HETEROGENEITY AND PLASTICITY OF LYMPHATIC ENDOTHELIAL CELLS
Identifieur interne : 003B26 ( Ncbi/Curation ); précédent : 003B25; suivant : 003B27HETEROGENEITY AND PLASTICITY OF LYMPHATIC ENDOTHELIAL CELLS
Auteurs : Sunju Lee ; Inho Choi ; Young-Kwon HongSource :
- Seminars in thrombosis and hemostasis [ 0094-6176 ] ; 2010.
Abstract
Endothelial cells are found in most organs and tissues in our body. Despite their apparent morphological and functional similarities, endothelial cells exhibit remarkable heterogeneity and plasticity. In a strict sense, no two endothelial cells are identical in terms of their biological, immunological, functional, metabolic, morphological and anatomical aspects. Their heterogeneity and plasticity are now known to be dependent upon and conferred by their microenvironments, arteriovenous-lymphatic cell identity, organ-specific vascular beds, fluid-dynamics, vessel sizes, anatomical locations, their physiological and pathological states and more. While abundant evidences are documented to demonstrate endothelial heterogeneity in the blood vascular system, studies of heterogeneity and plasticity of lymphatic endothelial cells are limited because of the short history of the lymphatic research. Nonetheless, a growing body of exciting begin to discover the heterogenic nature of lymphatic endothelial cells, comparable to that of blood vascular endothelial cells. In this article, we discuss heterogeneity and plasticity of lymphatic endothelial cells.
Url:
DOI: 10.1055/s-0030-1253457
PubMed: 20490985
PubMed Central: 3461948
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