Comparative susceptibility to anthelmintics of Brugia pahangi in jirds infected by different methods.
Identifieur interne : 004A50 ( Ncbi/Curation ); précédent : 004A49; suivant : 004A51Comparative susceptibility to anthelmintics of Brugia pahangi in jirds infected by different methods.
Auteurs : J. Surin [Royaume-Uni] ; D A DenhamSource :
- Journal of helminthology [ 0022-149X ] ; 1990.
Descripteurs français
- KwdFr :
- MESH :
- parasitologie : Filariose lymphatique.
- pharmacologie : Filaricides.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Filaricides.
- Animaux, Brugia, Femelle, Gerbillinae, Injections péritoneales, Injections sous-cutanées, Larve, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Filaricides.
- drug effects : Brugia, Larva.
- drug therapy : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- chemical , therapeutic use : Filaricides.
- Animals, Female, Gerbillinae, Injections, Intraperitoneal, Injections, Subcutaneous, Male.
Abstract
It is possible to infect jirds with Brugia pahangi by three methods. Infective larvae (L3) can be injected either intraperitoneally (ip), when adults develop in the peritoneal cavity, or sub-cutaneously (sc), when they develop in the lymphatics or the heart and blood vessels associated with the lungs. Alternatively adult worms which have been grown in the peritoneal cavities of jirds can be implanted into the peritoneal cavities of other jirds. This latter system has been widely used for screening for new filaricides. We have compared the activity of 9 macrofilaricidal compounds against these 3 types of infection. Mebendazole and albendazole were more active against implanted adults than against L3 induced adults in the peritoneal cavity. Oxibendazole, flubendazole, CGP24588A and oxfendazole were equally active against both types of worm. CGP20376, Mel Ga and Mel Ni were more active against adult worms derived from inoculated L3 than implanted worms. When comparing intra-lymphatic and ip adults (both derived from L3 infections and in the same jirds) albendazole and CGP20376 were active at the same levels against both types of infection. Mebendazole, flubendazole, oxfendazole, CGP24588A, Mel Ga and Mel Ni were more active against ip adults than intra-lymphatic adults. No drug was more active against intra-lymphatic adults than against adults.
PubMed: 2230033
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Surin</name><affiliation wicri:level="1"><nlm:affiliation>London School of Hygiene and Tropical Medicine, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2230033</idno><idno type="pmid">2230033</idno><idno type="wicri:Area/PubMed/Corpus">005D12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005D12</idno><idno type="wicri:Area/PubMed/Curation">005D12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005D12</idno><idno type="wicri:Area/PubMed/Checkpoint">005D12</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005D12</idno><idno type="wicri:Area/Ncbi/Merge">004A50</idno><idno type="wicri:Area/Ncbi/Curation">004A50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative susceptibility to anthelmintics of Brugia pahangi in jirds infected by different methods.</title><author><name sortKey="Surin, J" sort="Surin, J" uniqKey="Surin J" first="J" last="Surin">J. Surin</name><affiliation wicri:level="1"><nlm:affiliation>London School of Hygiene and Tropical Medicine, England, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, England</wicri:regionArea><wicri:noRegion>England</wicri:noRegion></affiliation></author><author><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></author></analytic><series><title level="j">Journal of helminthology</title><idno type="ISSN">0022-149X</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brugia (drug effects)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Filaricides (pharmacology)</term><term>Filaricides (therapeutic use)</term><term>Gerbillinae</term><term>Injections, Intraperitoneal</term><term>Injections, Subcutaneous</term><term>Larva (drug effects)</term><term>Male</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Brugia ()</term><term>Femelle</term><term>Filaricides (pharmacologie)</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Gerbillinae</term><term>Injections péritoneales</term><term>Injections sous-cutanées</term><term>Larve ()</term><term>Mâle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Gerbillinae</term><term>Injections, Intraperitoneal</term><term>Injections, Subcutaneous</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Brugia</term><term>Femelle</term><term>Gerbillinae</term><term>Injections péritoneales</term><term>Injections sous-cutanées</term><term>Larve</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is possible to infect jirds with Brugia pahangi by three methods. Infective larvae (L3) can be injected either intraperitoneally (ip), when adults develop in the peritoneal cavity, or sub-cutaneously (sc), when they develop in the lymphatics or the heart and blood vessels associated with the lungs. Alternatively adult worms which have been grown in the peritoneal cavities of jirds can be implanted into the peritoneal cavities of other jirds. This latter system has been widely used for screening for new filaricides. We have compared the activity of 9 macrofilaricidal compounds against these 3 types of infection. Mebendazole and albendazole were more active against implanted adults than against L3 induced adults in the peritoneal cavity. Oxibendazole, flubendazole, CGP24588A and oxfendazole were equally active against both types of worm. CGP20376, Mel Ga and Mel Ni were more active against adult worms derived from inoculated L3 than implanted worms. When comparing intra-lymphatic and ip adults (both derived from L3 infections and in the same jirds) albendazole and CGP20376 were active at the same levels against both types of infection. Mebendazole, flubendazole, oxfendazole, CGP24588A, Mel Ga and Mel Ni were more active against ip adults than intra-lymphatic adults. No drug was more active against intra-lymphatic adults than against adults.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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