey="Eigege A" first="A" last="Eigege">A. Eigege</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>The Carter Center, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>The Carter Center</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miri, E" sort="Miri, E" uniqKey="Miri E" first="E" last="Miri">E. Miri</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>The Carter Center, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>The Carter Center</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schulz, J" sort="Schulz, J" uniqKey="Schulz J" first="J" last="Schulz">J. Schulz</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Emory University, Rollings School of Public Health, Atlanta, GA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Emory University, Rollings School of Public Health, Atlanta, GA</wicri:regionArea>
<wicri:noRegion>GA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pede, E" sort="Pede, E" uniqKey="Pede E" first="E" last="Pede">E. Pede</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Plateau State Ministry of Health, Jos, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Plateau State Ministry of Health, Jos</wicri:regionArea>
<wicri:noRegion>Jos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Umbugadu, C" sort="Umbugadu, C" uniqKey="Umbugadu C" first="C" last="Umbugadu">C. Umbugadu</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Nasarawa State Ministry of Health, Lafia, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Nasarawa State Ministry of Health, Lafia</wicri:regionArea>
<wicri:noRegion>Lafia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ogbu Pearse, P" sort="Ogbu Pearse, P" uniqKey="Ogbu Pearse P" first="P" last="Ogbu-Pearse">P. Ogbu-Pearse</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Federal Ministry of Health, Abuja, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Federal Ministry of Health, Abuja</wicri:regionArea>
<wicri:noRegion>Abuja</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richards, F O" sort="Richards, F O" uniqKey="Richards F" first="F O" last="Richards">F O Richards</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307</wicri:regionArea>
<wicri:noRegion>GA 30307</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22325813</idno>
<idno type="pmc">4089800</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089800</idno>
<idno type="RBID">PMC:4089800</idno>
<idno type="doi">10.1179/2047773211Y.0000000010</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">002C28</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C28</idno>
<idno type="wicri:Area/Pmc/Curation">002C27</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C27</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003023</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003023</idno>
<idno type="wicri:Area/Ncbi/Merge">004A76</idno>
<idno type="wicri:Area/Ncbi/Curation">004A76</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria</title>
<author><name sortKey="Evans, D" sort="Evans, D" uniqKey="Evans D" first="D" last="Evans">D. Evans</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307</wicri:regionArea>
<wicri:noRegion>GA 30307</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcfarland, D" sort="Mcfarland, D" uniqKey="Mcfarland D" first="D" last="Mcfarland">D. Mcfarland</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Emory University, Rollings School of Public Health, Atlanta, GA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Emory University, Rollings School of Public Health, Atlanta, GA</wicri:regionArea>
<wicri:noRegion>GA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adamani, W" sort="Adamani, W" uniqKey="Adamani W" first="W" last="Adamani">W. Adamani</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>The Carter Center, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>The Carter Center</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eigege, A" sort="Eigege, A" uniqKey="Eigege A" first="A" last="Eigege">A. Eigege</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>The Carter Center, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>The Carter Center</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miri, E" sort="Miri, E" uniqKey="Miri E" first="E" last="Miri">E. Miri</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>The Carter Center, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>The Carter Center</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schulz, J" sort="Schulz, J" uniqKey="Schulz J" first="J" last="Schulz">J. Schulz</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Emory University, Rollings School of Public Health, Atlanta, GA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Emory University, Rollings School of Public Health, Atlanta, GA</wicri:regionArea>
<wicri:noRegion>GA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pede, E" sort="Pede, E" uniqKey="Pede E" first="E" last="Pede">E. Pede</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Plateau State Ministry of Health, Jos, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Plateau State Ministry of Health, Jos</wicri:regionArea>
<wicri:noRegion>Jos</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Umbugadu, C" sort="Umbugadu, C" uniqKey="Umbugadu C" first="C" last="Umbugadu">C. Umbugadu</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Nasarawa State Ministry of Health, Lafia, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Nasarawa State Ministry of Health, Lafia</wicri:regionArea>
<wicri:noRegion>Lafia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ogbu Pearse, P" sort="Ogbu Pearse, P" uniqKey="Ogbu Pearse P" first="P" last="Ogbu-Pearse">P. Ogbu-Pearse</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Federal Ministry of Health, Abuja, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Federal Ministry of Health, Abuja</wicri:regionArea>
<wicri:noRegion>Abuja</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richards, F O" sort="Richards, F O" uniqKey="Richards F" first="F O" last="Richards">F O Richards</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307</wicri:regionArea>
<wicri:noRegion>GA 30307</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of Tropical Medicine and Parasitology</title>
<idno type="ISSN">0003-4983</idno>
<idno type="eISSN">1364-8594</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Onchocerciasis, lymphatic filariasis (LF), schistosomiasis and soil transmitted, helminthiasis (STH) are all co-endemic in Nigeria. Annual mass drug administration (MDA) with ivermectin (for onchocerciasis), albendazole (for STH and with ivermectin for LF) and praziquantel (for schistosomiasis) is the WHO-recommended treatment strategy for preventive chemotherapy. Separate delivery rounds for distribution of these drugs have been the usual approach to MDA. All three drugs, however, have now been shown to be clinically and programmatically safe for co-administration with what has come to be known as triple drug administration (TDA). We examined the cost savings of converting from separate delivery rounds to TDA in two states in Nigeria. In 2008, eight local government areas received a single round of ivermectin with albendazole followed at least 1 week later by a single round of praziquantel to school-aged children. The following year, a single round was administered with TDA. The number of treated individuals was essentially unchanged during both years (1 301 864 in 2008 and 1 297 509 in 2009) and no change in adverse events was reported. The total programmatic costs for the MDA, not including drug and overhead costs, reduced by 41% from $123, 624 to $72, 870. Cost savings were limited in larger populations due to economies of scale. TDA is recommended for mature MDA.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004A76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 004A76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:4089800 |texte= Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:22325813" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |