Efficacy of ivermectin for control of microfilaremia recurring after treatment with diethylcarbamazine. I. Clinical and parasitologic observations.
Identifieur interne : 002F33 ( Ncbi/Curation ); précédent : 002F32; suivant : 002F34Efficacy of ivermectin for control of microfilaremia recurring after treatment with diethylcarbamazine. I. Clinical and parasitologic observations.
Auteurs : H J Zheng [République populaire de Chine] ; W F Piessens ; Z H Tao ; W F Cheng ; S H Wang ; S H Cheng ; Y M Ye ; L F Luo ; X R Chen ; G B GanSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1991.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (effets indésirables), Diéthylcarbamazine (pharmacocinétique), Diéthylcarbamazine (usage thérapeutique), Femelle, Filariose lymphatique (parasitologie), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Humains, Ivermectine (administration et posologie), Ivermectine (effets indésirables), Ivermectine (usage thérapeutique), Microfilaria (isolement et purification), Mâle, Méthode en double aveugle, Récidive, Wuchereria bancrofti (isolement et purification).
- MESH :
- administration et posologie : Diéthylcarbamazine, Ivermectine.
- effets indésirables : Diéthylcarbamazine, Ivermectine.
- isolement et purification : Microfilaria, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- pharmacocinétique : Diéthylcarbamazine.
- sang : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Ivermectine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Mâle, Méthode en double aveugle, Récidive.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (adverse effects), Diethylcarbamazine (pharmacokinetics), Diethylcarbamazine (therapeutic use), Double-Blind Method, Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Female, Humans, Ivermectin (administration & dosage), Ivermectin (adverse effects), Ivermectin (therapeutic use), Male, Microfilariae (isolation & purification), Middle Aged, Recurrence, Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , administration & dosage : Diethylcarbamazine, Ivermectin.
- chemical , adverse effects : Diethylcarbamazine, Ivermectin.
- chemical , pharmacokinetics : Diethylcarbamazine.
- chemical , therapeutic use : Diethylcarbamazine, Ivermectin.
- blood : Elephantiasis, Filarial.
- drug therapy : Elephantiasis, Filarial.
- isolation & purification : Microfilariae, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Double-Blind Method, Female, Humans, Male, Middle Aged, Recurrence.
Abstract
We compared the efficacy of a single dose of ivermectin with that of a standard course of diethylcarbamazine (DEC) for the control of microfilaremia in 60 patients with bancroftian filariasis who had developed recurrent microfilaremia after each of three or more prior treatments with DEC. The study was done as a randomized, double-blind trial. Complete, but in some cases, transient clearance of microfilaremia was observed in both treatment groups. At one year, recurrent microfilaremia was present in seven patients treated with ivermectin and in five treated with DEC. Pretreatment levels of microfilaremia were significantly higher in patients who relapsed within one year after treatment than in those who remained amicrofilaremic. Side effects with both treatments were common, but mild. Febrile reactions were more frequent in the ivermectin group; localized reactions consistent with a flare-up of acute filarial disease occurred mostly in the DEC group. We conclude that ivermectin is an effective and practical alternative to DEC for treatment of recurrent microfilaremia due to bancroftian filariasis.
PubMed: 1877711
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Clinical and parasitologic observations.</title><author><name sortKey="Zheng, H J" sort="Zheng, H J" uniqKey="Zheng H" first="H J" last="Zheng">H J Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Guizhou Provincial Institute of Parasitic Diseases, Guiyang, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guizhou Provincial Institute of Parasitic Diseases, Guiyang</wicri:regionArea><wicri:noRegion>Guiyang</wicri:noRegion></affiliation></author><author><name sortKey="Piessens, W F" sort="Piessens, W F" uniqKey="Piessens W" first="W F" last="Piessens">W F Piessens</name></author><author><name sortKey="Tao, Z H" sort="Tao, Z H" uniqKey="Tao Z" first="Z H" last="Tao">Z H Tao</name></author><author><name sortKey="Cheng, W F" sort="Cheng, W F" uniqKey="Cheng W" first="W F" last="Cheng">W F Cheng</name></author><author><name sortKey="Wang, S H" sort="Wang, S H" uniqKey="Wang S" first="S H" last="Wang">S H Wang</name></author><author><name sortKey="Cheng, S H" sort="Cheng, S H" uniqKey="Cheng S" first="S H" last="Cheng">S H Cheng</name></author><author><name sortKey="Ye, Y M" sort="Ye, Y M" uniqKey="Ye Y" first="Y M" last="Ye">Y M Ye</name></author><author><name sortKey="Luo, L F" sort="Luo, L F" uniqKey="Luo L" first="L F" last="Luo">L F Luo</name></author><author><name sortKey="Chen, X R" sort="Chen, X R" uniqKey="Chen X" first="X R" last="Chen">X R Chen</name></author><author><name sortKey="Gan, G B" sort="Gan, G B" uniqKey="Gan G" first="G B" last="Gan">G B Gan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1877711</idno><idno type="pmid">1877711</idno><idno type="wicri:Area/PubMed/Corpus">005B08</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005B08</idno><idno type="wicri:Area/PubMed/Curation">005B08</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005B08</idno><idno type="wicri:Area/PubMed/Checkpoint">005B08</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005B08</idno><idno type="wicri:Area/Ncbi/Merge">002F33</idno><idno type="wicri:Area/Ncbi/Curation">002F33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of ivermectin for control of microfilaremia recurring after treatment with diethylcarbamazine. I. Clinical and parasitologic observations.</title><author><name sortKey="Zheng, H J" sort="Zheng, H J" uniqKey="Zheng H" first="H J" last="Zheng">H J Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Guizhou Provincial Institute of Parasitic Diseases, Guiyang, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guizhou Provincial Institute of Parasitic Diseases, Guiyang</wicri:regionArea><wicri:noRegion>Guiyang</wicri:noRegion></affiliation></author><author><name sortKey="Piessens, W F" sort="Piessens, W F" uniqKey="Piessens W" first="W F" last="Piessens">W F Piessens</name></author><author><name sortKey="Tao, Z H" sort="Tao, Z H" uniqKey="Tao Z" first="Z H" last="Tao">Z H Tao</name></author><author><name sortKey="Cheng, W F" sort="Cheng, W F" uniqKey="Cheng W" first="W F" last="Cheng">W F Cheng</name></author><author><name sortKey="Wang, S H" sort="Wang, S H" uniqKey="Wang S" first="S H" last="Wang">S H Wang</name></author><author><name sortKey="Cheng, S H" sort="Cheng, S H" uniqKey="Cheng S" first="S H" last="Cheng">S H Cheng</name></author><author><name sortKey="Ye, Y M" sort="Ye, Y M" uniqKey="Ye Y" first="Y M" last="Ye">Y M Ye</name></author><author><name sortKey="Luo, L F" sort="Luo, L F" uniqKey="Luo L" first="L F" last="Luo">L F Luo</name></author><author><name sortKey="Chen, X R" sort="Chen, X R" uniqKey="Chen X" first="X R" last="Chen">X R Chen</name></author><author><name sortKey="Gan, G B" sort="Gan, G B" uniqKey="Gan G" first="G B" last="Gan">G B Gan</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Diethylcarbamazine (administration & dosage)</term><term>Diethylcarbamazine (adverse effects)</term><term>Diethylcarbamazine (pharmacokinetics)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Double-Blind Method</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Humans</term><term>Ivermectin (administration & dosage)</term><term>Ivermectin (adverse effects)</term><term>Ivermectin (therapeutic use)</term><term>Male</term><term>Microfilariae (isolation & purification)</term><term>Middle Aged</term><term>Recurrence</term><term>Wuchereria bancrofti (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Diéthylcarbamazine (administration et posologie)</term><term>Diéthylcarbamazine (effets indésirables)</term><term>Diéthylcarbamazine (pharmacocinétique)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (sang)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Ivermectine (administration et posologie)</term><term>Ivermectine (effets indésirables)</term><term>Ivermectine (usage thérapeutique)</term><term>Microfilaria (isolement et purification)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Récidive</term><term>Wuchereria bancrofti (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Diethylcarbamazine</term><term>Ivermectin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Diethylcarbamazine</term><term>Ivermectin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Ivermectine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Ivermectine</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Microfilaria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Ivermectine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Recurrence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Récidive</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared the efficacy of a single dose of ivermectin with that of a standard course of diethylcarbamazine (DEC) for the control of microfilaremia in 60 patients with bancroftian filariasis who had developed recurrent microfilaremia after each of three or more prior treatments with DEC. The study was done as a randomized, double-blind trial. Complete, but in some cases, transient clearance of microfilaremia was observed in both treatment groups. At one year, recurrent microfilaremia was present in seven patients treated with ivermectin and in five treated with DEC. Pretreatment levels of microfilaremia were significantly higher in patients who relapsed within one year after treatment than in those who remained amicrofilaremic. Side effects with both treatments were common, but mild. Febrile reactions were more frequent in the ivermectin group; localized reactions consistent with a flare-up of acute filarial disease occurred mostly in the DEC group. We conclude that ivermectin is an effective and practical alternative to DEC for treatment of recurrent microfilaremia due to bancroftian filariasis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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