Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium
Identifieur interne : 003C28 ( Ncbi/Curation ); précédent : 003C27; suivant : 003C29Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium
Auteurs : Giorgia Jurisic ; Maria Iolyeva ; Steven T. Proulx ; Cornelia Halin ; Michael DetmarSource :
- Experimental Cell Research [ 0014-4827 ] ; 2010.
Abstract
The lymphatic vascular system plays an important role in inflammation and cancer progression, although the molecular mechanisms involved are poorly understood. As determined by comparative transcriptional profiling studies of
Url:
DOI: 10.1016/j.yexcr.2010.06.013
PubMed: 20599951
PubMed Central: 3398154
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002772
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002771
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003174
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003C28
Links to Exploration step
PMC:3398154Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium</title>
<author><name sortKey="Jurisic, Giorgia" sort="Jurisic, Giorgia" uniqKey="Jurisic G" first="Giorgia" last="Jurisic">Giorgia Jurisic</name>
</author>
<author><name sortKey="Iolyeva, Maria" sort="Iolyeva, Maria" uniqKey="Iolyeva M" first="Maria" last="Iolyeva">Maria Iolyeva</name>
</author>
<author><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T" last="Proulx">Steven T. Proulx</name>
</author>
<author><name sortKey="Halin, Cornelia" sort="Halin, Cornelia" uniqKey="Halin C" first="Cornelia" last="Halin">Cornelia Halin</name>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20599951</idno>
<idno type="pmc">3398154</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398154</idno>
<idno type="RBID">PMC:3398154</idno>
<idno type="doi">10.1016/j.yexcr.2010.06.013</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">002772</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002772</idno>
<idno type="wicri:Area/Pmc/Curation">002771</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002771</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003174</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003174</idno>
<idno type="wicri:Area/Ncbi/Merge">003C28</idno>
<idno type="wicri:Area/Ncbi/Curation">003C28</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium</title>
<author><name sortKey="Jurisic, Giorgia" sort="Jurisic, Giorgia" uniqKey="Jurisic G" first="Giorgia" last="Jurisic">Giorgia Jurisic</name>
</author>
<author><name sortKey="Iolyeva, Maria" sort="Iolyeva, Maria" uniqKey="Iolyeva M" first="Maria" last="Iolyeva">Maria Iolyeva</name>
</author>
<author><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T" last="Proulx">Steven T. Proulx</name>
</author>
<author><name sortKey="Halin, Cornelia" sort="Halin, Cornelia" uniqKey="Halin C" first="Cornelia" last="Halin">Cornelia Halin</name>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
</author>
</analytic>
<series><title level="j">Experimental Cell Research</title>
<idno type="ISSN">0014-4827</idno>
<idno type="eISSN">1090-2422</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">The lymphatic vascular system plays an important role in inflammation and cancer progression, although the molecular mechanisms involved are poorly understood. As determined by comparative transcriptional profiling studies of <italic>ex vivo</italic>
isolated mouse intestinal lymphatic endothelial cells versus blood vascular endothelial cells, thymus cell antigen 1 (Thy1, CD90) was expressed at much higher levels in lymphatic endothelial cells than in blood vascular endothelial cells. These findings were confirmed by quantitative PCR, and at the protein level by FACS and immunofluorescence analyses. Thy1 was also strongly expressed by tumor-associated lymphatic vessels, as evaluated in a B16 melanoma footpad model in mice. Blockade of Thy1 inhibited tumor cell adhesion to cultured mouse lymphatic endothelial cells. Importantly, treatment of human dermal microvascular endothelial cells with tumor necrosis factor or phorbol 12-myristate 13-acetate resulted in Thy1 upregulation in podoplanin-expressing lymphatic endothelial cells, but not in podoplanin-negative blood vascular endothelial cells. Moreover, adhesion of human polymorphonuclear and mononuclear leukocytes to human lymphatic endothelial cells was Thy1-dependent. Together, these results identify Thy1 as a novel lymphatic vessel expressed gene and suggest its potential role in the cell adhesion processes required for tumor progression and inflammation.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C28 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 003C28 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:3398154 |texte= Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:20599951" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |