The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development
Identifieur interne : 002C39 ( Ncbi/Curation ); précédent : 002C38; suivant : 002C40The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development
Auteurs : Philip J. Gage [États-Unis] ; Min Qian [États-Unis] ; Dianqing Wu [États-Unis] ; Kevin I. Rosenberg [États-Unis]Source :
- Developmental biology [ 0012-1606 ] ; 2008.
Abstract
Local control of cell signaling activity and integration of inputs from multiple signaling pathways are central for normal development but the underlying mechanisms remain poorly understood. Here we show that
Url:
DOI: 10.1016/j.ydbio.2008.02.030
PubMed: 18367164
PubMed Central: 2387126
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<author><name sortKey="Gage, Philip J" sort="Gage, Philip J" uniqKey="Gage P" first="Philip J." last="Gage">Philip J. Gage</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor, MI 48105</nlm:aff>
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<wicri:cityArea> Department of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
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<author><name sortKey="Qian, Min" sort="Qian, Min" uniqKey="Qian M" first="Min" last="Qian">Min Qian</name>
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<author><name sortKey="Wu, Dianqing" sort="Wu, Dianqing" uniqKey="Wu D" first="Dianqing" last="Wu">Dianqing Wu</name>
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<wicri:cityArea> Department of Pharmacology, Yale University School of Medicine, New Haven</wicri:cityArea>
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<author><name sortKey="Rosenberg, Kevin I" sort="Rosenberg, Kevin I" uniqKey="Rosenberg K" first="Kevin I." last="Rosenberg">Kevin I. Rosenberg</name>
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<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor, MI 48105</nlm:aff>
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<wicri:cityArea> Department of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
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<wicri:cityArea> Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
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<author><name sortKey="Qian, Min" sort="Qian, Min" uniqKey="Qian M" first="Min" last="Qian">Min Qian</name>
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<wicri:cityArea> Department of Pharmacology, Yale University School of Medicine, New Haven</wicri:cityArea>
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<author><name sortKey="Rosenberg, Kevin I" sort="Rosenberg, Kevin I" uniqKey="Rosenberg K" first="Kevin I." last="Rosenberg">Kevin I. Rosenberg</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
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<wicri:cityArea> Department of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
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<series><title level="j">Developmental biology</title>
<idno type="ISSN">0012-1606</idno>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P3">Local control of cell signaling activity and integration of inputs from multiple signaling pathways are central for normal development but the underlying mechanisms remain poorly understood. Here we show that <italic>Dkk2</italic>
, encoding an antagonist of canonical Wnt signaling, is an essential downstream target of the PITX2 homeodomain transcription factor in neural crest during eye development. Canonical Wnt signaling is ectopically activated in central ocular surface ectoderm and underlying mesenchyme in <italic>Pitx2</italic>
and <italic>Dkk2</italic>
deficient mice. General ocular surface ectoderm identity is maintained during development in <italic>Dkk2</italic>
deficient mice but peripheral fates, including conjunctival goblet cells and eyelash follicles, are ectopically permitted within more central structures and eyelids are hypomorphic. Loss of DKK2 results in ectopic blood vessels within the periocular mesenchyme and PITX2 expression remains persistently high, providing evidence for a negative feedback loop. Collectively, these data suggest that activation of <italic>Dkk2</italic>
by PITX2 provides a mechanism to locally suppress canonical Wnt signaling activity during eye development, a paradigm that may be a model for achieving local or transient inhibition of pathway activity elsewhere during embryogenesis. We further propose a model placing PITX2 as an essential integration node between retinoic acid and canonical Wnt signaling during eye development.</p>
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