Breast cancer (non-metastatic)
Identifieur interne : 004491 ( Ncbi/Curation ); précédent : 004490; suivant : 004492Breast cancer (non-metastatic)
Auteurs : Justin Stebbing ; Geoff Delaney ; Alastair ThompsonSource :
- BMJ Clinical Evidence [ 1752-8526 ] ; 2011.
Abstract
Breast cancer affects at least 1 in 10 women in the UK, but most present with primary operable disease, which has an 80% 5-year survival rate overall.
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions after breast-conserving surgery for ductal carcinoma in situ? What are the effects of treatments for primary operable breast cancer? What are the effects of interventions in locally advanced breast cancer (stage 3B)? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
We found 83 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
In this systematic review we present information relating to the effectiveness and safety of the following interventions: adding chemotherapy (cyclophosphamide/methotrexate/fluorouracil and/or anthracycline and/or taxane-based regimens), or hormonal treatment to radiotherapy; adjuvant treatments (aromatase inhibitors, adjuvant anthracycline regimens, tamoxifen); axillary clearance; axillary dissection plus sentinel node dissection; axillary radiotherapy; axillary sampling; combined chemotherapy plus tamoxifen; chemotherapy plus monoclonal antibody (trastuzumab); extensive surgery; high-dose chemotherapy; hormonal treatment; less extensive mastectomy; less than whole-breast radiotherapy plus breast-conserving surgery; multimodal treatment; ovarian ablation; primary chemotherapy; prolonged adjuvant combination chemotherapy; radiotherapy (after breast-conserving surgery, after mastectomy, plus tamoxifen after breast-conserving surgery, to the internal mammary chain, and to the ipsilateral supraclavicular fossa, and total nodal radiotherapy); sentinel node biopsy; and standard chemotherapy regimens.
Url:
PubMed: 21718560
PubMed Central: 3217212
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004759
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :004758
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003070
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :004491
Links to Exploration step
PMC:3217212Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Breast cancer (non-metastatic)</title>
<author><name sortKey="Stebbing, Justin" sort="Stebbing, Justin" uniqKey="Stebbing J" first="Justin" last="Stebbing">Justin Stebbing</name>
</author>
<author><name sortKey="Delaney, Geoff" sort="Delaney, Geoff" uniqKey="Delaney G" first="Geoff" last="Delaney">Geoff Delaney</name>
</author>
<author><name sortKey="Thompson, Alastair" sort="Thompson, Alastair" uniqKey="Thompson A" first="Alastair" last="Thompson">Alastair Thompson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21718560</idno>
<idno type="pmc">3217212</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217212</idno>
<idno type="RBID">PMC:3217212</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">004759</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004759</idno>
<idno type="wicri:Area/Pmc/Curation">004758</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004758</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003070</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003070</idno>
<idno type="wicri:Area/Ncbi/Merge">004491</idno>
<idno type="wicri:Area/Ncbi/Curation">004491</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Breast cancer (non-metastatic)</title>
<author><name sortKey="Stebbing, Justin" sort="Stebbing, Justin" uniqKey="Stebbing J" first="Justin" last="Stebbing">Justin Stebbing</name>
</author>
<author><name sortKey="Delaney, Geoff" sort="Delaney, Geoff" uniqKey="Delaney G" first="Geoff" last="Delaney">Geoff Delaney</name>
</author>
<author><name sortKey="Thompson, Alastair" sort="Thompson, Alastair" uniqKey="Thompson A" first="Alastair" last="Thompson">Alastair Thompson</name>
</author>
</analytic>
<series><title level="j">BMJ Clinical Evidence</title>
<idno type="eISSN">1752-8526</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>Breast cancer affects at least 1 in 10 women in the UK, but most present with primary operable disease, which has an 80% 5-year survival rate overall.</p>
</sec>
<sec><title>Methods and outcomes</title>
<p>We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions after breast-conserving surgery for ductal carcinoma in situ? What are the effects of treatments for primary operable breast cancer? What are the effects of interventions in locally advanced breast cancer (stage 3B)? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).</p>
</sec>
<sec><title>Results</title>
<p>We found 83 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.</p>
</sec>
<sec><title>Conclusions</title>
<p>In this systematic review we present information relating to the effectiveness and safety of the following interventions: adding chemotherapy (cyclophosphamide/methotrexate/fluorouracil and/or anthracycline and/or taxane-based regimens), or hormonal treatment to radiotherapy; adjuvant treatments (aromatase inhibitors, adjuvant anthracycline regimens, tamoxifen); axillary clearance; axillary dissection plus sentinel node dissection; axillary radiotherapy; axillary sampling; combined chemotherapy plus tamoxifen; chemotherapy plus monoclonal antibody (trastuzumab); extensive surgery; high-dose chemotherapy; hormonal treatment; less extensive mastectomy; less than whole-breast radiotherapy plus breast-conserving surgery; multimodal treatment; ovarian ablation; primary chemotherapy; prolonged adjuvant combination chemotherapy; radiotherapy (after breast-conserving surgery, after mastectomy, plus tamoxifen after breast-conserving surgery, to the internal mammary chain, and to the ipsilateral supraclavicular fossa, and total nodal radiotherapy); sentinel node biopsy; and standard chemotherapy regimens.</p>
</sec>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004491 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 004491 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:3217212 |texte= Breast cancer (non-metastatic) }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:21718560" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |