Effect of diethylcarbamazine on HIV load, CD4%, and CD4/CD8 ratio in HIV-infected adult Tanzanians with or without lymphatic filariasis: randomized double-blind and placebo-controlled cross-over trial.
Identifieur interne : 002892 ( Ncbi/Curation ); précédent : 002891; suivant : 002893Effect of diethylcarbamazine on HIV load, CD4%, and CD4/CD8 ratio in HIV-infected adult Tanzanians with or without lymphatic filariasis: randomized double-blind and placebo-controlled cross-over trial.
Auteurs : Nina O. Nielsen [Danemark] ; Paul E. Simonsen ; Peter Dalgaard ; Henrik Krarup ; Pascal Magnussen ; Stephen Magesa ; Henrik FriisSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte, Antihelminthiques (pharmacologie), Charge virale, Diéthylcarbamazine (pharmacologie), Filariose lymphatique (), Filariose lymphatique (traitement médicamenteux), Humains, Infections à VIH (), Infections à VIH (immunologie), Infections à VIH (virologie), Lymphocytes T CD4+ (), Lymphocytes T CD4+ (cytologie), Lymphocytes T CD8+ (), Lymphocytes T CD8+ (cytologie), Méthode en double aveugle, Placebo, Rapport CD4-CD8, Tanzanie, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Études croisées.
- MESH :
- cytologie : Lymphocytes T CD4+, Lymphocytes T CD8+.
- immunologie : Infections à VIH.
- pharmacologie : Antihelminthiques, Diéthylcarbamazine.
- traitement médicamenteux : Filariose lymphatique.
- virologie : Infections à VIH.
- Adulte, Charge virale, Filariose lymphatique, Humains, Infections à VIH, Lymphocytes T CD4+, Lymphocytes T CD8+, Méthode en double aveugle, Placebo, Rapport CD4-CD8, Tanzanie, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Études croisées.
English descriptors
- KwdEn :
- Adult, Anthelmintics (pharmacology), CD4-CD8 Ratio, CD4-Positive T-Lymphocytes (cytology), CD4-Positive T-Lymphocytes (drug effects), CD8-Positive T-Lymphocytes (cytology), CD8-Positive T-Lymphocytes (drug effects), Cross-Over Studies, Diethylcarbamazine (pharmacology), Double-Blind Method, Elephantiasis, Filarial (complications), Elephantiasis, Filarial (drug therapy), HIV Infections (complications), HIV Infections (immunology), HIV Infections (virology), HIV-1, Humans, Placebos, Tanzania, Viral Load.
- MESH :
- chemical , pharmacology : Anthelmintics, Diethylcarbamazine.
- geographic : Tanzania.
- complications : Elephantiasis, Filarial, HIV Infections.
- cytology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes.
- drug effects : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes.
- drug therapy : Elephantiasis, Filarial.
- immunology : HIV Infections.
- virology : HIV Infections.
- Adult, CD4-CD8 Ratio, Cross-Over Studies, Double-Blind Method, HIV-1, Humans, Placebos, Viral Load.
Abstract
We assessed the effect of anti-filarial treatment (diethylcarbamazine, DEC) on HIV load, CD4%, and CD4/CD8 ratio in HIV-positive individuals with and without infection with the filarial parasite Wuchereria bancrofti in a randomized, double-blind, placebo-controlled cross-over trial. The study was conducted in Tanga Region, Tanzania, in 2002 and involved 27 adults. A significant decrease in HIV load (54%) and an insignificant increase in CD4% were observed in the HIV-positive individuals with filarial co-infection at 12 weeks after treatment. HIV load and CD4% both increased, although not statistically significantly, in the HIV-positive individuals without filarial infection. The findings suggest that DEC affected HIV load through its effect on the filarial infection rather than through a direct (pharmacodynamic) effect on HIV. Global efforts to control lymphatic filariasis by annual mass treatment with DEC may have a beneficial effect on the HIV/AIDS epidemic in areas where HIV and lymphatic filariasis co-exist.
PubMed: 17827369
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pubmed:17827369Le document en format XML
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croisées</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the effect of anti-filarial treatment (diethylcarbamazine, DEC) on HIV load, CD4%, and CD4/CD8 ratio in HIV-positive individuals with and without infection with the filarial parasite Wuchereria bancrofti in a randomized, double-blind, placebo-controlled cross-over trial. The study was conducted in Tanga Region, Tanzania, in 2002 and involved 27 adults. A significant decrease in HIV load (54%) and an insignificant increase in CD4% were observed in the HIV-positive individuals with filarial co-infection at 12 weeks after treatment. HIV load and CD4% both increased, although not statistically significantly, in the HIV-positive individuals without filarial infection. The findings suggest that DEC affected HIV load through its effect on the filarial infection rather than through a direct (pharmacodynamic) effect on HIV. Global efforts to control lymphatic filariasis by annual mass treatment with DEC may have a beneficial effect on the HIV/AIDS epidemic in areas where HIV and lymphatic filariasis co-exist.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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